Overview
Background
Emeritus Professor Mark Smithers is a surgical oncologist who specialises in surgery for oesophago-gastric diseases, melanoma, advanced skin cancer and soft tissue sarcoma. He was the Director of the Upper GI and Soft Tissue Unit at the Princess Alexandra Hospital, in Brisbane, Australia from 1998 - 2023. Commencing his academic career with the University of Queensland in 1987, he progressed to be the Mayne Chair in Surgery and head of the Academy of Surgery. He is the second University of Queensland Medical graduate to be appointed to this role. His research has been focussed on the development and assessment of outcomes from minimally invasive upper GI surgery, and trials assessing the role of perioperative multidisciplinary therapy for esophageal and gastric cancer. As well he has led, or been involved with, clinical trials from phase I to III, for all stages of melanoma through his role as the Chair of the Queensland Melanoma Project. More recently he has been involved with the assessment of access to, and outcomes from, surgery for cancer in Queensland, Australia.
He has overseen the administration and development of the surgery curriculum, and the teaching, in the Academy of Surgery, in the UQ Faculty of Medicine. He was on a number of committees relevant to the implementation of the UQ MD design course. He has held various leadership and committee roles with the Royal Australasian College of Surgeons, as well as leadership roles, including the Presidency, in the Australian and New Zealand Oesophago Gastric Surgeons Association. He has also been on the committees of international organisations related to oesophageal and gastric surgery. He has published 250 articles, eight book chapters, and has been on the editorial board of a number of surgical journals.
He has been recognised for his clinical and academic roles by the award of Member of the Order of Australia (AM). The citation reads, "for service to medicine in the fields of gastro-intestinal and melanoma surgery, to medical education and to professional organisations". The Royal Australasian College of Surgeons awarded him the Sir Hugh Devine medal, for services to surgery and the community. This is the College’s highest honour. Internationally, he has been awarded an honorary fellowship of the Royal College of Surgeons of Edinburgh and recently, in the United States, he was elected as an Honarary Fellow of the American Surgical Association.
Availability
- Professor Mark Smithers is:
- Not available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
- Honorary Fellow, American Surgical Association, American Surgical Association
- Fellow, Royal Australasian College of Surgeons, Royal Australasian College of Surgeons
- Fellow, Royal College of Surgeons of Edinburgh, Royal College of Surgeons of Edinburgh
- Fellow, Royal College of Surgeons of England, Royal College of Surgeons of England
Research interests
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Cutaneous Melanoma
epidemiology, public health issues and management of all stages
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Management of Oesophageal and Gastric Cancer
Investigation and management of benign and malignant diseases of the oesophagus and the stomach.
Works
Search Professor Mark Smithers’s works on UQ eSpace
2022
Journal Article
Therapeutic Value of Sentinel Lymph Node Biopsy in Patients With Melanoma: A Randomized Clinical Trial
Crystal, Jessica S., Thompson, John F., Hyngstrom, John, Caracò, Corrado, Zager, Jonathan S., Jahkola, Tiina, Bowles, Tawnya L., Pennacchioli, Elisabetta, Beitsch, Peter D., Hoekstra, Harald J., Moncrieff, Marc, Ingvar, Christian, Van Akkooi, Alexander, Sabel, Michael S., Levine, Edward A., Agnese, Doreen, Henderson, Michael, Dummer, Reinhard, Neves, Rogerio, Rossi, Carlo Riccardo, Kane, John M., Trocha, Steven, Wright, Frances, Byrd, David R., Matter, Maurice, Hsueh, Eddy C., Mackenzie-Ross, Alastair, Kelley, Mark, Terheyden, Patrick ... Multicenter Selective Lymphadenectomy Trials Study Group (2022). Therapeutic Value of Sentinel Lymph Node Biopsy in Patients With Melanoma: A Randomized Clinical Trial. JAMA Surgery, 157 (9), 835-842. doi: 10.1001/jamasurg.2022.2055
2022
Conference Publication
The association between BRAF-V600E mutations and death from thin (<=1.0 mm) melanoma: a population-based nested case-case study from Queensland, Australia
Claeson, Magdalena, Tan, S., Brown, S., Walsh, M. D., Lambie, D., Baade, P. D., Whitehead, K. J., Soyer, H. P., Smithers, B. M., Green, A. C., Whiteman, D. C. and Khosrotehrani, K. (2022). The association between BRAF-V600E mutations and death from thin (<=1.0 mm) melanoma: a population-based nested case-case study from Queensland, Australia. 35th Nordic Congress of Dermatology and Venereology, the NCDV 2022, Copenhagen, Denmark, 19-22 April 2022. Uppsala, Sweden: Society for the Publication of Acta Dermato - Venereologica.
2021
Journal Article
Responsiveness and convergent validity of QLU-C10D and EQ-5D-3L in assessing short-term quality of life following esophagectomy
Bulamu, Norma B., Vissapragada, Ravi, Chen, Gang, Ratcliffe, Julie, Mudge, Louise A., Smithers, B. Mark, Isenring, Elizabeth A., Smith, Lorelle, Jamieson, Glyn G., Watson, David I., Bessell, Justin, Barbour, Andrew, Aly, Ahmad, Archer, Stephen, Ballal, Mohammed, Barbon, Jessica, Benton, Katie, Bond, Melissa, Berryman, Melissa, Bright, Tim, Cade, Richard, Cardamis, Anna, Carroll, Rosemary, Cashman, Kara, Chan, Larissa, Chapman, Brooke, Chapman, Sally, Chen, Derek, Chisholm, Jacob ... on behalf of The Australian Immunonutrition Study Group (2021). Responsiveness and convergent validity of QLU-C10D and EQ-5D-3L in assessing short-term quality of life following esophagectomy. Health and Quality of Life Outcomes, 19 (1) 233, 1-11. doi: 10.1186/s12955-021-01867-w
2021
Journal Article
Comparative performance of predictors of death from thin (≤1.0 mm) melanoma
Claeson, M., Baade, P., Marchetti, M., Brown, S., Soyer, H.P., Smithers, B.M., Green, A.C., Whiteman, D.C. and Khosrotehrani, K. (2021). Comparative performance of predictors of death from thin (≤1.0 mm) melanoma. British Journal of Dermatology, 185 (4) bjd.20480, 849-851. doi: 10.1111/bjd.20480
2021
Journal Article
Procedure‐specific outcomes following gastrectomy for cancer compared by hospital volume and service capability
Tian, Kevin, Baade, Peter D., Aitken, Joanne F., Narendra, Aaditya and Smithers, B. Mark (2021). Procedure‐specific outcomes following gastrectomy for cancer compared by hospital volume and service capability. ANZ Journal of Surgery, 91 (11) ans.17132, 2430-2435. doi: 10.1111/ans.17132
2021
Journal Article
Contemporary management of locoregionally advanced melanoma in Australia and New Zealand and the role of adjuvant systemic therapy
Smithers, B. Mark, Saw, Robyn P. M., Gyorki, David E., Martin, Richard C. W., Atkinson, Victoria, Haydon, Andrew, Roberts‐Thomson, Rachel and Thompson, John F. (2021). Contemporary management of locoregionally advanced melanoma in Australia and New Zealand and the role of adjuvant systemic therapy. ANZ Journal of Surgery, 91 (S2), 3-13. doi: 10.1111/ans.17051
2021
Journal Article
Risk prediction model of 90-day mortality after esophagectomy for cancer
D'Journo, Xavier Benoit, Boulate, David, Fourdrain, Alex, Loundou, Anderson, Henegouwen, Mark I. van Berge, Gisbertz, Suzanne S., O'Neill, J. Robert, Hoelscher, Arnulf, Piessen, Guillaume, van Lanschot, Jan, Wijnhoven, Bas, Jobe, Blair, Davies, Andrew, Schneider, Paul M., Pera, Manuel, Nilsson, Magnus, Nafteux, Philippe, Kitagawa, Yuko, Morse, Christopher R., Hofstetter, Wayne, Molena, Daniela, So, Jimmy Bok-Yan, Immanuel, Arul, Parsons, Simon L., Larsen, Michael Hareskov, Dolan, James P., Wood, Stephanie G., Maynard, Nick, Smithers, Mark ... Low, Donald E. (2021). Risk prediction model of 90-day mortality after esophagectomy for cancer. JAMA Surgery, 156 (9), 836-845. doi: 10.1001/jamasurg.2021.2376
2021
Journal Article
Radiomics biomarkers correlate with CD8 expression and predict immune signatures in melanoma patients
Aoude, Lauren G., Wong, Bernadette, Bonazzi, Vanessa F, Brosda, Sandra, Walters, Shaun B., Koufariotis, Lambros T., Naeini, Marjan M., Pearson, John V, Oey, Harald, Patel, Kalpana, Bradford, Julia J., Bloxham, Conor J, Atkinson, Victoria, Law, Phillip, Strutton, Geoffrey, Bayley, Gerard, Yang, Samuel, Smithers, B. Mark, Waddell, Nicola, Miles, Kenneth and Barbour, Andrew P. (2021). Radiomics biomarkers correlate with CD8 expression and predict immune signatures in melanoma patients. Molecular Cancer Research, 19 (6) molcanres.1038.2020, 950-956. doi: 10.1158/1541-7786.mcr-20-1038
2021
Journal Article
Pulmonary metastasectomy in the era of targeted therapy and immunotherapy
Bong, Christopher Y., Smithers, B. Mark and Chua, Terence C. (2021). Pulmonary metastasectomy in the era of targeted therapy and immunotherapy. Journal of Thoracic Disease, 13 (4), 2618-2627. doi: 10.21037/jtd.2020.03.120
2021
Conference Publication
A randomised, placebo-controlled, phase II trial of adjuvant Avelumab in patients with stage I-III Merkel cell carcinoma (I-MAT Trial)
Xu, W., Poulsen, M., Atkinson, V., Fogarty, G., Veness, M., Smithers, B., Gyorki, D., Mar, V., Howle, J., Guminski, A., Williams, N. and Paton, E. (2021). A randomised, placebo-controlled, phase II trial of adjuvant Avelumab in patients with stage I-III Merkel cell carcinoma (I-MAT Trial). HOBOKEN: WILEY.
2021
Journal Article
Preoperative ultrasound assessment of regional lymph nodes in melanoma patients does not provide reliable nodal staging: results from a large multicenter trial
Thompson, John F., Haydu, Lauren E., Uren, Roger F., Andtbacka, Robert H., Zager, Jonathan S., Beitsch, Peter D., Agnese, Doreen M., Mozzillo, Nicola, Testori, Alessandro, Bowles, Tawnya L., Hoekstra, Harald J., Kelley, Mark C., Sussman, Jeffrey, Schneebaum, Schlomo, Smithers, B Mark, McKinnon, Gregory, Hsueh, Eddy, Jacobs, Lisa, Schultz, Erwin, Reintgen, Douglas, Kane, John M., Friedman, Erica B., Wang, Hejing, Van Kreuningen, Lisa, Schiller, Vicki, Elashoff, David A., Elashoff, Robert, Cochran, Alistair J., Stern, Stacey and Faries, Mark B. (2021). Preoperative ultrasound assessment of regional lymph nodes in melanoma patients does not provide reliable nodal staging: results from a large multicenter trial. Annals of Surgery, 273 (4), 814-820. doi: 10.1097/sla.0000000000003405
2021
Journal Article
Hospital characteristics associated with better ‘quality of surgery’ and survival following oesophagogastric cancer surgery in Queensland: a population-level study
Narendra, Aaditya, Baade, Peter D., Aitken, Joanne F., Fawcett, Jonathan, Leggett, Brandon, Leggett, Callum, Tian, Kevin, Sklavos, Theodore and Smithers, B. Mark (2021). Hospital characteristics associated with better ‘quality of surgery’ and survival following oesophagogastric cancer surgery in Queensland: a population-level study. ANZ Journal of Surgery, 91 (3), 323-328. doi: 10.1111/ans.16397
2021
Journal Article
Patient age and risk of recurrence of primary melanoma at high risk of spread
Ghiasvand, R., Khosrotehrani, K., Hughes, M.C.B., von Schuckmann, L. A., Beesley, V. L., Malt, M., Smithers, B. M. and Green, A. C. (2021). Patient age and risk of recurrence of primary melanoma at high risk of spread. British Journal of Dermatology, 184 (3) bjd.19601, 566-568. doi: 10.1111/bjd.19601
2021
Journal Article
Intra-abdominal desmoplastic small round cell tumour in a 56-year-old female: Case report of a very rare presentation of an unusual tumour
Laurens, Jason Russell, Frankel, Adam John and Smithers, Bernard Mark (2021). Intra-abdominal desmoplastic small round cell tumour in a 56-year-old female: Case report of a very rare presentation of an unusual tumour. International Journal of Surgery Case Reports, 79 (C), 323-326. doi: 10.1016/j.ijscr.2021.01.058
2021
Journal Article
Complications and survival after hybrid and fully minimally invasive oesophagectomy
Veenstra, M. M. K., Smithers, B. M., Visser, E., Edholm, D., Brosda, S., Thomas, J. M., Gotley, D. C., Thomson, I. G., Wijnhoven, B. P. L. and Barbour, A. P. (2021). Complications and survival after hybrid and fully minimally invasive oesophagectomy. BJS Open, 5 (1) zraa033, 1-7. doi: 10.1093/bjsopen/zraa033
2021
Journal Article
Increased melanoma recurrence in patients with multiple primary invasive melanomas
Green, Adele C., Hughes, Maria Celia B., Williams, Gail M., Malt, Maryrose, Beesley, Vanessa L., Khosrotehrani, Kiarash and Smithers, B. Mark (2021). Increased melanoma recurrence in patients with multiple primary invasive melanomas. Journal of the American Academy of Dermatology, 86 (6), 1366-1369. doi: 10.1016/j.jaad.2021.05.025
2020
Journal Article
Intraoperative fluid restriction during enhanced recovery after surgery versus liberal fluids for esophagectomy: a single center retrospective pilot study
Ng, Rachel L., Thomson, Iain G., Smithers, B. Mark and Booth, Anton W. G. (2020). Intraoperative fluid restriction during enhanced recovery after surgery versus liberal fluids for esophagectomy: a single center retrospective pilot study. Journal of Clinical Anesthesia, 67 110030, 110030. doi: 10.1016/j.jclinane.2020.110030
2020
Journal Article
Oncologic Outcomes After Isolated Limb Infusion for Advanced Melanoma: An International Comparison of the Procedure and Outcomes Between the United States and Australia
Carr, Michael J., Sun, James, Kroon, Hidde M., Miura, John T., Beasley, Georgia M., Farrow, Norma E., Mosca, Paul J., Lowe, Michael C., Farley, Clara R., Kim, Youngchul, Naqvi, Syeda Mahrukh Hussnain, Kirichenko, Dennis A., Potdar, Aishwarya, Daou, Hala, Mullen, Dean, Farma, Jeffrey M., Henderson, Michael A., Speakman, David, Serpell, Jonathan, Delman, Keith A., Smithers, B. Mark, Coventry, Brendon J., Tyler, Douglas S., Thompson, John F. and Zager, Jonathan S. (2020). Oncologic Outcomes After Isolated Limb Infusion for Advanced Melanoma: An International Comparison of the Procedure and Outcomes Between the United States and Australia. Annals of Surgical Oncology, 27 (13), 5107-5118. doi: 10.1245/s10434-020-09051-y
2020
Conference Publication
Tracking genomic and transcriptomic features of oesophageal adenocarcinoma for improving patients outcome
Naeini, Marjan, Newell, Felicity, Aoude, Lauren G., Bonazzi, Vanessa F., Patel, Kalpana, Koufariotis, Lambros T., Johnson, Rebecca, Addala, Venkateswar, Kondrashova, Olga, Holmes, Oliver, Leonard, Conrad, Wood, Scott, Xu, Christina, Nones, Katia, Pearson, John V., Smithers, Mark, Watson, David, Simes, John, Price, Tim, Gebski, Val, Barbour, Andrew P. and Waddell, Nic (2020). Tracking genomic and transcriptomic features of oesophageal adenocarcinoma for improving patients outcome. HOBOKEN: WILEY.
2020
Journal Article
Pathogenic germline variants are associated with poor survival in stage III/IV melanoma patients
Aoude, Lauren G., Bonazzi, Vanessa F., Brosda, Sandra, Patel, Kalpana, Koufariotis, Lambros T., Oey, Harald, Nones, Katia, Wood, Scott, Pearson, John V., Lonie, James M., Arneil, Melissa, Atkinson, Victoria, Smithers, B. Mark, Waddell, Nicola and Barbour, Andrew P. (2020). Pathogenic germline variants are associated with poor survival in stage III/IV melanoma patients. Scientific Reports, 10 (1) 17687, 17687. doi: 10.1038/s41598-020-74956-3
Funding
Current funding
Supervision
Availability
- Professor Mark Smithers is:
- Not available for supervision
Supervision history
Current supervision
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Master Philosophy
Assessment of the impact of treating service characteristics on surgical and oncological outcomes for patients with Retroperitoneal and Inguinal Sarcomas in Queensland
Principal Advisor
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Master Philosophy
Factors Influencing Anastomotic Complications after Oesophagectomy
Associate Advisor
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Doctor Philosophy
New tools for the multi-modal evaluation of pancreatic cancer and its precursor neoplasms.
Associate Advisor
Other advisors: Dr David Cavallucci
Completed supervision
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2020
Master Philosophy
An assessment of the impacts of centralising complex upper-gastrointestinal surgery in Queensland
Principal Advisor
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2024
Master Philosophy
In vivo Magnetic Resonance Spectroscopy (MRS) with 2-Dimensional (2D) COrrelated Spectroscopy (COSY) applied to breast cancer
Associate Advisor
-
2020
Doctor Philosophy
Natural history of high-risk cutaneous primary melanoma and risk factors for disease progression
Associate Advisor
Other advisors: Professor Kiarash Khosrotehrani
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2020
Doctor Philosophy
An evaluation of the role of locoregional treatments for the management of in-transit melanoma metastases
Associate Advisor
Other advisors: Professor Peter Soyer
Media
Enquiries
Contact Professor Mark Smithers directly for media enquiries about:
- Advanced endoscopic surgery
- Cancer surgery
- Endoscopic surgery
- General surgery
- Melanoma
- Surgery - cancer
- Surgery - oesophageal, gastric cancer
- Surgery - upper GI
- Upper GI surgery
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