Dr Angelo Keramidas
Dr

Angelo Keramidas

Email: 
Phone: 
+61 7 334 66362

Background

I am interested in ion channels in health and disease. Improved technologies for genetic screening is revealing an expanding catalogue of genetic variants to ion channels that give rise neurological disorders, such as epilespy syndromes, autism spectrum disorder and other neurodevelopmental disorders. My main research focus is on neurotransmitter-activated receptor ion channels that are found at neuronal synapses. These include GABA-A, glycine and glutamate (NMDA) receptors. I also work on other ion channesl such as voltage-gated sodium channels and synaptic receptors expressed in invertebrate nervous systems.

I am an expert at recording single ion channel, synaptic and conventional whole-cell currents for functional and pharmacological analyisis.

I collaborate with biophysicists, molecular biologists, geneticists, electrophysiologists and clinicians that specialise in genetic neurological disorders. I have active projects in collaboration with research groups in Australia, USA and Europe.

Availability

Dr Angelo Keramidas is:
Available for supervision

Fields of research

Neurosciences Zoology

Qualifications

  • Bachelor of Science, Institution to be confirmed
  • Doctor of Philosophy, Institution to be confirmed

Research impacts

I am collaborating with basic and clinical research groups that bring together a great diversity of research techniques with the common aim of developing personalised medicine for affected individuals with neurological disorders.

Search Professor Angelo Keramidas’s works on UQ eSpace

50 works between 1999 and 2024
All (50) Journal Article (47) Conference Publication (3)

1 - 20 of 50 works

2024

Journal Article

A venom peptide-induced NaV channel modulation mechanism involving the interplay between fixed channel charges and ionic gradients

Thapa, Ashvriya, Beh, Jia Hao, Robinson, Samuel D., Deuis, Jennifer R., Tran, Hue, Vetter, Irina and Keramidas, Angelo (2024). A venom peptide-induced NaV channel modulation mechanism involving the interplay between fixed channel charges and ionic gradients. Journal of Biological Chemistry, 300 (10) 107757, 107757. doi: 10.1016/j.jbc.2024.107757

A venom peptide-induced NaV channel modulation mechanism involving the interplay between fixed channel charges and ionic gradients

2024

Journal Article

The TMEM132B-GABAA receptor complex controls alcohol actions in the brain

Wang, Guohao, Peng, Shixiao, Reyes Mendez, Miriam, Keramidas, Angelo, Castellano, David, Wu, Kunwei, Han, Wenyan, Tian, Qingjun, Dong, Lijin, Li, Yan and Lu, Wei (2024). The TMEM132B-GABAA receptor complex controls alcohol actions in the brain. Cell, 187 (23), 6649-6668.e35. doi: 10.1016/j.cell.2024.09.006

The TMEM132B-GABAA receptor complex controls alcohol actions in the brain

2024

Journal Article

Correlations of receptor desensitization of gain-of-function GABRB3 variants with clinical severity

Lin, Susan X. N., Ahring, Philip K., Keramidas, Angelo, Liao, Vivian W. Y., Møller, Rikke S., Chebib, Mary and Absalom, Nathan L. (2024). Correlations of receptor desensitization of gain-of-function GABRB3 variants with clinical severity. Brain, 147 (1), 224-239. doi: 10.1093/brain/awad285

Correlations of receptor desensitization of gain-of-function GABRB3 variants with clinical severity

2024

Journal Article

Erythromelalgia caused by the missense mutation p.Arg220Pro in an alternatively spliced exon of SCN9A (NaV1.7)

Deuis, Jennifer R., Kumble, Smitha, Keramidas, Angelo, Ragnarsson, Lotten, Simons, Cas, Pais, Lynn, White, Susan M and Vetter, Irina (2024). Erythromelalgia caused by the missense mutation p.Arg220Pro in an alternatively spliced exon of SCN9A (NaV1.7). Human Molecular Genetics, 33 (2), 103-109. doi: 10.1093/hmg/ddad152

Erythromelalgia caused by the missense mutation p.Arg220Pro in an alternatively spliced exon of SCN9A (NaV1.7)

2023

Journal Article

GRIN1 variants associated with neurodevelopmental disorders reveal channel gating pathomechanisms

Ragnarsson, Lotten, Zhang, Zihan, Das, Sooraj S., Tran, Poanna, Andersson, Åsa, Portes, Vincent Des, Demestre, Cecilia Altuzzara, Remerand, Ganaelle, Labalme, Audrey, Chatron, Nicolas, Sanlaville, Damien, Lesca, Gaetan, Anggono, Victor, Vetter, Irina and Keramidas, Angelo (2023). GRIN1 variants associated with neurodevelopmental disorders reveal channel gating pathomechanisms. Epilepsia, 64 (12), 3377-3388. doi: 10.1111/epi.17776

GRIN1 variants associated with neurodevelopmental disorders reveal channel gating pathomechanisms

2023

Journal Article

Ant venoms contain vertebrate-selective pain-causing sodium channel toxins

Robinson, Samuel D., Deuis, Jennifer R., Touchard, Axel, Keramidas, Angelo, Mueller, Alexander, Schroeder, Christina I., Barassé, Valentine, Walker, Andrew A., Brinkwirth, Nina, Jami, Sina, Bonnafé, Elsa, Treilhou, Michel, Undheim, Eivind A. B., Schmidt, Justin O., King, Glenn F. and Vetter, Irina (2023). Ant venoms contain vertebrate-selective pain-causing sodium channel toxins. Nature Communications, 14 (1) 2977, 1-11. doi: 10.1038/s41467-023-38839-1

Ant venoms contain vertebrate-selective pain-causing sodium channel toxins

2022

Journal Article

Anti-seizure mechanisms of midazolam and valproate at the β2(L51M) variant of the GABAA receptor

Kuanyshbek, Alibek, Wang, Meng, Andersson, Åsa, Tuifua, Marie, Palmer, Elizabeth E., Sachdev, Rani K., Mu, Ting-Wei, Vetter, Irina and Keramidas, Angelo (2022). Anti-seizure mechanisms of midazolam and valproate at the β2(L51M) variant of the GABAA receptor. Neuropharmacology, 221 109295, 109295. doi: 10.1016/j.neuropharm.2022.109295

Anti-seizure mechanisms of midazolam and valproate at the β2(L51M) variant of the GABAA receptor

2022

Journal Article

Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors

Wang, Meng, Cotter, Edmund, Wang, Ya-Juan, Fu, Xu, Whittsette, Angela L., Lynch, Joseph W., Wiseman, R. Luke, Kelly, Jeffery W., Keramidas, Angelo and Mu, Ting-Wei (2022). Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors. Cell and Bioscience, 12 (1) 48, 1-20. doi: 10.1186/s13578-022-00783-w

Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors

2022

Journal Article

Shisa7-dependent regulation of GABAA receptor single-channel gating kinetics

Castellano, David, Wu, Kunwei, Keramidas, Angelo and Lu, Wei (2022). Shisa7-dependent regulation of GABAA receptor single-channel gating kinetics. Journal of Neuroscience, 42 (47), 8758-8766. doi: 10.1523/JNEUROSCI.0510-22.2022

Shisa7-dependent regulation of GABAA receptor single-channel gating kinetics

2021

Journal Article

A pain-causing and paralytic ant venom glycopeptide

Robinson, Samuel D., Kambanis, Lucas, Clayton, Daniel, Hinneburg, Hannes, Corcilius, Leo, Mueller, Alexander, Walker, Andrew A., Keramidas, Angelo, Kulkarni, Sameer S., Jones, Alun, Vetter, Irina, Thaysen-Andersen, Morten, Payne, Richard J., King, Glenn F. and Undheim, Eivind A.B. (2021). A pain-causing and paralytic ant venom glycopeptide. iScience, 24 (10) 103175, 1-21. doi: 10.1016/j.isci.2021.103175

A pain-causing and paralytic ant venom glycopeptide

2021

Journal Article

Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit

Yong, Xuan Ling Hilary, Zhang, Lingrui, Yang, Liming, Chen, Xiumin, Tan, Jing Zhi Anson, Yu, Xiaojun, Chandra, Mintu, Livingstone, Emma, Widagdo, Jocelyn, Vieira, Marta M., Roche, Katherine W., Lynch, Joseph W., Keramidas, Angelo, Collins, Brett M. and Anggono, Victor (2021). Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit. Cell Reports, 36 (1) 109338, 1-21. doi: 10.1016/j.celrep.2021.109338

Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit

2020

Journal Article

Proteostasis regulators restore function of epilepsy-associated GABAA receptors

Di, Xiao-Jing, Wang, Ya-Juan, Cotter, Edmund, Wang, Meng, Whittsette, Angela L., Han, Dong-Yun, Sangwung, Panjamaporn, Brown, Renae, Lynch, Joseph W., Keramidas, Angelo and Mu, Ting-Wei (2020). Proteostasis regulators restore function of epilepsy-associated GABAA receptors. Cell Chemical Biology, 27 (1), 1-e7. doi: 10.1016/j.chembiol.2020.08.012

Proteostasis regulators restore function of epilepsy-associated GABAA receptors

2020

Journal Article

Effects of GluN2A and GluN2B gain-of-function epilepsy mutations on synaptic currents mediated by diheteromeric and triheteromeric NMDA receptors

Chen, Xiumin, Keramidas, Angelo, Harvey, Robert J. and Lynch, Joseph W. (2020). Effects of GluN2A and GluN2B gain-of-function epilepsy mutations on synaptic currents mediated by diheteromeric and triheteromeric NMDA receptors. Neurobiology of Disease, 140 104850, 104850. doi: 10.1016/j.nbd.2020.104850

Effects of GluN2A and GluN2B gain-of-function epilepsy mutations on synaptic currents mediated by diheteromeric and triheteromeric NMDA receptors

2020

Journal Article

A novel glycine receptor variant with startle disease affects syndapin I and glycinergic inhibition

Langlhofer, Georg, Schaefer, Natascha, Maric, Hans M., Keramidas, Angelo, Zhang, Yan, Baumann, Peter, Blum, Robert, Breitinger, Ulrike, Strømgaard, Kristian, Schlosser, Andreas, Kessels, Michael M., Koch, Dennis, Qualmann, Britta, Breitinger, Hans-Georg, Lynch, Joseph W. and Villmann, Carmen (2020). A novel glycine receptor variant with startle disease affects syndapin I and glycinergic inhibition. Journal of Neuroscience, 40 (25), JN-RM. doi: 10.1523/jneurosci.2490-19.2020

A novel glycine receptor variant with startle disease affects syndapin I and glycinergic inhibition

2019

Journal Article

The effects of insecticides on two splice variants of the glutamate-gated chloride channel receptor of the major malaria vector, Anopheles gambiae

Atif, Mohammed, Lynch, Joseph W. and Keramidas, Angelo (2019). The effects of insecticides on two splice variants of the glutamate-gated chloride channel receptor of the major malaria vector, Anopheles gambiae. British Journal of Pharmacology, 177 (1) bph.14855, 175-187. doi: 10.1111/bph.14855

The effects of insecticides on two splice variants of the glutamate-gated chloride channel receptor of the major malaria vector, Anopheles gambiae

2019

Journal Article

GluClR-mediated inhibitory postsynaptic currents reveal targets for ivermectin and potential mechanisms of ivermectin resistance

Atif, Mohammed, Smith, Jennifer J., Estrada-Mondragon, Argel, Xiao, Xue, Salim, Angela A., Capon, Robert J., Lynch, Joseph W. and Keramidas, Angelo (2019). GluClR-mediated inhibitory postsynaptic currents reveal targets for ivermectin and potential mechanisms of ivermectin resistance. PLOS Pathogens, 15 (1) e1007570, e1007570. doi: 10.1371/journal.ppat.1007570

GluClR-mediated inhibitory postsynaptic currents reveal targets for ivermectin and potential mechanisms of ivermectin resistance

2018

Journal Article

SAHA (Vorinostat) corrects inhibitory synaptic deficits caused by missense epilepsy mutations to the GABA(A) receptor gamma 2 subunit

Durisic, Nela, Keramidas, Angelo, Dixon, Christine L. and Lynch, Joseph W. (2018). SAHA (Vorinostat) corrects inhibitory synaptic deficits caused by missense epilepsy mutations to the GABA(A) receptor gamma 2 subunit. Frontiers in Molecular Neuroscience, 11 89, 89. doi: 10.3389/fnmol.2018.00089

SAHA (Vorinostat) corrects inhibitory synaptic deficits caused by missense epilepsy mutations to the GABA(A) receptor gamma 2 subunit

2018

Journal Article

Structure/Function Studies of the alpha 4 Subunit Reveal Evolutionary Loss of a GlyR Subtype Involved in Startle and Escape Responses

Leacock, Sophie, Syed, Parnayan, James, Victoria M., Bode, Anna, Kawakami, Koichi, Keramidas, Angelo, Suster, Maximiliano, Lynch, Joseph W. and Harvey, Robert J. (2018). Structure/Function Studies of the alpha 4 Subunit Reveal Evolutionary Loss of a GlyR Subtype Involved in Startle and Escape Responses. Frontiers in Molecular Neuroscience, 11 23, 23. doi: 10.3389/fnmol.2018.00023

Structure/Function Studies of the alpha 4 Subunit Reveal Evolutionary Loss of a GlyR Subtype Involved in Startle and Escape Responses

2017

Journal Article

Inhibitory synapse deficits caused by familial α1 GABAA receptor mutations in epilepsy

Chen, Xiumin, Durisic, Nela, Lynch, Joseph W. and Keramidas, Angelo (2017). Inhibitory synapse deficits caused by familial α1 GABAA receptor mutations in epilepsy. Neurobiology of Disease, 108, 213-224. doi: 10.1016/j.nbd.2017.08.020

Inhibitory synapse deficits caused by familial α1 GABAA receptor mutations in epilepsy

2017

Journal Article

Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortus

Atif, Mohammed, Estrada-Mondragon, Argel, Nguyen, Bindi, Lynch, Joseph W. and Keramidas, Angelo (2017). Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortus. PLoS Pathogens, 13 (10) e1006663, e1006663. doi: 10.1371/journal.ppat.1006663

Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortus

Current funding

  • 2023 - 2026
    Tuning the activating stimulus of voltage-gated sodium channels
    ARC Discovery Projects
    Open grant

Past funding

  • 2023 - 2024
    GluCI Project
    Vestaron Corporation
    Open grant
  • 2019 - 2022
    Regulation of glutamate receptor dynamics in mammalian central neurons
    ARC Discovery Projects
    Open grant
  • 2019 - 2022
    Investigating NMDA receptor-mediated pathological mechanisms underlying epilepsy and associated neurological disorders (NHMRC Project Grant led by University of the Sunshine Coast)
    University of the Sunshine Coast
    Open grant
  • 2015 - 2017
    Using artificial synapses to investigate the functional pathology underlying epilepsy
    NHMRC Project Grant
    Open grant
  • 2012 - 2014
    Understanding the mechanisms of GABA type-A receptor activation and drug modulation
    ARC Discovery Projects
    Open grant

Availability

Dr Angelo Keramidas is:
Available for supervision

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Available projects

  • GABA-A and glycine receptor variants in epilepsy and autism

    New gene variants identified by our clinical collaborators to receptors that mediate neuronal inhibition. These variants lead to receptor functional deficits that manifest as neurological syndromes in young affected individuals.

    We aim to characterise the functional deficists in these receptors and explore personalised treatment options that are tailored to each receptor variant.

  • Glutamate (NMDA) receptors in develpmental delay

    Genetic variants to glutamate receptors have been discovered by our clinical geneticists. We aim the understand how these variants lead to developmental delay and co-morbid disorders in affected individuals and explore pharmacotherapies that correct the functional deficits in these important receptors.

  • Tuning the activating stimulus of voltage-gated sodium channels

    This project will use natural and modified peptides that are derived from venoms of different species, such as spiders and ants to probe and manipulate the functional properties of voltage-gated ion channels, which are critically important to the function of the nervous system.

    You will learn patch-clamp electrophysiology (whole-cell and single channels) and how to isolate, synthesise and determine the structure of venom peptides and their mechanisms of action at ion channels.

Supervision history

Current supervision

Completed supervision

Enquiries

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