Dr Angelo Keramidas
Dr

Angelo Keramidas

Email: 
Phone: 
+61 7 334 66362

Background

I am interested in ion channels in health and disease. Improved technologies for genetic screening is revealing an expanding catalogue of genetic variants to ion channels that give rise neurological disorders, such as epilespy syndromes, autism spectrum disorder and other neurodevelopmental disorders. My main research focus is on neurotransmitter-activated receptor ion channels that are found at neuronal synapses. These include GABA-A, glycine and glutamate (NMDA) receptors. I also work on other ion channesl such as voltage-gated sodium channels and synaptic receptors expressed in invertebrate nervous systems.

I am an expert at recording single ion channel, synaptic and conventional whole-cell currents for functional and pharmacological analyisis.

I collaborate with biophysicists, molecular biologists, geneticists, electrophysiologists and clinicians that specialise in genetic neurological disorders. I have active projects in collaboration with research groups in Australia, USA and Europe.

Availability

Dr Angelo Keramidas is:
Available for supervision

Fields of research

Neurosciences Zoology

Qualifications

  • Bachelor of Science, unknown
  • Doctor of Philosophy, unknown

Research impacts

I am collaborating with basic and clinical research groups that bring together a great diversity of research techniques with the common aim of developing personalised medicine for affected individuals with neurological disorders.

Search Professor Angelo Keramidas’s works on UQ eSpace

48 works between 1999 and 2024
All (48) Journal Article (45) Conference Publication (3)

21 - 40 of 48 works

2017

Journal Article

Structure-function analysis of the GlyR alpha 2 subunit autism mutation p.R323L reveals a gain-of-function

Zhang, Yan, Ho, Thi Nhu Thao, Harvey, Robert J., Lynch, Joseph W. and Keramidas, Angelo (2017). Structure-function analysis of the GlyR alpha 2 subunit autism mutation p.R323L reveals a gain-of-function. Frontiers in Molecular Neuroscience, 10 158, 158. doi: 10.3389/fnmol.2017.00158

Structure-function analysis of the GlyR alpha 2 subunit autism mutation p.R323L reveals a gain-of-function

2017

Journal Article

Probing the structural mechanism of partial agonism in glycine receptors using the fluorescent artificial amino acid, ANAP

Soh, Ming S., Estrada-Mondragon, Argel, Durisic, Nela, Keramidas, Angelo and Lynch, Joseph W. (2017). Probing the structural mechanism of partial agonism in glycine receptors using the fluorescent artificial amino acid, ANAP. ACS Chemical Biology, 12 (3), 805-813. doi: 10.1021/acschembio.6b00926

Probing the structural mechanism of partial agonism in glycine receptors using the fluorescent artificial amino acid, ANAP

2017

Journal Article

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

Chassagnon, Irene R., McCarthy, Claudia A., Chin, Yanni K.-Y., Pineda, Sandy S., Keramidas, Angelo, Mobli, Mehdi, Pham, Vi, De Silva, T. Michael, Lynch, Joseph W., Widdop, Robert E., Rash, Lachlan D. and King, Glenn F. (2017). Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a. Proceedings from the National Academy of Sciences of the United States of America, 114 (14), 3750-3755. doi: 10.1073/pnas.1614728114

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

2017

Journal Article

Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1

Inserra, Marco C., Isreal, Mathilde, Caldwell, Ashlee, Castro, Joel, Deuis, Jennifer R., Harrington, Andrea M., Keramidas, Angelo, Garcia-Caraballo, Sonia, Maddern, Jessica, Erickson, Andelain, Grundy, Luke, Rychkov, Grigori Y., Zimmerman, Katharina, Lewis, Richard J., Brierley, Stuart M. and Vetter, Irina (2017). Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1. Scientific Reports, 7 (1) 42810, 42810. doi: 10.1038/srep42810

Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1

2016

Journal Article

Ivermectin-activated, cation-permeable glycine receptors for the chemogenetic control of neuronal excitation

Islam, Robiul, Keramidas, Angelo, Xu, Li, Durisic, Nela, Sah, Pankaj and Lynch, Joseph W. (2016). Ivermectin-activated, cation-permeable glycine receptors for the chemogenetic control of neuronal excitation. ACS Chemical Neuroscience, 7 (12), 1647-1657. doi: 10.1021/acschemneuro.6b00168

Ivermectin-activated, cation-permeable glycine receptors for the chemogenetic control of neuronal excitation

2016

Journal Article

The free zinc concentration in the synaptic cleft of artificial glycinergic synapses rises to at least 1 µm

Zhang, Yan, Keramidas, Angelo and Lynch, Joseph W. (2016). The free zinc concentration in the synaptic cleft of artificial glycinergic synapses rises to at least 1 µm. Frontiers in Molecular Neuroscience, 9 (SEP2016) 88, 88. doi: 10.3389/fnmol.2016.00088

The free zinc concentration in the synaptic cleft of artificial glycinergic synapses rises to at least 1 µm

2016

Journal Article

Investigating the mechanism by which gain-of-function mutations to the a1 glycine receptor cause hyperekplexia

Zhang, Yan, Bode, Anna, Nguyen, Bindi, Angelo Keramidas and Lynch, Joseph W. (2016). Investigating the mechanism by which gain-of-function mutations to the a1 glycine receptor cause hyperekplexia. Journal of Biological Chemistry, 291 (29), 15332-15341. doi: 10.1074/jbc.M116.728592

Investigating the mechanism by which gain-of-function mutations to the a1 glycine receptor cause hyperekplexia

2015

Journal Article

Correlating structural and energetic changes in glycine receptor activation

Scott, Suzanne, Lynch, Joseph W and Keramidas, Angelo (2015). Correlating structural and energetic changes in glycine receptor activation. Journal of Biological Chemistry, 290 (9), 5621-5634. doi: 10.1074/jbc.M114.616573

Correlating structural and energetic changes in glycine receptor activation

2015

Journal Article

Zolpidem and eszopiclone prime α1β2γ2 GABAA receptors for longer duration of activity

Dixon, Christine L., Harrison, Neil L., Lynch, Joseph W. and Keramidas, Angelo (2015). Zolpidem and eszopiclone prime α1β2γ2 GABAA receptors for longer duration of activity. British Journal of Pharmacology, 172 (14), 3522-3536. doi: 10.1111/bph.13142

Zolpidem and eszopiclone prime α1β2γ2 GABAA receptors for longer duration of activity

2015

Journal Article

Functional reconstitution of glycinergic synapses incorporating defined glycine receptor subunit combinations

Zhang, Yan, Dixon, Christine L., Keramidas, Angelo and Lynch, Joseph W. (2015). Functional reconstitution of glycinergic synapses incorporating defined glycine receptor subunit combinations. Neuropharmacology, 89, 391-397. doi: 10.1016/j.neuropharm.2014.10.026

Functional reconstitution of glycinergic synapses incorporating defined glycine receptor subunit combinations

2014

Journal Article

GABAa receptor α and γ subunits shape synaptic currents via different mechanisms

Dixon, Christine, Sah, Pankaj, Lynch, Joseph W. and Keramidas, Angelo (2014). GABAa receptor α and γ subunits shape synaptic currents via different mechanisms. Journal of Biological Chemistry, 289 (9), 5399-5411. doi: 10.1074/jbc.M113.514695

GABAa receptor α and γ subunits shape synaptic currents via different mechanisms

2013

Journal Article

New hyperekplexia mutations provide insight into glycine receptor assembly, trafficking, and activation mechanisms

Bode, Anna, Wood, Sian-Elin, Mullins, Jonathan G. L., Keramidas, Angelo, Cushion, Thomas D., Thomas, Rhys H., Pickrell, William O., Drew, Cheney J. G., Masri, Amira, Jones, Elizabeth A., Vassallo, Grace, Born, Alfred P., Alehan, Fusun, Aharoni, Sharon, Bannasch, Gerald, Bartsch, Marius, Kara, Bulent, Krause, Amanda, Karam, Elie G., Matta, Stephanie, Jain, Vivek, Mandel, Hanna, Freilinger, Michael, Graham, Gail E., Hobson, Emma, Chatfield, Sue, Vincent-Delorme, Catherine, Rahme, Jubran E., Afawi, Zaid ... Lynch, Joseph W. (2013). New hyperekplexia mutations provide insight into glycine receptor assembly, trafficking, and activation mechanisms. Journal of Biological Chemistry, 288 (47), 33745-33759. doi: 10.1074/jbc.M113.509240

New hyperekplexia mutations provide insight into glycine receptor assembly, trafficking, and activation mechanisms

2013

Journal Article

Novel missense mutations in the glycine receptor β subunit gene (GLRB) in startle disease

James, Victoria M., Bode, Anna, Chung, Seo-Kyung, Gill, Jennifer L., Nielsen, Maartje, Cowan, Frances M., Vujic, Mihailo, Thomas, Rhys H., Rees, Mark I., Harvey, Kirsten, Keramidas, Angelo, Topf, Maya, Ginjaar, Ieke, Lynch, Joseph W. and Harvey, Robert J. (2013). Novel missense mutations in the glycine receptor β subunit gene (GLRB) in startle disease. Neurobiology of Disease, 52, 137-149. doi: 10.1016/j.nbd.2012.12.001

Novel missense mutations in the glycine receptor β subunit gene (GLRB) in startle disease

2012

Journal Article

An outline of desensitization in pentameric ligand-gated ion channel receptors

Keramidas, Angelo and Lynch, Joseph W. (2012). An outline of desensitization in pentameric ligand-gated ion channel receptors. Cellular and Molecular Life Sciences, 70 (7), 1241-1253. doi: 10.1007/s00018-012-1133-z

An outline of desensitization in pentameric ligand-gated ion channel receptors

2010

Journal Article

The activation mechanism of alpha(1)beta(2)gamma(2S) and alpha(3)beta(3)gamma(2S) GABA(A) receptors

Keramidas, Angelo and Harrison, Neil L. (2010). The activation mechanism of alpha(1)beta(2)gamma(2S) and alpha(3)beta(3)gamma(2S) GABA(A) receptors. Journal of General Physiology, 135 (1), 59-75. doi: 10.1085/jgp.200910317

The activation mechanism of alpha(1)beta(2)gamma(2S) and alpha(3)beta(3)gamma(2S) GABA(A) receptors

2008

Conference Publication

Agonist-dependent single channel current and Gating in alpha(4)beta(2)delta and alpha(1)beta(2)gamma(2S) GABA(A) receptors

Keramidas, Angelo and Harrison, Neil L. (2008). Agonist-dependent single channel current and Gating in alpha(4)beta(2)delta and alpha(1)beta(2)gamma(2S) GABA(A) receptors. New York, United States: Rockefeller University Press. doi: 10.1085/jgp.200709871

Agonist-dependent single channel current and Gating in alpha(4)beta(2)delta and alpha(1)beta(2)gamma(2S) GABA(A) receptors

2008

Journal Article

Taurine is a potent activator of extrasynaptic GABAA receptors in the thalamus

Jia, Fan, Yue, Minerva, Chandra, Dev, Keramidas, Angelo, Goldstein, Peter A., Homanics, Gregg E. and Harrison, Neil L. (2008). Taurine is a potent activator of extrasynaptic GABAA receptors in the thalamus. Journal of Neuroscience, 28 (1), 106-115. doi: 10.1523/JNEUROSCI.3996-07.2008

Taurine is a potent activator of extrasynaptic GABAA receptors in the thalamus

2006

Journal Article

The pre-M1 segment of the alpha 1 subunit is a transduction element in the activation of the GABA(A) receptor

Keramidas, Angelo, Kash, Thomas L. and Harrison, Neil L. (2006). The pre-M1 segment of the alpha 1 subunit is a transduction element in the activation of the GABA(A) receptor. The Journal of Physiology, 575 (1), 11-22. doi: 10.1113/jphysiol.2005.102756

The pre-M1 segment of the alpha 1 subunit is a transduction element in the activation of the GABA(A) receptor

2005

Journal Article

Identification of molluscan nicotinic acetylcholine receptor (nAChR) subunits involved in formation of cation- and anion-selective nAChRs

van Nierop, Pim, Keramidas, Angelo, Bertrand, Sonia, van Minnen, Jan, Gouwenberg, Yvonne, Bertrand, Daniel and Smit, August B. (2005). Identification of molluscan nicotinic acetylcholine receptor (nAChR) subunits involved in formation of cation- and anion-selective nAChRs. Journal of Neuroscience, 25 (46), 10617-10626. doi: 10.1523/JNEUROSCI.2015-05.2005

Identification of molluscan nicotinic acetylcholine receptor (nAChR) subunits involved in formation of cation- and anion-selective nAChRs

2004

Journal Article

Ligand-gated ion channels: Mechanisms underlying ion selectivity

Keramidas, Angelo, Moorhouse, Andrew J., Schofield, Peter R. and Barry, Peter H. (2004). Ligand-gated ion channels: Mechanisms underlying ion selectivity. Progress in Biophysics and Molecular Biology, 86 (2), 161-204. doi: 10.1016/j.pbiomolbio.2003.09.002

Ligand-gated ion channels: Mechanisms underlying ion selectivity

Current funding

  • 2023 - 2026
    Tuning the activating stimulus of voltage-gated sodium channels
    ARC Discovery Projects
    Open grant

Past funding

  • 2023 - 2024
    GluCI Project
    Vestaron Corporation
    Open grant
  • 2019 - 2022
    Regulation of glutamate receptor dynamics in mammalian central neurons
    ARC Discovery Projects
    Open grant
  • 2019 - 2022
    Investigating NMDA receptor-mediated pathological mechanisms underlying epilepsy and associated neurological disorders (NHMRC Project Grant led by University of the Sunshine Coast)
    University of the Sunshine Coast
    Open grant
  • 2015 - 2017
    Using artificial synapses to investigate the functional pathology underlying epilepsy
    NHMRC Project Grant
    Open grant
  • 2012 - 2014
    Understanding the mechanisms of GABA type-A receptor activation and drug modulation
    ARC Discovery Projects
    Open grant

Availability

Dr Angelo Keramidas is:
Available for supervision

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Available projects

  • GABA-A and glycine receptor variants in epilepsy and autism

    New gene variants identified by our clinical collaborators to receptors that mediate neuronal inhibition. These variants lead to receptor functional deficits that manifest as neurological syndromes in young affected individuals.

    We aim to characterise the functional deficists in these receptors and explore personalised treatment options that are tailored to each receptor variant.

  • Glutamate (NMDA) receptors in develpmental delay

    Genetic variants to glutamate receptors have been discovered by our clinical geneticists. We aim the understand how these variants lead to developmental delay and co-morbid disorders in affected individuals and explore pharmacotherapies that correct the functional deficits in these important receptors.

  • Tuning the activating stimulus of voltage-gated sodium channels

    This project will use natural and modified peptides that are derived from venoms of different species, such as spiders and ants to probe and manipulate the functional properties of voltage-gated ion channels, which are critically important to the function of the nervous system.

    You will learn patch-clamp electrophysiology (whole-cell and single channels) and how to isolate, synthesise and determine the structure of venom peptides and their mechanisms of action at ion channels.

Supervision history

Current supervision

Completed supervision

Enquiries

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