Dr Jennifer Deuis
Dr

Jennifer Deuis

Email: 
Phone: 
+61 7 334 62366

Background

My main research focus has been applying venom peptide pharmacology to pain pathway characterisation. This approach has led to the identification of novel pain mechanisms underlying the development of chemotherapy-induced pain, ciguatera, and burn-induced pain. In an addition, I have identified and characterised over 20 novel bioactive peptides, which includes a novel class of Nav1.7 inhibitors that is currently undergoing pre-clinical development as analgesics, and a novel class of stinging nettle toxins that act on a previously unidentified Nav1.7 interacting protein named TMEM233.

Availability

Dr Jennifer Deuis is:
Available for supervision

Qualifications

  • Doctor of Philosophy, The University of Queensland

Search Professor Jennifer Deuis’s works on UQ eSpace

75 works between 2013 and 2024
All (75) Journal Article (70) Book Chapter (2) Conference Publication (2) Other Outputs (1)

1 - 20 of 75 works

2024

Journal Article

A venom peptide-induced NaV channel modulation mechanism involving the interplay between fixed channel charges and ionic gradients

Thapa, Ashvriya, Beh, Jia Hao, Robinson, Samuel D., Deuis, Jennifer R., Tran, Hue, Vetter, Irina and Keramidas, Angelo (2024). A venom peptide-induced NaV channel modulation mechanism involving the interplay between fixed channel charges and ionic gradients. Journal of Biological Chemistry, 300 (10) 107757, 107757. doi: 10.1016/j.jbc.2024.107757

A venom peptide-induced NaV channel modulation mechanism involving the interplay between fixed channel charges and ionic gradients

2024

Journal Article

The ‘dispanins’ and related proteins in physiology and neurological disease

Deuis, Jennifer R., Klasfauseweh, Tabea, Walker, Lucinda and Vetter, Irina (2024). The ‘dispanins’ and related proteins in physiology and neurological disease. Trends in Neurosciences, 47 (8), 622-634. doi: 10.1016/j.tins.2024.06.004

The ‘dispanins’ and related proteins in physiology and neurological disease

2024

Journal Article

Structural basis of the bivalency of the TRPV1 agonist DkTx

Ramanujam, Venkatraman, Crawford, Theo, Cristofori-Armstrong, Ben, Deuis, Jennifer, Jia, Xinying, Maxwell, Michael, Jami, Sina, Ma, Linlin, Vetter, Irina and Mobli, Mehdi (2024). Structural basis of the bivalency of the TRPV1 agonist DkTx. Angewandte Chemie International Edition, 63 (3) e202314621, 1-8. doi: 10.1002/anie.202314621

Structural basis of the bivalency of the TRPV1 agonist DkTx

2024

Journal Article

Structural basis of the bivalency of the TRPV1 agonist DkTx

Ramanujam, Venkatraman, Crawford, Theo, Cristofori‐Armstrong, Ben, Deuis, Jennifer R., Jia, Xinying, Maxwell, Michael J., Jami, Sina, Ma, Linlin, Vetter, Irina and Mobli, Mehdi (2024). Structural basis of the bivalency of the TRPV1 agonist DkTx. Angewandte Chemie, 136 (3), 1-8. doi: 10.1002/ange.202314621

Structural basis of the bivalency of the TRPV1 agonist DkTx

2024

Journal Article

Erythromelalgia caused by the missense mutation p.Arg220Pro in an alternatively spliced exon of SCN9A (NaV1.7)

Deuis, Jennifer R., Kumble, Smitha, Keramidas, Angelo, Ragnarsson, Lotten, Simons, Cas, Pais, Lynn, White, Susan M and Vetter, Irina (2024). Erythromelalgia caused by the missense mutation p.Arg220Pro in an alternatively spliced exon of SCN9A (NaV1.7). Human Molecular Genetics, 33 (2), 103-109. doi: 10.1093/hmg/ddad152

Erythromelalgia caused by the missense mutation p.Arg220Pro in an alternatively spliced exon of SCN9A (NaV1.7)

2024

Journal Article

Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants

Robinson, Samuel D., Deuis, Jennifer R., Niu, Pancong, Touchard, Axel, Mueller, Alexander, Schendel, Vanessa, Brinkwirth, Nina, King, Glenn F., Vetter, Irina and Schmidt, Justin O. (2024). Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants. Journal of Biological Chemistry, 300 (1) 105577, 1-15. doi: 10.1016/j.jbc.2023.105577

Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants

2023

Journal Article

Natural compounds purified from the leaves of Aristotelia chilensis: Makomakinol, a new alkaloid and the effect of aristoteline and hobartine on NaV channels

Pérez, Rebeca, Figueredo, Claudia, Burgos, Viviana, Cabrera-Pardo, Jaime R., Schmidt, Bernd, Heydenreich, Matthias, Koch, Andreas, Deuis, Jennifer R., Vetter, Irina and Paz, Cristian (2023). Natural compounds purified from the leaves of Aristotelia chilensis: Makomakinol, a new alkaloid and the effect of aristoteline and hobartine on NaV channels. International Journal of Molecular Sciences, 24 (21) 15504, 1-10. doi: 10.3390/ijms242115504

Natural compounds purified from the leaves of Aristotelia chilensis: Makomakinol, a new alkaloid and the effect of aristoteline and hobartine on NaV channels

2023

Journal Article

Identification of sodium channel toxins from marine cone snails of the subgenera Textilia and Afonsoconus

McMahon, Kirsten L., O’Brien, Henrik, Schroeder, Christina I., Deuis, Jennifer R., Venkatachalam, Dhananjeyan, Huang, Di, Green, Brad R., Bandyopadhyay, Pradip K., Li, Qing, Yandell, Mark, Safavi-Hemami, Helena, Olivera, Baldomero M., Vetter, Irina and Robinson, Samuel D. (2023). Identification of sodium channel toxins from marine cone snails of the subgenera Textilia and Afonsoconus. Cellular and Molecular Life Sciences, 80 (10) 287, 287. doi: 10.1007/s00018-023-04935-0

Identification of sodium channel toxins from marine cone snails of the subgenera Textilia and Afonsoconus

2023

Journal Article

Structural conformation and activity of spider-derived inhibitory cystine knot peptide Pn3a are modulated by pH

Tran, Poanna, Crawford, Theo, Ragnarsson, Lotten, Deuis, Jennifer R., Mobli, Mehdi, Sharpe, Simon J., Schroeder, Christina I. and Vetter, Irina (2023). Structural conformation and activity of spider-derived inhibitory cystine knot peptide Pn3a are modulated by pH. ACS Omega, 8 (29), 26276-26286. doi: 10.1021/acsomega.3c02664

Structural conformation and activity of spider-derived inhibitory cystine knot peptide Pn3a are modulated by pH

2023

Journal Article

Changes in potency and subtype selectivity of bivalent NaV toxins are knot-specific

Tran, Poanna, Tran, Hue N. T., McMahon, Kirsten L., Deuis, Jennifer R., Ragnarsson, Lotten, Norman, Alexander, Sharpe, Simon J., Payne, Richard J., Vetter, Irina and Schroeder, Christina I. (2023). Changes in potency and subtype selectivity of bivalent NaV toxins are knot-specific. Bioconjugate Chemistry, 34 (6), 1072-1083. doi: 10.1021/acs.bioconjchem.3c00135

Changes in potency and subtype selectivity of bivalent NaV toxins are knot-specific

2023

Journal Article

Ant venoms contain vertebrate-selective pain-causing sodium channel toxins

Robinson, Samuel D., Deuis, Jennifer R., Touchard, Axel, Keramidas, Angelo, Mueller, Alexander, Schroeder, Christina I., Barassé, Valentine, Walker, Andrew A., Brinkwirth, Nina, Jami, Sina, Bonnafé, Elsa, Treilhou, Michel, Undheim, Eivind A. B., Schmidt, Justin O., King, Glenn F. and Vetter, Irina (2023). Ant venoms contain vertebrate-selective pain-causing sodium channel toxins. Nature Communications, 14 (1) 2977, 1-11. doi: 10.1038/s41467-023-38839-1

Ant venoms contain vertebrate-selective pain-causing sodium channel toxins

2023

Journal Article

Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function

Jami, Sina, Deuis, Jennifer R., Klasfauseweh, Tabea, Cheng, Xiaoyang, Kurdyukov, Sergey, Chung, Felicity, Okorokov, Andrei L., Li, Shengnan, Zhang, Jiangtao, Cristofori-Armstrong, Ben, Israel, Mathilde R., Ju, Robert J., Robinson, Samuel D., Zhao, Peng, Ragnarsson, Lotten, Andersson, Åsa, Tran, Poanna, Schendel, Vanessa, McMahon, Kirsten L., Tran, Hue N. T., Chin, Yanni K.-Y., Zhu, Yifei, Liu, Junyu, Crawford, Theo, Purushothamvasan, Saipriyaa, Habib, Abdella M., Andersson, David A., Rash, Lachlan D., Wood, John N. ... Vetter, Irina (2023). Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function. Nature Communications, 14 (1) 2442. doi: 10.1038/s41467-023-37963-2

Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function

2023

Journal Article

Pmu1a, a novel spider toxin with dual inhibitory activity at pain targets hNaV1.7 and hCaV3 voltage‐gated channels

Giribaldi, Julien, Chemin, Jean, Tuifua, Marie, Deuis, Jennifer R., Mary, Rosanna, Vetter, Irina, Wilson, David T., Daly, Norelle L., Schroeder, Christina I., Bourinet, Emmanuel and Dutertre, Sébastien (2023). Pmu1a, a novel spider toxin with dual inhibitory activity at pain targets hNaV1.7 and hCaV3 voltage‐gated channels. The FEBS Journal, 290 (14), 3688-3702. doi: 10.1111/febs.16773

Pmu1a, a novel spider toxin with dual inhibitory activity at pain targets hNaV1.7 and hCaV3 voltage‐gated channels

2022

Journal Article

Venom composition and pain-causing toxins of the Australian great carpenter bee Xylocopa aruana

Shi, Naiqi, Szanto, Tibor G., He, Jia, Schroeder, Christina I., Walker, Andrew A., Deuis, Jennifer R., Vetter, Irina, Panyi, György, King, Glenn F. and Robinson, Samuel D. (2022). Venom composition and pain-causing toxins of the Australian great carpenter bee Xylocopa aruana. Scientific Reports, 12 (1) 22168, 1-13. doi: 10.1038/s41598-022-26867-8

Venom composition and pain-causing toxins of the Australian great carpenter bee Xylocopa aruana

2022

Journal Article

Venom-derived pain-causing toxins: insights into sensory neuron function and pain mechanisms

Robinson, Samuel D., Deuis, Jennifer R., Klasfauseweh, Tabea, Schendel, Vanessa and Vetter, Irina (2022). Venom-derived pain-causing toxins: insights into sensory neuron function and pain mechanisms. Pain, 163 (S1), S46-S56. doi: 10.1097/j.pain.0000000000002701

Venom-derived pain-causing toxins: insights into sensory neuron function and pain mechanisms

2022

Journal Article

µ-Conotoxins targeting the human voltage-gated sodium channel subtype NaV1.7

McMahon, Kirsten L., Tran, Hue N. T., Deuis, Jennifer R., Craik, David J., Vetter, Irina and Schroeder, Christina I. (2022). µ-Conotoxins targeting the human voltage-gated sodium channel subtype NaV1.7. Toxins, 14 (9) 600, 1-16. doi: 10.3390/toxins14090600

µ-Conotoxins targeting the human voltage-gated sodium channel subtype NaV1.7

2022

Journal Article

Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox

Xie, Jing, Robinson, Samuel D., Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Rehm, Fabian B.H., Yap, Kuok, Ragnarsson, Lotten, Chan, Lai Yue, Hamilton, Brett R., Harvey, Peta J., Craik, David J., Vetter, Irina and Durek, Thomas (2022). Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox. Journal of Biological Chemistry, 298 (8) 102218, 1-12. doi: 10.1016/j.jbc.2022.102218

Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox

2022

Journal Article

Low potency inhibition of NaV1.7 by externally applied QX-314 via a depolarizing shift in the voltage-dependence of activation

Klasfauseweh, Tabea, Israel, Mathilde R., Ragnarsson, Lotten, Cox, James J., Durek, Thomas, Carter, David A., Leffler, Andreas, Vetter, Irina and Deuis, Jennifer R. (2022). Low potency inhibition of NaV1.7 by externally applied QX-314 via a depolarizing shift in the voltage-dependence of activation. European Journal of Pharmacology, 925 175013, 175013. doi: 10.1016/j.ejphar.2022.175013

Low potency inhibition of NaV1.7 by externally applied QX-314 via a depolarizing shift in the voltage-dependence of activation

2022

Journal Article

Structural and functional insights into inhibition of human voltage-gated sodium channels by μ‐conotoxin KIIIA disulfide isomers

Tran, Hue N. T., McMahon, Kirsten L., Deuis, Jennifer R., Vetter, Irina and Schroeder, Christina I. (2022). Structural and functional insights into inhibition of human voltage-gated sodium channels by μ‐conotoxin KIIIA disulfide isomers. Journal of Biological Chemistry, 298 (3) 101728, 1-13. doi: 10.1016/j.jbc.2022.101728

Structural and functional insights into inhibition of human voltage-gated sodium channels by μ‐conotoxin KIIIA disulfide isomers

2022

Journal Article

The tarantula venom peptide Eo1a binds to the domain II S3-S4 extracellular loop of voltage-gated sodium channel NaV1.8 to enhance activation

Deuis, Jennifer R., Ragnarsson, Lotten, Robinson, Samuel D., Dekan, Zoltan, Chan, Lerena, Jin, Ai-Hua, Tran, Poanna, McMahon, Kirsten L., Li, Shengnan, Wood, John N., Cox, James J., King, Glenn F., Herzig, Volker and Vetter, Irina (2022). The tarantula venom peptide Eo1a binds to the domain II S3-S4 extracellular loop of voltage-gated sodium channel NaV1.8 to enhance activation. Frontiers in Pharmacology, 12 789570, 789570. doi: 10.3389/fphar.2021.789570

The tarantula venom peptide Eo1a binds to the domain II S3-S4 extracellular loop of voltage-gated sodium channel NaV1.8 to enhance activation

Current funding

  • 2022 - 2024
    Using toxins to manipulate the gating of voltage-gated sodium channels
    ARC Discovery Early Career Researcher Award
    Open grant

Past funding

  • 2021 - 2024
    A new class of sodium channel toxin from ant venoms
    ARC Discovery Projects
    Open grant
  • 2021 - 2023
    Bivalent analgesics: rational design of selective ion channel inhibitors with optimised mechanism of action
    NHMRC IDEAS Grants
    Open grant
  • 2018
    High-throughput ion channel pharmacology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2021
    The role of ion channels in pain pathways
    NHMRC Early Career Fellowships
    Open grant
  • 2017 - 2019
    Developing novel treatment approaches for the rare genetic disease inherited erythromelalgia
    International Association for the Study of Pain
    Open grant
  • 2017
    Development of a high-throughput assay to screen for Nav1.9 inhibitors
    UQ Early Career Researcher
    Open grant
  • 2015 - 2016
    TRPC5 in teeth - a novel target for tooth pain treatment
    Go8 Australia - Germany Joint Research Co-operation Scheme
    Open grant

Availability

Dr Jennifer Deuis is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Using toxins as tools to understand sodium channel structure and function

    Principal Advisor

    Other advisors: Professor Irina Vetter

  • Doctor Philosophy

    Understanding the function of sodium channel accessory proteins to develop new treatments for chronic pain

    Associate Advisor

    Other advisors: Professor Mehdi Mobli, Professor Irina Vetter

  • Doctor Philosophy

    Investigating ion channel function and pathology using toxins as tools

    Associate Advisor

    Other advisors: Dr Angelo Keramidas, Professor Irina Vetter

  • Doctor Philosophy

    Structure and function of ion channels in pain pathways: a toxin perspective

    Associate Advisor

    Other advisors: Professor Irina Vetter

  • Doctor Philosophy

    Identification and characterisation of new pain-causing toxins from animal venoms

    Associate Advisor

    Other advisors: Professor Irina Vetter, Dr Sam Robinson

Completed supervision

Enquiries

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