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Professor Mark Smithers
Professor

Mark Smithers

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Overview

Background

Emeritus Professor Mark Smithers is a surgical oncologist who specialises in surgery for oesophago-gastric diseases, melanoma, advanced skin cancer and soft tissue sarcoma. He was the Director of the Upper GI and Soft Tissue Unit at the Princess Alexandra Hospital, in Brisbane, Australia from 1998 - 2023. Commencing his academic career with the University of Queensland in 1987, he progressed to be the Mayne Chair in Surgery and head of the Academy of Surgery. He is the second University of Queensland Medical graduate to be appointed to this role. His research has been focussed on the development and assessment of outcomes from minimally invasive upper GI surgery, and trials assessing the role of perioperative multidisciplinary therapy for esophageal and gastric cancer. As well he has led, or been involved with, clinical trials from phase I to III, for all stages of melanoma through his role as the Chair of the Queensland Melanoma Project. More recently he has been involved with the assessment of access to, and outcomes from, surgery for cancer in Queensland, Australia.

He has overseen the administration and development of the surgery curriculum, and the teaching, in the Academy of Surgery, in the UQ Faculty of Medicine. He was on a number of committees relevant to the implementation of the UQ MD design course. He has held various leadership and committee roles with the Royal Australasian College of Surgeons, as well as leadership roles, including the Presidency, in the Australian and New Zealand Oesophago Gastric Surgeons Association. He has also been on the committees of international organisations related to oesophageal and gastric surgery. He has published 250 articles, eight book chapters, and has been on the editorial board of a number of surgical journals.

He has been recognised for his clinical and academic roles by the award of Member of the Order of Australia (AM). The citation reads, "for service to medicine in the fields of gastro-intestinal and melanoma surgery, to medical education and to professional organisations". The Royal Australasian College of Surgeons awarded him the Sir Hugh Devine medal, for services to surgery and the community. This is the College’s highest honour. Internationally, he has been awarded an honorary fellowship of the Royal College of Surgeons of Edinburgh and recently, in the United States, he was elected as an Honarary Fellow of the American Surgical Association.

Availability

Professor Mark Smithers is:
Not available for supervision
Media expert

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Honorary Fellow, American Surgical Association, American Surgical Association
  • Fellow, Royal Australasian College of Surgeons, Royal Australasian College of Surgeons
  • Fellow, Royal College of Surgeons of Edinburgh, Royal College of Surgeons of Edinburgh
  • Fellow, Royal College of Surgeons of England, Royal College of Surgeons of England

Research interests

  • Cutaneous Melanoma

    epidemiology, public health issues and management of all stages

  • Management of Oesophageal and Gastric Cancer

    Investigation and management of benign and malignant diseases of the oesophagus and the stomach.

Works

Search Professor Mark Smithers’s works on UQ eSpace

419 works between 1983 and 2025

41 - 60 of 419 works

2023

Journal Article

Conditional survival in patients with stage IB‐IIIA melanoma undergoing sentinel node biopsy in Queensland: a longitudinal study

Tedman, Alexander James, Liyanage, Upekha E., Chong, Sharene, Rowe, Casey, von Schuckmann, Lena A., Malt, Maryrose, Green, Adele C., Smithers, B. Mark and Khosrotehrani, Kiarash (2023). Conditional survival in patients with stage IB‐IIIA melanoma undergoing sentinel node biopsy in Queensland: a longitudinal study. Australasian Journal of Dermatology, 64 (1), e34-e40. doi: 10.1111/ajd.13974

Conditional survival in patients with stage IB‐IIIA melanoma undergoing sentinel node biopsy in Queensland: a longitudinal study

2023

Book Chapter

Gastroesophageal reflux disease

Frankel, Adam and Smithers, B. Mark (2023). Gastroesophageal reflux disease. Mastering endo-laparoscopic and thoracoscopic surgery: ELSA manual. (pp. 219-227) edited by Davide Lomanto, William Tzu-Liang Chen and Marilou B. Fuentes. Singapore: Springer Nature Singapore. doi: 10.1007/978-981-19-3755-2_34

Gastroesophageal reflux disease

2022

Journal Article

Does Residual Invasive Disease in Wide Local Excision after Diagnosis with Partial Biopsy Technique Influence Survival in Melanoma? Matched-Pair Analysis of Multicenter Selective Lymphadenectomy Trial I and II, (vol 235, pg 49 2022)

Morton, Donald L., Faries, Mark B., Wang, He-Jing, Elashoff, Robert, Thompson, John F., Coventry, Brendon J., Smithers, B. Mark, Cochran, Alistair J., Elashoff, Robert, Wang, He-Jing, Mozzillo, Nicola, Nieweg, Omgo E., Roses, Daniel F., Hoekstra, Harald J., Karakousis, Constantine P., Kraybill, William G., Puleo, Christopher A., Kashani-Sabet, Mohammed, Paul, Eberhard and McKinnon, J. Gregory (2022). Does Residual Invasive Disease in Wide Local Excision after Diagnosis with Partial Biopsy Technique Influence Survival in Melanoma? Matched-Pair Analysis of Multicenter Selective Lymphadenectomy Trial I and II, (vol 235, pg 49 2022). Journal of the American College of Surgeons, 235 (6), 973-974. doi: 10.1097/XCS.0000000000000411

Does Residual Invasive Disease in Wide Local Excision after Diagnosis with Partial Biopsy Technique Influence Survival in Melanoma? Matched-Pair Analysis of Multicenter Selective Lymphadenectomy Trial I and II, (vol 235, pg 49 2022)

2022

Journal Article

Laparoscopic fundoplication versus laparoscopic Roux-en-Y gastric bypass for gastro-oesophageal reflux disease in obese patients: protocol for a randomized clinical trial

Frankel, Adam, Thomson, Iain, Shah, Ayesha, Chen, Chen, Zahir, Syeda Farah, Barbour, Andrew, Holtmann, Gerald and Mark Smithers, B (2022). Laparoscopic fundoplication versus laparoscopic Roux-en-Y gastric bypass for gastro-oesophageal reflux disease in obese patients: protocol for a randomized clinical trial. BJS Open, 6 (6) zrac132. doi: 10.1093/bjsopen/zrac132

Laparoscopic fundoplication versus laparoscopic Roux-en-Y gastric bypass for gastro-oesophageal reflux disease in obese patients: protocol for a randomized clinical trial

2022

Journal Article

Efficacy of laparoscopic fundoplication in patients with chronic cough and gastro-oesophageal reflux

Frankel, Adam, Ong, Hock Soo, Smithers, B. Mark, Nathanson, Les K. and Gotley, David C. (2022). Efficacy of laparoscopic fundoplication in patients with chronic cough and gastro-oesophageal reflux. Esophagus, 20 (1), 1-8. doi: 10.1007/s10388-022-00953-2

Efficacy of laparoscopic fundoplication in patients with chronic cough and gastro-oesophageal reflux

2022

Journal Article

It's time we measure more than Australia's gastrectomy mortality rate

Johnson, Mary Ann, Winter, Nicole and Smithers, Mark (2022). It's time we measure more than Australia's gastrectomy mortality rate. ANZ Journal of Surgery, 92 (9), 1972-1973. doi: 10.1111/ans.17997

It's time we measure more than Australia's gastrectomy mortality rate

2022

Conference Publication

Radiomics biomarkers are associated with survival in patients with oesophageal adenocarcinoma

Aoude, L.G., Bonazzi, V.F., Brosda, S., Wong, B., Moradi, H., Lonie, J., Bradford, J., Bloxham, C., Atkinson, V.G., Law, P., Lampe, G., Smithers, M., Waddell, N., Vegh, V., Miles, K. and Barbour, A.P. (2022). Radiomics biomarkers are associated with survival in patients with oesophageal adenocarcinoma. ESMO Congress 2022, Singapore, 9 - 13 September 2022. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.annonc.2022.07.1357

Radiomics biomarkers are associated with survival in patients with oesophageal adenocarcinoma

2022

Journal Article

Risk factors, diagnosis and management of chyle leak following esophagectomy for cancers: an international consensus statement

Kamarajah, Sivesh K., Siddaiah-Subramanya, Manjunath, Parente, Alessandro, Evans, Richard P. T., Adeyeye, Ademola, Ainsworth, Alan, Takahashi, Alberto M. L., Charalabopoulos, Alex, Chang, Andrew, Eroglue, Atila, Wijnhoven, Bas, Donohoe, Claire, Molena, Daniela, Talavera-Urquijo, Eider, Takeda, Flavio Roberto, Darling, Gail, Rosero, German, Piessen, Guillaume, Mahendran, Hans, Kuei, Hsu Po, Gockel, Ines, Negoi, Ionut, Weindelmayer, Jacopo, Rasanen, Jari, Bekele, Kebebe, Kim, Guowei, Depypere, Lieven, Ferri, Lorenzo, Nilsson, Magnus ... Griffiths, Ewen A. (2022). Risk factors, diagnosis and management of chyle leak following esophagectomy for cancers: an international consensus statement. Annals of Surgery Open, 3 (3) e192, 1-8. doi: 10.1097/as9.0000000000000192

Risk factors, diagnosis and management of chyle leak following esophagectomy for cancers: an international consensus statement

2022

Journal Article

Identifying a core symptom set triggering radiological and endoscopic investigations for suspected recurrent esophago-gastric cancer: a modified Delphi consensus process

Chidambaram, Swathikan, Patel, Nikhil M., Sounderajah, Viknesh, Alfieri, Rita, Bonavina, Luigi, Cheong, Edward, Cockbain, Andy, D'Journo, Xavier Benoit, Ferri, Lorenzo, Griffiths, Ewen A., Grimminger, Peter, Gronnier, Caroline, Gutschow, Christian, Hedberg, Jakob, Kauppila, Joonas H., Lagarde, Sjoerd, Low, Donald, Nafteux, Philippe, Nieuwenhuijzen, Grard, Nilsson, Magnus, Rosati, Riccardo, Schroeder, Wolfgang, Smithers, B. Mark, Henegouwen, Mark I. van Berge, van Hillegesberg, Richard, Watson, David, Vohra, Ravinder, Maynard, Nick and Markar, Sheraz R. (2022). Identifying a core symptom set triggering radiological and endoscopic investigations for suspected recurrent esophago-gastric cancer: a modified Delphi consensus process. Diseases of the Esophagus, 36 (1) doac038. doi: 10.1093/dote/doac038

Identifying a core symptom set triggering radiological and endoscopic investigations for suspected recurrent esophago-gastric cancer: a modified Delphi consensus process

2022

Journal Article

Neoadjuvant chemoradiotherapy and surgery for esophageal squamous cell carcinoma versus definitive chemoradiotherapy with salvage surgery as needed: The study protocol for the randomized controlled NEEDS trial

Nilsson, Magnus, Olafsdottir, Halla, Alexandersson von Döbeln, Gabriella, Villegas, Fernanda, Gagliardi, Giovanna, Hellström, Mats, Wang, Qiao-Li, Johansson, Hemming, Gebski, Val, Hedberg, Jakob, Klevebro, Fredrik, Markar, Sheraz, Smyth, Elizabeth, Lagergren, Pernilla, Al-Haidari, Ghazwan, Rekstad, Lars Cato, Aahlin, Eirik Kjus, Wallner, Bengt, Edholm, David, Johansson, Jan, Szabo, Eva, Reynolds, John V., Pramesh, C. S., Mummudi, Naveen, Joshi, Amit, Ferri, Lorenzo, Wong, Rebecca KS, O’Callaghan, Chris, Lukovic, Jelena ... Lordick, Florian (2022). Neoadjuvant chemoradiotherapy and surgery for esophageal squamous cell carcinoma versus definitive chemoradiotherapy with salvage surgery as needed: The study protocol for the randomized controlled NEEDS trial. Frontiers in Oncology, 12 917961, 917961. doi: 10.3389/fonc.2022.917961

Neoadjuvant chemoradiotherapy and surgery for esophageal squamous cell carcinoma versus definitive chemoradiotherapy with salvage surgery as needed: The study protocol for the randomized controlled NEEDS trial

2022

Conference Publication

Classification of esophageal adenocarcinoma into subgroups that are associated with patient survival using RNA-seq and immunohistochemistry

Sharma, Sowmya, Naeini, Marjan, Aoude, Lauren G., Bonazzi, Vanessa F., Gartside, Michael G., Loffler, Kelly A., Patel, Kalpana, Newell, Felicity, Lampe, Guy, Brosda, Sandra, Thomas, Janine, Smithers, Mark, Simes, John, Watson, David I., Pearson, John, Barbour, Andrew and Waddell, Nic (2022). Classification of esophageal adenocarcinoma into subgroups that are associated with patient survival using RNA-seq and immunohistochemistry. Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Electr Network, Jun 03-07, 2022. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.

Classification of esophageal adenocarcinoma into subgroups that are associated with patient survival using RNA-seq and immunohistochemistry

2022

Journal Article

Diet quality is associated with primary melanoma thickness

Hughes, M. C. B., Malt, M., Khosrotehrani, K., Smithers, B. M. and Green, A. C. (2022). Diet quality is associated with primary melanoma thickness. Journal of the European Academy of Dermatology and Venereology, 36 (10), 1745-1750. doi: 10.1111/jdv.18174

Diet quality is associated with primary melanoma thickness

2022

Journal Article

Hypothesised cutaneous sites of origin of stage III melanomas with unknown primary: a multi‐centre study

Clayton, Bethan, Muneeb, Ferhan, Hughes, Maria Celia B., Grant, Megan E., Khosrotehrani, Kiarash, Smithers, B. Mark, Spina, Romina, Campana, Luca G., Oudit, Deemesh and Green, Adele C. (2022). Hypothesised cutaneous sites of origin of stage III melanomas with unknown primary: a multi‐centre study. International Journal of Cancer, 151 (3), 396-401. doi: 10.1002/ijc.34020

Hypothesised cutaneous sites of origin of stage III melanomas with unknown primary: a multi‐centre study

2022

Journal Article

ctDNA as a biomarker of progression in oesophageal adenocarcinoma

Bonazzi, V. F., Aoude, L. G., Brosda, S., Lonie, J. M., Patel, K., Bradford, J. J., Koufariotis, L. T., Wood, S., Smithers, B. Mark, Waddell, N. and Barbour, A. P. (2022). ctDNA as a biomarker of progression in oesophageal adenocarcinoma. ESMO Open, 7 (3) 100452, 100452. doi: 10.1016/j.esmoop.2022.100452

ctDNA as a biomarker of progression in oesophageal adenocarcinoma

2022

Journal Article

Patient-reported outcome (PRO) results from the AGITG DOCTOR trial: a randomised phase 2 trial of tailored neoadjuvant therapy for resectable oesophageal adenocarcinoma

Mercieca-Bebber, R., Barnes, E. H., Wilson, K., Samoon, Z., Walpole, E., Mai, T., Ackland, S., Burge, M., Dickie, G., Watson, D., Leung, J., Wang, T., Bohmer, R., Cameron, D., Simes, J., Gebski, V., Smithers, M., Thomas, J., Zalcberg, J. and Barbour, A. P. (2022). Patient-reported outcome (PRO) results from the AGITG DOCTOR trial: a randomised phase 2 trial of tailored neoadjuvant therapy for resectable oesophageal adenocarcinoma. BMC Cancer, 22 (1) 276, 1-11. doi: 10.1186/s12885-022-09270-4

Patient-reported outcome (PRO) results from the AGITG DOCTOR trial: a randomised phase 2 trial of tailored neoadjuvant therapy for resectable oesophageal adenocarcinoma

2022

Journal Article

Reply to: A practical guide on the use of imiquimod cream to treat lentigo maligna

Muir, James, McCormack, Chris, De’Ambrosis, Brian, Brown, Hilary, Kennedy, Daniel, Louie, Brendan and Smithers, B. Mark (2022). Reply to: A practical guide on the use of imiquimod cream to treat lentigo maligna. Australasian Journal of Dermatology, 63 (2), e197-e198. doi: 10.1111/ajd.13771

Reply to: A practical guide on the use of imiquimod cream to treat lentigo maligna

2022

Journal Article

A rare case of a giant retroperitoneal lipoma with multiple limb and trunk lipomata without familial multiple lipomatosis

Laurens, Jason R., Frankel, Adam J., Smithers, Bernard M. and Strutton, Geoffrey (2022). A rare case of a giant retroperitoneal lipoma with multiple limb and trunk lipomata without familial multiple lipomatosis. Journal of Surgical Case Reports, 2022 (3), 1-3. doi: 10.1093/jscr/rjac121

A rare case of a giant retroperitoneal lipoma with multiple limb and trunk lipomata without familial multiple lipomatosis

2022

Journal Article

Impacts of UV-C irradiation on marine biofilm community succession

Naik, Abhishek, Smithers, Mark and Moisander, Pia H. (2022). Impacts of UV-C irradiation on marine biofilm community succession. Applied and Environmental Microbiology, 88 (4) e02298-21, 1-22. doi: 10.1128/aem.02298-21

Impacts of UV-C irradiation on marine biofilm community succession

2022

Journal Article

BRAF mutation testing for patients diagnosed with stage III or stage IV melanoma: practical guidance for the Australian setting

Scolyer, Richard A., Atkinson, Victoria, Gyorki, David E., Lambie, Duncan, O'Toole, Sandra, Saw, Robyn P.M., Amanuel, Benhur, Angel, Christopher M., Button-Sloan, Alison E., Carlino, Matteo S., Ch'ng, Sydney, Colebatch, Andrew J., Daneshvar, Dariush, Pires da Silva, Inês, Dawson, Tamara, Ferguson, Peter M., Foster-Smith, Erwin, Fox, Stephen B., Gill, Anthony J., Gupta, Ruta, Henderson, Michael A., Hong, Angela M., Howle, Julie R., Jackett, Louise A., James, Craig, Lee, C. Soon, Lochhead, Alistair, Loh, Daphne, McArthur, Grant A. ... Long, Georgina V. (2022). BRAF mutation testing for patients diagnosed with stage III or stage IV melanoma: practical guidance for the Australian setting. Pathology, 54 (1), 6-19. doi: 10.1016/j.pathol.2021.11.002

BRAF mutation testing for patients diagnosed with stage III or stage IV melanoma: practical guidance for the Australian setting

2022

Journal Article

Outcomes after totally minimally invasive versus hybrid and open Ivor Lewis oesophagectomy: results from the International Esodata Study Group

van der Wilk, Berend J., Hagens, Eliza R. C., Eyck, Ben M., Gisbertz, Suzanne S., van Hillegersberg, Richard, Nafteux, Philippe, Schröder, Wolfgang, Nilsson, Magnus, Wijnhoven, Bas P. L., Lagarde, Sjoerd M., van Berge Henegouwen, Mark I., International Esodata Study Group Collaborators , Smithers, Mark, Thomson, Iain, Barbour, Andrew and Thomas, Janine (2022). Outcomes after totally minimally invasive versus hybrid and open Ivor Lewis oesophagectomy: results from the International Esodata Study Group. British Journal of Surgery, 109 (3), 283-290. doi: 10.1093/bjs/znab432

Outcomes after totally minimally invasive versus hybrid and open Ivor Lewis oesophagectomy: results from the International Esodata Study Group

Funding

Current funding

  • 2024 - 2026
    Optimising the Diagnosis and Management of Unilateral Primary Aldosteronism
    Metro South Hospital and Health Service
    Open grant
  • 2021 - 2026
    AGITG TOP GEAR: A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer (CTCS: led by USyd)
    University of Sydney
    Open grant
  • 2019 - 2026
    A Randomised Phase II Trial of Adjuvant Avelumab in Patients with Early Stage Merkel Cell Carcinoma
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2019 - 2026
    Melanoma Margins Trial II - A Phase III, Multi-centre Randomised Controlled Trial Investigating 1cm v 2cm Wide Surgical Excision Margins.. (NHMRC Project Grant led by the University of Melbourne).
    University of Melbourne
    Open grant

Past funding

  • 2023 - 2026
    iCare - An interactive online portal to improve health and wellbeing for people living with complex cancers, and their informal carers: a Phase II randomised controlled trial (Ex led Deakin MRFF CTA)
    Deakin University
    Open grant
  • 2021 - 2024
    Advanced technological approach to predicting survival in patients diagnosed with locally invasive cutaneous melanoma
    Cancer Council Queensland
    Open grant
  • 2021 - 2024
    Establishing Australia's First Familial Melanoma Clinic (MSH RSS SERTA Program Grant led by Metro South Hospital and Health Service)
    Metro South Hospital and Health Service
    Open grant
  • 2020 - 2021
    Cancer Evolution Biobank
    PA Research Foundation
    Open grant
  • 2017 - 2019
    Predictors of mortality in thin melanomas
    Cancer Council Queensland
    Open grant
  • 2013 - 2015
    To identify and assess markers of prognosis, response and resistance to therapy in patients with Stage III metastatic melanoma
    Cancer Bequest Fund
    Open grant
  • 2011
    DOCetaxel with or without radiation Therapy for resectable Oesophageal adenocarcinoma based on early PET Response to induction chemotherapy (DOCTOR)
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Effects of nevogenesis susceptibility genes and phenotypic correlation with dermoscopic characteristics of nevi
    NHMRC Project Grant
    Open grant
  • 2010 - 2014
    Comparison of pre- and perioperative immunonutrition in patients undergoing surgical resection of oesophageal cancer (NHMRC Project Grant administered by the University of Adelaide)
    University of Adelaide
    Open grant
  • 2001 - 2002
    The epidemiology of oesophageal cancer: Risk and molecular markers
    Queensland Cancer Fund
    Open grant
  • 2000
    The role of TAP and MHC class I expression in the response to melanoma immunotherapy using autologous dendritic cells
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1999 - 2000
    A phase II clinical trial in patients with metastatic melanoma comparing autologous dendritic cells pulsed with autologous tumour peptides and melanoma associated peptides linked to the endoplasmic re
    Queensland Cancer Fund
    Open grant
  • 1998
    A Phase I/II Clinical Trial to Test Tumour Vaccines Comprising with Protein or Autologous Tumour Antigen Autologous Dandritic Cells Generated in a Closed Bag System Pulsed
    Mayne Bequest Fund
    Open grant
  • 1998
    Isolated limb infusion of melphalan and microdialysis technique in treatment of recurrent malignant melanoma
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1998 - 2000
    Treatment of Recurrent Malignant Melanoma by Limb Infusion of Cytotoxic Drugs and Other Techniques
    NHMRC Project Grant
    Open grant
  • 1997 - 1998
    Pharmacokinetics of tumour necrosis factor (TNF) in isolated rat hindlimb perfusions and infusions related to melanoma therapy
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1996 - 1997
    Targeting and monitoring drug delivery in specific tissues using iontophoresis and microdialysis
    Quality Funds Round 3
    Open grant
  • 1995 - 1997
    Pharmacokinetics of melphalan in isolated limb perfusion and infusion
    Queensland Cancer Fund
    Open grant

Supervision

Availability

Professor Mark Smithers is:
Not available for supervision

Supervision history

Current supervision

  • Master Philosophy

    Assessment of the impact of treating service characteristics on surgical and oncological outcomes for patients with Retroperitoneal and Inguinal Sarcomas in Queensland

    Principal Advisor

  • Master Philosophy

    Factors Influencing Anastomotic Complications after Oesophagectomy

    Associate Advisor

  • Doctor Philosophy

    New tools for the multi-modal evaluation of pancreatic cancer and its precursor neoplasms.

    Associate Advisor

    Other advisors: Dr David Cavallucci

Completed supervision

Media

Enquiries

Contact Professor Mark Smithers directly for media enquiries about:

  • Advanced endoscopic surgery
  • Cancer surgery
  • Endoscopic surgery
  • General surgery
  • Melanoma
  • Surgery - cancer
  • Surgery - oesophageal, gastric cancer
  • Surgery - upper GI
  • Upper GI surgery

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