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Professor Mark Smithers
Professor

Mark Smithers

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Overview

Background

Emeritus Professor Mark Smithers is a surgical oncologist who specialises in surgery for oesophago-gastric diseases, melanoma, advanced skin cancer and soft tissue sarcoma. He was the Director of the Upper GI and Soft Tissue Unit at the Princess Alexandra Hospital, in Brisbane, Australia from 1998 - 2023. Commencing his academic career with the University of Queensland in 1987, he progressed to be the Mayne Chair in Surgery and head of the Academy of Surgery. He is the second University of Queensland Medical graduate to be appointed to this role. His research has been focussed on the development and assessment of outcomes from minimally invasive upper GI surgery, and trials assessing the role of perioperative multidisciplinary therapy for esophageal and gastric cancer. As well he has led, or been involved with, clinical trials from phase I to III, for all stages of melanoma through his role as the Chair of the Queensland Melanoma Project. More recently he has been involved with the assessment of access to, and outcomes from, surgery for cancer in Queensland, Australia.

He has overseen the administration and development of the surgery curriculum, and the teaching, in the Academy of Surgery, in the UQ Faculty of Medicine. He was on a number of committees relevant to the implementation of the UQ MD design course. He has held various leadership and committee roles with the Royal Australasian College of Surgeons, as well as leadership roles, including the Presidency, in the Australian and New Zealand Oesophago Gastric Surgeons Association. He has also been on the committees of international organisations related to oesophageal and gastric surgery. He has published 250 articles, eight book chapters, and has been on the editorial board of a number of surgical journals.

He has been recognised for his clinical and academic roles by the award of Member of the Order of Australia (AM). The citation reads, "for service to medicine in the fields of gastro-intestinal and melanoma surgery, to medical education and to professional organisations". The Royal Australasian College of Surgeons awarded him the Sir Hugh Devine medal, for services to surgery and the community. This is the College’s highest honour. Internationally, he has been awarded an honorary fellowship of the Royal College of Surgeons of Edinburgh and recently, in the United States, he was elected as an Honarary Fellow of the American Surgical Association.

Availability

Professor Mark Smithers is:
Not available for supervision
Media expert

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Honorary Fellow, American Surgical Association, American Surgical Association
  • Fellow, Royal Australasian College of Surgeons, Royal Australasian College of Surgeons
  • Fellow, Royal College of Surgeons of Edinburgh, Royal College of Surgeons of Edinburgh
  • Fellow, Royal College of Surgeons of England, Royal College of Surgeons of England

Research interests

  • Cutaneous Melanoma

    epidemiology, public health issues and management of all stages

  • Management of Oesophageal and Gastric Cancer

    Investigation and management of benign and malignant diseases of the oesophagus and the stomach.

Works

Search Professor Mark Smithers’s works on UQ eSpace

410 works between 1983 and 2025

121 - 140 of 410 works

2019

Conference Publication

Patterns of response for combination of PV-10 oncolytic immunotherapy and checkpoint inhibition

Agarwala, Sanjiv S., Ross, Merrick I., Zager, Jonathan, Shirai, Keisuki, Essner, Richard, Smithers, Bernard M., Atkinson, Victoria, Sarson, David and Wachter, Eric A. (2019). Patterns of response for combination of PV-10 oncolytic immunotherapy and checkpoint inhibition. LONDON: BMC.

Patterns of response for combination of PV-10 oncolytic immunotherapy and checkpoint inhibition

2019

Journal Article

Patients with in-transit melanoma metastases have comparable survival outcomes following isolated limb infusion or intralesional PV-10-A propensity score matched, single center study

Read, Tavis, Fayers, Warren, Thomas, Janine, Wagels, Michael, Barbour, Andrew and Smithers, B. Mark (2019). Patients with in-transit melanoma metastases have comparable survival outcomes following isolated limb infusion or intralesional PV-10-A propensity score matched, single center study. Journal of Surgical Oncology, 119 (6), 717-727. doi: 10.1002/jso.25373

Patients with in-transit melanoma metastases have comparable survival outcomes following isolated limb infusion or intralesional PV-10-A propensity score matched, single center study

2019

Conference Publication

Long-term oncologic outcomes following isolated limb infusion for locoregional metastatic melanoma: an international multi-center analysis

Miura, J. T., Kroon, H. M., Beasley, G., Farrow, N. E., Mosca, P. J., Lowe, M., Farley, C., Kim, Y., Naqvi, S., Potdar, A., Daou, H., Sun, J., Mullen, D., Farma, J., Henderson, M., Serpell, J., Delman, K. A., Smithers, M., Coventry, B., Tyler, D. S., Thompson, J. and Zager, J. (2019). Long-term oncologic outcomes following isolated limb infusion for locoregional metastatic melanoma: an international multi-center analysis. 72nd Annual Cancer Symposium of the Society of Surgical Oncology (SSO), San Diego, California, 27-30 March 2019 . New York, NY, United States: Springer.

Long-term oncologic outcomes following isolated limb infusion for locoregional metastatic melanoma: an international multi-center analysis

2019

Conference Publication

Clinicopathological factors associated with death from thin (<= 1 mm) melanoma

Claeson, M., Baade, P., Brown, S., Soyer, P., Smithers, M., Green, A., Whiteman, D. and Khosrotehrani, K. (2019). Clinicopathological factors associated with death from thin (

Clinicopathological factors associated with death from thin (<= 1 mm) melanoma

2019

Conference Publication

FDG-PET response assessment in patients with locally advanced nodal melanoma undergoing high-dose neo-adjuvant or definitive radiotherapy

Trada, Y., Law, P. W., Bernard, A., Foote, M. C., Barbour, A., Lambie, D., Smithers, M., Burmeister, B. and Pinkham, M. B. (2019). FDG-PET response assessment in patients with locally advanced nodal melanoma undergoing high-dose neo-adjuvant or definitive radiotherapy. 61st Annual Meeting of the American Society for Radiation Oncology (ASTRO), Chicago, Illinois, 15-18 September 2019 . Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.ijrobp.2019.06.2489

FDG-PET response assessment in patients with locally advanced nodal melanoma undergoing high-dose neo-adjuvant or definitive radiotherapy

2019

Journal Article

Pancreaticoduodenectomy in a low-resection volume region: a population-level study examining the impact of hospital-volume on surgical quality and longer-term survival

Narendra, Aaditya, Baade, Peter D., Aitken, Joanne F., Fawcett, Jonathan and Smithers, Bernard Mark (2019). Pancreaticoduodenectomy in a low-resection volume region: a population-level study examining the impact of hospital-volume on surgical quality and longer-term survival. HPB, 22 (9), 1288-1294. doi: 10.1016/j.hpb.2019.11.015

Pancreaticoduodenectomy in a low-resection volume region: a population-level study examining the impact of hospital-volume on surgical quality and longer-term survival

2019

Book Chapter

Treatment of early oesophageal cancer

Smithers, B. Mark and Thomson, Iain (2019). Treatment of early oesophageal cancer. Oesophagogastric Surgery - A Companion to Specialist Surgical Practice. (pp. 89-99) edited by S. Michael Griffin. Edinburgh, Scotland: Elsevier.

Treatment of early oesophageal cancer

2019

Conference Publication

Melanoma patient survival: Prognostic value of pSTAT5 as a biomarker

Chong, S., Rowe, C., Malt, M., Brown, S., Smithers, M. and Khosrotehrani, K. (2019). Melanoma patient survival: Prognostic value of pSTAT5 as a biomarker. Australasian College of Dermatologists, 52nd Annual Scientific Meeting, Melbourne, VIC Australia, 18–21 May 2019. Richmond, VIC Australia: Wiley-Blackwell.

Melanoma patient survival: Prognostic value of pSTAT5 as a biomarker

2019

Conference Publication

Phase 1b study of PV-10 and anti-PD-1 in advanced cutaneous melanoma

Agarwala, Sanjiv S., Ross, Merrick I., Zager, Jonathan S., Shirai, Keisuke, Essner, Richard, Smithers, Bernard Mark, Atkinson, Victoria and Wachter, Eric Andrew (2019). Phase 1b study of PV-10 and anti-PD-1 in advanced cutaneous melanoma. Annual Meeting of the American Society of Clinical Oncology (ASCO), Chicago, Il, United States, May 31-June 4, 2019. Alexandria, VA, United States: American Society of Clinical Oncology. doi: 10.1200/JCO.2019.37.15_suppl.9559

Phase 1b study of PV-10 and anti-PD-1 in advanced cutaneous melanoma

2019

Journal Article

Sun protection behaviour after diagnosis of high-risk primary melanoma and risk of a subsequent primary

von Schuckmann, Lena A., Wilson, Louise F., Hughes, Maria Celia B., Beesley, Vanessa L., Janda, Monika, van der Pols, Jolieke C., Smithers, B. Mark, Khosrotehrani, Kiarash and Green, Adele C. (2019). Sun protection behaviour after diagnosis of high-risk primary melanoma and risk of a subsequent primary. Journal of the American Academy of Dermatology, 80 (1), 139-148.e4. doi: 10.1016/j.jaad.2018.06.068

Sun protection behaviour after diagnosis of high-risk primary melanoma and risk of a subsequent primary

2019

Conference Publication

IRF4 rs12203592*T/T genotype is associated with nodular melanoma

Rayner, Jenna E., McMeniman, Erin K., Duffy, David L., De'Ambrosis, Brian, Smithers, B Mark, Jagirdar, Kasturee, Lee, Katie J., Soyer, H. Peter and Sturm, Richard A. (2019). IRF4 rs12203592*T/T genotype is associated with nodular melanoma. ASDR Annual Scientific Meeting 2019, Melbourne, VIC, Australia, 16-17 May 2019.

IRF4 rs12203592*T/T genotype is associated with nodular melanoma

2019

Book Chapter

Ablation for patients with Barrett or Dysplasia

Smithers, B. Mark and Thomson, Iain (2019). Ablation for patients with Barrett or Dysplasia. Schakelford's Surgery of the Alimentary Tract. (pp. 350-361) edited by Charles J. Yeo, Steven R. DeMeester, David W. McFadden, Jeffrey B. Matthews and Fleshman James W.. Philadelphia, PA, United States: Elsevier. doi: 10.1016/B978-0-323-40232-3.00034-0

Ablation for patients with Barrett or Dysplasia

2019

Conference Publication

SOX18 activation in primary melanoma tumours

Chong, S., Rowe, C., Malt, M., Smithers, M., Green, A. and Khosrotehrani, K. (2019). SOX18 activation in primary melanoma tumours. Australasian College of Dermatologists, 52nd Annual Scientific Meeting, Melbourne, VIC Australia, 18–21 May 2019. Richmond, VIC Australia: Wiley-Blackwell.

SOX18 activation in primary melanoma tumours

2019

Conference Publication

Efficacy of immune checkpoint inhibitors (ICIs) for in-transit melanoma

Tie, Emilia Nan, Lai-Kwon, Julia Elizabeth, Na, Lumine, Rtshiladze, Michael Alexander, Bozzi, James, Read, Tavis, Atkinson, Victoria, Au-Yeung, George, Long, Georgina V., McArthur, Grant A., Sandhu, Shahneen Kaur, Saw, Robyn, Walpole, Euan Thomas, Menzies, Alexander M., Smithers, B. Mark and Gyorki, David E. (2019). Efficacy of immune checkpoint inhibitors (ICIs) for in-transit melanoma. Annual Meeting of the American Society of Clinical Oncology (ASCO), Chicago, IL United States, 31 May - 4 June 2019. Alexandria, VA United States: American Society of Clinical Oncology.

Efficacy of immune checkpoint inhibitors (ICIs) for in-transit melanoma

2019

Book Chapter

Esophageal Ulcers

Frankel, Adam J. and Smithers, B. Mark (2019). Esophageal Ulcers. Encyclopedia of Gastroenterology. (pp. 400-403) London, United Kingdom: Elsevier. doi: 10.1016/B978-0-12-801238-3.65935-4

Esophageal Ulcers

2019

Journal Article

Survival of patients with early invasive melanoma down-staged under the new 8 AJCC edition

von Schuckmann, Lena A., Hughes, Maria Celia B., Lee, Rebecca, Lorigan, Paul, Khosrotehrani, Kiarash, Smithers, B. Mark and Green, Adele C. (2019). Survival of patients with early invasive melanoma down-staged under the new 8 AJCC edition. Journal of the American Academy of Dermatology, 80 (1), 272-274. doi: 10.1016/j.jaad.2018.04.017

Survival of patients with early invasive melanoma down-staged under the new 8 AJCC edition

2018

Journal Article

Guidelines for perioperative care in esophagectomy: Enhanced Recovery After Surgery (ERAS®) Society recommendations

Low, Donald E., Allum, William, De Manzoni, Giovanni, Ferri, Lorenzo, Immanuel, Arul, Kuppusamy, Madhan Kumar, Law, Simon, Lindblad, Mats, Maynard, Nick, Neal, Joseph, Pramesh, C. S., Scott, Mike, Mark Smithers, B., Addor, Valérie and Ljungqvist, Olle (2018). Guidelines for perioperative care in esophagectomy: Enhanced Recovery After Surgery (ERAS®) Society recommendations. World Journal of Surgery, 43 (2), 299-330. doi: 10.1007/s00268-018-4786-4

Guidelines for perioperative care in esophagectomy: Enhanced Recovery After Surgery (ERAS®) Society recommendations

2018

Conference Publication

Progression-free survival and recurrence results for AGITG DOCTOR: Pre-op cisplatin, 5FU & DOCetaxel plus /-radiotherapy after poor early response to cisplatin & 5FU for resectable oesophageal adenocarcinoma

Barbour, A. P., Walpole, E. T., Mai, G. T., Barnes, L., Watson, D. I., Ackland, S. P., Wills, V., Martin, J., Burge, M., Karapetis, C. S., Shannon, J., Nott, L. M., Gebski, V., Oostendorp, M., Wilson, K., Thomas, J., Lampe, G., Zalcberg, J. R., Simes, J. and Smithers, M. (2018). Progression-free survival and recurrence results for AGITG DOCTOR: Pre-op cisplatin, 5FU & DOCetaxel plus /-radiotherapy after poor early response to cisplatin & 5FU for resectable oesophageal adenocarcinoma. 43rd ESMO Congress (ESMO), Munich Germany, Oct 19-23, 2018. OXFORD: OXFORD UNIV PRESS.

Progression-free survival and recurrence results for AGITG DOCTOR: Pre-op cisplatin, 5FU & DOCetaxel plus /-radiotherapy after poor early response to cisplatin & 5FU for resectable oesophageal adenocarcinoma

2018

Journal Article

Multicentre factorial randomized clinical trial of perioperative immunonutrition versus standard nutrition for patients undergoing surgical resection of oesophageal cancer

Mudge, L. A., Watson, D. I., Smithers, B. M., Isenring, E. A., Smith, L., Jamieson, G. G., Australian Immunonutrition Study Group and McFarlane, Catherine (2018). Multicentre factorial randomized clinical trial of perioperative immunonutrition versus standard nutrition for patients undergoing surgical resection of oesophageal cancer. The British Journal of Surgery, 105 (10), 1262-1272. doi: 10.1002/bjs.10923

Multicentre factorial randomized clinical trial of perioperative immunonutrition versus standard nutrition for patients undergoing surgical resection of oesophageal cancer

2018

Journal Article

In response to: immigration is the most likely reason for the generational change in melanoma incidence in Queensland, Australia

Aitken, Joanne F., Youlden, Danny R., Baade, Peter D., Soyer, H. Peter, Green, Adele C. and Smithers, B. Mark (2018). In response to: immigration is the most likely reason for the generational change in melanoma incidence in Queensland, Australia. International Journal of Cancer, 143 (3), 722-723. doi: 10.1002/ijc.31347

In response to: immigration is the most likely reason for the generational change in melanoma incidence in Queensland, Australia

Supervision

Availability

Professor Mark Smithers is:
Not available for supervision

Supervision history

Current supervision

  • Master Philosophy

    Retroperitoneal sarcoma: Impact of the patterns of care on patient outcomes in Queensland.

    Principal Advisor

    Other advisors: Professor Andrew Barbour

  • Master Philosophy

    Trends in the regional nodal management of cutaneous melanoma.

    Principal Advisor

    Other advisors: Professor Peter Soyer

  • Master Philosophy

    Factors Influencing Anastomotic Complications after Oesophagectomy

    Associate Advisor

  • Doctor Philosophy

    Utilising the Multi-Disciplinary Resources at Tertiary Centres to Improve Outcomes from Pancreatic Cancer

    Associate Advisor

    Other advisors: Dr David Cavallucci

Completed supervision

Media

Enquiries

Contact Professor Mark Smithers directly for media enquiries about:

  • Advanced endoscopic surgery
  • Cancer surgery
  • Endoscopic surgery
  • General surgery
  • Melanoma
  • Surgery - cancer
  • Surgery - oesophageal, gastric cancer
  • Surgery - upper GI
  • Upper GI surgery

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