Professor Mark Smithers
Professor

Mark Smithers

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Background

Emeritus Professor Mark Smithers is a surgical oncologist who specialises in surgery for oesophago-gastric diseases, melanoma, advanced skin cancer and soft tissue sarcoma. He was the Director of the Upper GI and Soft Tissue Unit at the Princess Alexandra Hospital, in Brisbane, Australia from 1998 - 2023. Commencing his academic career with the University of Queensland in 1987, he progressed to be the Mayne Chair in Surgery and head of the Academy of Surgery. He is the second University of Queensland Medical graduate to be appointed to this role. His research has been focussed on the development and assessment of outcomes from minimally invasive upper GI surgery, and trials assessing the role of perioperative multidisciplinary therapy for esophageal and gastric cancer. As well he has led, or been involved with, clinical trials from phase I to III, for all stages of melanoma through his role as the Chair of the Queensland Melanoma Project. More recently he has been involved with the assessment of access to, and outcomes from, surgery for cancer in Queensland, Australia.

He has overseen the administration and development of the surgery curriculum, and the teaching, in the Academy of Surgery, in the UQ Faculty of Medicine. He was on a number of committees relevant to the implementation of the UQ MD design course. He has held various leadership and committee roles with the Royal Australasian College of Surgeons, as well as leadership roles, including the Presidency, in the Australian and New Zealand Oesophago Gastric Surgeons Association. He has also been on the committees of international organisations related to oesophageal and gastric surgery. He has published 250 articles, eight book chapters, and has been on the editorial board of a number of surgical journals.

He has been recognised for his clinical and academic roles by the award of Member of the Order of Australia (AM). The citation reads, "for service to medicine in the fields of gastro-intestinal and melanoma surgery, to medical education and to professional organisations". The Royal Australasian College of Surgeons awarded him the Sir Hugh Devine medal, for services to surgery and the community. This is the College’s highest honour. Internationally, he has been awarded an honorary fellowship of the Royal College of Surgeons of Edinburgh and recently, in the United States, he was elected as an Honarary Fellow of the American Surgical Association.

Availability

Professor Mark Smithers is:
Not available for supervision
Media expert

Fields of research

Biomedical and Clinical Sciences Clinical sciences Health Sciences Oncology and carcinogenesis

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Honorary Fellow, American Surgical Association, American Surgical Association
  • Fellow, Royal Australasian College of Surgeons, Royal Australasian College of Surgeons
  • Fellow, Royal College of Surgeons of Edinburgh, Royal College of Surgeons of Edinburgh
  • Fellow, Royal College of Surgeons of England, Royal College of Surgeons of England

Research interests

  • Cutaneous Melanoma

    epidemiology, public health issues and management of all stages

  • Management of Oesophageal and Gastric Cancer

    Investigation and management of benign and malignant diseases of the oesophagus and the stomach.

Search Professor Mark Smithers’s works on UQ eSpace

410 works between 1983 and 2025
All (410) Journal Article (279) Book Chapter (9) Conference Publication (121) Book (1)

41 - 60 of 410 works

2022

Journal Article

Neoadjuvant chemoradiotherapy and surgery for esophageal squamous cell carcinoma versus definitive chemoradiotherapy with salvage surgery as needed: The study protocol for the randomized controlled NEEDS trial

Nilsson, Magnus, Olafsdottir, Halla, Alexandersson von Döbeln, Gabriella, Villegas, Fernanda, Gagliardi, Giovanna, Hellström, Mats, Wang, Qiao-Li, Johansson, Hemming, Gebski, Val, Hedberg, Jakob, Klevebro, Fredrik, Markar, Sheraz, Smyth, Elizabeth, Lagergren, Pernilla, Al-Haidari, Ghazwan, Rekstad, Lars Cato, Aahlin, Eirik Kjus, Wallner, Bengt, Edholm, David, Johansson, Jan, Szabo, Eva, Reynolds, John V., Pramesh, C. S., Mummudi, Naveen, Joshi, Amit, Ferri, Lorenzo, Wong, Rebecca KS, O’Callaghan, Chris, Lukovic, Jelena ... Lordick, Florian (2022). Neoadjuvant chemoradiotherapy and surgery for esophageal squamous cell carcinoma versus definitive chemoradiotherapy with salvage surgery as needed: The study protocol for the randomized controlled NEEDS trial. Frontiers in Oncology, 12 917961, 917961. doi: 10.3389/fonc.2022.917961

Neoadjuvant chemoradiotherapy and surgery for esophageal squamous cell carcinoma versus definitive chemoradiotherapy with salvage surgery as needed: The study protocol for the randomized controlled NEEDS trial

2022

Conference Publication

Classification of esophageal adenocarcinoma into subgroups that are associated with patient survival using RNA-seq and immunohistochemistry

Sharma, Sowmya, Naeini, Marjan, Aoude, Lauren G., Bonazzi, Vanessa F., Gartside, Michael G., Loffler, Kelly A., Patel, Kalpana, Newell, Felicity, Lampe, Guy, Brosda, Sandra, Thomas, Janine, Smithers, Mark, Simes, John, Watson, David I., Pearson, John, Barbour, Andrew and Waddell, Nic (2022). Classification of esophageal adenocarcinoma into subgroups that are associated with patient survival using RNA-seq and immunohistochemistry. Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Electr Network, Jun 03-07, 2022. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.

Classification of esophageal adenocarcinoma into subgroups that are associated with patient survival using RNA-seq and immunohistochemistry

2022

Journal Article

Diet quality is associated with primary melanoma thickness

Hughes, M. C. B., Malt, M., Khosrotehrani, K., Smithers, B. M. and Green, A. C. (2022). Diet quality is associated with primary melanoma thickness. Journal of the European Academy of Dermatology and Venereology, 36 (10), 1745-1750. doi: 10.1111/jdv.18174

Diet quality is associated with primary melanoma thickness

2022

Journal Article

Hypothesised cutaneous sites of origin of stage III melanomas with unknown primary: a multi‐centre study

Clayton, Bethan, Muneeb, Ferhan, Hughes, Maria Celia B., Grant, Megan E., Khosrotehrani, Kiarash, Smithers, B. Mark, Spina, Romina, Campana, Luca G., Oudit, Deemesh and Green, Adele C. (2022). Hypothesised cutaneous sites of origin of stage III melanomas with unknown primary: a multi‐centre study. International Journal of Cancer, 151 (3), 396-401. doi: 10.1002/ijc.34020

Hypothesised cutaneous sites of origin of stage III melanomas with unknown primary: a multi‐centre study

2022

Journal Article

ctDNA as a biomarker of progression in oesophageal adenocarcinoma

Bonazzi, V. F., Aoude, L. G., Brosda, S., Lonie, J. M., Patel, K., Bradford, J. J., Koufariotis, L. T., Wood, S., Smithers, B. Mark, Waddell, N. and Barbour, A. P. (2022). ctDNA as a biomarker of progression in oesophageal adenocarcinoma. ESMO Open, 7 (3) 100452, 100452. doi: 10.1016/j.esmoop.2022.100452

ctDNA as a biomarker of progression in oesophageal adenocarcinoma

2022

Journal Article

Patient-reported outcome (PRO) results from the AGITG DOCTOR trial: a randomised phase 2 trial of tailored neoadjuvant therapy for resectable oesophageal adenocarcinoma

Mercieca-Bebber, R., Barnes, E. H., Wilson, K., Samoon, Z., Walpole, E., Mai, T., Ackland, S., Burge, M., Dickie, G., Watson, D., Leung, J., Wang, T., Bohmer, R., Cameron, D., Simes, J., Gebski, V., Smithers, M., Thomas, J., Zalcberg, J. and Barbour, A. P. (2022). Patient-reported outcome (PRO) results from the AGITG DOCTOR trial: a randomised phase 2 trial of tailored neoadjuvant therapy for resectable oesophageal adenocarcinoma. BMC Cancer, 22 (1) 276, 1-11. doi: 10.1186/s12885-022-09270-4

Patient-reported outcome (PRO) results from the AGITG DOCTOR trial: a randomised phase 2 trial of tailored neoadjuvant therapy for resectable oesophageal adenocarcinoma

2022

Journal Article

Reply to: A practical guide on the use of imiquimod cream to treat lentigo maligna

Muir, James, McCormack, Chris, De’Ambrosis, Brian, Brown, Hilary, Kennedy, Daniel, Louie, Brendan and Smithers, B. Mark (2022). Reply to: A practical guide on the use of imiquimod cream to treat lentigo maligna. Australasian Journal of Dermatology, 63 (2), e197-e198. doi: 10.1111/ajd.13771

Reply to: A practical guide on the use of imiquimod cream to treat lentigo maligna

2022

Journal Article

A rare case of a giant retroperitoneal lipoma with multiple limb and trunk lipomata without familial multiple lipomatosis

Laurens, Jason R., Frankel, Adam J., Smithers, Bernard M. and Strutton, Geoffrey (2022). A rare case of a giant retroperitoneal lipoma with multiple limb and trunk lipomata without familial multiple lipomatosis. Journal of Surgical Case Reports, 2022 (3), 1-3. doi: 10.1093/jscr/rjac121

A rare case of a giant retroperitoneal lipoma with multiple limb and trunk lipomata without familial multiple lipomatosis

2022

Journal Article

Impacts of UV-C irradiation on marine biofilm community succession

Naik, Abhishek, Smithers, Mark and Moisander, Pia H. (2022). Impacts of UV-C irradiation on marine biofilm community succession. Applied and Environmental Microbiology, 88 (4) e02298-21, 1-22. doi: 10.1128/aem.02298-21

Impacts of UV-C irradiation on marine biofilm community succession

2022

Journal Article

BRAF mutation testing for patients diagnosed with stage III or stage IV melanoma: practical guidance for the Australian setting

Scolyer, Richard A., Atkinson, Victoria, Gyorki, David E., Lambie, Duncan, O'Toole, Sandra, Saw, Robyn P.M., Amanuel, Benhur, Angel, Christopher M., Button-Sloan, Alison E., Carlino, Matteo S., Ch'ng, Sydney, Colebatch, Andrew J., Daneshvar, Dariush, Pires da Silva, Inês, Dawson, Tamara, Ferguson, Peter M., Foster-Smith, Erwin, Fox, Stephen B., Gill, Anthony J., Gupta, Ruta, Henderson, Michael A., Hong, Angela M., Howle, Julie R., Jackett, Louise A., James, Craig, Lee, C. Soon, Lochhead, Alistair, Loh, Daphne, McArthur, Grant A. ... Long, Georgina V. (2022). BRAF mutation testing for patients diagnosed with stage III or stage IV melanoma: practical guidance for the Australian setting. Pathology, 54 (1), 6-19. doi: 10.1016/j.pathol.2021.11.002

BRAF mutation testing for patients diagnosed with stage III or stage IV melanoma: practical guidance for the Australian setting

2022

Journal Article

Outcomes after totally minimally invasive versus hybrid and open Ivor Lewis oesophagectomy: results from the International Esodata Study Group

van der Wilk, Berend J., Hagens, Eliza R. C., Eyck, Ben M., Gisbertz, Suzanne S., van Hillegersberg, Richard, Nafteux, Philippe, Schröder, Wolfgang, Nilsson, Magnus, Wijnhoven, Bas P. L., Lagarde, Sjoerd M., van Berge Henegouwen, Mark I., International Esodata Study Group Collaborators , Smithers, Mark, Thomson, Iain, Barbour, Andrew and Thomas, Janine (2022). Outcomes after totally minimally invasive versus hybrid and open Ivor Lewis oesophagectomy: results from the International Esodata Study Group. British Journal of Surgery, 109 (3), 283-290. doi: 10.1093/bjs/znab432

Outcomes after totally minimally invasive versus hybrid and open Ivor Lewis oesophagectomy: results from the International Esodata Study Group

2022

Conference Publication

The association between BRAF-V600E mutations and death from thin (<=1.0 mm) melanoma: a population-based nested case-case study from Queensland, Australia

Claeson, Magdalena, Tan, S., Brown, S., Walsh, M. D., Lambie, D., Baade, P. D., Whitehead, K. J., Soyer, H. P., Smithers, B. M., Green, A. C., Whiteman, D. C. and Khosrotehrani, K. (2022). The association between BRAF-V600E mutations and death from thin (<=1.0 mm) melanoma: a population-based nested case-case study from Queensland, Australia. 35th Nordic Congress of Dermatology and Venereology, the NCDV 2022, Copenhagen, Denmark, 19-22 April 2022. Uppsala, Sweden: Society for the Publication of Acta Dermato - Venereologica.

The association between BRAF-V600E mutations and death from thin (<=1.0 mm) melanoma: a population-based nested case-case study from Queensland, Australia

2022

Journal Article

Therapeutic Value of Sentinel Lymph Node Biopsy in Patients With Melanoma: A Randomized Clinical Trial

Crystal, Jessica S., Thompson, John F., Hyngstrom, John, Caracò, Corrado, Zager, Jonathan S., Jahkola, Tiina, Bowles, Tawnya L., Pennacchioli, Elisabetta, Beitsch, Peter D., Hoekstra, Harald J., Moncrieff, Marc, Ingvar, Christian, Van Akkooi, Alexander, Sabel, Michael S., Levine, Edward A., Agnese, Doreen, Henderson, Michael, Dummer, Reinhard, Neves, Rogerio, Rossi, Carlo Riccardo, Kane, John M., Trocha, Steven, Wright, Frances, Byrd, David R., Matter, Maurice, Hsueh, Eddy C., Mackenzie-Ross, Alastair, Kelley, Mark, Terheyden, Patrick ... Multicenter Selective Lymphadenectomy Trials Study Group (2022). Therapeutic Value of Sentinel Lymph Node Biopsy in Patients With Melanoma: A Randomized Clinical Trial. JAMA Surgery, 157 (9), 835-842. doi: 10.1001/jamasurg.2022.2055

Therapeutic Value of Sentinel Lymph Node Biopsy in Patients With Melanoma: A Randomized Clinical Trial

2021

Journal Article

Responsiveness and convergent validity of QLU-C10D and EQ-5D-3L in assessing short-term quality of life following esophagectomy

Bulamu, Norma B., Vissapragada, Ravi, Chen, Gang, Ratcliffe, Julie, Mudge, Louise A., Smithers, B. Mark, Isenring, Elizabeth A., Smith, Lorelle, Jamieson, Glyn G., Watson, David I., Bessell, Justin, Barbour, Andrew, Aly, Ahmad, Archer, Stephen, Ballal, Mohammed, Barbon, Jessica, Benton, Katie, Bond, Melissa, Berryman, Melissa, Bright, Tim, Cade, Richard, Cardamis, Anna, Carroll, Rosemary, Cashman, Kara, Chan, Larissa, Chapman, Brooke, Chapman, Sally, Chen, Derek, Chisholm, Jacob ... on behalf of The Australian Immunonutrition Study Group (2021). Responsiveness and convergent validity of QLU-C10D and EQ-5D-3L in assessing short-term quality of life following esophagectomy. Health and Quality of Life Outcomes, 19 (1) 233, 1-11. doi: 10.1186/s12955-021-01867-w

Responsiveness and convergent validity of QLU-C10D and EQ-5D-3L in assessing short-term quality of life following esophagectomy

2021

Journal Article

Comparative performance of predictors of death from thin (≤1.0 mm) melanoma

Claeson, M., Baade, P., Marchetti, M., Brown, S., Soyer, H.P., Smithers, B.M., Green, A.C., Whiteman, D.C. and Khosrotehrani, K. (2021). Comparative performance of predictors of death from thin (≤1.0 mm) melanoma. British Journal of Dermatology, 185 (4) bjd.20480, 849-851. doi: 10.1111/bjd.20480

Comparative performance of predictors of death from thin (≤1.0 mm) melanoma

2021

Journal Article

Procedure‐specific outcomes following gastrectomy for cancer compared by hospital volume and service capability

Tian, Kevin, Baade, Peter D., Aitken, Joanne F., Narendra, Aaditya and Smithers, B. Mark (2021). Procedure‐specific outcomes following gastrectomy for cancer compared by hospital volume and service capability. ANZ Journal of Surgery, 91 (11) ans.17132, 2430-2435. doi: 10.1111/ans.17132

Procedure‐specific outcomes following gastrectomy for cancer compared by hospital volume and service capability

2021

Journal Article

Contemporary management of locoregionally advanced melanoma in Australia and New Zealand and the role of adjuvant systemic therapy

Smithers, B. Mark, Saw, Robyn P. M., Gyorki, David E., Martin, Richard C. W., Atkinson, Victoria, Haydon, Andrew, Roberts‐Thomson, Rachel and Thompson, John F. (2021). Contemporary management of locoregionally advanced melanoma in Australia and New Zealand and the role of adjuvant systemic therapy. ANZ Journal of Surgery, 91 (S2), 3-13. doi: 10.1111/ans.17051

Contemporary management of locoregionally advanced melanoma in Australia and New Zealand and the role of adjuvant systemic therapy

2021

Journal Article

Risk prediction model of 90-day mortality after esophagectomy for cancer

D'Journo, Xavier Benoit, Boulate, David, Fourdrain, Alex, Loundou, Anderson, Henegouwen, Mark I. van Berge, Gisbertz, Suzanne S., O'Neill, J. Robert, Hoelscher, Arnulf, Piessen, Guillaume, van Lanschot, Jan, Wijnhoven, Bas, Jobe, Blair, Davies, Andrew, Schneider, Paul M., Pera, Manuel, Nilsson, Magnus, Nafteux, Philippe, Kitagawa, Yuko, Morse, Christopher R., Hofstetter, Wayne, Molena, Daniela, So, Jimmy Bok-Yan, Immanuel, Arul, Parsons, Simon L., Larsen, Michael Hareskov, Dolan, James P., Wood, Stephanie G., Maynard, Nick, Smithers, Mark ... Low, Donald E. (2021). Risk prediction model of 90-day mortality after esophagectomy for cancer. JAMA Surgery, 156 (9), 836-845. doi: 10.1001/jamasurg.2021.2376

Risk prediction model of 90-day mortality after esophagectomy for cancer

2021

Journal Article

Radiomics biomarkers correlate with CD8 expression and predict immune signatures in melanoma patients

Aoude, Lauren G., Wong, Bernadette, Bonazzi, Vanessa F, Brosda, Sandra, Walters, Shaun B., Koufariotis, Lambros T., Naeini, Marjan M., Pearson, John V, Oey, Harald, Patel, Kalpana, Bradford, Julia J., Bloxham, Conor J, Atkinson, Victoria, Law, Phillip, Strutton, Geoffrey, Bayley, Gerard, Yang, Samuel, Smithers, B. Mark, Waddell, Nicola, Miles, Kenneth and Barbour, Andrew P. (2021). Radiomics biomarkers correlate with CD8 expression and predict immune signatures in melanoma patients. Molecular Cancer Research, 19 (6) molcanres.1038.2020, 950-956. doi: 10.1158/1541-7786.mcr-20-1038

Radiomics biomarkers correlate with CD8 expression and predict immune signatures in melanoma patients

2021

Journal Article

Preoperative ultrasound assessment of regional lymph nodes in melanoma patients does not provide reliable nodal staging: results from a large multicenter trial

Thompson, John F., Haydu, Lauren E., Uren, Roger F., Andtbacka, Robert H., Zager, Jonathan S., Beitsch, Peter D., Agnese, Doreen M., Mozzillo, Nicola, Testori, Alessandro, Bowles, Tawnya L., Hoekstra, Harald J., Kelley, Mark C., Sussman, Jeffrey, Schneebaum, Schlomo, Smithers, B Mark, McKinnon, Gregory, Hsueh, Eddy, Jacobs, Lisa, Schultz, Erwin, Reintgen, Douglas, Kane, John M., Friedman, Erica B., Wang, Hejing, Van Kreuningen, Lisa, Schiller, Vicki, Elashoff, David A., Elashoff, Robert, Cochran, Alistair J., Stern, Stacey and Faries, Mark B. (2021). Preoperative ultrasound assessment of regional lymph nodes in melanoma patients does not provide reliable nodal staging: results from a large multicenter trial. Annals of Surgery, 273 (4), 814-820. doi: 10.1097/sla.0000000000003405

Preoperative ultrasound assessment of regional lymph nodes in melanoma patients does not provide reliable nodal staging: results from a large multicenter trial

Availability

Professor Mark Smithers is:
Not available for supervision

Supervision history

Current supervision

  • Master Philosophy

    Trends in the regional nodal management of cutaneous melanoma.

    Principal Advisor

    Other advisors: Professor Peter Soyer

  • Master Philosophy

    Retroperitoneal sarcoma: Impact of the patterns of care on patient outcomes in Queensland.

    Principal Advisor

    Other advisors: Professor Andrew Barbour

  • Master Philosophy

    Factors Influencing Anastomotic Complications after Oesophagectomy

    Associate Advisor

  • Doctor Philosophy

    Utilising the Multi-Disciplinary Resources at Tertiary Centres to Improve Outcomes from Pancreatic Cancer

    Associate Advisor

    Other advisors: Dr David Cavallucci

Completed supervision

Enquiries

Contact Professor Mark Smithers directly for media enquiries about:

  • Advanced endoscopic surgery
  • Cancer surgery
  • Endoscopic surgery
  • General surgery
  • Melanoma
  • Surgery - cancer
  • Surgery - oesophageal, gastric cancer
  • Surgery - upper GI
  • Upper GI surgery

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