Dr Jennifer Deuis
Dr

Jennifer Deuis

Email: 
Phone: 
+61 7 334 62366

Background

My main research focus has been applying venom peptide pharmacology to pain pathway characterisation. This approach has led to the identification of novel pain mechanisms underlying the development of chemotherapy-induced pain, ciguatera, and burn-induced pain. In an addition, I have identified and characterised over 20 novel bioactive peptides, which includes a novel class of Nav1.7 inhibitors that is currently undergoing pre-clinical development as analgesics, and a novel class of stinging nettle toxins that act on a previously unidentified Nav1.7 interacting protein named TMEM233.

Availability

Dr Jennifer Deuis is:
Available for supervision

Qualifications

  • Doctor of Philosophy, The University of Queensland

Search Professor Jennifer Deuis’s works on UQ eSpace

75 works between 2013 and 2024
All (75) Journal Article (70) Book Chapter (2) Conference Publication (2) Other Outputs (1)

21 - 40 of 75 works

2022

Journal Article

Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system

Wu, Yue, Cui, Zhenling, Huang, Yen-Hua, de Veer, Simon J., Aralov, Andrey V., Guo, Zhong, Moradi, Shayli V., Hinton, Alexandra O., Deuis, Jennifer R., Guo, Shaodong, Chen, Kai-En, Collins, Brett M., Vetter, Irina, Herzig, Volker, Jones, Alun, Cooper, Matthew A., King, Glenn F., Craik, David J., Alexandrov, Kirill and Mureev, Sergey (2022). Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system. Nature Communications, 13 (1) 260, 260. doi: 10.1038/s41467-021-27854-9

Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system

2022

Journal Article

Polygodial, a drimane sesquiterpenoid dialdehyde purified from Drimys winteri, inhibits voltage-gated sodium channels

Paz, Cristian, Ortiz, Leandro, Deuis, Jennifer R. and Vetter, Irina (2022). Polygodial, a drimane sesquiterpenoid dialdehyde purified from Drimys winteri, inhibits voltage-gated sodium channels. Natural Product Research, 36 (24), 1-6. doi: 10.1080/14786419.2022.2025592

Polygodial, a drimane sesquiterpenoid dialdehyde purified from Drimys winteri, inhibits voltage-gated sodium channels

2021

Journal Article

Novel neurotoxic activity in Calliophis intestinalis venom

Dashevsky, Daniel, Deuis, Jennifer R., Vetter, Irina, Huynh, Tam, Hodgson, Wayne C., Tan, Choo Hock, Nouwens, Amanda and Fry, Bryan G. (2021). Novel neurotoxic activity in Calliophis intestinalis venom. Neurotoxicity Research, 40 (1), 173-178. doi: 10.1007/s12640-021-00413-2

Novel neurotoxic activity in Calliophis intestinalis venom

2021

Journal Article

Evaluation of efficient non-reducing enzymatic and chemical ligation strategies for complex disulfide-rich peptides

Tran, Hue N. T., Tran, Poanna, Deuis, Jennifer R., McMahon, Kirsten L., Yap, Kuok, Craik, David J., Vetter, Irina and Schroeder, Christina I. (2021). Evaluation of efficient non-reducing enzymatic and chemical ligation strategies for complex disulfide-rich peptides. Bioconjugate Chemistry, 32 (11) acs.bioconjchem.1c00452, 2407-2419. doi: 10.1021/acs.bioconjchem.1c00452

Evaluation of efficient non-reducing enzymatic and chemical ligation strategies for complex disulfide-rich peptides

2021

Journal Article

Engineering of a spider peptide via conserved structure-function traits optimizes sodium channel inhibition in vitro and anti-nociception in vivo

Hu, Huiyu, Mawlawi, Saja, Zhao, Tianjiao, Jami, Sina, Deuis, Jennifer R., Vetter, Irina, Lewis, Richard J. and Cardoso, Fernanda C. (2021). Engineering of a spider peptide via conserved structure-function traits optimizes sodium channel inhibition in vitro and anti-nociception in vivo. Frontiers in Molecular Biosciences, 8 742457, 742457. doi: 10.3389/fmolb.2021.742457

Engineering of a spider peptide via conserved structure-function traits optimizes sodium channel inhibition in vitro and anti-nociception in vivo

2021

Journal Article

Venom chemistry underlying the painful stings of velvet ants (Hymenoptera: Mutillidae)

Jensen, Timo, Walker, Andrew A., Nguyen, Son H., Jin, Ai-Hua, Deuis, Jennifer R., Vetter, Irina, King, Glenn F., Schmidt, Justin O. and Robinson, Samuel D. (2021). Venom chemistry underlying the painful stings of velvet ants (Hymenoptera: Mutillidae). Cellular and Molecular Life Sciences, 78 (12), 5163-5177. doi: 10.1007/s00018-021-03847-1

Venom chemistry underlying the painful stings of velvet ants (Hymenoptera: Mutillidae)

2021

Journal Article

Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release

Starobova, Hana, Monteleone, Mercedes, Adolphe, Christelle, Batoon, Lena, Sandrock, Cheyenne J., Tay, Bryan, Deuis, Jennifer R., Smith, Alexandra V., Mueller, Alexander, Nadar, Evelyn Israel, Lawrence, Grace Pamo, Mayor, Amanda, Tolson, Elissa, Levesque, Jean-Pierre, Pettit, Allison R., Wainwright, Brandon J., Schroder, Kate and Vetter, Irina (2021). Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release. Journal of Experimental Medicine, 218 (5) e20201452. doi: 10.1084/jem.20201452

Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release

2020

Journal Article

Discovery, pharmacological characterisation and NMR structure of the novel µ-Conotoxin SxIIIC, a potent and irreversible NaV channel inhibitor

McMahon, Kirsten L., Tran, Hue N.T., Deuis, Jennifer R., Lewis, Richard J., Vetter, Irina and Schroeder, Christina I. (2020). Discovery, pharmacological characterisation and NMR structure of the novel µ-Conotoxin SxIIIC, a potent and irreversible NaV channel inhibitor. Biomedicines, 8 (10) 391, 1-15. doi: 10.3390/biomedicines8100391

Discovery, pharmacological characterisation and NMR structure of the novel µ-Conotoxin SxIIIC, a potent and irreversible NaV channel inhibitor

2020

Journal Article

Neurotoxic peptides from the venom of the giant Australian stinging tree

Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Israel, Mathilde R., Harvey, Peta J., Poth, Aaron G., Rehm, Fabian B. H., Stow, Jennifer L., Robinson, Samuel D., Yap, Kuok, Brown, Darren L., Hamilton, Brett R., Andersson, David, Craik, David J., Vetter, Irina and Durek, Thomas (2020). Neurotoxic peptides from the venom of the giant Australian stinging tree. Science Advances, 6 (38) eabb8828, 1-10. doi: 10.1126/sciadv.abb8828

Neurotoxic peptides from the venom of the giant Australian stinging tree

2020

Journal Article

Recombinant production, bioconjugation and membrane binding studies ofPn3a, a selective Nav1.7 inhibitor

Sharma, Gagan, Deuis, Jennifer R., Jia, Xinying, Mueller, Alexander, Vetter, Irina and Mobli, Mehdi (2020). Recombinant production, bioconjugation and membrane binding studies ofPn3a, a selective Nav1.7 inhibitor. Biochemical Pharmacology, 181 114148, 114148. doi: 10.1016/j.bcp.2020.114148

Recombinant production, bioconjugation and membrane binding studies ofPn3a, a selective Nav1.7 inhibitor

2020

Journal Article

Characterization of synthetic Tf2 as a NaV1.3 selective pharmacological probe

Israel, Mathilde R., Dash, Thomas S., Bothe, Stefanie N., Robinson, Samuel D., Deuis, Jennifer R., Craik, David J., Lampert, Angelika, Vetter, Irina and Durek, Thomas (2020). Characterization of synthetic Tf2 as a NaV1.3 selective pharmacological probe. Biomedicines, 8 (6) 155, 155. doi: 10.3390/biomedicines8060155

Characterization of synthetic Tf2 as a NaV1.3 selective pharmacological probe

2020

Journal Article

Pharmacological activity and NMR solution structure of the leech peptide HSTX-I

McMahon, Kirsten L., Tay, Bryan, Deuis, Jennifer R., Tanaka, Brian S., Peigneur, Steve, Jin, Ai-Hua, Tytgat, Jan, Waxman, Stephen G., Dib-Hajj, Sulayman D., Vetter, Irina and Schroeder, Christina I. (2020). Pharmacological activity and NMR solution structure of the leech peptide HSTX-I. Biochemical Pharmacology, 181 114082, 114082. doi: 10.1016/j.bcp.2020.114082

Pharmacological activity and NMR solution structure of the leech peptide HSTX-I

2020

Journal Article

Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7

Agwa, Akello J., Tran, Poanna, Mueller, Alexander, Tran, Hue N. T., Deuis, Jennifer R., Israel, Mathilde R., McMahon, Kirsten L., Craik, David J., Vetter, Irina and Schroeder, Christina I. (2020). Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7. The Journal of Biological Chemistry, 295 (15), 5067-5080. doi: 10.1074/jbc.ra119.012281

Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7

2020

Journal Article

Mapping the molecular surface of the analgesic NaV1.7-selective peptide Pn3a reveals residues essential for membrane and channel interactions

Mueller, Alexander, Dekan, Zoltan, Kaas, Quentin, Agwa, Akello J., Starobova, Hana, Alewood, Paul F., Schroeder, Christina I., Mobli, Mehdi, Deuis, Jennifer R. and Vetter, Irina (2020). Mapping the molecular surface of the analgesic NaV1.7-selective peptide Pn3a reveals residues essential for membrane and channel interactions. ACS Pharmacology and Translational Science. doi: 10.1021/acsptsci.0c00002

Mapping the molecular surface of the analgesic NaV1.7-selective peptide Pn3a reveals residues essential for membrane and channel interactions

2020

Journal Article

Addition of K22 converts spider venom peptide Pme2a from an activator to an inhibitor of NaV1.7

Yin, Kathleen, Deuis, Jennifer R., Dekan, Zoltan, Jin, Ai-Hua, Alewood, Paul F., King, Glenn F., Herzig, Volker and Vetter, Irina (2020). Addition of K22 converts spider venom peptide Pme2a from an activator to an inhibitor of NaV1.7. Biomedicines, 8 (2) 37, 37. doi: 10.3390/biomedicines8020037

Addition of K22 converts spider venom peptide Pme2a from an activator to an inhibitor of NaV1.7

2020

Book Chapter

High-throughput fluorescence assays for ion channels and GPCRs

Vetter, Irina, Carter, David, Bassett, John, Deuis, Jennifer R., Tay, Bryan, Jami, Sina and Robinson, Samuel D. (2020). High-throughput fluorescence assays for ion channels and GPCRs. Calcium Signaling. (pp. 27-72) edited by Md. Shahidul Islam. Cham, Switzerland: Springer. doi: 10.1007/978-3-030-12457-1_3

High-throughput fluorescence assays for ion channels and GPCRs

2019

Journal Article

Enzymatic ligation of a pore blocker toxin and gating modifier toxin; creating double-knotted peptides with improved sodium channel NaV1.7 inhibition

Tran, Hue, Tran, Poanna, Deuis, Jennifer R., Agwa, Akello Joanna, Zhang, Alan H., Vetter, Irina and Schroeder, Christina I (2019). Enzymatic ligation of a pore blocker toxin and gating modifier toxin; creating double-knotted peptides with improved sodium channel NaV1.7 inhibition. Bioconjugate Chemistry, 31 (1) acs.bioconjchem.9b00744, 64-73. doi: 10.1021/acs.bioconjchem.9b00744

Enzymatic ligation of a pore blocker toxin and gating modifier toxin; creating double-knotted peptides with improved sodium channel NaV1.7 inhibition

2019

Journal Article

Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen

Mueller, Alexander, Starobova, Hana, Morgan, Michael, Dekan, Zoltan, Cheneval, Olivier, Schroeder, Christina I., Alewood, Paul F., Deuis, Jennifer R. and Vetter, Irina (2019). Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen. Pain, 160 (8), 1766-1780. doi: 10.1097/j.pain.0000000000001567

Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen

2019

Journal Article

Inflammatory and neuropathic gene expression signatures of chemotherapy-induced neuropathy induced by vincristine, cisplatin and oxaliplatin in C57BL/6J mice

Starobova, Hana, Mueller, Alexander, Deuis, Jennifer R., Carter, David A. and Vetter, Irina (2019). Inflammatory and neuropathic gene expression signatures of chemotherapy-induced neuropathy induced by vincristine, cisplatin and oxaliplatin in C57BL/6J mice. The Journal of Pain, 21 (1-2), 182-194. doi: 10.1016/j.jpain.2019.06.008

Inflammatory and neuropathic gene expression signatures of chemotherapy-induced neuropathy induced by vincristine, cisplatin and oxaliplatin in C57BL/6J mice

2019

Journal Article

NaV1.6 regulates excitability of mechanosensitive sensory neurons

Israel, Mathilde R., Tanaka, Brian S., Castro, Joel, Thongyoo, Panumart, Robinson, Samuel D., Zhao, Peng, Deuis, Jennifer R., Craik, David J., Durek, Thomas, Brierley, Stuart M., Waxman, Stephen G, Dib-Hajj, Sulayman D. and Vetter, Irina (2019). NaV1.6 regulates excitability of mechanosensitive sensory neurons. Journal of Physiology, 597 (14), 3751-3768. doi: 10.1113/JP278148

NaV1.6 regulates excitability of mechanosensitive sensory neurons

Current funding

  • 2025 - 2026
    Benchmarking a novel non-opioid analgesic against competitor drugs
    Research Donation Generic
    Open grant

Past funding

  • 2022 - 2024
    Using toxins to manipulate the gating of voltage-gated sodium channels
    ARC Discovery Early Career Researcher Award
    Open grant
  • 2021 - 2024
    A new class of sodium channel toxin from ant venoms
    ARC Discovery Projects
    Open grant
  • 2021 - 2023
    Bivalent analgesics: rational design of selective ion channel inhibitors with optimised mechanism of action
    NHMRC IDEAS Grants
    Open grant
  • 2018
    High-throughput ion channel pharmacology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2021
    The role of ion channels in pain pathways
    NHMRC Early Career Fellowships
    Open grant
  • 2017 - 2019
    Developing novel treatment approaches for the rare genetic disease inherited erythromelalgia
    International Association for the Study of Pain
    Open grant
  • 2017
    Development of a high-throughput assay to screen for Nav1.9 inhibitors
    UQ Early Career Researcher
    Open grant
  • 2015 - 2016
    TRPC5 in teeth - a novel target for tooth pain treatment
    Go8 Australia - Germany Joint Research Co-operation Scheme
    Open grant

Availability

Dr Jennifer Deuis is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Using toxins as tools to understand sodium channel structure and function

    Principal Advisor

    Other advisors: Professor Irina Vetter

  • Doctor Philosophy

    Investigating ion channel function and pathology using toxins as tools

    Associate Advisor

    Other advisors: Dr Angelo Keramidas, Professor Irina Vetter

  • Doctor Philosophy

    Identification and characterisation of new pain-causing toxins from animal venoms

    Associate Advisor

    Other advisors: Professor Irina Vetter, Dr Sam Robinson

  • Doctor Philosophy

    Structure and function of ion channels in pain pathways: a toxin perspective

    Associate Advisor

    Other advisors: Professor Irina Vetter

  • Doctor Philosophy

    Identification and characterisation of new pain-causing toxins from animal venoms

    Associate Advisor

    Other advisors: Professor Irina Vetter, Dr Sam Robinson

  • Master Philosophy

    Using peptide toxins to understand the nociceptor signallosome

    Associate Advisor

    Other advisors: Professor Irina Vetter

  • Doctor Philosophy

    Understanding the function of sodium channel accessory proteins to develop new treatments for chronic pain

    Associate Advisor

    Other advisors: Professor Mehdi Mobli, Professor Irina Vetter

Completed supervision

Enquiries

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