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Professor Mark Smithers
Professor

Mark Smithers

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Overview

Background

Emeritus Professor Mark Smithers is a surgical oncologist who specialises in surgery for oesophago-gastric diseases, melanoma, advanced skin cancer and soft tissue sarcoma. He was the Director of the Upper GI and Soft Tissue Unit at the Princess Alexandra Hospital, in Brisbane, Australia from 1998 - 2023. Commencing his academic career with the University of Queensland in 1987, he progressed to be the Mayne Chair in Surgery and head of the Academy of Surgery. He is the second University of Queensland Medical graduate to be appointed to this role. His research has been focussed on the development and assessment of outcomes from minimally invasive upper GI surgery, and trials assessing the role of perioperative multidisciplinary therapy for esophageal and gastric cancer. As well he has led, or been involved with, clinical trials from phase I to III, for all stages of melanoma through his role as the Chair of the Queensland Melanoma Project. More recently he has been involved with the assessment of access to, and outcomes from, surgery for cancer in Queensland, Australia.

He has overseen the administration and development of the surgery curriculum, and the teaching, in the Academy of Surgery, in the UQ Faculty of Medicine. He was on a number of committees relevant to the implementation of the UQ MD design course. He has held various leadership and committee roles with the Royal Australasian College of Surgeons, as well as leadership roles, including the Presidency, in the Australian and New Zealand Oesophago Gastric Surgeons Association. He has also been on the committees of international organisations related to oesophageal and gastric surgery. He has published 250 articles, eight book chapters, and has been on the editorial board of a number of surgical journals.

He has been recognised for his clinical and academic roles by the award of Member of the Order of Australia (AM). The citation reads, "for service to medicine in the fields of gastro-intestinal and melanoma surgery, to medical education and to professional organisations". The Royal Australasian College of Surgeons awarded him the Sir Hugh Devine medal, for services to surgery and the community. This is the College’s highest honour. Internationally, he has been awarded an honorary fellowship of the Royal College of Surgeons of Edinburgh and recently, in the United States, he was elected as an Honarary Fellow of the American Surgical Association.

Availability

Professor Mark Smithers is:
Not available for supervision
Media expert

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Honorary Fellow, American Surgical Association, American Surgical Association
  • Fellow, Royal Australasian College of Surgeons, Royal Australasian College of Surgeons
  • Fellow, Royal College of Surgeons of Edinburgh, Royal College of Surgeons of Edinburgh
  • Fellow, Royal College of Surgeons of England, Royal College of Surgeons of England

Research interests

  • Cutaneous Melanoma

    epidemiology, public health issues and management of all stages

  • Management of Oesophageal and Gastric Cancer

    Investigation and management of benign and malignant diseases of the oesophagus and the stomach.

Works

Search Professor Mark Smithers’s works on UQ eSpace

414 works between 1983 and 2025

181 - 200 of 414 works

2016

Journal Article

Variations in supportive care needs of patients after diagnosis of localised cutaneous melanoma: a 2-year follow-up study

Beesley, Vanessa L., Smithers, B. Mark, O'Rourke, Peter, Janda, Monika, Khosrotehrani, Kiarash and Green, Adèle C. (2016). Variations in supportive care needs of patients after diagnosis of localised cutaneous melanoma: a 2-year follow-up study. Supportive Care in Cancer, 25 (1), 1-10. doi: 10.1007/s00520-016-3378-9

Variations in supportive care needs of patients after diagnosis of localised cutaneous melanoma: a 2-year follow-up study

2016

Journal Article

Molecular markers to complement sentinel node status in predicting survival in patients with high-risk locally invasive melanoma

Rowe, Casey J., Tang, Fiona, Hughes, Maria Celia B., Rodero, Mathieu P., Malt, Maryrose, Lambie, Duncan, Barbour, Andrew, Hayward, Nicholas K., Smithers, B. Mark, Green, Adele C. and Khosrotehrani, Kiarash (2016). Molecular markers to complement sentinel node status in predicting survival in patients with high-risk locally invasive melanoma. International Journal of Cancer, 139 (3), 664-672. doi: 10.1002/ijc.30085

Molecular markers to complement sentinel node status in predicting survival in patients with high-risk locally invasive melanoma

2016

Conference Publication

Intralesional rose bengal for treatment of melanoma

Agarwala, Sanjiv S., Andtbacka, Robert Hans Ingemar, Rice, Kristen N., Ross, Merrick I., Scoggins, Charles Raben, Smithers, Bernard Mark, Whitman, Eric D. and Wachter, Eric Andrew (2016). Intralesional rose bengal for treatment of melanoma. Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Chicago Il, Jun 03-07, 2016. ALEXANDRIA: AMER SOC CLINICAL ONCOLOGY. doi: 10.1200/JCO.2016.34.15_suppl.TPS9600

Intralesional rose bengal for treatment of melanoma

2016

Journal Article

Assessment of morbidity following regional nodal dissection in the axilla and groin for metastatic melanoma

Theodore, Jane E., Frankel, Adam J., Thomas, Janine M., Barbour, Andrew P., Bayley, Gerard J., Allan, Christopher P., Wagels, Michael and Smithers, B. Mark (2016). Assessment of morbidity following regional nodal dissection in the axilla and groin for metastatic melanoma. ANZ journal of surgery, 87 (1-2), 44-48. doi: 10.1111/ans.13526

Assessment of morbidity following regional nodal dissection in the axilla and groin for metastatic melanoma

2016

Journal Article

Australian multicenter study of isolated limb infusion for melanoma

Kroon, Hidde M., Coventry, Brendon J., Giles, Mitchell H., Henderson, Michael A., Speakman, David, Wall, Mark, Barbour, Andrew, Serpell, Jonathan, Paddle, Paul, Coventry, Alexander G. J., Sullivan, Thomas, Smithers, Bernard Mark and Thompson, John F. (2016). Australian multicenter study of isolated limb infusion for melanoma. Annals of Surgical Oncology, 23 (4), 1096-1103. doi: 10.1245/s10434-015-4969-2

Australian multicenter study of isolated limb infusion for melanoma

2016

Conference Publication

Prognostic value of nomograms incorporating biomarkers vs. sentinel node status in patients with stage IB and II melanoma

Rowe, C., Tang, F., Hughes, M. C., Rodero, M., Malt, M., Lambie, D., Barbour, A., Hayward, N., Smithers, B. M., Green, A. and Khosrotehrani, K. (2016). Prognostic value of nomograms incorporating biomarkers vs. sentinel node status in patients with stage IB and II melanoma. Australasian College of Dermatologists 49th Annual Scientific Meeting, Perth, Australia, 14–17 May, 2016. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12480

Prognostic value of nomograms incorporating biomarkers vs. sentinel node status in patients with stage IB and II melanoma

2016

Conference Publication

A phase 2 study of intralesional PV-10 followed by radiotherapy for localized in transit or recurrent metastatic melanoma.

Foote, Matthew C., Burmeister, Bryan H., Thomas, Janine, Read, Tavis and Smithers, Bernard Mark (2016). A phase 2 study of intralesional PV-10 followed by radiotherapy for localized in transit or recurrent metastatic melanoma.. Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Chicago Il, Jun 02-06, 2017. ALEXANDRIA: AMER SOC CLINICAL ONCOLOGY. doi: 10.1200/JCO.2016.34.15_suppl.e21072

A phase 2 study of intralesional PV-10 followed by radiotherapy for localized in transit or recurrent metastatic melanoma.

2016

Conference Publication

An AGITG trial - A randomised phase II study of pre-operative cisplatin, fluorouracil and DOCetaxel plus /-radio Therapy based on poOR early response to cisplatin and fluorouracil for resectable esophageal adenocarcinoma

Barbour, A., Walpole, E., Mai, G. T., Chan, H., Barnes, E., Watson, D., Ackland, S., Wills, V., Martin, J., Burge, M., Karapetis, C., Shannon, J., Nott, L., Gebski, V., Wilson, K., Thomas, J., Lampe, G., Zalcberg, J., Simes, J. and Smithers, M. (2016). An AGITG trial - A randomised phase II study of pre-operative cisplatin, fluorouracil and DOCetaxel plus /-radio Therapy based on poOR early response to cisplatin and fluorouracil for resectable esophageal adenocarcinoma. 41st Congress of the European-Society-for-Medical-Oncology (ESMO), Copenhagen, Denmark, 7-11 October 2016. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/annonc/mdw371.02

An AGITG trial - A randomised phase II study of pre-operative cisplatin, fluorouracil and DOCetaxel plus /-radio Therapy based on poOR early response to cisplatin and fluorouracil for resectable esophageal adenocarcinoma

2016

Conference Publication

Long-term prospective assessment of quality of life and lymphedema after inguinal or inguinal and pelvic lymphadenectomy for recurrent melanoma in the groin

Henderson, M. A., Fisher, R., Di Iulio, J., Gyorki, D., Spillane, J., Speakman, D., Burmeister, B., Smithers, B., Hong, A., Shannon, K., Ainslie, J., Scolyer, R., Carruthers, S., Coventry, B., Babington, S., Duprat, J., Hoekstra, H. and Thompson, J. (2016). Long-term prospective assessment of quality of life and lymphedema after inguinal or inguinal and pelvic lymphadenectomy for recurrent melanoma in the groin. 69th Annual Cancer Symposium of the Society of Surgical Oncology, Boston, United States, Mar 02-05, 2016. New York, United States: Springer New York LLC. doi: 10.1245/s10434-015-5010-5

Long-term prospective assessment of quality of life and lymphedema after inguinal or inguinal and pelvic lymphadenectomy for recurrent melanoma in the groin

2016

Conference Publication

Intralesional rose bengal for stage III and IV melanoma

Agarwala, S. S., Andtbacka, R. H. I., Hauschild, A., Rice, K. N., Ross, M., Scoggins, C. R., Smithers, M., Whitman, E. and Wachter, E. A. (2016). Intralesional rose bengal for stage III and IV melanoma. 41st Congress of the European-Society-for-Medical-Oncology (ESMO), Copenhagen, Denmark, 7-11 October, 2016. OXFORD: Oxford University Press. doi: 10.1093/annonc/mdw379.52

Intralesional rose bengal for stage III and IV melanoma

2015

Journal Article

Sentinel node biopsy in patients with intermediate and thick melanomas - A balanced view

Saw, Robyn, Allan, Christopher, Barbour, Andrew, Ch'ng, Sydney, Coventry, Brendon J., Gyorki, David, Henderson, Michael, Howle, Julie, Hughes, T. Michael, Lee, Kenneth, Neuhaus, Susan, Saunders, Christobel, Shannon, Kerwin, Smithers, Mark, Speakman, David, Spillane, John and Stretch, Jonathan (2015). Sentinel node biopsy in patients with intermediate and thick melanomas - A balanced view. Australian Family Physician, 44 (12), 876-876.

Sentinel node biopsy in patients with intermediate and thick melanomas - A balanced view

2015

Journal Article

Building a sustainable clinical academic workforce to meet the future healthcare needs of Australia and New Zealand: Report from the first summit meeting

Windsor, J., Searle, J., Hanney, R., Chapman, A., Grigg, M., Choong, P., Mackay, A., Smithers, B.M., Churchill, J.A., Carney, S., Smith, J.A., Wainer, Z., Talley, N.J. and Gladman, M.A. (2015). Building a sustainable clinical academic workforce to meet the future healthcare needs of Australia and New Zealand: Report from the first summit meeting. Internal Medicine Journal, 45 (9), 965-971. doi: 10.1111/imj.12854

Building a sustainable clinical academic workforce to meet the future healthcare needs of Australia and New Zealand: Report from the first summit meeting

2015

Journal Article

Prospective study of patterns of surgical management in adults with primary cutaneous melanoma at high risk of spread, in Queensland, Australia

Smithers, B.Mark, Hughes, Maria Celia B., Beesley, Vanessa L., Barbour, Andrew P., Malt, Maryrose K., Weedon, David, Zonta, Mark J., Wood, Dominic J., Triscott, Joseph A., Bayley, Gerard J., Brown, Lee J., Allan, Christopher P., D'Arcy, Justin, Williamson, Richard, Khosrotehrani, Kiarash and Green, Adele C. (2015). Prospective study of patterns of surgical management in adults with primary cutaneous melanoma at high risk of spread, in Queensland, Australia. Journal of Surgical Oncology, 112 (4), 359-365. doi: 10.1002/jso.24013

Prospective study of patterns of surgical management in adults with primary cutaneous melanoma at high risk of spread, in Queensland, Australia

2015

Conference Publication

TOPGEAR: A randomized phase II/III trial of perioperative ECF chemotherapy versus preoperative chemoradiation plus perioperative ECF chemotherapy for resectable gastric cancer. Interim results from an international, intergroup trial of the AGITG/TROG/NCIC CTG/EORTC

Leong, T., Smithers, B. M., Michael, M., Gebski, V., Simes, J., Boussioutas, A., Miller, D., Zalcberg, J., O'Connell, R., Swallow, C., Darling, G., Wong, R., Schuhmacher, C., Lordick, F. and Haustermans, K. (2015). TOPGEAR: A randomized phase II/III trial of perioperative ECF chemotherapy versus preoperative chemoradiation plus perioperative ECF chemotherapy for resectable gastric cancer. Interim results from an international, intergroup trial of the AGITG/TROG/NCIC CTG/EORTC. European Cancer Congress, Vienna Austria, 2015. OXFORD: ELSEVIER SCI LTD. doi: 10.1016/S0959-8049(15)30043-5

TOPGEAR: A randomized phase II/III trial of perioperative ECF chemotherapy versus preoperative chemoradiation plus perioperative ECF chemotherapy for resectable gastric cancer. Interim results from an international, intergroup trial of the AGITG/TROG/NCIC CTG/EORTC

2015

Journal Article

A systematic review of non-surgical treatments for lentigo maligna

Read, T., Noonan, C., David, M., Wagels, M., Foote, M., Schaider, H., Soyer, H. P. and Smithers, B. M. (2015). A systematic review of non-surgical treatments for lentigo maligna. Journal of the European Academy of Dermatology and Venereology, 30 (5), 1-6. doi: 10.1111/jdv.13252

A systematic review of non-surgical treatments for lentigo maligna

2015

Journal Article

TOPGEAR: A randomised phase III trial of perioperative ECF chemotherapy versus preoperative chemoradiation plus perioperative ECF chemotherapy for resectable gastric cancer (an international, intergroup trial of the AGITG/TROG/EORTC/NCIC CTG)

Leong, Trevor, Smithers, B. Mark, Michael, Michael, Gebski, Val, Boussioutas, Alex, Miller, Danielle, Simes, John, Zalcberg, John, Haustermans, Karin, Lordick, Florian, Schuhmacher, Christoph, Swallow, Carol, Darling, Gail and Wong, Rebecca (2015). TOPGEAR: A randomised phase III trial of perioperative ECF chemotherapy versus preoperative chemoradiation plus perioperative ECF chemotherapy for resectable gastric cancer (an international, intergroup trial of the AGITG/TROG/EORTC/NCIC CTG). BMC Cancer, 15 (532) 532, 2252-2258. doi: 10.1186/s12885-015-1529-x

TOPGEAR: A randomised phase III trial of perioperative ECF chemotherapy versus preoperative chemoradiation plus perioperative ECF chemotherapy for resectable gastric cancer (an international, intergroup trial of the AGITG/TROG/EORTC/NCIC CTG)

2015

Journal Article

Adjuvant lymph-node field radiotherapy versus observation only in patients with melanoma at high risk of further lymph-node field relapse after lymphadenectomy (ANZMTG 01.02/TROG 02.01): 6-year follow-up of a phase 3, randomised controlled trial

Henderson Michael A., Burmeister, Bryan H., Ainslie, Jill, Fisher, Richard, Di Iulio, Juliana, Smithers, B. Mark, Hon, Angela, Shannon, Kerwin, Scolyer, Richard A., Carruthers, Scott, Coventry, Brendon J., Babington, Scott, Duprat, Joao, Hoekstra, Harald J. and Thompson, John F. (2015). Adjuvant lymph-node field radiotherapy versus observation only in patients with melanoma at high risk of further lymph-node field relapse after lymphadenectomy (ANZMTG 01.02/TROG 02.01): 6-year follow-up of a phase 3, randomised controlled trial. The Lancet Oncology, 16 (9) 155, 1049-1060. doi: 10.1016/S1470-2045(15)00187-4

Adjuvant lymph-node field radiotherapy versus observation only in patients with melanoma at high risk of further lymph-node field relapse after lymphadenectomy (ANZMTG 01.02/TROG 02.01): 6-year follow-up of a phase 3, randomised controlled trial

2015

Journal Article

Two cases of NSAID-induced gastropathy and enteropathy of the ileum

Auld, Michael C., Dodd, Benjamin R., Barbour, Andrew P. and Smithers, Mark (2015). Two cases of NSAID-induced gastropathy and enteropathy of the ileum. ANZ Journal of Surgery, 85 (7-8), 584-585. doi: 10.1111/ans.12462

Two cases of NSAID-induced gastropathy and enteropathy of the ileum

2015

Journal Article

Australian clinical practice guidelines for the diagnosis and management of Barrett's esophagus and early esophageal adenocarcinoma

Whiteman, David C., Appleyard, Mark, Bahin, Farzan F., Bobryshev, Yuri V., Bourke, Michael J., Brown, Ian, Chung, Adrian, Clouston, Andrew, Dickins, Emma, Emery, Jon, Eslick, Guy D., Gordon, Louisa G., Grimpen, Florian, Hebbard, Geoff, Holliday, Laura, Hourigan, Luke F., Kendall, Bradley J., Lee, Eric Y. T., Levert-Mignon A., Lord, Reginald V., Lord, Sarah J., Maule, Derek, Moss, Alan, Norton, Ian, Olver, Ian, Pavey, Darren, Raftopoulos, Spiro, Rajendra, Shan, Schoeman, Mark ... Yusoff, Ian F. (2015). Australian clinical practice guidelines for the diagnosis and management of Barrett's esophagus and early esophageal adenocarcinoma. Journal of Gastroenterology and Hepatology (Australia), 30 (5), 804-820. doi: 10.1111/jgh.12913

Australian clinical practice guidelines for the diagnosis and management of Barrett's esophagus and early esophageal adenocarcinoma

2015

Journal Article

International consensus on standardization of data collection for complications associated with esophagectomy: Esophagectomy Complications Consensus Group (ECCG)

Low, Donald E., Alderson, Derek, Cecconello, Ivan, Chang, Andrew C., Darling, Gail E., D'Journo, Xavier Benoit, Griffin, S. Michael, Holscher, Arnulf H., Hofstetter, Wayne L., Jobe, Blair A., Kitagawa, Yuko, Kucharczuk, John C., Law, Simon Ying Kit, Lerut, Toni E., Maynard, Nick, Pera, Manuel, Peters, Jeffrey H., Pramesh, C. S., Reynolds, John V., Smithers, B. Mark and van Lanschot, J. Jan B. (2015). International consensus on standardization of data collection for complications associated with esophagectomy: Esophagectomy Complications Consensus Group (ECCG). Annals of Surgery, 262 (2), 286-294. doi: 10.1097/SLA.0000000000001098

International consensus on standardization of data collection for complications associated with esophagectomy: Esophagectomy Complications Consensus Group (ECCG)

Funding

Current funding

  • 2024 - 2025
    Optimising the Diagnosis and Management of Unilateral Primary Aldosteronism (MSH SERTA Grant led by Metro South HHS)
    Metro South Hospital and Health Service
    Open grant
  • 2023 - 2026
    iCare - An interactive online portal to improve health and wellbeing for people living with complex cancers, and their informal carers: a Phase II randomised controlled trial (Ex led Deakin MRFF CTA)
    Deakin University
    Open grant
  • 2021 - 2026
    AGITG TOP GEAR: A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer (CTCS: led by USyd)
    University of Sydney
    Open grant
  • 2019 - 2026
    A Randomised Phase II Trial of Adjuvant Avelumab in Patients with Early Stage Merkel Cell Carcinoma
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2019 - 2025
    Melanoma Margins Trial II - A Phase III, Multi-centre Randomised Controlled Trial Investigating 1cm v 2cm Wide Surgical Excision Margins.. (NHMRC Project Grant led by the University of Melbourne).
    University of Melbourne
    Open grant

Past funding

  • 2021 - 2024
    Advanced technological approach to predicting survival in patients diagnosed with locally invasive cutaneous melanoma
    Cancer Council Queensland
    Open grant
  • 2021 - 2024
    Establishing Australia's First Familial Melanoma Clinic (MSH RSS SERTA Program Grant led by Metro South Hospital and Health Service)
    Metro South Hospital and Health Service
    Open grant
  • 2020 - 2021
    Cancer Evolution Biobank
    PA Research Foundation
    Open grant
  • 2017 - 2019
    Predictors of mortality in thin melanomas
    Cancer Council Queensland
    Open grant
  • 2013 - 2015
    To identify and assess markers of prognosis, response and resistance to therapy in patients with Stage III metastatic melanoma
    Cancer Bequest Fund
    Open grant
  • 2011
    DOCetaxel with or without radiation Therapy for resectable Oesophageal adenocarcinoma based on early PET Response to induction chemotherapy (DOCTOR)
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Effects of nevogenesis susceptibility genes and phenotypic correlation with dermoscopic characteristics of nevi
    NHMRC Project Grant
    Open grant
  • 2010 - 2014
    Comparison of pre- and perioperative immunonutrition in patients undergoing surgical resection of oesophageal cancer (NHMRC Project Grant administered by the University of Adelaide)
    University of Adelaide
    Open grant
  • 2001 - 2002
    The epidemiology of oesophageal cancer: Risk and molecular markers
    Queensland Cancer Fund
    Open grant
  • 2000
    The role of TAP and MHC class I expression in the response to melanoma immunotherapy using autologous dendritic cells
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1999 - 2000
    A phase II clinical trial in patients with metastatic melanoma comparing autologous dendritic cells pulsed with autologous tumour peptides and melanoma associated peptides linked to the endoplasmic re
    Queensland Cancer Fund
    Open grant
  • 1998
    A Phase I/II Clinical Trial to Test Tumour Vaccines Comprising with Protein or Autologous Tumour Antigen Autologous Dandritic Cells Generated in a Closed Bag System Pulsed
    Mayne Bequest Fund
    Open grant
  • 1998
    Isolated limb infusion of melphalan and microdialysis technique in treatment of recurrent malignant melanoma
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1998 - 2000
    Treatment of Recurrent Malignant Melanoma by Limb Infusion of Cytotoxic Drugs and Other Techniques
    NHMRC Project Grant
    Open grant
  • 1997 - 1998
    Pharmacokinetics of tumour necrosis factor (TNF) in isolated rat hindlimb perfusions and infusions related to melanoma therapy
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1996 - 1997
    Targeting and monitoring drug delivery in specific tissues using iontophoresis and microdialysis
    Quality Funds Round 3
    Open grant
  • 1995 - 1997
    Pharmacokinetics of melphalan in isolated limb perfusion and infusion
    Queensland Cancer Fund
    Open grant

Supervision

Availability

Professor Mark Smithers is:
Not available for supervision

Supervision history

Current supervision

  • Master Philosophy

    Assessment of the impact of treating service characteristics on surgical and oncological outcomes for patients with Retroperitoneal and Inguinal Sarcomas in Queensland

    Principal Advisor

    Other advisors: Professor Andrew Barbour

  • Master Philosophy

    Factors Influencing Anastomotic Complications after Oesophagectomy

    Associate Advisor

  • Doctor Philosophy

    New tools for the multi-modal evaluation of pancreatic cancer and its precursor neoplasms.

    Associate Advisor

    Other advisors: Dr David Cavallucci

Completed supervision

Media

Enquiries

Contact Professor Mark Smithers directly for media enquiries about:

  • Advanced endoscopic surgery
  • Cancer surgery
  • Endoscopic surgery
  • General surgery
  • Melanoma
  • Surgery - cancer
  • Surgery - oesophageal, gastric cancer
  • Surgery - upper GI
  • Upper GI surgery

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