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Dr

Christian Nefzger

Email: 
Phone: 
+61 7 334 62053

Overview

Background

Kindly visit my laboratory's webpage for more information

Availability

Dr Christian Nefzger is:
Available for supervision

Qualifications

  • Doctor of Philosophy, Monash University

Research impacts

Kindly visit my laboratory's webpage for more information

Works

Search Professor Christian Nefzger’s works on UQ eSpace

53 works between 2011 and 2024

1 - 20 of 53 works

2024

Journal Article

The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening

Patrick, Ralph, Naval-Sanchez, Marina, Deshpande, Nikita, Huang, Yifei, Zhang, Jingyu, Chen, Xiaoli, Yang, Ying, Tiwari, Kanupriya, Esmaeili, Mohammadhossein, Tran, Minh, Mohamed, Amin R., Wang, Binxu, Xia, Di, Ma, Jun, Bayliss, Jacqueline, Wong, Kahlia, Hun, Michael L., Sun, Xuan, Cao, Benjamin, Cottle, Denny L., Catterall, Tara, Barzilai-Tutsch, Hila, Troskie, Robin-Lee, Chen, Zhian, Wise, Andrea F., Saini, Sheetal, Soe, Ye Mon, Kumari, Snehlata, Sweet, Matthew J. ... Nefzger, Christian M. (2024). The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening. Cell Metabolism, 36 (8), 1858-1881.e23. doi: 10.1016/j.cmet.2024.06.006

The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening

2024

Journal Article

Superior induced pluripotent stem cell generation through Phactr-3-driven mechano-modulation of both early and late phases of cell reprogramming

Chowdhury, Mohammad Mahfuz, Zimmerman, Samuel, Leeson, Hannah, Nefzger, Christian Maximilian, Mar, Jessica Cara, Laslett, Andrew, Polo, Jose Maria, Wolvetang, Ernst and Cooper-White, Justin (2024). Superior induced pluripotent stem cell generation through Phactr-3-driven mechano-modulation of both early and late phases of cell reprogramming. Biomaterials Research, 28 0025, 0025. doi: 10.34133/bmr.0025

Superior induced pluripotent stem cell generation through Phactr-3-driven mechano-modulation of both early and late phases of cell reprogramming

2024

Journal Article

Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm

Wu, Zhixuan, Shen, Sophie, Mizikovsky, Dalia, Cao, Yuanzhao, Naval-Sanchez, Marina, Tan, Siew Zhuan, Alvarez, Yanina D., Sun, Yuliangzi, Chen, Xiaoli, Zhao, Qiongyi, Kim, Daniel, Yang, Pengyi, Hill, Timothy A., Jones, Alun, Fairlie, David P., Pébay, Alice, Hewitt, Alex W., Tam, Patrick P.L., White, Melanie D., Nefzger, Christian M. and Palpant, Nathan J. (2024). Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm. Developmental Cell, 59 (6), 705-722.e8. doi: 10.1016/j.devcel.2024.01.019

Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm

2023

Journal Article

Transient naive reprogramming corrects hiPS cells functionally and epigenetically

Buckberry, Sam, Liu, Xiaodong, Poppe, Daniel, Tan, Jia Ping, Sun, Guizhi, Chen, Joseph, Nguyen, Trung Viet, de Mendoza, Alex, Pflueger, Jahnvi, Frazer, Thomas, Vargas-Landín, Dulce B., Paynter, Jacob M., Smits, Nathan, Liu, Ning, Ouyang, John F., Rossello, Fernando J., Chy, Hun S., Rackham, Owen J. L., Laslett, Andrew L., Breen, James, Faulkner, Geoffrey J., Nefzger, Christian M., Polo, Jose M. and Lister, Ryan (2023). Transient naive reprogramming corrects hiPS cells functionally and epigenetically. Nature, 620 (7975), 863-872. doi: 10.1038/s41586-023-06424-7

Transient naive reprogramming corrects hiPS cells functionally and epigenetically

2023

Journal Article

Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release

Labzin, Larisa I., Chew, Keng Yih, Eschke, Kathrin, Wang, Xiaohui, Esposito, Tyron, Stocks, Claudia J., Rae, James, Patrick, Ralph, Mostafavi, Helen, Hill, Brittany, Yordanov, Teodor E., Holley, Caroline L., Emming, Stefan, Fritzlar, Svenja, Mordant, Francesca L., Steinfort, Daniel P., Subbarao, Kanta, Nefzger, Christian M., Lagendijk, Anne K., Gordon, Emma J., Parton, Robert G., Short, Kirsty R., Londrigan, Sarah L. and Schroder, Kate (2023). Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release. Science Signaling, 16 (782) eabq1366, eabq1366. doi: 10.1126/scisignal.abq1366

Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release

2023

Journal Article

High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production

Heazlewood, Shen Y., Ahmad, Tanveer, Cao, Benjamin, Cao, Huimin, Domingues, Melanie, Sun, Xuan, Heazlewood, Chad K., Li, Songhui, Williams, Brenda, Fulton, Madeline, White, Jacinta F., Nebl, Tom, Nefzger, Christian M., Polo, Jose M., Kile, Benjamin T., Kraus, Felix, Ryan, Michael T., Sun, Yu B., Choong, Peter F. M., Ellis, Sarah L., Anko, Minna-Liisa and Nilsson, Susan K. (2023). High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production. Nature Communications, 14 (1) 2099, 1-18. doi: 10.1038/s41467-023-37780-7

High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production

2022

Journal Article

Retrotransposon instability dominates the acquired mutation landscape of mouse induced pluripotent stem cells

Gerdes, Patricia, Lim, Sue Mei, Ewing, Adam D., Larcombe, Michael R., Chan, Dorothy, Sanchez-Luque, Francisco J., Walker, Lucinda, Carleton, Alexander L., James, Cini, Knaupp, Anja S., Carreira, Patricia E., Nefzger, Christian M., Lister, Ryan, Richardson, Sandra R., Polo, Jose M. and Faulkner, Geoffrey J. (2022). Retrotransposon instability dominates the acquired mutation landscape of mouse induced pluripotent stem cells. Nature Communications, 13 (1) 7470, 1-18. doi: 10.1038/s41467-022-35180-x

Retrotransposon instability dominates the acquired mutation landscape of mouse induced pluripotent stem cells

Featured

2022

Journal Article

Organization of gene programs revealed by unsupervised analysis of diverse gene–trait associations

Mizikovsky, Dalia, Naval Sanchez, Marina, Nefzger, Christian M, Cuellar Partida, Gabriel and Palpant, Nathan J (2022). Organization of gene programs revealed by unsupervised analysis of diverse gene–trait associations. Nucleic Acids Research, 50 (15) e87, 1-12. doi: 10.1093/nar/gkac413

Organization of gene programs revealed by unsupervised analysis of diverse gene–trait associations

2022

Journal Article

Benchmarking of ATAC Sequencing Data From BGI’s Low-Cost DNBSEQ-G400 Instrument for Identification of Open and Occupied Chromatin Regions

Naval-Sanchez, Marina, Deshpande, Nikita, Tran, Minh, Zhang, Jingyu, Alhomrani, Majid, Alsanie, Walaa, Nguyen, Quan and Nefzger, Christian M. (2022). Benchmarking of ATAC Sequencing Data From BGI’s Low-Cost DNBSEQ-G400 Instrument for Identification of Open and Occupied Chromatin Regions. Frontiers in Molecular Biosciences, 9 900323, 1-15. doi: 10.3389/fmolb.2022.900323

Benchmarking of ATAC Sequencing Data From BGI’s Low-Cost DNBSEQ-G400 Instrument for Identification of Open and Occupied Chromatin Regions

2022

Journal Article

Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential

Nefzger, Christian M., Jardé, Thierry, Srivastava, Akanksha, Schroeder, Jan, Rossello, Fernando J., Horvay, Katja, Prasko, Mirsada, Paynter, Jacob M., Chen, Joseph, Weng, Chen-Fang, Sun, Yu B. Y., Liu, Xiaodong, Chan, Eva, Deshpande, Nikita, Chen, Xiaoli, Li, Y. Jinhua, Pflueger, Jahnvi, Engel, Rebekah M., Knaupp, Anja S., Tsyganov, Kirill, Nilsson, Susan K., Lister, Ryan, Rackham, Owen J. L., Abud, Helen E. and Polo, Jose M. (2022). Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential. npj Regenerative Medicine, 7 (1) 31, 1-8. doi: 10.1038/s41536-022-00226-7

Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential

2022

Journal Article

Temporal perturbation of histone deacetylase activity reveals a requirement for HDAC1–3 in mesendoderm cell differentiation

Sinniah, Enakshi, Wu, Zhixuan, Shen, Sophie, Naval-Sanchez, Marina, Chen, Xiaoli, Lim, Junxian, Helfer, Abbigail, Iyer, Abishek, Tng, Jiahui, Lucke, Andrew J., Reid, Robert C., Redd, Meredith A., Nefzger, Christian M., Fairlie, David P. and Palpant, Nathan J. (2022). Temporal perturbation of histone deacetylase activity reveals a requirement for HDAC1–3 in mesendoderm cell differentiation. Cell Reports, 39 (7) 110818, 1-21. doi: 10.1016/j.celrep.2022.110818

Temporal perturbation of histone deacetylase activity reveals a requirement for HDAC1–3 in mesendoderm cell differentiation

2022

Conference Publication

Softer, faster, better! - Substrate mechanics drives superior somatic cell reprogramming outcomes

Cooper-White, Justin, Chowdhury, Mahfuz, Wolvetang, Ernst, Zimmerman, Samuel, Mar, Jessica, Polo, Jose, Laslett, Andrew and Nefzger, Christian (2022). Softer, faster, better! - Substrate mechanics drives superior somatic cell reprogramming outcomes. TERMIS 6th World Congress, Maastricht, Netherlands, 15-19 November 2021. New Rochelle, NY United States: Mary Ann Liebert.

Softer, faster, better! - Substrate mechanics drives superior somatic cell reprogramming outcomes

2022

Journal Article

BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation

Keniry, Andrew, Jansz, Natasha, Gearing, Linden J., Wanigasuriya, Iromi, Chen, Joseph, Nefzger, Christian M., Hickey, Peter F., Gouil, Quentin, Liu, Joy, Breslin, Kelsey A., Iminitoff, Megan, Beck, Tamara, Tapia del Fierro, Andres, Whitehead, Lachlan, Jarratt, Andrew, Kinkel, Sarah A., Taberlay, Phillippa C., Willson, Tracy, Pakusch, Miha, Ritchie, Matthew E., Hilton, Douglas J., Polo, Jose M. and Blewitt, Marnie E. (2022). BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation. Nature Communications, 13 (1) 1658, 1658. doi: 10.1038/s41467-022-29333-1

BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation

2022

Journal Article

Breaking constraint of mammalian axial formulae

Hauswirth, Gabriel M., Garside, Victoria C., Wong, Lisa S. F., Bildsoe, Heidi, Manent, Jan, Chang, Yi-Cheng, Nefzger, Christian M., Firas, Jaber, Chen, Joseph, Rossello, Fernando J., Polo, Jose M. and McGlinn, Edwina (2022). Breaking constraint of mammalian axial formulae. Nature Communications, 13 (1) 243, 1-12. doi: 10.1038/s41467-021-27335-z

Breaking constraint of mammalian axial formulae

2021

Journal Article

Bone marrow regulatory T cells are a unique population, supported by niche-specific cytokines and plasmacytoid dendritic cells, and required for chronic graft-versus-host disease control

Nicholls, Jemma, Cao, Benjamin, Le Texier, Laetitia, Xiong, Laura Yan, Hunter, Christopher R., Llanes, Genesis, Aguliar, Ethan G., Schroder, Wayne A., Phipps, Simon, Lynch, Jason P., Cao, Huimin, Heazlewood, Shen Y., Williams, Brenda, Clouston, Andrew D., Nefzger, Christian M., Polo, Jose M., Nilsson, Susan K., Blazar, Bruce R. and MacDonald, Kelli P. A. (2021). Bone marrow regulatory T cells are a unique population, supported by niche-specific cytokines and plasmacytoid dendritic cells, and required for chronic graft-versus-host disease control. Frontiers in Cell and Developmental Biology, 9 737880, 737880. doi: 10.3389/fcell.2021.737880

Bone marrow regulatory T cells are a unique population, supported by niche-specific cytokines and plasmacytoid dendritic cells, and required for chronic graft-versus-host disease control

2021

Journal Article

Interplay between the EMT transcription factors ZEB1 and ZEB2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity

Wang, Jueqiong, Farkas, Carlos, Benyoucef, Aissa, Carmichael, Catherine, Haigh, Katharina, Wong, Nick, Huylebroeck, Danny, Stemmler, Marc P., Brabletz, Simone, Brabletz, Thomas, Nefzger, Christian M., Goossens, Steven, Berx, Geert, Polo, Jose M. and Haigh, Jody J. (2021). Interplay between the EMT transcription factors ZEB1 and ZEB2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity. PLoS Biology, 19 (9) e3001394, 1-33. doi: 10.1371/journal.pbio.3001394

Interplay between the EMT transcription factors ZEB1 and ZEB2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity

2021

Journal Article

Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells

Sun, Xuan, Cao, Benjamin, Naval-Sanchez, Marina, Pham, Tony, Sun, Yu Bo Yang, Williams, Brenda, Heazlewood, Shen Y, Deshpande, Nikita, Li, Jinhua, Kraus, Felix, Rae, James, Nguyen, Quan, Yari, Hamed, Schröder, Jan, Heazlewood, Chad K, Fulton, Madeline, Hatwell-Humble, Jessica, Das Gupta, Kaustav, Kapetanovic, Ronan, Chen, Xiaoli, Sweet, Matthew J, Parton, Robert G, Ryan, Michael T, Polo, Jose M, Nefzger, Christian M and Nilsson, Susan K (2021). Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells. Nature Communications, 12 (1) 2665, 1-17. doi: 10.1038/s41467-021-22863-0

Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells

2020

Journal Article

TINC- A Method to Dissect Regulatory Complexes at Single-Locus Resolution- Reveals an Extensive Protein Complex at the Nanog Promoter

Knaupp, Anja S, Mohenska, Monika, Larcombe, Michael R, Ford, Ethan, Lim, Sue Mei, Wong, Kayla, Chen, Joseph, Firas, Jaber, Huang, Cheng, Liu, Xiaodong, Nguyen, Trung, Sun, Yu B Y, Holmes, Melissa L, Tripathi, Pratibha, Pflueger, Jahnvi, Rossello, Fernando J, Schröder, Jan, Davidson, Kathryn C, Nefzger, Christian M, Das, Partha P, Haigh, Jody J, Lister, Ryan, Schittenhelm, Ralf B and Polo, Jose M (2020). TINC- A Method to Dissect Regulatory Complexes at Single-Locus Resolution- Reveals an Extensive Protein Complex at the Nanog Promoter. Stem Cell Reports, 15 (6), 1246-1259. doi: 10.1016/j.stemcr.2020.11.005

TINC- A Method to Dissect Regulatory Complexes at Single-Locus Resolution- Reveals an Extensive Protein Complex at the Nanog Promoter

2020

Journal Article

Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium

Jardé, Thierry, Chan, Wing Hei, Rossello, Fernando J., Kaur Kahlon, Tanvir, Theocharous, Mandy, Kurian Arackal, Teni, Flores, Tracey, Giraud, Mégane, Richards, Elizabeth, Chan, Eva, Kerr, Genevieve, Engel, Rebekah M., Prasko, Mirsada, Donoghue, Jacqueline F., Abe, Shin-ichi, Phesse, Toby J., Nefzger, Christian M., McMurrick, Paul J., Powell, David R., Daly, Roger J., Polo, Jose M. and Abud, Helen E. (2020). Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium. Cell Stem Cell, 27 (4), 646-662.e7. doi: 10.1016/j.stem.2020.06.021

Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium

2020

Journal Article

Reprogramming roadmap reveals route to human induced trophoblast stem cells

Liu, Xiaodong, Ouyang, John F., Rossello, Fernando J., Tan, Jia Ping, Davidson, Kathryn C., Valdes, Daniela S., Schröder, Jan, Sun, Yu B. Y., Chen, Joseph, Knaupp, Anja S., Sun, Guizhi, Chy, Hun S., Huang, Ziyi, Pflueger, Jahnvi, Firas, Jaber, Tano, Vincent, Buckberry, Sam, Paynter, Jacob M., Larcombe, Michael R., Poppe, Daniel, Choo, Xin Yi, O’Brien, Carmel M., Pastor, William A., Chen, Di, Leichter, Anna L., Naeem, Haroon, Tripathi, Pratibha, Das, Partha P., Grubman, Alexandra ... Polo, Jose M. (2020). Reprogramming roadmap reveals route to human induced trophoblast stem cells. Nature, 586 (7827), 101-107. doi: 10.1038/s41586-020-2734-6

Reprogramming roadmap reveals route to human induced trophoblast stem cells

Funding

Current funding

  • 2024
    Leveraging Spatial Transcriptomics to Study Liver ageing (Taif University administered Hevolution grant)
    Taif University
    Open grant
  • 2022 - 2024
    Reinforcing the cell identity network to improve the function of aged cells
    NHMRC IDEAS Grants
    Open grant
  • 2020 - 2024
    Investigation of genetic drivers of Autism in the Saudi population (Taif University internal scheme grant led by Taif University)
    Taif University
    Open grant

Past funding

  • 2022 - 2023
    Expanding The Scope Of Multimodal Single Cell Sequencing To Establishing A Gene Screening Platform
    Innovation Connections
    Open grant
  • 2021
    Gene screening platform
    Innovation Connections
    Open grant
  • 2020 - 2024
    Investigation of genetic drivers of Attention-deficit/hyperactivity disorder in the Saudi population (Taif University internal funding scheme led by Taif University)
    Taif University
    Open grant
  • 2020 - 2022
    Generation of human intestinal stem cells by direct reprogramming
    NHMRC Project Grant
    Open grant

Supervision

Availability

Dr Christian Nefzger is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Understanding and controlling the age-stage of somatic cells

    Principal Advisor

    Other advisors: Professor Di Yu

  • Doctor Philosophy

    Leveraging integrative multiomic data to enable controlled cell state transition

    Principal Advisor

    Other advisors: Professor Matt Sweet

  • Doctor Philosophy

    Network reinforcement to improve the function of aged cells

    Principal Advisor

  • Doctor Philosophy

    Deciphering the age-altered transcription factor network and its control over regenerative potential

    Principal Advisor

    Other advisors: Dr Quan Nguyen

Completed supervision

Media

Enquiries

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