
Overview
Background
Emeritus Professor Mark Smithers is a surgical oncologist who specialises in surgery for oesophago-gastric diseases, melanoma, advanced skin cancer and soft tissue sarcoma. He was the Director of the Upper GI and Soft Tissue Unit at the Princess Alexandra Hospital, in Brisbane, Australia from 1998 - 2023. Commencing his academic career with the University of Queensland in 1987, he progressed to be the Mayne Chair in Surgery and head of the Academy of Surgery. He is the second University of Queensland Medical graduate to be appointed to this role. His research has been focussed on the development and assessment of outcomes from minimally invasive upper GI surgery, and trials assessing the role of perioperative multidisciplinary therapy for esophageal and gastric cancer. As well he has led, or been involved with, clinical trials from phase I to III, for all stages of melanoma through his role as the Chair of the Queensland Melanoma Project. More recently he has been involved with the assessment of access to, and outcomes from, surgery for cancer in Queensland, Australia.
He has overseen the administration and development of the surgery curriculum, and the teaching, in the Academy of Surgery, in the UQ Faculty of Medicine. He was on a number of committees relevant to the implementation of the UQ MD design course. He has held various leadership and committee roles with the Royal Australasian College of Surgeons, as well as leadership roles, including the Presidency, in the Australian and New Zealand Oesophago Gastric Surgeons Association. He has also been on the committees of international organisations related to oesophageal and gastric surgery. He has published 250 articles, eight book chapters, and has been on the editorial board of a number of surgical journals.
He has been recognised for his clinical and academic roles by the award of Member of the Order of Australia (AM). The citation reads, "for service to medicine in the fields of gastro-intestinal and melanoma surgery, to medical education and to professional organisations". The Royal Australasian College of Surgeons awarded him the Sir Hugh Devine medal, for services to surgery and the community. This is the College’s highest honour. Internationally, he has been awarded an honorary fellowship of the Royal College of Surgeons of Edinburgh and recently, in the United States, he was elected as an Honarary Fellow of the American Surgical Association.
Availability
- Professor Mark Smithers is:
- Not available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
- Honorary Fellow, American Surgical Association, American Surgical Association
- Fellow, Royal Australasian College of Surgeons, Royal Australasian College of Surgeons
- Fellow, Royal College of Surgeons of Edinburgh, Royal College of Surgeons of Edinburgh
- Fellow, Royal College of Surgeons of England, Royal College of Surgeons of England
Research interests
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Cutaneous Melanoma
epidemiology, public health issues and management of all stages
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Management of Oesophageal and Gastric Cancer
Investigation and management of benign and malignant diseases of the oesophagus and the stomach.
Works
Search Professor Mark Smithers’s works on UQ eSpace
2021
Conference Publication
A randomised, placebo-controlled, phase II trial of adjuvant Avelumab in patients with stage I-III Merkel cell carcinoma (I-MAT Trial)
Xu, W., Poulsen, M., Atkinson, V., Fogarty, G., Veness, M., Smithers, B., Gyorki, D., Mar, V., Howle, J., Guminski, A., Williams, N. and Paton, E. (2021). A randomised, placebo-controlled, phase II trial of adjuvant Avelumab in patients with stage I-III Merkel cell carcinoma (I-MAT Trial). HOBOKEN: WILEY.
2021
Journal Article
Preoperative ultrasound assessment of regional lymph nodes in melanoma patients does not provide reliable nodal staging: results from a large multicenter trial
Thompson, John F., Haydu, Lauren E., Uren, Roger F., Andtbacka, Robert H., Zager, Jonathan S., Beitsch, Peter D., Agnese, Doreen M., Mozzillo, Nicola, Testori, Alessandro, Bowles, Tawnya L., Hoekstra, Harald J., Kelley, Mark C., Sussman, Jeffrey, Schneebaum, Schlomo, Smithers, B Mark, McKinnon, Gregory, Hsueh, Eddy, Jacobs, Lisa, Schultz, Erwin, Reintgen, Douglas, Kane, John M., Friedman, Erica B., Wang, Hejing, Van Kreuningen, Lisa, Schiller, Vicki, Elashoff, David A., Elashoff, Robert, Cochran, Alistair J., Stern, Stacey and Faries, Mark B. (2021). Preoperative ultrasound assessment of regional lymph nodes in melanoma patients does not provide reliable nodal staging: results from a large multicenter trial. Annals of Surgery, 273 (4), 814-820. doi: 10.1097/sla.0000000000003405
2021
Journal Article
Hospital characteristics associated with better ‘quality of surgery’ and survival following oesophagogastric cancer surgery in Queensland: a population-level study
Narendra, Aaditya, Baade, Peter D., Aitken, Joanne F., Fawcett, Jonathan, Leggett, Brandon, Leggett, Callum, Tian, Kevin, Sklavos, Theodore and Smithers, B. Mark (2021). Hospital characteristics associated with better ‘quality of surgery’ and survival following oesophagogastric cancer surgery in Queensland: a population-level study. ANZ Journal of Surgery, 91 (3), 323-328. doi: 10.1111/ans.16397
2021
Journal Article
Patient age and risk of recurrence of primary melanoma at high risk of spread
Ghiasvand, R., Khosrotehrani, K., Hughes, M.C.B., von Schuckmann, L. A., Beesley, V. L., Malt, M., Smithers, B. M. and Green, A. C. (2021). Patient age and risk of recurrence of primary melanoma at high risk of spread. British Journal of Dermatology, 184 (3) bjd.19601, 566-568. doi: 10.1111/bjd.19601
2021
Journal Article
Intra-abdominal desmoplastic small round cell tumour in a 56-year-old female: Case report of a very rare presentation of an unusual tumour
Laurens, Jason Russell, Frankel, Adam John and Smithers, Bernard Mark (2021). Intra-abdominal desmoplastic small round cell tumour in a 56-year-old female: Case report of a very rare presentation of an unusual tumour. International Journal of Surgery Case Reports, 79, 323-326. doi: 10.1016/j.ijscr.2021.01.058
2021
Journal Article
Complications and survival after hybrid and fully minimally invasive oesophagectomy
Veenstra, M. M. K., Smithers, B. M., Visser, E., Edholm, D., Brosda, S., Thomas, J. M., Gotley, D. C., Thomson, I. G., Wijnhoven, B. P. L. and Barbour, A. P. (2021). Complications and survival after hybrid and fully minimally invasive oesophagectomy. BJS Open, 5 (1) zraa033, 1-7. doi: 10.1093/bjsopen/zraa033
2021
Journal Article
Increased melanoma recurrence in patients with multiple primary invasive melanomas
Green, Adele C., Hughes, Maria Celia B., Williams, Gail M., Malt, Maryrose, Beesley, Vanessa L., Khosrotehrani, Kiarash and Smithers, B. Mark (2021). Increased melanoma recurrence in patients with multiple primary invasive melanomas. Journal of the American Academy of Dermatology, 86 (6), 1366-1369. doi: 10.1016/j.jaad.2021.05.025
2020
Journal Article
Intraoperative fluid restriction during enhanced recovery after surgery versus liberal fluids for esophagectomy: a single center retrospective pilot study
Ng, Rachel L., Thomson, Iain G., Smithers, B. Mark and Booth, Anton W. G. (2020). Intraoperative fluid restriction during enhanced recovery after surgery versus liberal fluids for esophagectomy: a single center retrospective pilot study. Journal of Clinical Anesthesia, 67 110030, 110030. doi: 10.1016/j.jclinane.2020.110030
2020
Journal Article
Oncologic Outcomes After Isolated Limb Infusion for Advanced Melanoma: An International Comparison of the Procedure and Outcomes Between the United States and Australia
Carr, Michael J., Sun, James, Kroon, Hidde M., Miura, John T., Beasley, Georgia M., Farrow, Norma E., Mosca, Paul J., Lowe, Michael C., Farley, Clara R., Kim, Youngchul, Naqvi, Syeda Mahrukh Hussnain, Kirichenko, Dennis A., Potdar, Aishwarya, Daou, Hala, Mullen, Dean, Farma, Jeffrey M., Henderson, Michael A., Speakman, David, Serpell, Jonathan, Delman, Keith A., Smithers, B. Mark, Coventry, Brendon J., Tyler, Douglas S., Thompson, John F. and Zager, Jonathan S. (2020). Oncologic Outcomes After Isolated Limb Infusion for Advanced Melanoma: An International Comparison of the Procedure and Outcomes Between the United States and Australia. Annals of Surgical Oncology, 27 (13), 5107-5118. doi: 10.1245/s10434-020-09051-y
2020
Conference Publication
Tracking genomic and transcriptomic features of oesophageal adenocarcinoma for improving patients outcome
Naeini, Marjan, Newell, Felicity, Aoude, Lauren G., Bonazzi, Vanessa F., Patel, Kalpana, Koufariotis, Lambros T., Johnson, Rebecca, Addala, Venkateswar, Kondrashova, Olga, Holmes, Oliver, Leonard, Conrad, Wood, Scott, Xu, Christina, Nones, Katia, Pearson, John V., Smithers, Mark, Watson, David, Simes, John, Price, Tim, Gebski, Val, Barbour, Andrew P. and Waddell, Nic (2020). Tracking genomic and transcriptomic features of oesophageal adenocarcinoma for improving patients outcome. HOBOKEN: WILEY.
2020
Journal Article
Pathogenic germline variants are associated with poor survival in stage III/IV melanoma patients
Aoude, Lauren G., Bonazzi, Vanessa F., Brosda, Sandra, Patel, Kalpana, Koufariotis, Lambros T., Oey, Harald, Nones, Katia, Wood, Scott, Pearson, John V., Lonie, James M., Arneil, Melissa, Atkinson, Victoria, Smithers, B. Mark, Waddell, Nicola and Barbour, Andrew P. (2020). Pathogenic germline variants are associated with poor survival in stage III/IV melanoma patients. Scientific Reports, 10 (1) 17687, 17687. doi: 10.1038/s41598-020-74956-3
2020
Journal Article
Germline and somatic albinism variants in amelanotic/hypomelanotic melanoma: increased carriage of TYR and OCA2 variants
Rayner, Jenna E., Duffy, David L., Smit, Darren J., Jagirdar, Kasturee, Lee, Katie J., De’Ambrosis, Brian, Smithers, B. Mark, McMeniman, Erin K., McInerney-Leo, Aideen M., Schaider, Helmut, Stark, Mitchell S., Soyer, H. Peter and Sturm, Richard A. (2020). Germline and somatic albinism variants in amelanotic/hypomelanotic melanoma: increased carriage of TYR and OCA2 variants. PLoS ONE, 15 (9) e0238529, e0238529. doi: 10.1371/journal.pone.0238529
2020
Conference Publication
A phase Ib study of rose bengal disodium and anti-PD-1 in metastatic cutaneous melanoma: Results in patients naive to immune checkpoint blockade
Agarwala, S. S., Ross, M., Zager, J. S., Sarnaik, A. S., Shirai, K., Lu, G., Essner, R., Smithers, B., Atkinson, V. Victoria and Wachter, E. (2020). A phase Ib study of rose bengal disodium and anti-PD-1 in metastatic cutaneous melanoma: Results in patients naive to immune checkpoint blockade. ESMO Virtual Congress, Electr Network, Sep 19-Oct 18, 2020. AMSTERDAM: ELSEVIER. doi: 10.1016/j.annonc.2020.08.1248
2020
Conference Publication
A phase Ib study of rose bengal disodium and anti-PD-1 in metastatic cutaneous melanoma: Initial results in patients refractory to checkpoint blockade
Zager, J. S., Sarnaik, A. S., Pilon-Thomas, S., Beatty, M., Han, D., Lu, G., Agarwala, S. S., Ross, M., Shirai, K., Essner, R., Smithers, B., Atkinson, V. Victoria and Wachter, E. (2020). A phase Ib study of rose bengal disodium and anti-PD-1 in metastatic cutaneous melanoma: Initial results in patients refractory to checkpoint blockade. ESMO Virtual Congress, Electr Network, Sep 19-Oct 18, 2020. AMSTERDAM: ELSEVIER. doi: 10.1016/j.annonc.2020.08.1246
2020
Conference Publication
Patient-reported outcome (PRO) results from AGITG DOCTOR: A randomised phase II trial of tailored neoadjuvant therapy for resectable oesophageal adenocarcinoma
Mercieca-Bebber, R., Barnes, E. H., Wilson, K., Samoon, Z., Walpole, E. T., Mai, T., Ackland, S., Burge, M., Dickie, G., Watson, D., Leung, J., Wang, T., Bohmer, R., Cameron, D., Simes, R., Gebski, V., Smithers, M., Thomas, J., Zalcberg, J. R. and Barbour, A. (2020). Patient-reported outcome (PRO) results from AGITG DOCTOR: A randomised phase II trial of tailored neoadjuvant therapy for resectable oesophageal adenocarcinoma. ESMO Virtual Congress, Electr Network, Sep 19-Oct 18, 2020. AMSTERDAM: ELSEVIER. doi: 10.1016/j.annonc.2020.08.1936
2020
Journal Article
Factors predicting toxicity and response following isolated limb infusion for melanoma: an international multi-centre study
Kenyon-Smith, Timothy J., Kroon, Hidde M., Miura, John T., Teras, Jüri, Beasley, Georgia M., Mullen, Dean, Farrow, Norma E., Mosca, Paul J., Lowe, Michael C., Farley, Clara R., Potdar, Aishwarya, Daou, Hala, Sun, James, Farma, Jeffrey M., Henderson, Michael A., Speakman, David, Serpell, Jonathan, Delman, Keith A., Smithers, B. Mark, Barbour, Andrew, Coventry, Brendon J., Tyler, Douglas S., Zager, Jonathan S. and Thompson, John F. (2020). Factors predicting toxicity and response following isolated limb infusion for melanoma: an international multi-centre study. European Journal of Surgical Oncology, 46 (11), 2140-2146. doi: 10.1016/j.ejso.2020.06.040
2020
Journal Article
Anxiety and depression after diagnosis of high-risk primary cutaneous melanoma: a 4-year longitudinal study
Beesley, Vanessa L., Hughes, Maria Celia B., Smithers, B. Mark, Khosrotehrani, Kiarash, Malt, Maryrose K., von Schuckmann, Lena A. and Green, Adèle C. (2020). Anxiety and depression after diagnosis of high-risk primary cutaneous melanoma: a 4-year longitudinal study. Journal of Cancer Survivorship, 14 (5), 712-719. doi: 10.1007/s11764-020-00885-9
2020
Journal Article
Prognostic implications of biopsy with tumor transection for patients with high-risk primary melanoma
von Schuckmann, Lena A., Khosrotehrani, Kiarash, Hughes, Maria Celia B., van der Pols, Jolieke C., Malt, Maryrose, Smithers, B. Mark and Green, Adele C. (2020). Prognostic implications of biopsy with tumor transection for patients with high-risk primary melanoma. Journal of the American Academy of Dermatology, 82 (6), 1521-1524. doi: 10.1016/j.jaad.2020.01.067
2020
Journal Article
Patterns of Omega-3 and Omega-6 Fatty Acid Dietary Intake and Melanoma Thickness at Diagnosis
Mahamat-Saleh, Yahya, Hughes, Maria Celia B., Miura, Kyoko, Malt, Maryrose K., von Schuckmann, Lena, Khosrotehrani, Kiarash, Smithers, B. Mark and Green, Adèle C. (2020). Patterns of Omega-3 and Omega-6 Fatty Acid Dietary Intake and Melanoma Thickness at Diagnosis. Cancer Epidemiology Biomarkers & Prevention, 29 (8), 1647-1653. doi: 10.1158/1055-9965.epi-20-0319
2020
Journal Article
Efficacy of immune checkpoint inhibitors for in-transit melanoma
Nan Tie, Emilia, Lai-Kwon, Julia, Rtshiladze, Michael Alexander, Na, Lumine, Bozzi, James, Read, Tavis, Atkinson, Victoria, Au-Yeung, George, Long, Georgina V., McArthur, Grant A., Sandhu, Shahneen, Saw, Robyn, Walpole, Euan, Menzies, Alexander, Smithers, Mark and Gyorki, David E. (2020). Efficacy of immune checkpoint inhibitors for in-transit melanoma. Journal for Immunotherapy of Cancer, 8 (1) e000440, 1-6. doi: 10.1136/jitc-2019-000440
Supervision
Availability
- Professor Mark Smithers is:
- Not available for supervision
Supervision history
Current supervision
-
Master Philosophy
Retroperitoneal sarcoma: Impact of the patterns of care on patient outcomes in Queensland.
Principal Advisor
Other advisors: Professor Andrew Barbour
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Master Philosophy
Trends in the regional nodal management of cutaneous melanoma.
Principal Advisor
Other advisors: Professor Peter Soyer
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Doctor Philosophy
Utilising the Multi-Disciplinary Resources at Tertiary Centres to Improve Outcomes from Pancreatic Cancer
Associate Advisor
Other advisors: Dr David Cavallucci
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Master Philosophy
Factors Influencing Anastomotic Complications after Oesophagectomy
Associate Advisor
Completed supervision
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2020
Master Philosophy
An assessment of the impacts of centralising complex upper-gastrointestinal surgery in Queensland
Principal Advisor
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2024
Master Philosophy
In vivo Magnetic Resonance Spectroscopy (MRS) with 2-Dimensional (2D) COrrelated Spectroscopy (COSY) applied to breast cancer
Associate Advisor
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2020
Doctor Philosophy
Natural history of high-risk cutaneous primary melanoma and risk factors for disease progression
Associate Advisor
Other advisors: Professor Kiarash Khosrotehrani
-
2020
Doctor Philosophy
An evaluation of the role of locoregional treatments for the management of in-transit melanoma metastases
Associate Advisor
Other advisors: Professor Peter Soyer, Associate Professor Helmut Schaider
Media
Enquiries
Contact Professor Mark Smithers directly for media enquiries about:
- Advanced endoscopic surgery
- Cancer surgery
- Endoscopic surgery
- General surgery
- Melanoma
- Surgery - cancer
- Surgery - oesophageal, gastric cancer
- Surgery - upper GI
- Upper GI surgery
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