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Professor Mark Smithers
Professor

Mark Smithers

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Overview

Background

Emeritus Professor Mark Smithers is a surgical oncologist who specialises in surgery for oesophago-gastric diseases, melanoma, advanced skin cancer and soft tissue sarcoma. He was the Director of the Upper GI and Soft Tissue Unit at the Princess Alexandra Hospital, in Brisbane, Australia from 1998 - 2023. Commencing his academic career with the University of Queensland in 1987, he progressed to be the Mayne Chair in Surgery and head of the Academy of Surgery. He is the second University of Queensland Medical graduate to be appointed to this role. His research has been focussed on the development and assessment of outcomes from minimally invasive upper GI surgery, and trials assessing the role of perioperative multidisciplinary therapy for esophageal and gastric cancer. As well he has led, or been involved with, clinical trials from phase I to III, for all stages of melanoma through his role as the Chair of the Queensland Melanoma Project. More recently he has been involved with the assessment of access to, and outcomes from, surgery for cancer in Queensland, Australia.

He has overseen the administration and development of the surgery curriculum, and the teaching, in the Academy of Surgery, in the UQ Faculty of Medicine. He was on a number of committees relevant to the implementation of the UQ MD design course. He has held various leadership and committee roles with the Royal Australasian College of Surgeons, as well as leadership roles, including the Presidency, in the Australian and New Zealand Oesophago Gastric Surgeons Association. He has also been on the committees of international organisations related to oesophageal and gastric surgery. He has published 250 articles, eight book chapters, and has been on the editorial board of a number of surgical journals.

He has been recognised for his clinical and academic roles by the award of Member of the Order of Australia (AM). The citation reads, "for service to medicine in the fields of gastro-intestinal and melanoma surgery, to medical education and to professional organisations". The Royal Australasian College of Surgeons awarded him the Sir Hugh Devine medal, for services to surgery and the community. This is the College’s highest honour. Internationally, he has been awarded an honorary fellowship of the Royal College of Surgeons of Edinburgh and recently, in the United States, he was elected as an Honarary Fellow of the American Surgical Association.

Availability

Professor Mark Smithers is:
Not available for supervision
Media expert

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Honorary Fellow, American Surgical Association, American Surgical Association
  • Fellow, Royal Australasian College of Surgeons, Royal Australasian College of Surgeons
  • Fellow, Royal College of Surgeons of Edinburgh, Royal College of Surgeons of Edinburgh
  • Fellow, Royal College of Surgeons of England, Royal College of Surgeons of England

Research interests

  • Cutaneous Melanoma

    epidemiology, public health issues and management of all stages

  • Management of Oesophageal and Gastric Cancer

    Investigation and management of benign and malignant diseases of the oesophagus and the stomach.

Works

Search Professor Mark Smithers’s works on UQ eSpace

414 works between 1983 and 2025

261 - 280 of 414 works

2011

Journal Article

Is concurrent radiation therapy required in patients receiving preoperative chemotherapy for adenocarcinoma of the oesophagus? A randomised phase II trial

Burmeister, Bryan H., Thomas, Janine M., Burmeister, Elizabeth A., Walpole, Euan T., Harvey, Jennifer A., Thomson, Damien B., Barbour, Andrew P., Gotley, David C. and Smithers, B. Mark (2011). Is concurrent radiation therapy required in patients receiving preoperative chemotherapy for adenocarcinoma of the oesophagus? A randomised phase II trial. European Journal of Cancer, 47 (3), 354-360. doi: 10.1016/j.ejca.2010.09.009

Is concurrent radiation therapy required in patients receiving preoperative chemotherapy for adenocarcinoma of the oesophagus? A randomised phase II trial

2011

Journal Article

Dermoscopic naevus patterns in people at high versus moderate/low melanoma risk in Queensland

Douglas, Nicola C, Borgovan, Theo, Carroll, Melissa J., Williams, Patricia F., Berry, Elizabeth G., Victor Siskind, Hoedl, Andreas F., Wurm, Elisabeth M.T., Smithers, B. Mark, Green, Adele C. and Soyer, H. Peter (2011). Dermoscopic naevus patterns in people at high versus moderate/low melanoma risk in Queensland. Australasian Journal of Dermatology, 52 (4), 248-253. doi: 10.1111/j.1440-0960.2011.00798.x

Dermoscopic naevus patterns in people at high versus moderate/low melanoma risk in Queensland

2011

Conference Publication

A phase I, open-label, cohort study of two doses of coxsackievirus A21 given intratumorally in stage IV melanoma.

Shafren, D., Smithers, B. M. and Formby, M. (2011). A phase I, open-label, cohort study of two doses of coxsackievirus A21 given intratumorally in stage IV melanoma.. 2011 ASCO Annual Meeting, Chicago, Illinois, 3-7 June 2011. Alexandria, VA, United States: American Society of Clinical Oncology. doi: 10.1200/jco.2011.29.15_suppl.8573

A phase I, open-label, cohort study of two doses of coxsackievirus A21 given intratumorally in stage IV melanoma.

2011

Journal Article

Factors associated with postoperative pulmonary morbidity after esophagectomy for cancer

Zingg, Urs, Smithers, Bernard M., Gotley, David C., Smith, Garett, Aly, Ahmad, Clough, Anthony, Esterman, Adrian J., Jamieson, Glyn G. and Watson, David I. (2011). Factors associated with postoperative pulmonary morbidity after esophagectomy for cancer. Annals of Surgical Oncology, 18 (5), 1460-1468. doi: 10.1245/s10434-010-1474-5

Factors associated with postoperative pulmonary morbidity after esophagectomy for cancer

2010

Journal Article

Symptoms, investigations and management of patients with cancer of the oesophagus and gastro-oesophageal junction in Australia

Smithers, Bernard M., Fahey, Paul P., Corish, Tracie, Gotley, David C, Falk, Gregory L., Smith, Garett S., Kiroff, George K., Clouston, Andrew D., Watson, David I. and Whiteman, David C. (2010). Symptoms, investigations and management of patients with cancer of the oesophagus and gastro-oesophageal junction in Australia. Medical Journal of Australia, 193 (10), 572-577. doi: 10.5694/j.1326-5377.2010.tb04064.x

Symptoms, investigations and management of patients with cancer of the oesophagus and gastro-oesophageal junction in Australia

2010

Journal Article

No role for melanoma treatment in the association between melanoma and amyotrophic lateral sclerosis or Parkinson's disease

Baade, Peter D., Herrero Hernández, Elena, Freedman, D. Michal, Smithers, B. Mark and Fritschi, Lin (2010). No role for melanoma treatment in the association between melanoma and amyotrophic lateral sclerosis or Parkinson's disease. Neuroepidemiology, 35 (4), 303-304. doi: 10.1159/000321177

No role for melanoma treatment in the association between melanoma and amyotrophic lateral sclerosis or Parkinson's disease

2010

Journal Article

Risk stratification for early esophageal adenocarcinoma: Analysis of lymphatic spread

Barbour, Andrew P., Jones, Mark, Brown, Ian, Gotley, David C., Martin, Ian, Thomas, Janine, Clouston, Andre and Smithers, B. Mark (2010). Risk stratification for early esophageal adenocarcinoma: Analysis of lymphatic spread. Annals of Surgical Oncology, 17 (9), 2494-2502. doi: 10.1245/s10434-010-1025-0

Risk stratification for early esophageal adenocarcinoma: Analysis of lymphatic spread

2010

Journal Article

High-risk human papillomavirus in esophageal squamous cell carcinoma

Antonsson, Annika, Nancarrow, Derek J., Brown, Ian S., Green, Adele C., Drew, Paul A., Watson, David I., Hayward, Nicholas K., Whiteman, David C., For the Australian Cancer Study, Gotley, David and Smithers, B. Mark (2010). High-risk human papillomavirus in esophageal squamous cell carcinoma. Cancer Epidemiology Biomarkers & Prevention, 19 (8), 2080-2087. doi: 10.1158/1055-9965.EPI-10-0033

High-risk human papillomavirus in esophageal squamous cell carcinoma

2010

Journal Article

Thoracoscopic-assisted esophagectomy for esophageal cancer: Analysis of patterns and prognostic factors for recurrence

Thomson, Iain G., Smithers, Bernard M., Gotley, David C., Martin, Ian, Thomas, Janine M., O'Rourke, Peter and Barbour, Andrew P. (2010). Thoracoscopic-assisted esophagectomy for esophageal cancer: Analysis of patterns and prognostic factors for recurrence. Annals of Surgery, 252 (2), 281-291. doi: 10.1097/SLA.0b013e3181e909a2

Thoracoscopic-assisted esophagectomy for esophageal cancer: Analysis of patterns and prognostic factors for recurrence

2010

Journal Article

A novel treatment for metastatic melanoma with intralesional rose bengal and radiotherapy: A case series

Foote, Matthew C., Burmeister, Bryan H., Thomas, Janine and Smithers, B. Mark (2010). A novel treatment for metastatic melanoma with intralesional rose bengal and radiotherapy: A case series. Melanoma Research, 20 (1), 48-51. doi: 10.1097/CMR.0b013e328331caa2

A novel treatment for metastatic melanoma with intralesional rose bengal and radiotherapy: A case series

2010

Journal Article

Minimally invasive esophagectomy: An overview

Smithers, B. Mark (2010). Minimally invasive esophagectomy: An overview. Expert Review of Gastroenterology and Hepatology, 4 (1), 91-99. doi: 10.1586/EGH.09.62

Minimally invasive esophagectomy: An overview

2010

Conference Publication

Chemoablation of metastatic melanoma with rose bengal (PV-10)

Agarwala, S. S., Thompson, J. F., Smithers, B. M., Rose, M. I., Coventry, B. J., Minor, D. R., Scoggins, C. R. and Wachter, E. A. (2010). Chemoablation of metastatic melanoma with rose bengal (PV-10). Melanoma 2010 Congress, Sydney, Australia, 4-7 November 2010. Alexandria, VA, United States: American Society of Clinical Oncology .

Chemoablation of metastatic melanoma with rose bengal (PV-10)

2009

Journal Article

Isolated limb infusion for malignant melanoma: Predictors of response and outcome

Barbour, A. P., Thomas, J., Suffolk, J., Beller, E. and Smithers, B. M, (2009). Isolated limb infusion for malignant melanoma: Predictors of response and outcome. Annals of Surgical Oncology, 16 (12), 3463-3472. doi: 10.1245/s10434-009-0717-9

Isolated limb infusion for malignant melanoma: Predictors of response and outcome

2009

Journal Article

Prognostic value maximum standardized uptake value from preoperative positron emission tomography in resectable adenocarcinoma of the esophagus treated by surgery alone

Shenfine, J., Barbour, A. P., Wong, D., Martin, I., Gotley, D. C. and Smithers, B. M. (2009). Prognostic value maximum standardized uptake value from preoperative positron emission tomography in resectable adenocarcinoma of the esophagus treated by surgery alone. Diseases of the Esophagus, 22 (8), 668-675. doi: 10.1111/j.1442-2050.2009.00941.x

Prognostic value maximum standardized uptake value from preoperative positron emission tomography in resectable adenocarcinoma of the esophagus treated by surgery alone

2009

Conference Publication

Successful management of an aortoesophageal fistula caused by a fish bone - Case report and review of literature

Kelly, Stephen L., Peters, Paul, Ogg, Murray J., Li, Alan and Smithers, Bernard M. (2009). Successful management of an aortoesophageal fistula caused by a fish bone - Case report and review of literature. Conjoint Annual Scientific Congress of the Royal Australian College of Surgeons/College of Surgeons of Hong Kong, Hong Kong, Peoples Republic of China, May 2008. London, United Kingdom: BioMed Central. doi: 10.1186/1749-8090-4-21

Successful management of an aortoesophageal fistula caused by a fish bone - Case report and review of literature

2009

Journal Article

Salvage definitive chemo-radiotherapy for locally recurrent oesophageal carcinoma after primary surgery: Retrospective review

Baxi, S.H., Burmeister, B., Harvey, J., Smithers, B.M. and Thomas, J. (2009). Salvage definitive chemo-radiotherapy for locally recurrent oesophageal carcinoma after primary surgery: Retrospective review. Journal of Medical Imaging and Radiation Oncology, 52 (6), 583-587. doi: 10.1111/j.1440-1673.2008.02023.x

Salvage definitive chemo-radiotherapy for locally recurrent oesophageal carcinoma after primary surgery: Retrospective review

2009

Conference Publication

Adjuvant Radiotherapy Improves Regional (Lymph Node Field) Control in Melanoma Patients after Lymphadenectomy: Results of an Intergroup Randomized Trial (TROG 02.01/ANZMTG 01.02)

Burmeister, B., Henderson, M., Thompson, J., Fisher, R., Di Iulio, J., Smithers, M., Hong, A., Carruthers, S., Hoekstra, H. and Ainslie, J. (2009). Adjuvant Radiotherapy Improves Regional (Lymph Node Field) Control in Melanoma Patients after Lymphadenectomy: Results of an Intergroup Randomized Trial (TROG 02.01/ANZMTG 01.02). 51st Annual Meeting of the American-Society-for-Radiation-Oncology, Chicago, IL, 1-5 November 2009. United States: Elsevier. doi: 10.1016/j.ijrobp.2009.07.031

Adjuvant Radiotherapy Improves Regional (Lymph Node Field) Control in Melanoma Patients after Lymphadenectomy: Results of an Intergroup Randomized Trial (TROG 02.01/ANZMTG 01.02)

2009

Journal Article

A phase II trial of chemoradiation therapy with weekly oxaliplatin and protracted infusion of 5-fluorouracil for esophageal cancer

Burmeister, B., Walpole, E., D'Arcy, N., Burmeister, E.A., Cox, S., Thomson, D.B., Harvey, J. and Smithers, B.M. (2009). A phase II trial of chemoradiation therapy with weekly oxaliplatin and protracted infusion of 5-fluorouracil for esophageal cancer. Investigational New Drugs, 27 (3), 275-279. doi: 10.1007/s10637-008-9178-4

A phase II trial of chemoradiation therapy with weekly oxaliplatin and protracted infusion of 5-fluorouracil for esophageal cancer

2009

Conference Publication

Chemoablation of melanoma with intralesional rose bengal (PV-10)

Agarwala, S. S., Thompson, J., Smithers, M., Ross, M., Coventry, B., Minor, D., Scoggins, C., Hersey, P. and Wachter, E. (2009). Chemoablation of melanoma with intralesional rose bengal (PV-10). 45th Annual Meeting of the American Society of Clinical Oncology, Orlando, FL, U.S.A., 29 May - 2 June 2009. Alexandria, VA, U.S.A.: American Society of Clinical Oncology.

Chemoablation of melanoma with intralesional rose bengal (PV-10)

2008

Journal Article

Similarity of aberrant DNA methylation in Barrett's esophagus and esophageal adenocarcinoma

Smith, Eric, De Young, Neville J., Pavey, Sandra J., Hayward, Nicholas K., Nancarrow, Derek J., Whiteman, David C., Smithers, B. Mark, Ruszkiewicz, Andrew R., Clouston, Andrew D., Gotley, David C., Devitt, Peter G., Jamieson, Glyn G. and Drew, Paul A. (2008). Similarity of aberrant DNA methylation in Barrett's esophagus and esophageal adenocarcinoma. Molecular Cancer, 7 (1) 75, 75.1-75.12. doi: 10.1186/1476-4598-7-75

Similarity of aberrant DNA methylation in Barrett's esophagus and esophageal adenocarcinoma

Funding

Current funding

  • 2024 - 2025
    Optimising the Diagnosis and Management of Unilateral Primary Aldosteronism (MSH SERTA Grant led by Metro South HHS)
    Metro South Hospital and Health Service
    Open grant
  • 2023 - 2026
    iCare - An interactive online portal to improve health and wellbeing for people living with complex cancers, and their informal carers: a Phase II randomised controlled trial (Ex led Deakin MRFF CTA)
    Deakin University
    Open grant
  • 2021 - 2026
    AGITG TOP GEAR: A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer (CTCS: led by USyd)
    University of Sydney
    Open grant
  • 2019 - 2026
    A Randomised Phase II Trial of Adjuvant Avelumab in Patients with Early Stage Merkel Cell Carcinoma
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2019 - 2025
    Melanoma Margins Trial II - A Phase III, Multi-centre Randomised Controlled Trial Investigating 1cm v 2cm Wide Surgical Excision Margins.. (NHMRC Project Grant led by the University of Melbourne).
    University of Melbourne
    Open grant

Past funding

  • 2021 - 2024
    Advanced technological approach to predicting survival in patients diagnosed with locally invasive cutaneous melanoma
    Cancer Council Queensland
    Open grant
  • 2021 - 2024
    Establishing Australia's First Familial Melanoma Clinic (MSH RSS SERTA Program Grant led by Metro South Hospital and Health Service)
    Metro South Hospital and Health Service
    Open grant
  • 2020 - 2021
    Cancer Evolution Biobank
    PA Research Foundation
    Open grant
  • 2017 - 2019
    Predictors of mortality in thin melanomas
    Cancer Council Queensland
    Open grant
  • 2013 - 2015
    To identify and assess markers of prognosis, response and resistance to therapy in patients with Stage III metastatic melanoma
    Cancer Bequest Fund
    Open grant
  • 2011
    DOCetaxel with or without radiation Therapy for resectable Oesophageal adenocarcinoma based on early PET Response to induction chemotherapy (DOCTOR)
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Effects of nevogenesis susceptibility genes and phenotypic correlation with dermoscopic characteristics of nevi
    NHMRC Project Grant
    Open grant
  • 2010 - 2014
    Comparison of pre- and perioperative immunonutrition in patients undergoing surgical resection of oesophageal cancer (NHMRC Project Grant administered by the University of Adelaide)
    University of Adelaide
    Open grant
  • 2001 - 2002
    The epidemiology of oesophageal cancer: Risk and molecular markers
    Queensland Cancer Fund
    Open grant
  • 2000
    The role of TAP and MHC class I expression in the response to melanoma immunotherapy using autologous dendritic cells
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1999 - 2000
    A phase II clinical trial in patients with metastatic melanoma comparing autologous dendritic cells pulsed with autologous tumour peptides and melanoma associated peptides linked to the endoplasmic re
    Queensland Cancer Fund
    Open grant
  • 1998
    A Phase I/II Clinical Trial to Test Tumour Vaccines Comprising with Protein or Autologous Tumour Antigen Autologous Dandritic Cells Generated in a Closed Bag System Pulsed
    Mayne Bequest Fund
    Open grant
  • 1998
    Isolated limb infusion of melphalan and microdialysis technique in treatment of recurrent malignant melanoma
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1998 - 2000
    Treatment of Recurrent Malignant Melanoma by Limb Infusion of Cytotoxic Drugs and Other Techniques
    NHMRC Project Grant
    Open grant
  • 1997 - 1998
    Pharmacokinetics of tumour necrosis factor (TNF) in isolated rat hindlimb perfusions and infusions related to melanoma therapy
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1996 - 1997
    Targeting and monitoring drug delivery in specific tissues using iontophoresis and microdialysis
    Quality Funds Round 3
    Open grant
  • 1995 - 1997
    Pharmacokinetics of melphalan in isolated limb perfusion and infusion
    Queensland Cancer Fund
    Open grant

Supervision

Availability

Professor Mark Smithers is:
Not available for supervision

Supervision history

Current supervision

  • Master Philosophy

    Assessment of the impact of treating service characteristics on surgical and oncological outcomes for patients with Retroperitoneal and Inguinal Sarcomas in Queensland

    Principal Advisor

    Other advisors: Professor Andrew Barbour

  • Doctor Philosophy

    New tools for the multi-modal evaluation of pancreatic cancer and its precursor neoplasms.

    Associate Advisor

    Other advisors: Dr David Cavallucci

  • Master Philosophy

    Factors Influencing Anastomotic Complications after Oesophagectomy

    Associate Advisor

Completed supervision

Media

Enquiries

Contact Professor Mark Smithers directly for media enquiries about:

  • Advanced endoscopic surgery
  • Cancer surgery
  • Endoscopic surgery
  • General surgery
  • Melanoma
  • Surgery - cancer
  • Surgery - oesophageal, gastric cancer
  • Surgery - upper GI
  • Upper GI surgery

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