
Overview
Background
Emeritus Professor Mark Smithers is a surgical oncologist who specialises in surgery for oesophago-gastric diseases, melanoma, advanced skin cancer and soft tissue sarcoma. He was the Director of the Upper GI and Soft Tissue Unit at the Princess Alexandra Hospital, in Brisbane, Australia from 1998 - 2023. Commencing his academic career with the University of Queensland in 1987, he progressed to be the Mayne Chair in Surgery and head of the Academy of Surgery. He is the second University of Queensland Medical graduate to be appointed to this role. His research has been focussed on the development and assessment of outcomes from minimally invasive upper GI surgery, and trials assessing the role of perioperative multidisciplinary therapy for esophageal and gastric cancer. As well he has led, or been involved with, clinical trials from phase I to III, for all stages of melanoma through his role as the Chair of the Queensland Melanoma Project. More recently he has been involved with the assessment of access to, and outcomes from, surgery for cancer in Queensland, Australia.
He has overseen the administration and development of the surgery curriculum, and the teaching, in the Academy of Surgery, in the UQ Faculty of Medicine. He was on a number of committees relevant to the implementation of the UQ MD design course. He has held various leadership and committee roles with the Royal Australasian College of Surgeons, as well as leadership roles, including the Presidency, in the Australian and New Zealand Oesophago Gastric Surgeons Association. He has also been on the committees of international organisations related to oesophageal and gastric surgery. He has published 250 articles, eight book chapters, and has been on the editorial board of a number of surgical journals.
He has been recognised for his clinical and academic roles by the award of Member of the Order of Australia (AM). The citation reads, "for service to medicine in the fields of gastro-intestinal and melanoma surgery, to medical education and to professional organisations". The Royal Australasian College of Surgeons awarded him the Sir Hugh Devine medal, for services to surgery and the community. This is the College’s highest honour. Internationally, he has been awarded an honorary fellowship of the Royal College of Surgeons of Edinburgh and recently, in the United States, he was elected as an Honarary Fellow of the American Surgical Association.
Availability
- Professor Mark Smithers is:
- Not available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
- Honorary Fellow, American Surgical Association, American Surgical Association
- Fellow, Royal Australasian College of Surgeons, Royal Australasian College of Surgeons
- Fellow, Royal College of Surgeons of Edinburgh, Royal College of Surgeons of Edinburgh
- Fellow, Royal College of Surgeons of England, Royal College of Surgeons of England
Research interests
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Cutaneous Melanoma
epidemiology, public health issues and management of all stages
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Management of Oesophageal and Gastric Cancer
Investigation and management of benign and malignant diseases of the oesophagus and the stomach.
Works
Search Professor Mark Smithers’s works on UQ eSpace
2012
Journal Article
An innovative approach for locally advanced stage III cutaneous melanoma: radiotherapy, followed by nodal dissection
Foote, Matthew, Burmeister, Bryan, Dwyer, Patrick, Burmeister, Elizabeth, Lambie, Duncan, Allan, Christopher, Barbour, Andrew, Bayley, Gerard, Pullar, Andrew, Meakin, Janelle, Thomas, Janine and Smithers, Mark (2012). An innovative approach for locally advanced stage III cutaneous melanoma: radiotherapy, followed by nodal dissection. Melanoma Research, 22 (3), 257-262. doi: 10.1097/CMR.0b013e3283531335
2012
Journal Article
Adjuvant radiotherapy versus observation alone for patients at risk of lymph-node field relapse after therapeutic lymphadenectomy for melanoma: a randomised trial
Burmeister, Bryan H., Henderson, Michael A., Ainslie, Jill, Fisher, Richard, Di Iulio, Juliana, Smithers, B. Mark, Hong, Angela, Shannon, Kerwin, Scolyer, Richard A., Carruthers, Scott, Coventry, Brendon J., Babington, Scott, Duprat, Joao, Hoekstra, Harald J. and Thompson, John F. (2012). Adjuvant radiotherapy versus observation alone for patients at risk of lymph-node field relapse after therapeutic lymphadenectomy for melanoma: a randomised trial. Lancet Oncology, 13 (6), 589-597. doi: 10.1016/S1470-2045(12)70138-9
2012
Conference Publication
TOPGEAR: An international randomized phase III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer (AGITG/TROG/EORTC/NCIC CTG)
Leong, Trevor, Smithers, Mark, Michael, Michael, Gebski, Val, Boussioutas, Alex, Miller, Danielle, Zalcberg, John Raymond, Wong, Rebecca and Haustermans, Karin (2012). TOPGEAR: An international randomized phase III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer (AGITG/TROG/EORTC/NCIC CTG). 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Chicago Il, Jun 01-06, 2012. ALEXANDRIA: AMER SOC CLINICAL ONCOLOGY.
2012
Conference Publication
Long-term cure after complete resection and adjuvant immunotherapy for distant melanoma metastases
Morton, Donald L., Mozzillo, Nicola, Kashani-Sabet, Mohammed, Thompson, John F., Kelley, Mark C., De Conti, Ronald C., Lee, Jeffrey Edwin, Huth, James F., Faries, Mark B., Dalgleish, Angus George, Wagner, Jeffrey D., Hersh, Evan, Schneebaum, Schlomo, Anderson, Clay M., Smithers, Mark, Schuchter, Lynn Mara, McMasters, Kelly M., Testori, Alessandro, Karakousis, C. P. and Elashoff, Robert (2012). Long-term cure after complete resection and adjuvant immunotherapy for distant melanoma metastases. 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Chicago Il, Jun 01-06, 2012. ALEXANDRIA: AMER SOC CLINICAL ONCOLOGY.
2012
Journal Article
Population-based 20-year survival among people diagnosed with thin melanomas in Queensland, Australia
Green, Adele C., Baade, Peter, Coory, Michael, Aitken, Joanne F. and Smithers, Mark (2012). Population-based 20-year survival among people diagnosed with thin melanomas in Queensland, Australia. Journal of Clinical Oncology, 30 (13), 1462-1467. doi: 10.1200/JCO.2011.38.8561
2012
Conference Publication
TOPGEAR: An international randomized phase III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer (AGITG/TROG/EORTC/NCIC CTG)
Leong, Trevor, Smithers, Mark, Michael, Michael, Gebski, Val, Boussioutas, Alex, Miller, Danielle, Zalcberg, John Raymond, Wong, Rebecca and Haustermans, Karin (2012). TOPGEAR: An international randomized phase III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer (AGITG/TROG/EORTC/NCIC CTG). 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Chicago Il, Jun 01-06, 2012. ALEXANDRIA: AMER SOC CLINICAL ONCOLOGY.
2012
Journal Article
Predictors of survival among patients diagnosed with adenocarcinoma of the esophagus and gastroesophageal junction
Thrift, Aaron P., Nagle, Christina M., Fahey, Paul P., Smithers, Bernard M., Watson, David I. and Whiteman, David C. (2012). Predictors of survival among patients diagnosed with adenocarcinoma of the esophagus and gastroesophageal junction. Cancer Causes and Control, 23 (4), 555-564. doi: 10.1007/s10552-012-9913-1
2012
Conference Publication
Melanoma brain metastases: the impact of nodal disease
Jackson, J., Burmeister, B. H., Burmeister, E., Foote, M. C., Thomas, J. M. and Smithers, B. M. (2012). Melanoma brain metastases: the impact of nodal disease. 54th Annual Meeting of the American Society for Radiation Oncology (ASTRO), Boston, MA United States, 28-31 October 2012. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.ijrobp.2012.07.1748
2012
Conference Publication
DOCTOR: A randomized phase II trial of preoperative cisplatin, 5-fluorouracil, and docetaxel with or without radiotherapy based on poor early response to standard chemotherapy for resectable adenocarcinoma of the esophagus and/or OG junction
Barbour, Andrew, Smithers, Bernard Mark, Burmeister, Bryan, Zalcberg, John Raymond, Spry, Nigel, Smith, Garrett, Wilson, Kate, Roff, Kate, Yip, Sonia and Walpole, Euan Thomas (2012). DOCTOR: A randomized phase II trial of preoperative cisplatin, 5-fluorouracil, and docetaxel with or without radiotherapy based on poor early response to standard chemotherapy for resectable adenocarcinoma of the esophagus and/or OG junction. 48th Annual Meeting of the American Society of Clinical Oncology (ASCO), Chicago, Il United States, 01-06 June 2012. Alexandria, VA United States: American Society of Clinical Oncology.
2012
Conference Publication
Immuno-chemoablation of metastatic melanoma with intralesional Rose Bengal
Agarwala, S. S., Thompson, J. F., Smithers, B. M., Ross, M., Coventry, B. J., Minor, D. R., Scoggins, C. R. and Wachter, E. (2012). Immuno-chemoablation of metastatic melanoma with intralesional Rose Bengal. 37th Congress of the European Society for Medical Oncology (ESMO), Vienna Austria, 28 September-02 October 2012. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/annonc/mds404
2012
Journal Article
The influence of pre-diagnostic demographic and lifestyle factors on oesophageal squamous cell carcinoma survival
Thrift, Aaron P., Nagle, Christina M., Fahey, Paul P., Russell, Anne, Smithers, Bernard M., Watson, David I., Whiteman, David C. and for the Australian Cancer Study Clinical Follow-Up Study (2012). The influence of pre-diagnostic demographic and lifestyle factors on oesophageal squamous cell carcinoma survival. International Journal of Cancer, Early online (5), 1-29. doi: 10.1002/ijc.27420
2012
Conference Publication
Activation of stat5 is an indicator of good prognosis in stage Ib and II melanomas
Rodero, M., Wright, A., Malt, M., Smithers, M., Green, A. and Khosrotehrani, K. (2012). Activation of stat5 is an indicator of good prognosis in stage Ib and II melanomas. The Australasian College of Dermatologists 45th Annual Scientific Meeting, Brisbane, QLD, Australia, 20-23 May 2012. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-0960.2012.00892.x
2012
Conference Publication
MAGE-A3 expression in patients screened for the DERMA trial: a phase III trial testing MAGE-A3 immunotherapeutic in the adjuvant setting for stage IIIB-C-Tx melanoma
Thompson, John F., Santinami, Mario, Jouary, Thomas, Levchenko, Eugeny, Smithers, Bernard Mark, Mortier, Laurent, Grob, Jean Jacques, Trefzer, Uwe, Gutzmer, Ralf, Jamoul, Corinne, Peeters, Olivier, Dreno, Brigitte and Kirkwood, John M. (2012). MAGE-A3 expression in patients screened for the DERMA trial: a phase III trial testing MAGE-A3 immunotherapeutic in the adjuvant setting for stage IIIB-C-Tx melanoma. 48th Annual Meeting of the American Society of Clinical Oncology (ASCO), Chicago, Illinois, 1-6 June 2012 . Alexandria, VA, United States : American Society of Clinical Oncology.
2012
Conference Publication
Gene expression analysis of EAC in association with PET response.
Wayte, Nicola, Nancarrow, Derek, Walpole, Euan Thomas, Lampe, Guy, Gotley, David, Smithers, Bernard Mark and Barbour, Andrew (2012). Gene expression analysis of EAC in association with PET response.. ASCO GI Symposium, San Diego, CA United States, 24 January 2012. Alexandria, VA United States: American Society of Clinical Oncology. doi: 10.1200/jco.2012.30.4_suppl.50
2011
Journal Article
Local therapies and resection in Barrett's oesophagus and early oesophagogastric cancer
Tan, Alyisha, Macrae, Finlay and Smithers B. Mark (2011). Local therapies and resection in Barrett's oesophagus and early oesophagogastric cancer. Cancer Forum, 35 (3), 141-145.
2011
Journal Article
Whole genome expression array profiling highlights differences in mucosal defense genes in barrett's esophagus and esophageal adenocarcinoma
Nancarrow, Derek J., Clouston, Andrew D., Smithers, B. Mark, Gotley, David C., Drew, Paul A., Watson, David I., Tyagi, Sonika, Hayward, Nicholas K. and Whiteman, David C. (2011). Whole genome expression array profiling highlights differences in mucosal defense genes in barrett's esophagus and esophageal adenocarcinoma. Plos One, 6 (7) e22513, e22513-1-e22513-15. doi: 10.1371/journal.pone.0022513
2011
Journal Article
Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis
Sjoquist, Katrin M., Burmeister, Bryan H., Smithers, B. Mark, Zalcberg, John R., Simes, R. John, Barbour, Andrew, Gebski, Val and for the Australasian Gastro-Intestinal Trials Group (2011). Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis. Lancet Oncology, 12 (7), 681-692. doi: 10.1016/S1470-2045(11)70142-5
2011
Journal Article
Defining cure for esophageal cancer: Analysis of actual 5-year survivors following esophagectomy
Hirst, Jodi, Smithers, Bernard Mark, Gotley, David C., Thomas, Janine and Barbour, Andrew (2011). Defining cure for esophageal cancer: Analysis of actual 5-year survivors following esophagectomy. Annals of Surgical Oncology, 18 (6), 1766-1774. doi: 10.1245/s10434-010-1508-z
2011
Conference Publication
Dermoscopic naevus patterns by age and body site in the high risk and general Queensland populations
Douglas, N. C., Borgovan, T., Carroll, M. J., Siskind, V., Wurm, E. M. T., Smithers, B. M., Green, A. C. and Soyer, H. P. (2011). Dermoscopic naevus patterns by age and body site in the high risk and general Queensland populations. MALDEN: WILEY-BLACKWELL.
2011
Journal Article
Trends in melanoma incidence among children: Possible influence of sun-protection programs
Baade, Peter D., Green, Adele C., Smithers, Bernard Mark and Aitken, Joanne F. (2011). Trends in melanoma incidence among children: Possible influence of sun-protection programs. Expert Review of Anticancer Therapy, 11 (5), 661-664. doi: 10.1586/ERA.11.28
Funding
Current funding
Supervision
Availability
- Professor Mark Smithers is:
- Not available for supervision
Supervision history
Current supervision
-
Master Philosophy
Assessment of the impact of treating service characteristics on surgical and oncological outcomes for patients with Retroperitoneal and Inguinal Sarcomas in Queensland
Principal Advisor
Other advisors: Professor Andrew Barbour
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Master Philosophy
Factors Influencing Anastomotic Complications after Oesophagectomy
Associate Advisor
-
Doctor Philosophy
New tools for the multi-modal evaluation of pancreatic cancer and its precursor neoplasms.
Associate Advisor
Other advisors: Dr David Cavallucci
Completed supervision
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2020
Master Philosophy
An assessment of the impacts of centralising complex upper-gastrointestinal surgery in Queensland
Principal Advisor
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2024
Master Philosophy
In vivo Magnetic Resonance Spectroscopy (MRS) with 2-Dimensional (2D) COrrelated Spectroscopy (COSY) applied to breast cancer
Associate Advisor
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2020
Doctor Philosophy
Natural history of high-risk cutaneous primary melanoma and risk factors for disease progression
Associate Advisor
Other advisors: Professor Kiarash Khosrotehrani
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2020
Doctor Philosophy
An evaluation of the role of locoregional treatments for the management of in-transit melanoma metastases
Associate Advisor
Other advisors: Professor Peter Soyer, Associate Professor Helmut Schaider
Media
Enquiries
Contact Professor Mark Smithers directly for media enquiries about:
- Advanced endoscopic surgery
- Cancer surgery
- Endoscopic surgery
- General surgery
- Melanoma
- Surgery - cancer
- Surgery - oesophageal, gastric cancer
- Surgery - upper GI
- Upper GI surgery
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