
Overview
Background
Emeritus Professor Mark Smithers is a surgical oncologist who specialises in surgery for oesophago-gastric diseases, melanoma, advanced skin cancer and soft tissue sarcoma. He was the Director of the Upper GI and Soft Tissue Unit at the Princess Alexandra Hospital, in Brisbane, Australia from 1998 - 2023. Commencing his academic career with the University of Queensland in 1987, he progressed to be the Mayne Chair in Surgery and head of the Academy of Surgery. He is the second University of Queensland Medical graduate to be appointed to this role. His research has been focussed on the development and assessment of outcomes from minimally invasive upper GI surgery, and trials assessing the role of perioperative multidisciplinary therapy for esophageal and gastric cancer. As well he has led, or been involved with, clinical trials from phase I to III, for all stages of melanoma through his role as the Chair of the Queensland Melanoma Project. More recently he has been involved with the assessment of access to, and outcomes from, surgery for cancer in Queensland, Australia.
He has overseen the administration and development of the surgery curriculum, and the teaching, in the Academy of Surgery, in the UQ Faculty of Medicine. He was on a number of committees relevant to the implementation of the UQ MD design course. He has held various leadership and committee roles with the Royal Australasian College of Surgeons, as well as leadership roles, including the Presidency, in the Australian and New Zealand Oesophago Gastric Surgeons Association. He has also been on the committees of international organisations related to oesophageal and gastric surgery. He has published 250 articles, eight book chapters, and has been on the editorial board of a number of surgical journals.
He has been recognised for his clinical and academic roles by the award of Member of the Order of Australia (AM). The citation reads, "for service to medicine in the fields of gastro-intestinal and melanoma surgery, to medical education and to professional organisations". The Royal Australasian College of Surgeons awarded him the Sir Hugh Devine medal, for services to surgery and the community. This is the College’s highest honour. Internationally, he has been awarded an honorary fellowship of the Royal College of Surgeons of Edinburgh and recently, in the United States, he was elected as an Honarary Fellow of the American Surgical Association.
Availability
- Professor Mark Smithers is:
- Not available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
- Honorary Fellow, American Surgical Association, American Surgical Association
- Fellow, Royal Australasian College of Surgeons, Royal Australasian College of Surgeons
- Fellow, Royal College of Surgeons of Edinburgh, Royal College of Surgeons of Edinburgh
- Fellow, Royal College of Surgeons of England, Royal College of Surgeons of England
Research interests
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Cutaneous Melanoma
epidemiology, public health issues and management of all stages
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Management of Oesophageal and Gastric Cancer
Investigation and management of benign and malignant diseases of the oesophagus and the stomach.
Works
Search Professor Mark Smithers’s works on UQ eSpace
2019
Journal Article
Baseline neutrophil–lymphocyte ratio holds no prognostic value for esophageal and junctional adenocarcinoma in patients treated with neoadjuvant chemotherapy
van Hootegem, S. J. M., Smithers, B. M., Gotley, D. C., Brosda, S., Thomson, I. G., Thomas, J. M., Gartside, M. and Barbour, A. P. (2019). Baseline neutrophil–lymphocyte ratio holds no prognostic value for esophageal and junctional adenocarcinoma in patients treated with neoadjuvant chemotherapy. Diseases of the Esophagus, 33 (6) doz082. doi: 10.1093/dote/doz082
2019
Journal Article
Response to Stahlie et al regarding “A systematic review and meta-analysis of locoregional treatments for in-transit melanoma”
Read, Tavis, Lonne, Michael, Sparks, David S., David, Michael, Wagels, Michael, Schaider, Helmut, Soyer, Peter H. and Smithers, Mark B. (2019). Response to Stahlie et al regarding “A systematic review and meta-analysis of locoregional treatments for in-transit melanoma”. Journal of Surgical Oncology, 120 (6), 1058-1059. doi: 10.1002/jso.25686
2019
Conference Publication
An international randomised trial of post-operative radiation therapy following wide excision of neurotropic melanoma of the head and neck
Foote, Matthew, Smithers, Mark, Hong, Angela, Fogarty, Gerald, Scolyer, Richard, Paton, Elizabeth, Barker, Christopher, Chua, Margaret, Shannon, Kerwin, Burmeister, Bryan, Nobes, Jenny and Williams, Narelle (2019). An international randomised trial of post-operative radiation therapy following wide excision of neurotropic melanoma of the head and neck. HOBOKEN: WILEY.
2019
Journal Article
Assessment of hospital characteristics associated with improved mortality following complex upper gastrointestinal cancer surgery in Queensland
Narendra, Aaditya, Baade, Peter D., Aitken, Joanne F., Fawcett, Jonathan and Smithers, Bernard M. (2019). Assessment of hospital characteristics associated with improved mortality following complex upper gastrointestinal cancer surgery in Queensland. ANZ Journal of Surgery, 89 (11), 1404-1409. doi: 10.1111/ans.15389
2019
Conference Publication
A randomised, double-blind, placebo-controlled, multi-institutional phase II study of adjuvant anti-PD-1 in patients with stage I-III Merkel cell carcinoma [I-MAT study]
Xu, Wen, Poulsen, Michael, Atkinson, Victoria, Fogarty, Gerald, Veness, Michael, Smithers, Bernard, Gyorki, David, Mar, Victoria, Howle, Julie, Guminski, Alexander, Williams, Narelle and Paton, Elizabeth (2019). A randomised, double-blind, placebo-controlled, multi-institutional phase II study of adjuvant anti-PD-1 in patients with stage I-III Merkel cell carcinoma [I-MAT study]. HOBOKEN: WILEY.
2019
Journal Article
New treatment paradigms for clinically apparent metastatic melanoma in regional lymph nodes
Henderson, Michael A., Spillane, John, Hughes, T. Michael, Spillane, Andrew J., Smithers, B. Mark and Thompson, John F. (2019). New treatment paradigms for clinically apparent metastatic melanoma in regional lymph nodes. ANZ Journal of Surgery, 89 (10), 1187-1189. doi: 10.1111/ans.15407
2019
Journal Article
Clinicopathological factors associated with death from thin (≤ 1·00 mm) melanoma
Claeson, M., Baade, P., Brown, S., Soyer, H. P., Smithers, B. M., Green, A. C., Whiteman, D. C. and Khosrotehrani, K. (2019). Clinicopathological factors associated with death from thin (≤ 1·00 mm) melanoma. British Journal of Dermatology, 182 (4) bjd.18560, 927-931. doi: 10.1111/bjd.18560
2019
Journal Article
The impact of signet ring cell differentiation on outcome in patients with esophageal and gastroesophageal junction adenocarcinoma
van Hootegem, Sander J. M., Smithers, B. Mark, Gotley, David C., Brosda, Sandra, Thomson, Iain G., Thomas, Janine M., Gartside, Michael, van Lanschot, Jan J. B., Lagarde, Sjoerd M., Wijnhoven, Bas P. L. and Barbour, Andrew P. (2019). The impact of signet ring cell differentiation on outcome in patients with esophageal and gastroesophageal junction adenocarcinoma. Annals of Surgical Oncology, 26 (8), 2375-2384. doi: 10.1245/s10434-019-07322-x
2019
Journal Article
IRF4 rs12203592*T/T genotype is associated with nodular melanoma
Rayner, Jenna E., McMeniman, Erin K., Duffy, David L., De'Ambrosis, Brian, Smithers, B Mark, Jagirdar, Kasturee, Lee, Katie J., Soyer, H Peter and Sturm, Richard A. (2019). IRF4 rs12203592*T/T genotype is associated with nodular melanoma. Melanoma Research, 29 (4), 445-446. doi: 10.1097/CMR.0000000000000596
2019
Journal Article
Multidisciplinary cancer care in Australia
Walpole, Euan, Smithers, Mark, Cossio, Danica, Harden, Hazel, Thiele, David and Janda, Monika (2019). Multidisciplinary cancer care in Australia. Asia-Pacific Journal of Clinical Oncology, 15 (4), 197-198. doi: 10.1111/ajco.13164
2019
Journal Article
Future is bright for academic surgery in Australasia: highlights of the 2018 Academic Meetings
Lee, James C., Mukherjee, Payal, Koh, Cherry and Smithers, Mark (2019). Future is bright for academic surgery in Australasia: highlights of the 2018 Academic Meetings. ANZ Journal of Surgery, 89 (7-8), 798-799. doi: 10.1111/ans.15341
2019
Journal Article
Phenotypic and genotypic analysis of amelanotic and hypomelanotic melanoma patients
Rayner, J. E., McMeniman, E. K., Duffy, D. L., De'Ambrosis, B., Smithers, B. M., Jagirdar, K., Lee, K. J., Soyer, H. P. and Sturm, R. A. (2019). Phenotypic and genotypic analysis of amelanotic and hypomelanotic melanoma patients. Journal of the European Academy of Dermatology and Venereology, 33 (6) jdv.15446, 1076-1083. doi: 10.1111/jdv.15446
2019
Journal Article
Evaluation of the efficacy and toxicity of upper extremity isolated limb infusion chemotherapy for melanoma: an Australian multi-center study
Kroon, Hidde M., Coventry, Brendon J., Henderson, Michael A., Barbour, Andrew, Serpell, Jonathan, Smithers, B. Mark and Thompson, John F. (2019). Evaluation of the efficacy and toxicity of upper extremity isolated limb infusion chemotherapy for melanoma: an Australian multi-center study. European Journal of Surgical Oncology, 45 (5), 832-837. doi: 10.1016/j.ejso.2019.02.026
2019
Journal Article
Risk of melanoma recurrence after diagnosis of a high-risk primary tumor
Von Schuckmann, Lena A., Hughes, Maria Celia B., Ghiasvand, Reza, Malt, Maryrose, Van Der Pols, Jolieke C., Beesley, Vanessa L., Khosrotehrani, Kiarash, Smithers, B. Mark and Green, Adele C. (2019). Risk of melanoma recurrence after diagnosis of a high-risk primary tumor. JAMA Dermatology, 155 (6), 688-693. doi: 10.1001/jamadermatol.2019.0440
2019
Conference Publication
ANZMTG 01.09 An International randomised trial of post-operative radiation therapy following wide excision of neurotropic melanoma of the head and neck
Foote, M., Smithers, M., Hong, A., Fogarty, G., Scolyer, R., Paton, E., Barker, C., Chua, M., Shannon, K., Burmeister, B. and Nobes, J. (2019). ANZMTG 01.09 An International randomised trial of post-operative radiation therapy following wide excision of neurotropic melanoma of the head and neck. HOBOKEN: WILEY.
2019
Journal Article
Conclusions from quality of life studies in patients with resected high-risk melanoma: one part of the full story
Smithers, B. Mark (2019). Conclusions from quality of life studies in patients with resected high-risk melanoma: one part of the full story. The Lancet Oncology, 20 (5), 611-612. doi: 10.1016/S1470-2045(19)30176-7
2019
Journal Article
Long–term oncologic outcomes after isolated limb infusion for locoregionally metastatic melanoma: an international multicenter analysis
Miura, John T., Kroon, Hidde M., Beasley, Georgia M., Mullen, Dean, Farrow, Norma E., Mosca, Paul J., Lowe, Michael C., Farley, Clara R., Kim, Youngchul, Naqvi, Syeda Mahrukh Hussnain, Potdar, Aishwarya, Daou, Hala, Sun, James, Farma, Jeffrey M., Henderson, Michael A., Speakman, David, Serpell, Jonathan, Delman, Keith A., Smithers, B. Mark , Coventry, Brendon J., Tyler, Douglas S., Thompson, John F. and Zager, Jonathan S. (2019). Long–term oncologic outcomes after isolated limb infusion for locoregionally metastatic melanoma: an international multicenter analysis. Annals of Surgical Oncology, 26 (8), 2486-2494. doi: 10.1245/s10434-019-07288-w
2019
Journal Article
Predictors of staging accuracy, pathologic nodal involvement, and overall survival for cT2N0 carcinoma of the esophagus
Atay, Scott M., Correa, Arlene, Hofstetter, Wayne L., Swisher, Stephen G., Ajani, Jaffer, Altorki, Nassar K., Blackmon, Shanda H., Blackstone, Eugene H., Rice, Thomas W., Crabtree, Traves D., D'Amico, Thomas A., Darling, Gail E., DeMeester, Steven R., DeMeester, Thomas R., Worrell, Stephanie G., Ferri, Lorenzo E., Gaissert, Henning A., Krasna, Mark J., Lerut, Antoon, Nafteux, Phillippe, Moons, Johnny, Little, Alex G., Low, Donald E., Carrott, Phillip W., Schmidt, Henner M., Miller, Daniel, Nason, Katie S., Luketich, James D., Orringer, Mark B. ... Yang, Stephen C. (2019). Predictors of staging accuracy, pathologic nodal involvement, and overall survival for cT2N0 carcinoma of the esophagus. Journal of Thoracic and Cardiovascular Surgery, 157 (3), 1264-1272.e6. doi: 10.1016/j.jtcvs.2018.10.057
2019
Journal Article
A systematic review and meta-analysis of locoregional treatments for in-transit melanoma
Read, Tavis, Lonne, Michael, Sparks, David S., David, Michael, Wagels, Michael, Schaider, Helmut, Soyer, H. Peter and Smithers, B. Mark (2019). A systematic review and meta-analysis of locoregional treatments for in-transit melanoma. Journal of Surgical Oncology, 119 (7) jso.25686, 887-896. doi: 10.1002/jso.25400
2019
Conference Publication
Obesity Paradox in Early Stage Melanoma: Long-Term Follow-up in MSLT-I
Rand, J. G., Kirchoff, D., Deutsch, G., Stern, S., Thompson, J., Cochran, A., Mozzillo, N., Nieweg, O., Roses, D., Hoekstra, H., Sondak, V., Coventry, B., Kashani-Sabet, M., Smithers, M., Paul, E., Kraybill, W., Elashoff, R., Lee, D. and Faries, M. B. (2019). Obesity Paradox in Early Stage Melanoma: Long-Term Follow-up in MSLT-I. 72nd Annual Cancer Symposium of the Society-of-Surgical-Oncology (SSO), San Diego Ca, Mar 27-30, 2019. NEW YORK: SPRINGER.
Supervision
Availability
- Professor Mark Smithers is:
- Not available for supervision
Supervision history
Current supervision
-
Master Philosophy
Retroperitoneal sarcoma: Impact of the patterns of care on patient outcomes in Queensland.
Principal Advisor
Other advisors: Professor Andrew Barbour
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Master Philosophy
Trends in the regional nodal management of cutaneous melanoma.
Principal Advisor
Other advisors: Professor Peter Soyer
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Master Philosophy
Factors Influencing Anastomotic Complications after Oesophagectomy
Associate Advisor
-
Doctor Philosophy
Utilising the Multi-Disciplinary Resources at Tertiary Centres to Improve Outcomes from Pancreatic Cancer
Associate Advisor
Other advisors: Dr David Cavallucci
Completed supervision
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2020
Master Philosophy
An assessment of the impacts of centralising complex upper-gastrointestinal surgery in Queensland
Principal Advisor
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2024
Master Philosophy
In vivo Magnetic Resonance Spectroscopy (MRS) with 2-Dimensional (2D) COrrelated Spectroscopy (COSY) applied to breast cancer
Associate Advisor
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2020
Doctor Philosophy
Natural history of high-risk cutaneous primary melanoma and risk factors for disease progression
Associate Advisor
Other advisors: Professor Kiarash Khosrotehrani
-
2020
Doctor Philosophy
An evaluation of the role of locoregional treatments for the management of in-transit melanoma metastases
Associate Advisor
Other advisors: Professor Peter Soyer, Associate Professor Helmut Schaider
Media
Enquiries
Contact Professor Mark Smithers directly for media enquiries about:
- Advanced endoscopic surgery
- Cancer surgery
- Endoscopic surgery
- General surgery
- Melanoma
- Surgery - cancer
- Surgery - oesophageal, gastric cancer
- Surgery - upper GI
- Upper GI surgery
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