Overview
Background
Emeritus Professor Mark Smithers is a surgical oncologist who specialises in surgery for oesophago-gastric diseases, melanoma, advanced skin cancer and soft tissue sarcoma. He was the Director of the Upper GI and Soft Tissue Unit at the Princess Alexandra Hospital, in Brisbane, Australia from 1998 - 2023. Commencing his academic career with the University of Queensland in 1987, he progressed to be the Mayne Chair in Surgery and head of the Academy of Surgery. He is the second University of Queensland Medical graduate to be appointed to this role. His research has been focussed on the development and assessment of outcomes from minimally invasive upper GI surgery, and trials assessing the role of perioperative multidisciplinary therapy for esophageal and gastric cancer. As well he has led, or been involved with, clinical trials from phase I to III, for all stages of melanoma through his role as the Chair of the Queensland Melanoma Project. More recently he has been involved with the assessment of access to, and outcomes from, surgery for cancer in Queensland, Australia.
He has overseen the administration and development of the surgery curriculum, and the teaching, in the Academy of Surgery, in the UQ Faculty of Medicine. He was on a number of committees relevant to the implementation of the UQ MD design course. He has held various leadership and committee roles with the Royal Australasian College of Surgeons, as well as leadership roles, including the Presidency, in the Australian and New Zealand Oesophago Gastric Surgeons Association. He has also been on the committees of international organisations related to oesophageal and gastric surgery. He has published 250 articles, eight book chapters, and has been on the editorial board of a number of surgical journals.
He has been recognised for his clinical and academic roles by the award of Member of the Order of Australia (AM). The citation reads, "for service to medicine in the fields of gastro-intestinal and melanoma surgery, to medical education and to professional organisations". The Royal Australasian College of Surgeons awarded him the Sir Hugh Devine medal, for services to surgery and the community. This is the College’s highest honour. Internationally, he has been awarded an honorary fellowship of the Royal College of Surgeons of Edinburgh and recently, in the United States, he was elected as an Honarary Fellow of the American Surgical Association.
Availability
- Professor Mark Smithers is:
- Not available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
- Honorary Fellow, American Surgical Association, American Surgical Association
- Fellow, Royal Australasian College of Surgeons, Royal Australasian College of Surgeons
- Fellow, Royal College of Surgeons of Edinburgh, Royal College of Surgeons of Edinburgh
- Fellow, Royal College of Surgeons of England, Royal College of Surgeons of England
Research interests
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Cutaneous Melanoma
epidemiology, public health issues and management of all stages
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Management of Oesophageal and Gastric Cancer
Investigation and management of benign and malignant diseases of the oesophagus and the stomach.
Works
Search Professor Mark Smithers’s works on UQ eSpace
2023
Journal Article
Conditional survival in patients with stage IB‐IIIA melanoma undergoing sentinel node biopsy in Queensland: a longitudinal study
Tedman, Alexander James, Liyanage, Upekha E., Chong, Sharene, Rowe, Casey, von Schuckmann, Lena A., Malt, Maryrose, Green, Adele C., Smithers, B. Mark and Khosrotehrani, Kiarash (2023). Conditional survival in patients with stage IB‐IIIA melanoma undergoing sentinel node biopsy in Queensland: a longitudinal study. Australasian Journal of Dermatology, 64 (1), e34-e40. doi: 10.1111/ajd.13974
2023
Book Chapter
Gastroesophageal reflux disease
Frankel, Adam and Smithers, B. Mark (2023). Gastroesophageal reflux disease. Mastering endo-laparoscopic and thoracoscopic surgery: ELSA manual. (pp. 219-227) edited by Davide Lomanto, William Tzu-Liang Chen and Marilou B. Fuentes. Singapore: Springer Nature Singapore. doi: 10.1007/978-981-19-3755-2_34
2022
Journal Article
Does Residual Invasive Disease in Wide Local Excision after Diagnosis with Partial Biopsy Technique Influence Survival in Melanoma? Matched-Pair Analysis of Multicenter Selective Lymphadenectomy Trial I and II, (vol 235, pg 49 2022)
Morton, Donald L., Faries, Mark B., Wang, He-Jing, Elashoff, Robert, Thompson, John F., Coventry, Brendon J., Smithers, B. Mark, Cochran, Alistair J., Elashoff, Robert, Wang, He-Jing, Mozzillo, Nicola, Nieweg, Omgo E., Roses, Daniel F., Hoekstra, Harald J., Karakousis, Constantine P., Kraybill, William G., Puleo, Christopher A., Kashani-Sabet, Mohammed, Paul, Eberhard and McKinnon, J. Gregory (2022). Does Residual Invasive Disease in Wide Local Excision after Diagnosis with Partial Biopsy Technique Influence Survival in Melanoma? Matched-Pair Analysis of Multicenter Selective Lymphadenectomy Trial I and II, (vol 235, pg 49 2022). Journal of the American College of Surgeons, 235 (6), 973-974. doi: 10.1097/XCS.0000000000000411
2022
Journal Article
Laparoscopic fundoplication versus laparoscopic Roux-en-Y gastric bypass for gastro-oesophageal reflux disease in obese patients: protocol for a randomized clinical trial
Frankel, Adam, Thomson, Iain, Shah, Ayesha, Chen, Chen, Zahir, Syeda Farah, Barbour, Andrew, Holtmann, Gerald and Mark Smithers, B (2022). Laparoscopic fundoplication versus laparoscopic Roux-en-Y gastric bypass for gastro-oesophageal reflux disease in obese patients: protocol for a randomized clinical trial. BJS Open, 6 (6) zrac132. doi: 10.1093/bjsopen/zrac132
2022
Journal Article
Efficacy of laparoscopic fundoplication in patients with chronic cough and gastro-oesophageal reflux
Frankel, Adam, Ong, Hock Soo, Smithers, B. Mark, Nathanson, Les K. and Gotley, David C. (2022). Efficacy of laparoscopic fundoplication in patients with chronic cough and gastro-oesophageal reflux. Esophagus, 20 (1), 1-8. doi: 10.1007/s10388-022-00953-2
2022
Journal Article
It's time we measure more than Australia's gastrectomy mortality rate
Johnson, Mary Ann, Winter, Nicole and Smithers, Mark (2022). It's time we measure more than Australia's gastrectomy mortality rate. ANZ Journal of Surgery, 92 (9), 1972-1973. doi: 10.1111/ans.17997
2022
Conference Publication
Radiomics biomarkers are associated with survival in patients with oesophageal adenocarcinoma
Aoude, L.G., Bonazzi, V.F., Brosda, S., Wong, B., Moradi, H., Lonie, J., Bradford, J., Bloxham, C., Atkinson, V.G., Law, P., Lampe, G., Smithers, M., Waddell, N., Vegh, V., Miles, K. and Barbour, A.P. (2022). Radiomics biomarkers are associated with survival in patients with oesophageal adenocarcinoma. ESMO Congress 2022, Singapore, 9 - 13 September 2022. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.annonc.2022.07.1357
2022
Journal Article
Risk factors, diagnosis and management of chyle leak following esophagectomy for cancers: an international consensus statement
Kamarajah, Sivesh K., Siddaiah-Subramanya, Manjunath, Parente, Alessandro, Evans, Richard P. T., Adeyeye, Ademola, Ainsworth, Alan, Takahashi, Alberto M. L., Charalabopoulos, Alex, Chang, Andrew, Eroglue, Atila, Wijnhoven, Bas, Donohoe, Claire, Molena, Daniela, Talavera-Urquijo, Eider, Takeda, Flavio Roberto, Darling, Gail, Rosero, German, Piessen, Guillaume, Mahendran, Hans, Kuei, Hsu Po, Gockel, Ines, Negoi, Ionut, Weindelmayer, Jacopo, Rasanen, Jari, Bekele, Kebebe, Kim, Guowei, Depypere, Lieven, Ferri, Lorenzo, Nilsson, Magnus ... Griffiths, Ewen A. (2022). Risk factors, diagnosis and management of chyle leak following esophagectomy for cancers: an international consensus statement. Annals of Surgery Open, 3 (3) e192, 1-8. doi: 10.1097/as9.0000000000000192
2022
Journal Article
Identifying a core symptom set triggering radiological and endoscopic investigations for suspected recurrent esophago-gastric cancer: a modified Delphi consensus process
Chidambaram, Swathikan, Patel, Nikhil M., Sounderajah, Viknesh, Alfieri, Rita, Bonavina, Luigi, Cheong, Edward, Cockbain, Andy, D'Journo, Xavier Benoit, Ferri, Lorenzo, Griffiths, Ewen A., Grimminger, Peter, Gronnier, Caroline, Gutschow, Christian, Hedberg, Jakob, Kauppila, Joonas H., Lagarde, Sjoerd, Low, Donald, Nafteux, Philippe, Nieuwenhuijzen, Grard, Nilsson, Magnus, Rosati, Riccardo, Schroeder, Wolfgang, Smithers, B. Mark, Henegouwen, Mark I. van Berge, van Hillegesberg, Richard, Watson, David, Vohra, Ravinder, Maynard, Nick and Markar, Sheraz R. (2022). Identifying a core symptom set triggering radiological and endoscopic investigations for suspected recurrent esophago-gastric cancer: a modified Delphi consensus process. Diseases of the Esophagus, 36 (1) doac038. doi: 10.1093/dote/doac038
2022
Journal Article
Neoadjuvant chemoradiotherapy and surgery for esophageal squamous cell carcinoma versus definitive chemoradiotherapy with salvage surgery as needed: The study protocol for the randomized controlled NEEDS trial
Nilsson, Magnus, Olafsdottir, Halla, Alexandersson von Döbeln, Gabriella, Villegas, Fernanda, Gagliardi, Giovanna, Hellström, Mats, Wang, Qiao-Li, Johansson, Hemming, Gebski, Val, Hedberg, Jakob, Klevebro, Fredrik, Markar, Sheraz, Smyth, Elizabeth, Lagergren, Pernilla, Al-Haidari, Ghazwan, Rekstad, Lars Cato, Aahlin, Eirik Kjus, Wallner, Bengt, Edholm, David, Johansson, Jan, Szabo, Eva, Reynolds, John V., Pramesh, C. S., Mummudi, Naveen, Joshi, Amit, Ferri, Lorenzo, Wong, Rebecca KS, O’Callaghan, Chris, Lukovic, Jelena ... Lordick, Florian (2022). Neoadjuvant chemoradiotherapy and surgery for esophageal squamous cell carcinoma versus definitive chemoradiotherapy with salvage surgery as needed: The study protocol for the randomized controlled NEEDS trial. Frontiers in Oncology, 12 917961, 917961. doi: 10.3389/fonc.2022.917961
2022
Conference Publication
Classification of esophageal adenocarcinoma into subgroups that are associated with patient survival using RNA-seq and immunohistochemistry
Sharma, Sowmya, Naeini, Marjan, Aoude, Lauren G., Bonazzi, Vanessa F., Gartside, Michael G., Loffler, Kelly A., Patel, Kalpana, Newell, Felicity, Lampe, Guy, Brosda, Sandra, Thomas, Janine, Smithers, Mark, Simes, John, Watson, David I., Pearson, John, Barbour, Andrew and Waddell, Nic (2022). Classification of esophageal adenocarcinoma into subgroups that are associated with patient survival using RNA-seq and immunohistochemistry. Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Electr Network, Jun 03-07, 2022. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
2022
Journal Article
Diet quality is associated with primary melanoma thickness
Hughes, M. C. B., Malt, M., Khosrotehrani, K., Smithers, B. M. and Green, A. C. (2022). Diet quality is associated with primary melanoma thickness. Journal of the European Academy of Dermatology and Venereology, 36 (10), 1745-1750. doi: 10.1111/jdv.18174
2022
Journal Article
Hypothesised cutaneous sites of origin of stage III melanomas with unknown primary: a multi‐centre study
Clayton, Bethan, Muneeb, Ferhan, Hughes, Maria Celia B., Grant, Megan E., Khosrotehrani, Kiarash, Smithers, B. Mark, Spina, Romina, Campana, Luca G., Oudit, Deemesh and Green, Adele C. (2022). Hypothesised cutaneous sites of origin of stage III melanomas with unknown primary: a multi‐centre study. International Journal of Cancer, 151 (3), 396-401. doi: 10.1002/ijc.34020
2022
Journal Article
ctDNA as a biomarker of progression in oesophageal adenocarcinoma
Bonazzi, V. F., Aoude, L. G., Brosda, S., Lonie, J. M., Patel, K., Bradford, J. J., Koufariotis, L. T., Wood, S., Smithers, B. Mark, Waddell, N. and Barbour, A. P. (2022). ctDNA as a biomarker of progression in oesophageal adenocarcinoma. ESMO Open, 7 (3) 100452, 100452. doi: 10.1016/j.esmoop.2022.100452
2022
Journal Article
Patient-reported outcome (PRO) results from the AGITG DOCTOR trial: a randomised phase 2 trial of tailored neoadjuvant therapy for resectable oesophageal adenocarcinoma
Mercieca-Bebber, R., Barnes, E. H., Wilson, K., Samoon, Z., Walpole, E., Mai, T., Ackland, S., Burge, M., Dickie, G., Watson, D., Leung, J., Wang, T., Bohmer, R., Cameron, D., Simes, J., Gebski, V., Smithers, M., Thomas, J., Zalcberg, J. and Barbour, A. P. (2022). Patient-reported outcome (PRO) results from the AGITG DOCTOR trial: a randomised phase 2 trial of tailored neoadjuvant therapy for resectable oesophageal adenocarcinoma. BMC Cancer, 22 (1) 276, 1-11. doi: 10.1186/s12885-022-09270-4
2022
Journal Article
Reply to: A practical guide on the use of imiquimod cream to treat lentigo maligna
Muir, James, McCormack, Chris, De’Ambrosis, Brian, Brown, Hilary, Kennedy, Daniel, Louie, Brendan and Smithers, B. Mark (2022). Reply to: A practical guide on the use of imiquimod cream to treat lentigo maligna. Australasian Journal of Dermatology, 63 (2), e197-e198. doi: 10.1111/ajd.13771
2022
Journal Article
A rare case of a giant retroperitoneal lipoma with multiple limb and trunk lipomata without familial multiple lipomatosis
Laurens, Jason R., Frankel, Adam J., Smithers, Bernard M. and Strutton, Geoffrey (2022). A rare case of a giant retroperitoneal lipoma with multiple limb and trunk lipomata without familial multiple lipomatosis. Journal of Surgical Case Reports, 2022 (3), 1-3. doi: 10.1093/jscr/rjac121
2022
Journal Article
Impacts of UV-C irradiation on marine biofilm community succession
Naik, Abhishek, Smithers, Mark and Moisander, Pia H. (2022). Impacts of UV-C irradiation on marine biofilm community succession. Applied and Environmental Microbiology, 88 (4) e02298-21, 1-22. doi: 10.1128/aem.02298-21
2022
Journal Article
BRAF mutation testing for patients diagnosed with stage III or stage IV melanoma: practical guidance for the Australian setting
Scolyer, Richard A., Atkinson, Victoria, Gyorki, David E., Lambie, Duncan, O'Toole, Sandra, Saw, Robyn P.M., Amanuel, Benhur, Angel, Christopher M., Button-Sloan, Alison E., Carlino, Matteo S., Ch'ng, Sydney, Colebatch, Andrew J., Daneshvar, Dariush, Pires da Silva, Inês, Dawson, Tamara, Ferguson, Peter M., Foster-Smith, Erwin, Fox, Stephen B., Gill, Anthony J., Gupta, Ruta, Henderson, Michael A., Hong, Angela M., Howle, Julie R., Jackett, Louise A., James, Craig, Lee, C. Soon, Lochhead, Alistair, Loh, Daphne, McArthur, Grant A. ... Long, Georgina V. (2022). BRAF mutation testing for patients diagnosed with stage III or stage IV melanoma: practical guidance for the Australian setting. Pathology, 54 (1), 6-19. doi: 10.1016/j.pathol.2021.11.002
2022
Journal Article
Outcomes after totally minimally invasive versus hybrid and open Ivor Lewis oesophagectomy: results from the International Esodata Study Group
van der Wilk, Berend J., Hagens, Eliza R. C., Eyck, Ben M., Gisbertz, Suzanne S., van Hillegersberg, Richard, Nafteux, Philippe, Schröder, Wolfgang, Nilsson, Magnus, Wijnhoven, Bas P. L., Lagarde, Sjoerd M., van Berge Henegouwen, Mark I., International Esodata Study Group Collaborators , Smithers, Mark, Thomson, Iain, Barbour, Andrew and Thomas, Janine (2022). Outcomes after totally minimally invasive versus hybrid and open Ivor Lewis oesophagectomy: results from the International Esodata Study Group. British Journal of Surgery, 109 (3), 283-290. doi: 10.1093/bjs/znab432
Funding
Current funding
Supervision
Availability
- Professor Mark Smithers is:
- Not available for supervision
Supervision history
Current supervision
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Master Philosophy
Assessment of the impact of treating service characteristics on surgical and oncological outcomes for patients with Retroperitoneal and Inguinal Sarcomas in Queensland
Principal Advisor
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Master Philosophy
Factors Influencing Anastomotic Complications after Oesophagectomy
Associate Advisor
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Doctor Philosophy
New tools for the multi-modal evaluation of pancreatic cancer and its precursor neoplasms.
Associate Advisor
Other advisors: Dr David Cavallucci
Completed supervision
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2020
Master Philosophy
An assessment of the impacts of centralising complex upper-gastrointestinal surgery in Queensland
Principal Advisor
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2024
Master Philosophy
In vivo Magnetic Resonance Spectroscopy (MRS) with 2-Dimensional (2D) COrrelated Spectroscopy (COSY) applied to breast cancer
Associate Advisor
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2020
Doctor Philosophy
Natural history of high-risk cutaneous primary melanoma and risk factors for disease progression
Associate Advisor
Other advisors: Professor Kiarash Khosrotehrani
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2020
Doctor Philosophy
An evaluation of the role of locoregional treatments for the management of in-transit melanoma metastases
Associate Advisor
Other advisors: Professor Peter Soyer
Media
Enquiries
Contact Professor Mark Smithers directly for media enquiries about:
- Advanced endoscopic surgery
- Cancer surgery
- Endoscopic surgery
- General surgery
- Melanoma
- Surgery - cancer
- Surgery - oesophageal, gastric cancer
- Surgery - upper GI
- Upper GI surgery
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