Dr Jennifer Deuis
Dr

Jennifer Deuis

Email: 
Phone: 
+61 7 334 62366

Background

My main research focus has been applying venom peptide pharmacology to pain pathway characterisation. This approach has led to the identification of novel pain mechanisms underlying the development of chemotherapy-induced pain, ciguatera, and burn-induced pain. In an addition, I have identified and characterised over 20 novel bioactive peptides, which includes a novel class of Nav1.7 inhibitors that is currently undergoing pre-clinical development as analgesics, and a novel class of stinging nettle toxins that act on a previously unidentified Nav1.7 interacting protein named TMEM233.

Availability

Dr Jennifer Deuis is:
Available for supervision

Qualifications

  • Doctor of Philosophy, The University of Queensland

Search Professor Jennifer Deuis’s works on UQ eSpace

76 works between 2013 and 2025
All (76) Journal Article (71) Book Chapter (2) Conference Publication (2) Other Outputs (1)

61 - 76 of 76 works

2016

Journal Article

NaV1.7 as a pain target – from gene to pharmacology

Vetter, Irina, Deuis, Jennifer, Mueller, Alexander, Israel, Mathilde R., Hana Starobova, Zhang, Alan, Rash, Lachlan D. and Mobli, Mehdi (2016). NaV1.7 as a pain target – from gene to pharmacology. Pharmacology and Therapeutics, 172, 73-100. doi: 10.1016/j.pharmthera.2016.11.015

NaV1.7 as a pain target – from gene to pharmacology

2016

Journal Article

The snake with the scorpion's sting: novel three-finger toxin sodium channel activators from the venom of the long-glanded blue coral snake (Calliophis bivirgatus)

Yang, Daryl C., Deuis, Jennifer R., Dashevsky, Daniel, Dobson, James, Jackson, Timothy N. W., Brust, Andreas, Xie, Bing, Koludarov, Ivan, Debono, Jordan, Hendrikx, Iwan, Hodgson, Wayne C., Josh, Peter, Nouwens, Amanda, Baillie, Gregory J., Bruxner, Timothy J. C., Alewood, Paul F., Peng Lim, Kelvin Kok, Frank, Nathaniel, Vetter, Irina and Fry, Bryan G. (2016). The snake with the scorpion's sting: novel three-finger toxin sodium channel activators from the venom of the long-glanded blue coral snake (Calliophis bivirgatus). Toxins, 8 (10) A034, 303. doi: 10.3390/toxins8100303

The snake with the scorpion's sting: novel three-finger toxin sodium channel activators from the venom of the long-glanded blue coral snake (Calliophis bivirgatus)

2016

Journal Article

Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target

Yin, Kathleen, Deuis, Jennifer R., Lewis, Richard J. and Vetter, Irina (2016). Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target. Molecular Pain, 12, 1-13. doi: 10.1177/1744806916665366

Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target

2016

Journal Article

Development of a μO-conotoxin analogue with improved lipid membrane interactions and potency for the analgesic target NaV1.8

Deuis, Jennifer R, Dekan, Zoltan, Inserra, Marco C., Lee, Tzong-Hsien, Aguilar, Marie-Isabel, Craik, David J., Lewis, Richard J., Alewood, Paul F., Mobli, Mehdi, Schroeder, Christina I., Henriques, Sónia Troeira and Vetter, Irina (2016). Development of a μO-conotoxin analogue with improved lipid membrane interactions and potency for the analgesic target NaV1.8. Journal of Biological Chemistry, 291 (22), 11829-11842. doi: 10.1074/jbc.M116.721662

Development of a μO-conotoxin analogue with improved lipid membrane interactions and potency for the analgesic target NaV1.8

2016

Journal Article

Analgesic effects of GpTx-1, PF-04856264 and CNV1014802 in a mouse model of NaV1.7-Mediated pain

Deuis, Jennifer R., Wingerd, Joshua S., Winter, Zoltan, Durek, Thomas, Dekan, Zoltan, Sousa, Silmara R., Zimmermann, Katharina, Hoffmann, Tali, Weidner, Christian, Nassar, Mohammed A., Alewood, Paul F., Lewis, Richard J. and Vetter, Irina (2016). Analgesic effects of GpTx-1, PF-04856264 and CNV1014802 in a mouse model of NaV1.7-Mediated pain. Toxins, 8 (3) 78, 78. doi: 10.3390/toxins8030078

Analgesic effects of GpTx-1, PF-04856264 and CNV1014802 in a mouse model of NaV1.7-Mediated pain

2016

Journal Article

The thermal probe test: a novel behavioral assay to quantify thermal paw withdrawal thresholds in mice

Deuis, Jennifer R. and Vetter, Irina (2016). The thermal probe test: a novel behavioral assay to quantify thermal paw withdrawal thresholds in mice. Temperature, 3 (2), 199-207. doi: 10.1080/23328940.2016.1157668

The thermal probe test: a novel behavioral assay to quantify thermal paw withdrawal thresholds in mice

2016

Other Outputs

Using toxins to elucidate the role of voltage-gated sodium channels in pain

Deuis, Jennifer (2016). Using toxins to elucidate the role of voltage-gated sodium channels in pain. PhD Thesis, School of Pharmacy, The University of Queensland. doi: 10.14264/uql.2016.53

Using toxins to elucidate the role of voltage-gated sodium channels in pain

2016

Conference Publication

Rational design and synthesis of a novel membrane binding NaV1.8 selective inhibitor with in vivo activity in pain models

Schroeder, Christina I., Deuis, Jennifer, Henriques, Sonia Troeria, Dekan, Zoltan, Inserra, Marco, Mobli, Mehdi and Vetter, Irina (2016). Rational design and synthesis of a novel membrane binding NaV1.8 selective inhibitor with in vivo activity in pain models. 60th Annual Meeting of the Biophysical Society, Los Angeles, CA, United States, 27 Feb - 2 Mar 2016. CAMBRIDGE: CELL PRESS. doi: 10.1016/j.bpj.2015.11.247

Rational design and synthesis of a novel membrane binding NaV1.8 selective inhibitor with in vivo activity in pain models

2015

Journal Article

Activation of k opioid receptors in cutaneous nerve endings by conorphin-1, a novel subtype-selective conopeptide, does not mediate peripheral analgesia

Deuis, Jennifer, Whately, Ella, Brust, Andreas, Inserra, Marco, Asvadi, Naghmeh Hajarol, Lewis, Richard J., Alewood, Paul F., Cabot, Peter J. and Vetter, Irina (2015). Activation of k opioid receptors in cutaneous nerve endings by conorphin-1, a novel subtype-selective conopeptide, does not mediate peripheral analgesia. ACS Chemical Neuroscience, 6 (10), 1751-1758. doi: 10.1021/acschemneuro.5b00113

Activation of k opioid receptors in cutaneous nerve endings by conorphin-1, a novel subtype-selective conopeptide, does not mediate peripheral analgesia

2015

Journal Article

Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens

Cardoso, Fernanda C., Deka, Zoltan, Rosengren, K. Johan, Erickson, Andelain, Vetter, Irina, Deuis, Jennifer R., Herzig, Volker, Alewood, Paul F., King, Glenn F. and Lewis, Richard J. (2015). Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens. Molecular Pharmacology, 88 (2), 291-303. doi: 10.1124/mol.115.098178

Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens

2015

Journal Article

α-conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors

Mueller, Alexander, Starobova, Hana, Inserra, Marco C., Jin, Ai-Hua, Deuis, Jennifer R., Dutertre, Sebastien, Lewis, Richard J., Alewood, Paul F., Daly, Norelle L. and Vetter, Irina (2015). α-conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors. Biochemical Pharmacology, 94 (2), 155-163. doi: 10.1016/j.bcp.2015.01.011

α-conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors

2015

Conference Publication

Rational development of novel analgesics for the treatment of chronic pain: Structure-Function studies of an engineered Nav1.7 blocker

Rahnama, S., Lachlan, R., Cardoso, F. C., Smith, J., Deuis, J., Vetter, I., King, G. F. and Mobli, M. (2015). Rational development of novel analgesics for the treatment of chronic pain: Structure-Function studies of an engineered Nav1.7 blocker. The 40th Lorne Conference on Protein Structure and Function, Lorne VIC, Australia, 8-12 February 2015.

Rational development of novel analgesics for the treatment of chronic pain: Structure-Function studies of an engineered Nav1.7 blocker

2014

Journal Article

Analgesic effects of clinically used compounds in novel mouse models of polyneuropathy induced by oxaliplatin and cisplatin

Deuis, Jennifer R., Lim, Yu Ling, Rodrigues de Sousa, Silmara, Lewis, Richard J., Alewood, Paul F., Cabot, Peter J. and Vetter, Irina (2014). Analgesic effects of clinically used compounds in novel mouse models of polyneuropathy induced by oxaliplatin and cisplatin. Neuro-Oncology, 16 (10), 1324-1332. doi: 10.1093/neuonc/nou048

Analgesic effects of clinically used compounds in novel mouse models of polyneuropathy induced by oxaliplatin and cisplatin

2013

Journal Article

Analgesic treatment of ciguatoxin-induced cold allodynia

Zimmermann, Katharina, Deuis, Jennifer R., Inserra, Marco C., Collins, Lindon S., Namer, Barbara, Cabot, Peter J., Reeh, Peter W., Lewis, Richard J. and Vetter, Irina (2013). Analgesic treatment of ciguatoxin-induced cold allodynia. Pain, 154 (10), 1999-2006. doi: 10.1016/j.pain.2013.06.015

Analgesic treatment of ciguatoxin-induced cold allodynia

2013

Journal Article

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Na(v)1.6 in peripheral pain pathways

Deuis, Jennifer R., Zimmermann, Katharina, Romanovsky, Andrej A., Possani, Lourival D., Cabot, Peter J., Lewis, Richard J. and Vetter, Irina (2013). An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Na(v)1.6 in peripheral pain pathways. Pain, 154 (9), 1749-1757. doi: 10.1016/j.pain.2013.05.032

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Na(v)1.6 in peripheral pain pathways

2013

Book Chapter

Characterizing response properties of cutaneous nociceptors using in vitro skin-nerve preparations

Deuis, Jennifer, Vetter, Irina and Zimmermann, Katharina (2013). Characterizing response properties of cutaneous nociceptors using in vitro skin-nerve preparations. Pain models: translational relevance and applications. (pp. 33-46) edited by Hermann Handwerker and Lars Arendt-nielsen. Washington, United States: IASP Press.

Characterizing response properties of cutaneous nociceptors using in vitro skin-nerve preparations

Current funding

  • 2025 - 2026
    Benchmarking a novel non-opioid analgesic against competitor drugs
    Research Donation Generic
    Open grant

Past funding

  • 2022 - 2024
    Using toxins to manipulate the gating of voltage-gated sodium channels
    ARC Discovery Early Career Researcher Award
    Open grant
  • 2021 - 2024
    A new class of sodium channel toxin from ant venoms
    ARC Discovery Projects
    Open grant
  • 2021 - 2023
    Bivalent analgesics: rational design of selective ion channel inhibitors with optimised mechanism of action
    NHMRC IDEAS Grants
    Open grant
  • 2018
    High-throughput ion channel pharmacology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2021
    The role of ion channels in pain pathways
    NHMRC Early Career Fellowships
    Open grant
  • 2017 - 2019
    Developing novel treatment approaches for the rare genetic disease inherited erythromelalgia
    International Association for the Study of Pain
    Open grant
  • 2017
    Development of a high-throughput assay to screen for Nav1.9 inhibitors
    UQ Early Career Researcher
    Open grant
  • 2015 - 2016
    TRPC5 in teeth - a novel target for tooth pain treatment
    Go8 Australia - Germany Joint Research Co-operation Scheme
    Open grant

Availability

Dr Jennifer Deuis is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Using toxins as tools to understand sodium channel structure and function

    Principal Advisor

    Other advisors: Professor Irina Vetter

  • Doctor Philosophy

    Structure and function of ion channels in pain pathways: a toxin perspective

    Associate Advisor

    Other advisors: Professor Irina Vetter

  • Doctor Philosophy

    Identification and characterisation of new pain-causing toxins from animal venoms

    Associate Advisor

    Other advisors: Professor Irina Vetter, Dr Sam Robinson

  • Master Philosophy

    Using peptide toxins to understand the nociceptor signallosome

    Associate Advisor

    Other advisors: Professor Irina Vetter

  • Doctor Philosophy

    Understanding the function of sodium channel accessory proteins to develop new treatments for chronic pain

    Associate Advisor

    Other advisors: Professor Mehdi Mobli, Professor Irina Vetter

  • Doctor Philosophy

    Investigating ion channel function and pathology using toxins as tools

    Associate Advisor

    Other advisors: Dr Angelo Keramidas, Professor Irina Vetter

  • Doctor Philosophy

    Identification and characterisation of new pain-causing toxins from animal venoms

    Associate Advisor

    Other advisors: Professor Irina Vetter, Dr Sam Robinson

Completed supervision

Enquiries

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