2024 Journal Article A venom peptide-induced NaV channel modulation mechanism involving the interplay between fixed channel charges and ionic gradientsThapa, Ashvriya, Beh, Jia Hao, Robinson, Samuel D., Deuis, Jennifer R., Tran, Hue, Vetter, Irina and Keramidas, Angelo (2024). A venom peptide-induced NaV channel modulation mechanism involving the interplay between fixed channel charges and ionic gradients. Journal of Biological Chemistry, 300 (10) 107757, 107757. doi: 10.1016/j.jbc.2024.107757 |
2024 Journal Article The ‘dispanins’ and related proteins in physiology and neurological diseaseDeuis, Jennifer R., Klasfauseweh, Tabea, Walker, Lucinda and Vetter, Irina (2024). The ‘dispanins’ and related proteins in physiology and neurological disease. Trends in Neurosciences, 47 (8), 622-634. doi: 10.1016/j.tins.2024.06.004 |
2024 Journal Article Structural basis of the bivalency of the TRPV1 agonist DkTxRamanujam, Venkatraman, Crawford, Theo, Cristofori‐Armstrong, Ben, Deuis, Jennifer R., Jia, Xinying, Maxwell, Michael J., Jami, Sina, Ma, Linlin, Vetter, Irina and Mobli, Mehdi (2024). Structural basis of the bivalency of the TRPV1 agonist DkTx. Angewandte Chemie, 136 (3), 1-8. doi: 10.1002/ange.202314621 |
2024 Journal Article Structural basis of the bivalency of the TRPV1 agonist DkTxRamanujam, Venkatraman, Crawford, Theo, Cristofori-Armstrong, Ben, Deuis, Jennifer, Jia, Xinying, Maxwell, Michael, Jami, Sina, Ma, Linlin, Vetter, Irina and Mobli, Mehdi (2024). Structural basis of the bivalency of the TRPV1 agonist DkTx. Angewandte Chemie International Edition, 63 (3) e202314621, 1-8. doi: 10.1002/anie.202314621 |
2024 Journal Article Erythromelalgia caused by the missense mutation p.Arg220Pro in an alternatively spliced exon of SCN9A (NaV1.7)Deuis, Jennifer R., Kumble, Smitha, Keramidas, Angelo, Ragnarsson, Lotten, Simons, Cas, Pais, Lynn, White, Susan M and Vetter, Irina (2024). Erythromelalgia caused by the missense mutation p.Arg220Pro in an alternatively spliced exon of SCN9A (NaV1.7). Human Molecular Genetics, 33 (2), 103-109. doi: 10.1093/hmg/ddad152 |
2024 Journal Article Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester antsRobinson, Samuel D., Deuis, Jennifer R., Niu, Pancong, Touchard, Axel, Mueller, Alexander, Schendel, Vanessa, Brinkwirth, Nina, King, Glenn F., Vetter, Irina and Schmidt, Justin O. (2024). Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants. Journal of Biological Chemistry, 300 (1) 105577, 1-15. doi: 10.1016/j.jbc.2023.105577 |
2023 Journal Article Natural compounds purified from the leaves of Aristotelia chilensis: Makomakinol, a new alkaloid and the effect of aristoteline and hobartine on NaV channelsPérez, Rebeca, Figueredo, Claudia, Burgos, Viviana, Cabrera-Pardo, Jaime R., Schmidt, Bernd, Heydenreich, Matthias, Koch, Andreas, Deuis, Jennifer R., Vetter, Irina and Paz, Cristian (2023). Natural compounds purified from the leaves of Aristotelia chilensis: Makomakinol, a new alkaloid and the effect of aristoteline and hobartine on NaV channels. International Journal of Molecular Sciences, 24 (21) 15504, 1-10. doi: 10.3390/ijms242115504 |
2023 Journal Article Identification of sodium channel toxins from marine cone snails of the subgenera Textilia and AfonsoconusMcMahon, Kirsten L., O’Brien, Henrik, Schroeder, Christina I., Deuis, Jennifer R., Venkatachalam, Dhananjeyan, Huang, Di, Green, Brad R., Bandyopadhyay, Pradip K., Li, Qing, Yandell, Mark, Safavi-Hemami, Helena, Olivera, Baldomero M., Vetter, Irina and Robinson, Samuel D. (2023). Identification of sodium channel toxins from marine cone snails of the subgenera Textilia and Afonsoconus. Cellular and Molecular Life Sciences, 80 (10) 287, 287. doi: 10.1007/s00018-023-04935-0 |
2023 Journal Article Structural conformation and activity of spider-derived inhibitory cystine knot peptide Pn3a are modulated by pHTran, Poanna, Crawford, Theo, Ragnarsson, Lotten, Deuis, Jennifer R., Mobli, Mehdi, Sharpe, Simon J., Schroeder, Christina I. and Vetter, Irina (2023). Structural conformation and activity of spider-derived inhibitory cystine knot peptide Pn3a are modulated by pH. ACS Omega, 8 (29), 26276-26286. doi: 10.1021/acsomega.3c02664 |
2023 Journal Article Changes in potency and subtype selectivity of bivalent NaV toxins are knot-specificTran, Poanna, Tran, Hue N. T., McMahon, Kirsten L., Deuis, Jennifer R., Ragnarsson, Lotten, Norman, Alexander, Sharpe, Simon J., Payne, Richard J., Vetter, Irina and Schroeder, Christina I. (2023). Changes in potency and subtype selectivity of bivalent NaV toxins are knot-specific. Bioconjugate Chemistry, 34 (6), 1072-1083. doi: 10.1021/acs.bioconjchem.3c00135 |
2023 Journal Article Ant venoms contain vertebrate-selective pain-causing sodium channel toxinsRobinson, Samuel D., Deuis, Jennifer R., Touchard, Axel, Keramidas, Angelo, Mueller, Alexander, Schroeder, Christina I., Barassé, Valentine, Walker, Andrew A., Brinkwirth, Nina, Jami, Sina, Bonnafé, Elsa, Treilhou, Michel, Undheim, Eivind A. B., Schmidt, Justin O., King, Glenn F. and Vetter, Irina (2023). Ant venoms contain vertebrate-selective pain-causing sodium channel toxins. Nature Communications, 14 (1) 2977, 1-11. doi: 10.1038/s41467-023-38839-1 |
2023 Journal Article Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 functionJami, Sina, Deuis, Jennifer R., Klasfauseweh, Tabea, Cheng, Xiaoyang, Kurdyukov, Sergey, Chung, Felicity, Okorokov, Andrei L., Li, Shengnan, Zhang, Jiangtao, Cristofori-Armstrong, Ben, Israel, Mathilde R., Ju, Robert J., Robinson, Samuel D., Zhao, Peng, Ragnarsson, Lotten, Andersson, Åsa, Tran, Poanna, Schendel, Vanessa, McMahon, Kirsten L., Tran, Hue N. T., Chin, Yanni K.-Y., Zhu, Yifei, Liu, Junyu, Crawford, Theo, Purushothamvasan, Saipriyaa, Habib, Abdella M., Andersson, David A., Rash, Lachlan D., Wood, John N. ... Vetter, Irina (2023). Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function. Nature Communications, 14 (1) 2442. doi: 10.1038/s41467-023-37963-2 |
2023 Journal Article Pmu1a, a novel spider toxin with dual inhibitory activity at pain targets hNaV1.7 and hCaV3 voltage‐gated channelsGiribaldi, Julien, Chemin, Jean, Tuifua, Marie, Deuis, Jennifer R., Mary, Rosanna, Vetter, Irina, Wilson, David T., Daly, Norelle L., Schroeder, Christina I., Bourinet, Emmanuel and Dutertre, Sébastien (2023). Pmu1a, a novel spider toxin with dual inhibitory activity at pain targets hNaV1.7 and hCaV3 voltage‐gated channels. The FEBS Journal, 290 (14), 3688-3702. doi: 10.1111/febs.16773 |
2022 Journal Article Venom composition and pain-causing toxins of the Australian great carpenter bee Xylocopa aruanaShi, Naiqi, Szanto, Tibor G., He, Jia, Schroeder, Christina I., Walker, Andrew A., Deuis, Jennifer R., Vetter, Irina, Panyi, György, King, Glenn F. and Robinson, Samuel D. (2022). Venom composition and pain-causing toxins of the Australian great carpenter bee Xylocopa aruana. Scientific Reports, 12 (1) 22168, 1-13. doi: 10.1038/s41598-022-26867-8 |
2022 Journal Article Venom-derived pain-causing toxins: insights into sensory neuron function and pain mechanismsRobinson, Samuel D., Deuis, Jennifer R., Klasfauseweh, Tabea, Schendel, Vanessa and Vetter, Irina (2022). Venom-derived pain-causing toxins: insights into sensory neuron function and pain mechanisms. Pain, 163 (S1), S46-S56. doi: 10.1097/j.pain.0000000000002701 |
2022 Journal Article µ-Conotoxins targeting the human voltage-gated sodium channel subtype NaV1.7McMahon, Kirsten L., Tran, Hue N. T., Deuis, Jennifer R., Craik, David J., Vetter, Irina and Schroeder, Christina I. (2022). µ-Conotoxins targeting the human voltage-gated sodium channel subtype NaV1.7. Toxins, 14 (9) 600, 1-16. doi: 10.3390/toxins14090600 |
2022 Journal Article Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica feroxXie, Jing, Robinson, Samuel D., Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Rehm, Fabian B.H., Yap, Kuok, Ragnarsson, Lotten, Chan, Lai Yue, Hamilton, Brett R., Harvey, Peta J., Craik, David J., Vetter, Irina and Durek, Thomas (2022). Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox. Journal of Biological Chemistry, 298 (8) 102218, 1-12. doi: 10.1016/j.jbc.2022.102218 |
2022 Journal Article Low potency inhibition of NaV1.7 by externally applied QX-314 via a depolarizing shift in the voltage-dependence of activationKlasfauseweh, Tabea, Israel, Mathilde R., Ragnarsson, Lotten, Cox, James J., Durek, Thomas, Carter, David A., Leffler, Andreas, Vetter, Irina and Deuis, Jennifer R. (2022). Low potency inhibition of NaV1.7 by externally applied QX-314 via a depolarizing shift in the voltage-dependence of activation. European Journal of Pharmacology, 925 175013, 175013. doi: 10.1016/j.ejphar.2022.175013 |
2022 Journal Article Structural and functional insights into inhibition of human voltage-gated sodium channels by μ‐conotoxin KIIIA disulfide isomersTran, Hue N. T., McMahon, Kirsten L., Deuis, Jennifer R., Vetter, Irina and Schroeder, Christina I. (2022). Structural and functional insights into inhibition of human voltage-gated sodium channels by μ‐conotoxin KIIIA disulfide isomers. Journal of Biological Chemistry, 298 (3) 101728, 1-13. doi: 10.1016/j.jbc.2022.101728 |
2022 Journal Article The tarantula venom peptide Eo1a binds to the domain II S3-S4 extracellular loop of voltage-gated sodium channel NaV1.8 to enhance activationDeuis, Jennifer R., Ragnarsson, Lotten, Robinson, Samuel D., Dekan, Zoltan, Chan, Lerena, Jin, Ai-Hua, Tran, Poanna, McMahon, Kirsten L., Li, Shengnan, Wood, John N., Cox, James J., King, Glenn F., Herzig, Volker and Vetter, Irina (2022). The tarantula venom peptide Eo1a binds to the domain II S3-S4 extracellular loop of voltage-gated sodium channel NaV1.8 to enhance activation. Frontiers in Pharmacology, 12 789570, 789570. doi: 10.3389/fphar.2021.789570 |