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Professor Mark Smithers
Professor

Mark Smithers

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Overview

Background

Emeritus Professor Mark Smithers is a surgical oncologist who specialises in surgery for oesophago-gastric diseases, melanoma, advanced skin cancer and soft tissue sarcoma. He was the Director of the Upper GI and Soft Tissue Unit at the Princess Alexandra Hospital, in Brisbane, Australia from 1998 - 2023. Commencing his academic career with the University of Queensland in 1987, he progressed to be the Mayne Chair in Surgery and head of the Academy of Surgery. He is the second University of Queensland Medical graduate to be appointed to this role. His research has been focussed on the development and assessment of outcomes from minimally invasive upper GI surgery, and trials assessing the role of perioperative multidisciplinary therapy for esophageal and gastric cancer. As well he has led, or been involved with, clinical trials from phase I to III, for all stages of melanoma through his role as the Chair of the Queensland Melanoma Project. More recently he has been involved with the assessment of access to, and outcomes from, surgery for cancer in Queensland, Australia.

He has overseen the administration and development of the surgery curriculum, and the teaching, in the Academy of Surgery, in the UQ Faculty of Medicine. He was on a number of committees relevant to the implementation of the UQ MD design course. He has held various leadership and committee roles with the Royal Australasian College of Surgeons, as well as leadership roles, including the Presidency, in the Australian and New Zealand Oesophago Gastric Surgeons Association. He has also been on the committees of international organisations related to oesophageal and gastric surgery. He has published 250 articles, eight book chapters, and has been on the editorial board of a number of surgical journals.

He has been recognised for his clinical and academic roles by the award of Member of the Order of Australia (AM). The citation reads, "for service to medicine in the fields of gastro-intestinal and melanoma surgery, to medical education and to professional organisations". The Royal Australasian College of Surgeons awarded him the Sir Hugh Devine medal, for services to surgery and the community. This is the College’s highest honour. Internationally, he has been awarded an honorary fellowship of the Royal College of Surgeons of Edinburgh and recently, in the United States, he was elected as an Honarary Fellow of the American Surgical Association.

Availability

Professor Mark Smithers is:
Not available for supervision
Media expert

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Honorary Fellow, American Surgical Association, American Surgical Association
  • Fellow, Royal Australasian College of Surgeons, Royal Australasian College of Surgeons
  • Fellow, Royal College of Surgeons of Edinburgh, Royal College of Surgeons of Edinburgh
  • Fellow, Royal College of Surgeons of England, Royal College of Surgeons of England

Research interests

  • Cutaneous Melanoma

    epidemiology, public health issues and management of all stages

  • Management of Oesophageal and Gastric Cancer

    Investigation and management of benign and malignant diseases of the oesophagus and the stomach.

Works

Search Professor Mark Smithers’s works on UQ eSpace

419 works between 1983 and 2025

61 - 80 of 419 works

2022

Journal Article

Therapeutic Value of Sentinel Lymph Node Biopsy in Patients With Melanoma: A Randomized Clinical Trial

Crystal, Jessica S., Thompson, John F., Hyngstrom, John, Caracò, Corrado, Zager, Jonathan S., Jahkola, Tiina, Bowles, Tawnya L., Pennacchioli, Elisabetta, Beitsch, Peter D., Hoekstra, Harald J., Moncrieff, Marc, Ingvar, Christian, Van Akkooi, Alexander, Sabel, Michael S., Levine, Edward A., Agnese, Doreen, Henderson, Michael, Dummer, Reinhard, Neves, Rogerio, Rossi, Carlo Riccardo, Kane, John M., Trocha, Steven, Wright, Frances, Byrd, David R., Matter, Maurice, Hsueh, Eddy C., Mackenzie-Ross, Alastair, Kelley, Mark, Terheyden, Patrick ... Multicenter Selective Lymphadenectomy Trials Study Group (2022). Therapeutic Value of Sentinel Lymph Node Biopsy in Patients With Melanoma: A Randomized Clinical Trial. JAMA Surgery, 157 (9), 835-842. doi: 10.1001/jamasurg.2022.2055

Therapeutic Value of Sentinel Lymph Node Biopsy in Patients With Melanoma: A Randomized Clinical Trial

2022

Conference Publication

The association between BRAF-V600E mutations and death from thin (<=1.0 mm) melanoma: a population-based nested case-case study from Queensland, Australia

Claeson, Magdalena, Tan, S., Brown, S., Walsh, M. D., Lambie, D., Baade, P. D., Whitehead, K. J., Soyer, H. P., Smithers, B. M., Green, A. C., Whiteman, D. C. and Khosrotehrani, K. (2022). The association between BRAF-V600E mutations and death from thin (<=1.0 mm) melanoma: a population-based nested case-case study from Queensland, Australia. 35th Nordic Congress of Dermatology and Venereology, the NCDV 2022, Copenhagen, Denmark, 19-22 April 2022. Uppsala, Sweden: Society for the Publication of Acta Dermato - Venereologica.

The association between BRAF-V600E mutations and death from thin (<=1.0 mm) melanoma: a population-based nested case-case study from Queensland, Australia

2021

Journal Article

Responsiveness and convergent validity of QLU-C10D and EQ-5D-3L in assessing short-term quality of life following esophagectomy

Bulamu, Norma B., Vissapragada, Ravi, Chen, Gang, Ratcliffe, Julie, Mudge, Louise A., Smithers, B. Mark, Isenring, Elizabeth A., Smith, Lorelle, Jamieson, Glyn G., Watson, David I., Bessell, Justin, Barbour, Andrew, Aly, Ahmad, Archer, Stephen, Ballal, Mohammed, Barbon, Jessica, Benton, Katie, Bond, Melissa, Berryman, Melissa, Bright, Tim, Cade, Richard, Cardamis, Anna, Carroll, Rosemary, Cashman, Kara, Chan, Larissa, Chapman, Brooke, Chapman, Sally, Chen, Derek, Chisholm, Jacob ... on behalf of The Australian Immunonutrition Study Group (2021). Responsiveness and convergent validity of QLU-C10D and EQ-5D-3L in assessing short-term quality of life following esophagectomy. Health and Quality of Life Outcomes, 19 (1) 233, 1-11. doi: 10.1186/s12955-021-01867-w

Responsiveness and convergent validity of QLU-C10D and EQ-5D-3L in assessing short-term quality of life following esophagectomy

2021

Journal Article

Comparative performance of predictors of death from thin (≤1.0 mm) melanoma

Claeson, M., Baade, P., Marchetti, M., Brown, S., Soyer, H.P., Smithers, B.M., Green, A.C., Whiteman, D.C. and Khosrotehrani, K. (2021). Comparative performance of predictors of death from thin (≤1.0 mm) melanoma. British Journal of Dermatology, 185 (4) bjd.20480, 849-851. doi: 10.1111/bjd.20480

Comparative performance of predictors of death from thin (≤1.0 mm) melanoma

2021

Journal Article

Procedure‐specific outcomes following gastrectomy for cancer compared by hospital volume and service capability

Tian, Kevin, Baade, Peter D., Aitken, Joanne F., Narendra, Aaditya and Smithers, B. Mark (2021). Procedure‐specific outcomes following gastrectomy for cancer compared by hospital volume and service capability. ANZ Journal of Surgery, 91 (11) ans.17132, 2430-2435. doi: 10.1111/ans.17132

Procedure‐specific outcomes following gastrectomy for cancer compared by hospital volume and service capability

2021

Journal Article

Contemporary management of locoregionally advanced melanoma in Australia and New Zealand and the role of adjuvant systemic therapy

Smithers, B. Mark, Saw, Robyn P. M., Gyorki, David E., Martin, Richard C. W., Atkinson, Victoria, Haydon, Andrew, Roberts‐Thomson, Rachel and Thompson, John F. (2021). Contemporary management of locoregionally advanced melanoma in Australia and New Zealand and the role of adjuvant systemic therapy. ANZ Journal of Surgery, 91 (S2), 3-13. doi: 10.1111/ans.17051

Contemporary management of locoregionally advanced melanoma in Australia and New Zealand and the role of adjuvant systemic therapy

2021

Journal Article

Risk prediction model of 90-day mortality after esophagectomy for cancer

D'Journo, Xavier Benoit, Boulate, David, Fourdrain, Alex, Loundou, Anderson, Henegouwen, Mark I. van Berge, Gisbertz, Suzanne S., O'Neill, J. Robert, Hoelscher, Arnulf, Piessen, Guillaume, van Lanschot, Jan, Wijnhoven, Bas, Jobe, Blair, Davies, Andrew, Schneider, Paul M., Pera, Manuel, Nilsson, Magnus, Nafteux, Philippe, Kitagawa, Yuko, Morse, Christopher R., Hofstetter, Wayne, Molena, Daniela, So, Jimmy Bok-Yan, Immanuel, Arul, Parsons, Simon L., Larsen, Michael Hareskov, Dolan, James P., Wood, Stephanie G., Maynard, Nick, Smithers, Mark ... Low, Donald E. (2021). Risk prediction model of 90-day mortality after esophagectomy for cancer. JAMA Surgery, 156 (9), 836-845. doi: 10.1001/jamasurg.2021.2376

Risk prediction model of 90-day mortality after esophagectomy for cancer

2021

Journal Article

Radiomics biomarkers correlate with CD8 expression and predict immune signatures in melanoma patients

Aoude, Lauren G., Wong, Bernadette, Bonazzi, Vanessa F, Brosda, Sandra, Walters, Shaun B., Koufariotis, Lambros T., Naeini, Marjan M., Pearson, John V, Oey, Harald, Patel, Kalpana, Bradford, Julia J., Bloxham, Conor J, Atkinson, Victoria, Law, Phillip, Strutton, Geoffrey, Bayley, Gerard, Yang, Samuel, Smithers, B. Mark, Waddell, Nicola, Miles, Kenneth and Barbour, Andrew P. (2021). Radiomics biomarkers correlate with CD8 expression and predict immune signatures in melanoma patients. Molecular Cancer Research, 19 (6) molcanres.1038.2020, 950-956. doi: 10.1158/1541-7786.mcr-20-1038

Radiomics biomarkers correlate with CD8 expression and predict immune signatures in melanoma patients

2021

Journal Article

Pulmonary metastasectomy in the era of targeted therapy and immunotherapy

Bong, Christopher Y., Smithers, B. Mark and Chua, Terence C. (2021). Pulmonary metastasectomy in the era of targeted therapy and immunotherapy. Journal of Thoracic Disease, 13 (4), 2618-2627. doi: 10.21037/jtd.2020.03.120

Pulmonary metastasectomy in the era of targeted therapy and immunotherapy

2021

Conference Publication

A randomised, placebo-controlled, phase II trial of adjuvant Avelumab in patients with stage I-III Merkel cell carcinoma (I-MAT Trial)

Xu, W., Poulsen, M., Atkinson, V., Fogarty, G., Veness, M., Smithers, B., Gyorki, D., Mar, V., Howle, J., Guminski, A., Williams, N. and Paton, E. (2021). A randomised, placebo-controlled, phase II trial of adjuvant Avelumab in patients with stage I-III Merkel cell carcinoma (I-MAT Trial). HOBOKEN: WILEY.

A randomised, placebo-controlled, phase II trial of adjuvant Avelumab in patients with stage I-III Merkel cell carcinoma (I-MAT Trial)

2021

Journal Article

Preoperative ultrasound assessment of regional lymph nodes in melanoma patients does not provide reliable nodal staging: results from a large multicenter trial

Thompson, John F., Haydu, Lauren E., Uren, Roger F., Andtbacka, Robert H., Zager, Jonathan S., Beitsch, Peter D., Agnese, Doreen M., Mozzillo, Nicola, Testori, Alessandro, Bowles, Tawnya L., Hoekstra, Harald J., Kelley, Mark C., Sussman, Jeffrey, Schneebaum, Schlomo, Smithers, B Mark, McKinnon, Gregory, Hsueh, Eddy, Jacobs, Lisa, Schultz, Erwin, Reintgen, Douglas, Kane, John M., Friedman, Erica B., Wang, Hejing, Van Kreuningen, Lisa, Schiller, Vicki, Elashoff, David A., Elashoff, Robert, Cochran, Alistair J., Stern, Stacey and Faries, Mark B. (2021). Preoperative ultrasound assessment of regional lymph nodes in melanoma patients does not provide reliable nodal staging: results from a large multicenter trial. Annals of Surgery, 273 (4), 814-820. doi: 10.1097/sla.0000000000003405

Preoperative ultrasound assessment of regional lymph nodes in melanoma patients does not provide reliable nodal staging: results from a large multicenter trial

2021

Journal Article

Hospital characteristics associated with better ‘quality of surgery’ and survival following oesophagogastric cancer surgery in Queensland: a population-level study

Narendra, Aaditya, Baade, Peter D., Aitken, Joanne F., Fawcett, Jonathan, Leggett, Brandon, Leggett, Callum, Tian, Kevin, Sklavos, Theodore and Smithers, B. Mark (2021). Hospital characteristics associated with better ‘quality of surgery’ and survival following oesophagogastric cancer surgery in Queensland: a population-level study. ANZ Journal of Surgery, 91 (3), 323-328. doi: 10.1111/ans.16397

Hospital characteristics associated with better ‘quality of surgery’ and survival following oesophagogastric cancer surgery in Queensland: a population-level study

2021

Journal Article

Patient age and risk of recurrence of primary melanoma at high risk of spread

Ghiasvand, R., Khosrotehrani, K., Hughes, M.C.B., von Schuckmann, L. A., Beesley, V. L., Malt, M., Smithers, B. M. and Green, A. C. (2021). Patient age and risk of recurrence of primary melanoma at high risk of spread. British Journal of Dermatology, 184 (3) bjd.19601, 566-568. doi: 10.1111/bjd.19601

Patient age and risk of recurrence of primary melanoma at high risk of spread

2021

Journal Article

Intra-abdominal desmoplastic small round cell tumour in a 56-year-old female: Case report of a very rare presentation of an unusual tumour

Laurens, Jason Russell, Frankel, Adam John and Smithers, Bernard Mark (2021). Intra-abdominal desmoplastic small round cell tumour in a 56-year-old female: Case report of a very rare presentation of an unusual tumour. International Journal of Surgery Case Reports, 79 (C), 323-326. doi: 10.1016/j.ijscr.2021.01.058

Intra-abdominal desmoplastic small round cell tumour in a 56-year-old female: Case report of a very rare presentation of an unusual tumour

2021

Journal Article

Complications and survival after hybrid and fully minimally invasive oesophagectomy

Veenstra, M. M. K., Smithers, B. M., Visser, E., Edholm, D., Brosda, S., Thomas, J. M., Gotley, D. C., Thomson, I. G., Wijnhoven, B. P. L. and Barbour, A. P. (2021). Complications and survival after hybrid and fully minimally invasive oesophagectomy. BJS Open, 5 (1) zraa033, 1-7. doi: 10.1093/bjsopen/zraa033

Complications and survival after hybrid and fully minimally invasive oesophagectomy

2021

Journal Article

Increased melanoma recurrence in patients with multiple primary invasive melanomas

Green, Adele C., Hughes, Maria Celia B., Williams, Gail M., Malt, Maryrose, Beesley, Vanessa L., Khosrotehrani, Kiarash and Smithers, B. Mark (2021). Increased melanoma recurrence in patients with multiple primary invasive melanomas. Journal of the American Academy of Dermatology, 86 (6), 1366-1369. doi: 10.1016/j.jaad.2021.05.025

Increased melanoma recurrence in patients with multiple primary invasive melanomas

2020

Journal Article

Intraoperative fluid restriction during enhanced recovery after surgery versus liberal fluids for esophagectomy: a single center retrospective pilot study

Ng, Rachel L., Thomson, Iain G., Smithers, B. Mark and Booth, Anton W. G. (2020). Intraoperative fluid restriction during enhanced recovery after surgery versus liberal fluids for esophagectomy: a single center retrospective pilot study. Journal of Clinical Anesthesia, 67 110030, 110030. doi: 10.1016/j.jclinane.2020.110030

Intraoperative fluid restriction during enhanced recovery after surgery versus liberal fluids for esophagectomy: a single center retrospective pilot study

2020

Journal Article

Oncologic Outcomes After Isolated Limb Infusion for Advanced Melanoma: An International Comparison of the Procedure and Outcomes Between the United States and Australia

Carr, Michael J., Sun, James, Kroon, Hidde M., Miura, John T., Beasley, Georgia M., Farrow, Norma E., Mosca, Paul J., Lowe, Michael C., Farley, Clara R., Kim, Youngchul, Naqvi, Syeda Mahrukh Hussnain, Kirichenko, Dennis A., Potdar, Aishwarya, Daou, Hala, Mullen, Dean, Farma, Jeffrey M., Henderson, Michael A., Speakman, David, Serpell, Jonathan, Delman, Keith A., Smithers, B. Mark, Coventry, Brendon J., Tyler, Douglas S., Thompson, John F. and Zager, Jonathan S. (2020). Oncologic Outcomes After Isolated Limb Infusion for Advanced Melanoma: An International Comparison of the Procedure and Outcomes Between the United States and Australia. Annals of Surgical Oncology, 27 (13), 5107-5118. doi: 10.1245/s10434-020-09051-y

Oncologic Outcomes After Isolated Limb Infusion for Advanced Melanoma: An International Comparison of the Procedure and Outcomes Between the United States and Australia

2020

Conference Publication

Tracking genomic and transcriptomic features of oesophageal adenocarcinoma for improving patients outcome

Naeini, Marjan, Newell, Felicity, Aoude, Lauren G., Bonazzi, Vanessa F., Patel, Kalpana, Koufariotis, Lambros T., Johnson, Rebecca, Addala, Venkateswar, Kondrashova, Olga, Holmes, Oliver, Leonard, Conrad, Wood, Scott, Xu, Christina, Nones, Katia, Pearson, John V., Smithers, Mark, Watson, David, Simes, John, Price, Tim, Gebski, Val, Barbour, Andrew P. and Waddell, Nic (2020). Tracking genomic and transcriptomic features of oesophageal adenocarcinoma for improving patients outcome. HOBOKEN: WILEY.

Tracking genomic and transcriptomic features of oesophageal adenocarcinoma for improving patients outcome

2020

Journal Article

Pathogenic germline variants are associated with poor survival in stage III/IV melanoma patients

Aoude, Lauren G., Bonazzi, Vanessa F., Brosda, Sandra, Patel, Kalpana, Koufariotis, Lambros T., Oey, Harald, Nones, Katia, Wood, Scott, Pearson, John V., Lonie, James M., Arneil, Melissa, Atkinson, Victoria, Smithers, B. Mark, Waddell, Nicola and Barbour, Andrew P. (2020). Pathogenic germline variants are associated with poor survival in stage III/IV melanoma patients. Scientific Reports, 10 (1) 17687, 17687. doi: 10.1038/s41598-020-74956-3

Pathogenic germline variants are associated with poor survival in stage III/IV melanoma patients

Funding

Current funding

  • 2024 - 2026
    Optimising the Diagnosis and Management of Unilateral Primary Aldosteronism
    Metro South Hospital and Health Service
    Open grant
  • 2021 - 2026
    AGITG TOP GEAR: A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer (CTCS: led by USyd)
    University of Sydney
    Open grant
  • 2019 - 2026
    A Randomised Phase II Trial of Adjuvant Avelumab in Patients with Early Stage Merkel Cell Carcinoma
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2019 - 2026
    Melanoma Margins Trial II - A Phase III, Multi-centre Randomised Controlled Trial Investigating 1cm v 2cm Wide Surgical Excision Margins.. (NHMRC Project Grant led by the University of Melbourne).
    University of Melbourne
    Open grant

Past funding

  • 2023 - 2026
    iCare - An interactive online portal to improve health and wellbeing for people living with complex cancers, and their informal carers: a Phase II randomised controlled trial (Ex led Deakin MRFF CTA)
    Deakin University
    Open grant
  • 2021 - 2024
    Advanced technological approach to predicting survival in patients diagnosed with locally invasive cutaneous melanoma
    Cancer Council Queensland
    Open grant
  • 2021 - 2024
    Establishing Australia's First Familial Melanoma Clinic (MSH RSS SERTA Program Grant led by Metro South Hospital and Health Service)
    Metro South Hospital and Health Service
    Open grant
  • 2020 - 2021
    Cancer Evolution Biobank
    PA Research Foundation
    Open grant
  • 2017 - 2019
    Predictors of mortality in thin melanomas
    Cancer Council Queensland
    Open grant
  • 2013 - 2015
    To identify and assess markers of prognosis, response and resistance to therapy in patients with Stage III metastatic melanoma
    Cancer Bequest Fund
    Open grant
  • 2011
    DOCetaxel with or without radiation Therapy for resectable Oesophageal adenocarcinoma based on early PET Response to induction chemotherapy (DOCTOR)
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Effects of nevogenesis susceptibility genes and phenotypic correlation with dermoscopic characteristics of nevi
    NHMRC Project Grant
    Open grant
  • 2010 - 2014
    Comparison of pre- and perioperative immunonutrition in patients undergoing surgical resection of oesophageal cancer (NHMRC Project Grant administered by the University of Adelaide)
    University of Adelaide
    Open grant
  • 2001 - 2002
    The epidemiology of oesophageal cancer: Risk and molecular markers
    Queensland Cancer Fund
    Open grant
  • 2000
    The role of TAP and MHC class I expression in the response to melanoma immunotherapy using autologous dendritic cells
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1999 - 2000
    A phase II clinical trial in patients with metastatic melanoma comparing autologous dendritic cells pulsed with autologous tumour peptides and melanoma associated peptides linked to the endoplasmic re
    Queensland Cancer Fund
    Open grant
  • 1998
    A Phase I/II Clinical Trial to Test Tumour Vaccines Comprising with Protein or Autologous Tumour Antigen Autologous Dandritic Cells Generated in a Closed Bag System Pulsed
    Mayne Bequest Fund
    Open grant
  • 1998
    Isolated limb infusion of melphalan and microdialysis technique in treatment of recurrent malignant melanoma
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1998 - 2000
    Treatment of Recurrent Malignant Melanoma by Limb Infusion of Cytotoxic Drugs and Other Techniques
    NHMRC Project Grant
    Open grant
  • 1997 - 1998
    Pharmacokinetics of tumour necrosis factor (TNF) in isolated rat hindlimb perfusions and infusions related to melanoma therapy
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1996 - 1997
    Targeting and monitoring drug delivery in specific tissues using iontophoresis and microdialysis
    Quality Funds Round 3
    Open grant
  • 1995 - 1997
    Pharmacokinetics of melphalan in isolated limb perfusion and infusion
    Queensland Cancer Fund
    Open grant

Supervision

Availability

Professor Mark Smithers is:
Not available for supervision

Supervision history

Current supervision

  • Master Philosophy

    Assessment of the impact of treating service characteristics on surgical and oncological outcomes for patients with Retroperitoneal and Inguinal Sarcomas in Queensland

    Principal Advisor

  • Master Philosophy

    Factors Influencing Anastomotic Complications after Oesophagectomy

    Associate Advisor

  • Doctor Philosophy

    New tools for the multi-modal evaluation of pancreatic cancer and its precursor neoplasms.

    Associate Advisor

    Other advisors: Dr David Cavallucci

Completed supervision

Media

Enquiries

Contact Professor Mark Smithers directly for media enquiries about:

  • Advanced endoscopic surgery
  • Cancer surgery
  • Endoscopic surgery
  • General surgery
  • Melanoma
  • Surgery - cancer
  • Surgery - oesophageal, gastric cancer
  • Surgery - upper GI
  • Upper GI surgery

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au