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Professor Mark Smithers
Professor

Mark Smithers

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Overview

Background

Emeritus Professor Mark Smithers is a surgical oncologist who specialises in surgery for oesophago-gastric diseases, melanoma, advanced skin cancer and soft tissue sarcoma. He was the Director of the Upper GI and Soft Tissue Unit at the Princess Alexandra Hospital, in Brisbane, Australia from 1998 - 2023. Commencing his academic career with the University of Queensland in 1987, he progressed to be the Mayne Chair in Surgery and head of the Academy of Surgery. He is the second University of Queensland Medical graduate to be appointed to this role. His research has been focussed on the development and assessment of outcomes from minimally invasive upper GI surgery, and trials assessing the role of perioperative multidisciplinary therapy for esophageal and gastric cancer. As well he has led, or been involved with, clinical trials from phase I to III, for all stages of melanoma through his role as the Chair of the Queensland Melanoma Project. More recently he has been involved with the assessment of access to, and outcomes from, surgery for cancer in Queensland, Australia.

He has overseen the administration and development of the surgery curriculum, and the teaching, in the Academy of Surgery, in the UQ Faculty of Medicine. He was on a number of committees relevant to the implementation of the UQ MD design course. He has held various leadership and committee roles with the Royal Australasian College of Surgeons, as well as leadership roles, including the Presidency, in the Australian and New Zealand Oesophago Gastric Surgeons Association. He has also been on the committees of international organisations related to oesophageal and gastric surgery. He has published 250 articles, eight book chapters, and has been on the editorial board of a number of surgical journals.

He has been recognised for his clinical and academic roles by the award of Member of the Order of Australia (AM). The citation reads, "for service to medicine in the fields of gastro-intestinal and melanoma surgery, to medical education and to professional organisations". The Royal Australasian College of Surgeons awarded him the Sir Hugh Devine medal, for services to surgery and the community. This is the College’s highest honour. Internationally, he has been awarded an honorary fellowship of the Royal College of Surgeons of Edinburgh and recently, in the United States, he was elected as an Honarary Fellow of the American Surgical Association.

Availability

Professor Mark Smithers is:
Not available for supervision
Media expert

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Honorary Fellow, American Surgical Association, American Surgical Association
  • Fellow, Royal Australasian College of Surgeons, Royal Australasian College of Surgeons
  • Fellow, Royal College of Surgeons of Edinburgh, Royal College of Surgeons of Edinburgh
  • Fellow, Royal College of Surgeons of England, Royal College of Surgeons of England

Research interests

  • Cutaneous Melanoma

    epidemiology, public health issues and management of all stages

  • Management of Oesophageal and Gastric Cancer

    Investigation and management of benign and malignant diseases of the oesophagus and the stomach.

Works

Search Professor Mark Smithers’s works on UQ eSpace

414 works between 1983 and 2025

101 - 120 of 414 works

2019

Journal Article

Impact of hospital resection volume and service capability on post‐operative mortality following gastrectomy

Narendra, Aaditya, Baade, Peter D., Aitken, Joanne F., Fawcett, Jonathan and Smithers, B. Mark (2019). Impact of hospital resection volume and service capability on post‐operative mortality following gastrectomy. ANZ Journal of Surgery, 90 (1-2) ans.15616, 86-91. doi: 10.1111/ans.15616

Impact of hospital resection volume and service capability on post‐operative mortality following gastrectomy

2019

Journal Article

The interplay of sun-damage and genetic risk in Australian multiple and single primary melanoma cases and controls

McMeniman, E. K., Duffy, D. L., Jagirdar, K., Lee, K. J., Peach, E., McInerney-Leo, A. M., De'Ambrosis, B., Rayner, J. E., Smithers, B. M., Soyer, H. P. and Sturm, R. A. (2019). The interplay of sun-damage and genetic risk in Australian multiple and single primary melanoma cases and controls. British Journal of Dermatology, 183 (2) bjd.18777, 357-366. doi: 10.1111/bjd.18777

The interplay of sun-damage and genetic risk in Australian multiple and single primary melanoma cases and controls

2019

Journal Article

Inguinal and ilio-inguinal lymphadenectomy in management of palpable melanoma lymph node metastasis: A long-term prospective evaluation of morbidity and quality of life

Henderson, Michael A., Gyorki, D., Burmeister, B. H., Ainslie, J., Fisher, R., Di Iulio, J., Smithers, B. M., Hong, A., Shannon, K., Scolyer, R. A., Carruthers, S., Coventry, B. J., Babington, S., Duprat, J., Hoekstra, H. J. and Thompson, J. F. (2019). Inguinal and ilio-inguinal lymphadenectomy in management of palpable melanoma lymph node metastasis: A long-term prospective evaluation of morbidity and quality of life. Annals of Surgical Oncology, 26 (13), 4663-4672. doi: 10.1245/s10434-019-07810-0

Inguinal and ilio-inguinal lymphadenectomy in management of palpable melanoma lymph node metastasis: A long-term prospective evaluation of morbidity and quality of life

2019

Journal Article

Evaluation of the efficacy of 3D total-body photography with sequential digital dermoscopy in a high-risk melanoma cohort: protocol for a randomised controlled trial

Primiero, Clare Amy, McInerney-Leo, Aideen M., Betz-Stablein, Brigid, Whiteman, David C., Gordon, Louisa, Caffery, Liam, Aitken, Joanne F., Eakin, Elizabeth, Osborne, Sonya, Gray, Len, Smithers, B. Mark, Janda, Monika, Soyer, H. Peter and Finnane, Anna (2019). Evaluation of the efficacy of 3D total-body photography with sequential digital dermoscopy in a high-risk melanoma cohort: protocol for a randomised controlled trial. BMJ Open, 9 (11) e032969, e032969. doi: 10.1136/bmjopen-2019-032969

Evaluation of the efficacy of 3D total-body photography with sequential digital dermoscopy in a high-risk melanoma cohort: protocol for a randomised controlled trial

2019

Journal Article

Baseline neutrophil–lymphocyte ratio holds no prognostic value for esophageal and junctional adenocarcinoma in patients treated with neoadjuvant chemotherapy

van Hootegem, S. J. M., Smithers, B. M., Gotley, D. C., Brosda, S., Thomson, I. G., Thomas, J. M., Gartside, M. and Barbour, A. P. (2019). Baseline neutrophil–lymphocyte ratio holds no prognostic value for esophageal and junctional adenocarcinoma in patients treated with neoadjuvant chemotherapy. Diseases of the Esophagus, 33 (6) doz082. doi: 10.1093/dote/doz082

Baseline neutrophil–lymphocyte ratio holds no prognostic value for esophageal and junctional adenocarcinoma in patients treated with neoadjuvant chemotherapy

2019

Conference Publication

A randomised, double-blind, placebo-controlled, multi-institutional phase II study of adjuvant anti-PD-1 in patients with stage I-III Merkel cell carcinoma [I-MAT study]

Xu, Wen, Poulsen, Michael, Atkinson, Victoria, Fogarty, Gerald, Veness, Michael, Smithers, Bernard, Gyorki, David, Mar, Victoria, Howle, Julie, Guminski, Alexander, Williams, Narelle and Paton, Elizabeth (2019). A randomised, double-blind, placebo-controlled, multi-institutional phase II study of adjuvant anti-PD-1 in patients with stage I-III Merkel cell carcinoma [I-MAT study]. HOBOKEN: WILEY.

A randomised, double-blind, placebo-controlled, multi-institutional phase II study of adjuvant anti-PD-1 in patients with stage I-III Merkel cell carcinoma [I-MAT study]

2019

Journal Article

Response to Stahlie et al regarding “A systematic review and meta-analysis of locoregional treatments for in-transit melanoma”

Read, Tavis, Lonne, Michael, Sparks, David S., David, Michael, Wagels, Michael, Schaider, Helmut, Soyer, Peter H. and Smithers, Mark B. (2019). Response to Stahlie et al regarding “A systematic review and meta-analysis of locoregional treatments for in-transit melanoma”. Journal of Surgical Oncology, 120 (6), 1058-1059. doi: 10.1002/jso.25686

Response to Stahlie et al regarding “A systematic review and meta-analysis of locoregional treatments for in-transit melanoma”

2019

Conference Publication

An international randomised trial of post-operative radiation therapy following wide excision of neurotropic melanoma of the head and neck

Foote, Matthew, Smithers, Mark, Hong, Angela, Fogarty, Gerald, Scolyer, Richard, Paton, Elizabeth, Barker, Christopher, Chua, Margaret, Shannon, Kerwin, Burmeister, Bryan, Nobes, Jenny and Williams, Narelle (2019). An international randomised trial of post-operative radiation therapy following wide excision of neurotropic melanoma of the head and neck. HOBOKEN: WILEY.

An international randomised trial of post-operative radiation therapy following wide excision of neurotropic melanoma of the head and neck

2019

Journal Article

Assessment of hospital characteristics associated with improved mortality following complex upper gastrointestinal cancer surgery in Queensland

Narendra, Aaditya, Baade, Peter D., Aitken, Joanne F., Fawcett, Jonathan and Smithers, Bernard M. (2019). Assessment of hospital characteristics associated with improved mortality following complex upper gastrointestinal cancer surgery in Queensland. ANZ Journal of Surgery, 89 (11), 1404-1409. doi: 10.1111/ans.15389

Assessment of hospital characteristics associated with improved mortality following complex upper gastrointestinal cancer surgery in Queensland

2019

Journal Article

New treatment paradigms for clinically apparent metastatic melanoma in regional lymph nodes

Henderson, Michael A., Spillane, John, Hughes, T. Michael, Spillane, Andrew J., Smithers, B. Mark and Thompson, John F. (2019). New treatment paradigms for clinically apparent metastatic melanoma in regional lymph nodes. ANZ Journal of Surgery, 89 (10), 1187-1189. doi: 10.1111/ans.15407

New treatment paradigms for clinically apparent metastatic melanoma in regional lymph nodes

2019

Journal Article

Clinicopathological factors associated with death from thin (≤ 1·00 mm) melanoma

Claeson, M., Baade, P., Brown, S., Soyer, H. P., Smithers, B. M., Green, A. C., Whiteman, D. C. and Khosrotehrani, K. (2019). Clinicopathological factors associated with death from thin (≤ 1·00 mm) melanoma. British Journal of Dermatology, 182 (4) bjd.18560, 927-931. doi: 10.1111/bjd.18560

Clinicopathological factors associated with death from thin (≤ 1·00 mm) melanoma

2019

Journal Article

The impact of signet ring cell differentiation on outcome in patients with esophageal and gastroesophageal junction adenocarcinoma

van Hootegem, Sander J. M., Smithers, B. Mark, Gotley, David C., Brosda, Sandra, Thomson, Iain G., Thomas, Janine M., Gartside, Michael, van Lanschot, Jan J. B., Lagarde, Sjoerd M., Wijnhoven, Bas P. L. and Barbour, Andrew P. (2019). The impact of signet ring cell differentiation on outcome in patients with esophageal and gastroesophageal junction adenocarcinoma. Annals of Surgical Oncology, 26 (8), 2375-2384. doi: 10.1245/s10434-019-07322-x

The impact of signet ring cell differentiation on outcome in patients with esophageal and gastroesophageal junction adenocarcinoma

2019

Journal Article

Multidisciplinary cancer care in Australia

Walpole, Euan, Smithers, Mark, Cossio, Danica, Harden, Hazel, Thiele, David and Janda, Monika (2019). Multidisciplinary cancer care in Australia. Asia-Pacific Journal of Clinical Oncology, 15 (4), 197-198. doi: 10.1111/ajco.13164

Multidisciplinary cancer care in Australia

2019

Journal Article

IRF4 rs12203592*T/T genotype is associated with nodular melanoma

Rayner, Jenna E., McMeniman, Erin K., Duffy, David L., De'Ambrosis, Brian, Smithers, B Mark, Jagirdar, Kasturee, Lee, Katie J., Soyer, H Peter and Sturm, Richard A. (2019). IRF4 rs12203592*T/T genotype is associated with nodular melanoma. Melanoma Research, 29 (4), 445-446. doi: 10.1097/CMR.0000000000000596

IRF4 rs12203592*T/T genotype is associated with nodular melanoma

2019

Journal Article

Future is bright for academic surgery in Australasia: highlights of the 2018 Academic Meetings

Lee, James C., Mukherjee, Payal, Koh, Cherry and Smithers, Mark (2019). Future is bright for academic surgery in Australasia: highlights of the 2018 Academic Meetings. ANZ Journal of Surgery, 89 (7-8), 798-799. doi: 10.1111/ans.15341

Future is bright for academic surgery in Australasia: highlights of the 2018 Academic Meetings

2019

Journal Article

Phenotypic and genotypic analysis of amelanotic and hypomelanotic melanoma patients

Rayner, J. E., McMeniman, E. K., Duffy, D. L., De'Ambrosis, B., Smithers, B. M., Jagirdar, K., Lee, K. J., Soyer, H. P. and Sturm, R. A. (2019). Phenotypic and genotypic analysis of amelanotic and hypomelanotic melanoma patients. Journal of the European Academy of Dermatology and Venereology, 33 (6) jdv.15446, 1076-1083. doi: 10.1111/jdv.15446

Phenotypic and genotypic analysis of amelanotic and hypomelanotic melanoma patients

2019

Journal Article

Conclusions from quality of life studies in patients with resected high-risk melanoma: one part of the full story

Smithers, B. Mark (2019). Conclusions from quality of life studies in patients with resected high-risk melanoma: one part of the full story. The Lancet Oncology, 20 (5), 611-612. doi: 10.1016/S1470-2045(19)30176-7

Conclusions from quality of life studies in patients with resected high-risk melanoma: one part of the full story

2019

Journal Article

Evaluation of the efficacy and toxicity of upper extremity isolated limb infusion chemotherapy for melanoma: an Australian multi-center study

Kroon, Hidde M., Coventry, Brendon J., Henderson, Michael A., Barbour, Andrew, Serpell, Jonathan, Smithers, B. Mark and Thompson, John F. (2019). Evaluation of the efficacy and toxicity of upper extremity isolated limb infusion chemotherapy for melanoma: an Australian multi-center study. European Journal of Surgical Oncology, 45 (5), 832-837. doi: 10.1016/j.ejso.2019.02.026

Evaluation of the efficacy and toxicity of upper extremity isolated limb infusion chemotherapy for melanoma: an Australian multi-center study

2019

Journal Article

Risk of melanoma recurrence after diagnosis of a high-risk primary tumor

Von Schuckmann, Lena A., Hughes, Maria Celia B., Ghiasvand, Reza, Malt, Maryrose, Van Der Pols, Jolieke C., Beesley, Vanessa L., Khosrotehrani, Kiarash, Smithers, B. Mark and Green, Adele C. (2019). Risk of melanoma recurrence after diagnosis of a high-risk primary tumor. JAMA Dermatology, 155 (6), 688-693. doi: 10.1001/jamadermatol.2019.0440

Risk of melanoma recurrence after diagnosis of a high-risk primary tumor

2019

Conference Publication

ANZMTG 01.09 An International randomised trial of post-operative radiation therapy following wide excision of neurotropic melanoma of the head and neck

Foote, M., Smithers, M., Hong, A., Fogarty, G., Scolyer, R., Paton, E., Barker, C., Chua, M., Shannon, K., Burmeister, B. and Nobes, J. (2019). ANZMTG 01.09 An International randomised trial of post-operative radiation therapy following wide excision of neurotropic melanoma of the head and neck. HOBOKEN: WILEY.

ANZMTG 01.09 An International randomised trial of post-operative radiation therapy following wide excision of neurotropic melanoma of the head and neck

Funding

Current funding

  • 2024 - 2025
    Optimising the Diagnosis and Management of Unilateral Primary Aldosteronism (MSH SERTA Grant led by Metro South HHS)
    Metro South Hospital and Health Service
    Open grant
  • 2023 - 2026
    iCare - An interactive online portal to improve health and wellbeing for people living with complex cancers, and their informal carers: a Phase II randomised controlled trial (Ex led Deakin MRFF CTA)
    Deakin University
    Open grant
  • 2021 - 2026
    AGITG TOP GEAR: A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer (CTCS: led by USyd)
    University of Sydney
    Open grant
  • 2019 - 2026
    A Randomised Phase II Trial of Adjuvant Avelumab in Patients with Early Stage Merkel Cell Carcinoma
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2019 - 2025
    Melanoma Margins Trial II - A Phase III, Multi-centre Randomised Controlled Trial Investigating 1cm v 2cm Wide Surgical Excision Margins.. (NHMRC Project Grant led by the University of Melbourne).
    University of Melbourne
    Open grant

Past funding

  • 2021 - 2024
    Advanced technological approach to predicting survival in patients diagnosed with locally invasive cutaneous melanoma
    Cancer Council Queensland
    Open grant
  • 2021 - 2024
    Establishing Australia's First Familial Melanoma Clinic (MSH RSS SERTA Program Grant led by Metro South Hospital and Health Service)
    Metro South Hospital and Health Service
    Open grant
  • 2020 - 2021
    Cancer Evolution Biobank
    PA Research Foundation
    Open grant
  • 2017 - 2019
    Predictors of mortality in thin melanomas
    Cancer Council Queensland
    Open grant
  • 2013 - 2015
    To identify and assess markers of prognosis, response and resistance to therapy in patients with Stage III metastatic melanoma
    Cancer Bequest Fund
    Open grant
  • 2011
    DOCetaxel with or without radiation Therapy for resectable Oesophageal adenocarcinoma based on early PET Response to induction chemotherapy (DOCTOR)
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Effects of nevogenesis susceptibility genes and phenotypic correlation with dermoscopic characteristics of nevi
    NHMRC Project Grant
    Open grant
  • 2010 - 2014
    Comparison of pre- and perioperative immunonutrition in patients undergoing surgical resection of oesophageal cancer (NHMRC Project Grant administered by the University of Adelaide)
    University of Adelaide
    Open grant
  • 2001 - 2002
    The epidemiology of oesophageal cancer: Risk and molecular markers
    Queensland Cancer Fund
    Open grant
  • 2000
    The role of TAP and MHC class I expression in the response to melanoma immunotherapy using autologous dendritic cells
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1999 - 2000
    A phase II clinical trial in patients with metastatic melanoma comparing autologous dendritic cells pulsed with autologous tumour peptides and melanoma associated peptides linked to the endoplasmic re
    Queensland Cancer Fund
    Open grant
  • 1998
    A Phase I/II Clinical Trial to Test Tumour Vaccines Comprising with Protein or Autologous Tumour Antigen Autologous Dandritic Cells Generated in a Closed Bag System Pulsed
    Mayne Bequest Fund
    Open grant
  • 1998
    Isolated limb infusion of melphalan and microdialysis technique in treatment of recurrent malignant melanoma
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1998 - 2000
    Treatment of Recurrent Malignant Melanoma by Limb Infusion of Cytotoxic Drugs and Other Techniques
    NHMRC Project Grant
    Open grant
  • 1997 - 1998
    Pharmacokinetics of tumour necrosis factor (TNF) in isolated rat hindlimb perfusions and infusions related to melanoma therapy
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1996 - 1997
    Targeting and monitoring drug delivery in specific tissues using iontophoresis and microdialysis
    Quality Funds Round 3
    Open grant
  • 1995 - 1997
    Pharmacokinetics of melphalan in isolated limb perfusion and infusion
    Queensland Cancer Fund
    Open grant

Supervision

Availability

Professor Mark Smithers is:
Not available for supervision

Supervision history

Current supervision

  • Master Philosophy

    Assessment of the impact of treating service characteristics on surgical and oncological outcomes for patients with Retroperitoneal and Inguinal Sarcomas in Queensland

    Principal Advisor

    Other advisors: Professor Andrew Barbour

  • Master Philosophy

    Factors Influencing Anastomotic Complications after Oesophagectomy

    Associate Advisor

  • Doctor Philosophy

    New tools for the multi-modal evaluation of pancreatic cancer and its precursor neoplasms.

    Associate Advisor

    Other advisors: Dr David Cavallucci

Completed supervision

Media

Enquiries

Contact Professor Mark Smithers directly for media enquiries about:

  • Advanced endoscopic surgery
  • Cancer surgery
  • Endoscopic surgery
  • General surgery
  • Melanoma
  • Surgery - cancer
  • Surgery - oesophageal, gastric cancer
  • Surgery - upper GI
  • Upper GI surgery

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