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Professor Mark Smithers
Professor

Mark Smithers

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Overview

Background

Emeritus Professor Mark Smithers is a surgical oncologist who specialises in surgery for oesophago-gastric diseases, melanoma, advanced skin cancer and soft tissue sarcoma. He was the Director of the Upper GI and Soft Tissue Unit at the Princess Alexandra Hospital, in Brisbane, Australia from 1998 - 2023. Commencing his academic career with the University of Queensland in 1987, he progressed to be the Mayne Chair in Surgery and head of the Academy of Surgery. He is the second University of Queensland Medical graduate to be appointed to this role. His research has been focussed on the development and assessment of outcomes from minimally invasive upper GI surgery, and trials assessing the role of perioperative multidisciplinary therapy for esophageal and gastric cancer. As well he has led, or been involved with, clinical trials from phase I to III, for all stages of melanoma through his role as the Chair of the Queensland Melanoma Project. More recently he has been involved with the assessment of access to, and outcomes from, surgery for cancer in Queensland, Australia.

He has overseen the administration and development of the surgery curriculum, and the teaching, in the Academy of Surgery, in the UQ Faculty of Medicine. He was on a number of committees relevant to the implementation of the UQ MD design course. He has held various leadership and committee roles with the Royal Australasian College of Surgeons, as well as leadership roles, including the Presidency, in the Australian and New Zealand Oesophago Gastric Surgeons Association. He has also been on the committees of international organisations related to oesophageal and gastric surgery. He has published 250 articles, eight book chapters, and has been on the editorial board of a number of surgical journals.

He has been recognised for his clinical and academic roles by the award of Member of the Order of Australia (AM). The citation reads, "for service to medicine in the fields of gastro-intestinal and melanoma surgery, to medical education and to professional organisations". The Royal Australasian College of Surgeons awarded him the Sir Hugh Devine medal, for services to surgery and the community. This is the College’s highest honour. Internationally, he has been awarded an honorary fellowship of the Royal College of Surgeons of Edinburgh and recently, in the United States, he was elected as an Honarary Fellow of the American Surgical Association.

Availability

Professor Mark Smithers is:
Not available for supervision
Media expert

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Honorary Fellow, American Surgical Association, American Surgical Association
  • Fellow, Royal Australasian College of Surgeons, Royal Australasian College of Surgeons
  • Fellow, Royal College of Surgeons of Edinburgh, Royal College of Surgeons of Edinburgh
  • Fellow, Royal College of Surgeons of England, Royal College of Surgeons of England

Research interests

  • Cutaneous Melanoma

    epidemiology, public health issues and management of all stages

  • Management of Oesophageal and Gastric Cancer

    Investigation and management of benign and malignant diseases of the oesophagus and the stomach.

Works

Search Professor Mark Smithers’s works on UQ eSpace

414 works between 1983 and 2025

281 - 300 of 414 works

2008

Journal Article

Refining esophageal cancer staging after neoadjuvant therapy: importance of treatment response

Barbour, A.P., Jones, M., Gonen, M., Gotley, D.C., Thomas, J., Thomson, D.B., Burmeister, B. and Smithers, B.M. (2008). Refining esophageal cancer staging after neoadjuvant therapy: importance of treatment response. Annals of Surgical Oncology, 15 (10), 2894-2902. doi: 10.1245/s10434-008-0084-y

Refining esophageal cancer staging after neoadjuvant therapy: importance of treatment response

2008

Journal Article

Genome-wide copy number analysis in esophageal adenocarcinoma using high-density single-nucleotide polymorphism arrays

Nancarrow, D.J., Handoko, H. Y., Smithers, B.M., Gotley, D. C., Drew, P.A., Watson, D.I., Clouston, A. D., Hayward, N. and Whiteman, D. C. (2008). Genome-wide copy number analysis in esophageal adenocarcinoma using high-density single-nucleotide polymorphism arrays. Cancer Research, 68 (11), 4163-4172. doi: 10.1158/0008-5472.CAN-07-6710

Genome-wide copy number analysis in esophageal adenocarcinoma using high-density single-nucleotide polymorphism arrays

2008

Journal Article

Consideration of mesh-related complications: Letters and comments

Shenfine, Jon, Barbour, Andrew, Martin, Ian, Smithers, B. Mark and Gotley, David C. (2008). Consideration of mesh-related complications: Letters and comments. Annals of the Royal College of Surgeons of England, 90 (2), 175-176. doi: 10.1308/003588408X261780

Consideration of mesh-related complications: Letters and comments

2008

Journal Article

Re: Comparison of the outcomes between open and minimally invasive esophagectomy - Reply

Smithers, Bernard M. and Gotley, David (2008). Re: Comparison of the outcomes between open and minimally invasive esophagectomy - Reply. Annals of Surgery, 247 (2), 397-398. doi: 10.1097/SLA.0b013e3181640266

Re: Comparison of the outcomes between open and minimally invasive esophagectomy - Reply

2008

Conference Publication

Melanoma Patients Australia: A focus on patient support and advocacy

McFadyen, L., Herlaar, H. and Smithers, M. (2008). Melanoma Patients Australia: A focus on patient support and advocacy. Clinical Oncological Society of Australia and the International Association of Cancer Registries Joint Scientific Meeting, held in conjunction with the Australian and New Zealand Gastro-Oesophageal Surgery Association, Sydney, Australia, 18-20 November 2008. United Kingdom: Wiley-Blackwell. doi: 10.1111/j.1743-7563.2008.00201_2.x

Melanoma Patients Australia: A focus on patient support and advocacy

2008

Conference Publication

Jejunally fed patients post oesophagectomy / gastrectomy: Are they getting all they need? An audit at the Princess Alexandra Hospital

Baumgartner, L., Vivanti, A. and Smithers, M. (2008). Jejunally fed patients post oesophagectomy / gastrectomy: Are they getting all they need? An audit at the Princess Alexandra Hospital. Clinical Oncological Society of Australia and the International Association of Cancer Registries Joint Scientific Meeting, Sydney, NSW Australia, 18-20 November 2008. Chichester, West Sussex United Kingdom: Wiley-Blackwell. doi: 10.1111/j.1743-7563.2008.00201_2.x

Jejunally fed patients post oesophagectomy / gastrectomy: Are they getting all they need? An audit at the Princess Alexandra Hospital

2008

Journal Article

Positron emission tomography and pathological evidence of response to neoadjuvant therapy in adenocarcinoma of the esophagus

Smithers, B .M., Couper, G. C., Thomas, J. M., Wong, D., Gotley, D. C., Martin, I., Harvey, J., Thomson, D. B., Walpole, E., Watts, N. and Burmeister, B. (2008). Positron emission tomography and pathological evidence of response to neoadjuvant therapy in adenocarcinoma of the esophagus. Diseases of the Esophagus, 21 (2), 151-158. doi: 10.1111/j.1442-2050.2007.00732.x

Positron emission tomography and pathological evidence of response to neoadjuvant therapy in adenocarcinoma of the esophagus

2008

Conference Publication

A randomised phase II trial comparing pre-operative chemotherapy with pre-operative chemoradiation therapy for localized carcinoma of the oesophagus

Burmeister, B. H., Smithers, B. M., Thomas, J., Burmeister, E., Walpole, E., Harvey, J., Thomson, D., Barbour, A. and Gotley D. (2008). A randomised phase II trial comparing pre-operative chemotherapy with pre-operative chemoradiation therapy for localized carcinoma of the oesophagus. Clinical Oncological Society of Australia and the International Association of Cancer Registries Joint Scientific Meeting, held in conjunction with the Australian and New Zealand Gastro-Oesophageal Surgery Association, Sydney, Australia, 18-20 November 2008. United Kingdom: Wiley-Blackwell. doi: 10.1111/j.1743-7563.2008.00201_1.x

A randomised phase II trial comparing pre-operative chemotherapy with pre-operative chemoradiation therapy for localized carcinoma of the oesophagus

2008

Conference Publication

Chemoablation of cutaneous and subcutaneous metastatic melanoma using PV-1

Thompson, J. F., Hersey, P., Smithers, B. M., Coventry, B., Ross, M. I. and Wachter, E. A. (2008). Chemoablation of cutaneous and subcutaneous metastatic melanoma using PV-1. Clinical Oncological Society of Australia and the International Association of Cancer Registries Joint Scientific Meeting, held in conjunction with the Australian and New Zealand Gastro-Oesophageal Surgery Association, Sydney, Australia, 18–20 November 2008. Asia: Blackwell Publishing. doi: 10.1111/j.1743-7563.2008.00201_1.x

Chemoablation of cutaneous and subcutaneous metastatic melanoma using PV-1

2008

Journal Article

Combined effects of obesity, acid reflux and smoking on adenocarcinomas of the oesophagus

Whiteman, D. C., Sadeghi, S., Pandeya, N., Smithers, B. M., Gotley, D. C., Bain, C. J., Webb, P. M. and Green, A. C. (2008). Combined effects of obesity, acid reflux and smoking on adenocarcinomas of the oesophagus. Gut, 57 (2), 173-180. doi: 10.1136/gut.2007.131375

Combined effects of obesity, acid reflux and smoking on adenocarcinomas of the oesophagus

2008

Journal Article

Desmoplastic melanoma: the role of radiotherapy in improving local control

Foote, M. C., Burmeister, B., Burmeister, E., Bayley, G. and Smithers, B. M. (2008). Desmoplastic melanoma: the role of radiotherapy in improving local control. Australian and New Zealand Journal of Surgery, 78 (4), 273-276. doi: 10.1111/j.1445-2197.2008.04436.x

Desmoplastic melanoma: the role of radiotherapy in improving local control

2008

Book

Clinical practice guidelines for the management of melanoma in Australia and New Zealand

Aitken, Joanne F., Barbour, Andrew, Burmeister, Bryan, Taylor, Simon, Walpole, Euan, Australian Cancer Network, Smithers, Bernhard M. and Melanoma Guidelines Revision Working Party (2008). Clinical practice guidelines for the management of melanoma in Australia and New Zealand. Sydney, Australia: Cancer Council Australia; Australian Cancer Network; Ministry of Health, New Zealand.

Clinical practice guidelines for the management of melanoma in Australia and New Zealand

2008

Conference Publication

The epidemiology of oesophageal cancer

Whiteman, D. C., Smithers, B. M., Gotley, D. C., Pandeyal, N., Sadeghi, S., Green, A. C. and Webb, P. M. (2008). The epidemiology of oesophageal cancer. Clinical Oncological Society of Australia and the International Association of Cancer Registries Joint Scientific Meeting, Sydney, Australia, 18-20 November 2008. United Kingdom: Wiley-Blackwell. doi: 10.1111/j.1743-7563.2008.00201_1.x

The epidemiology of oesophageal cancer

2008

Conference Publication

Minimally invasive esophagectomy for esophageal cancer: Analysis of recurrence patterns and prognostic factors of recurrence

Barbour, A., Thompson, I., Gotley, D. C., Jones, M., Thomas, J., Martin, I. and Smithers, M. B. (2008). Minimally invasive esophagectomy for esophageal cancer: Analysis of recurrence patterns and prognostic factors of recurrence. Clinical Oncological Society of Australia and the International Association of Cancer Registries Joint Scientific Meeting, held in conjunction with the Australian and New Zealand Gastro-Oesophageal Surgery Association, Sydney, Australia, 18–20 November 2008. United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/j.1743-7563.2008.00201_2.x

Minimally invasive esophagectomy for esophageal cancer: Analysis of recurrence patterns and prognostic factors of recurrence

2007

Journal Article

Randomized clinical trial of the effects of perioperative use of immune-enhancing enteral formula on metabolic immunological status in patients undergoing esophagectomy

Smithers, B. (2007). Randomized clinical trial of the effects of perioperative use of immune-enhancing enteral formula on metabolic immunological status in patients undergoing esophagectomy. World Journal of Surgery, 31 (11), 2158-2159. doi: 10.1007/s00268-007-9230-0

Randomized clinical trial of the effects of perioperative use of immune-enhancing enteral formula on metabolic immunological status in patients undergoing esophagectomy

2007

Journal Article

Two cases of esophageal carcinoma following corrosive esophagitis successfully treated with chemoradiation therapy

Burmeister, Bryan H., Walpole, Euan T., Thomas, Janine and Smithers, B. Mark (2007). Two cases of esophageal carcinoma following corrosive esophagitis successfully treated with chemoradiation therapy. Asia–Pacific Journal of Clinical Oncology, 3 (2), 108-111. doi: 10.1111/j.1743-7563.2007.00096.x

Two cases of esophageal carcinoma following corrosive esophagitis successfully treated with chemoradiation therapy

2007

Journal Article

Comparison of the outcomes between open and minimally invasive esophagectomy

Smithers, Bernard M., Gotley, David C., Martin, Ian and Thomas, Janine M. (2007). Comparison of the outcomes between open and minimally invasive esophagectomy. Annals of Surgery, 245 (2), 232-240. doi: 10.1097/01.sla.0000225093.58071.c6

Comparison of the outcomes between open and minimally invasive esophagectomy

2007

Journal Article

Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: a meta-analysis

Gebski, V., Burmeister, B., Smithers, B. M., Foo, K., Zalcberg, J. and Simes, J. (2007). Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: a meta-analysis. Lancet Oncology, 8 (3), 226-234. doi: 10.1016/S1470-2045(07)70039-6

Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: a meta-analysis

2007

Conference Publication

Surgery for early esophageal adenocarcinoma: Analysis of lymphatic spread and prognostic factors

Hughes, A., Smithers, B. M., Thomas, J., Martin, I., Gotley, D. C. and Barbour, A. P. (2007). Surgery for early esophageal adenocarcinoma: Analysis of lymphatic spread and prognostic factors. 60th Annual Cancer Symposium of the Society of Surgical Oncology, Washington, DC, USA, 15-18 Mar, 2007. Hagerstown, U.S.A.: Springer.

Surgery for early esophageal adenocarcinoma: Analysis of lymphatic spread and prognostic factors

2007

Conference Publication

The role of obesity, gastroesophageal reflux and smoking in adenocarcinomas of the esophagus and esophago-gastric junction

Whiteman, David, Sadeghi, Shahram, Pandeya, Nirmala, Smithers, Mark, Gotley, David, Bain, Christopher and Green, Adele (2007). The role of obesity, gastroesophageal reflux and smoking in adenocarcinomas of the esophagus and esophago-gastric junction. Digestive Disease Weeking Meeting/ASGE Postgraduate Course Meeting, Washington DC, United States, 19-24 May 2007. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.

The role of obesity, gastroesophageal reflux and smoking in adenocarcinomas of the esophagus and esophago-gastric junction

Funding

Current funding

  • 2024 - 2025
    Optimising the Diagnosis and Management of Unilateral Primary Aldosteronism (MSH SERTA Grant led by Metro South HHS)
    Metro South Hospital and Health Service
    Open grant
  • 2023 - 2026
    iCare - An interactive online portal to improve health and wellbeing for people living with complex cancers, and their informal carers: a Phase II randomised controlled trial (Ex led Deakin MRFF CTA)
    Deakin University
    Open grant
  • 2021 - 2026
    AGITG TOP GEAR: A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer (CTCS: led by USyd)
    University of Sydney
    Open grant
  • 2019 - 2026
    A Randomised Phase II Trial of Adjuvant Avelumab in Patients with Early Stage Merkel Cell Carcinoma
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2019 - 2025
    Melanoma Margins Trial II - A Phase III, Multi-centre Randomised Controlled Trial Investigating 1cm v 2cm Wide Surgical Excision Margins.. (NHMRC Project Grant led by the University of Melbourne).
    University of Melbourne
    Open grant

Past funding

  • 2021 - 2024
    Advanced technological approach to predicting survival in patients diagnosed with locally invasive cutaneous melanoma
    Cancer Council Queensland
    Open grant
  • 2021 - 2024
    Establishing Australia's First Familial Melanoma Clinic (MSH RSS SERTA Program Grant led by Metro South Hospital and Health Service)
    Metro South Hospital and Health Service
    Open grant
  • 2020 - 2021
    Cancer Evolution Biobank
    PA Research Foundation
    Open grant
  • 2017 - 2019
    Predictors of mortality in thin melanomas
    Cancer Council Queensland
    Open grant
  • 2013 - 2015
    To identify and assess markers of prognosis, response and resistance to therapy in patients with Stage III metastatic melanoma
    Cancer Bequest Fund
    Open grant
  • 2011
    DOCetaxel with or without radiation Therapy for resectable Oesophageal adenocarcinoma based on early PET Response to induction chemotherapy (DOCTOR)
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Effects of nevogenesis susceptibility genes and phenotypic correlation with dermoscopic characteristics of nevi
    NHMRC Project Grant
    Open grant
  • 2010 - 2014
    Comparison of pre- and perioperative immunonutrition in patients undergoing surgical resection of oesophageal cancer (NHMRC Project Grant administered by the University of Adelaide)
    University of Adelaide
    Open grant
  • 2001 - 2002
    The epidemiology of oesophageal cancer: Risk and molecular markers
    Queensland Cancer Fund
    Open grant
  • 2000
    The role of TAP and MHC class I expression in the response to melanoma immunotherapy using autologous dendritic cells
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1999 - 2000
    A phase II clinical trial in patients with metastatic melanoma comparing autologous dendritic cells pulsed with autologous tumour peptides and melanoma associated peptides linked to the endoplasmic re
    Queensland Cancer Fund
    Open grant
  • 1998
    A Phase I/II Clinical Trial to Test Tumour Vaccines Comprising with Protein or Autologous Tumour Antigen Autologous Dandritic Cells Generated in a Closed Bag System Pulsed
    Mayne Bequest Fund
    Open grant
  • 1998
    Isolated limb infusion of melphalan and microdialysis technique in treatment of recurrent malignant melanoma
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1998 - 2000
    Treatment of Recurrent Malignant Melanoma by Limb Infusion of Cytotoxic Drugs and Other Techniques
    NHMRC Project Grant
    Open grant
  • 1997 - 1998
    Pharmacokinetics of tumour necrosis factor (TNF) in isolated rat hindlimb perfusions and infusions related to melanoma therapy
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1996 - 1997
    Targeting and monitoring drug delivery in specific tissues using iontophoresis and microdialysis
    Quality Funds Round 3
    Open grant
  • 1995 - 1997
    Pharmacokinetics of melphalan in isolated limb perfusion and infusion
    Queensland Cancer Fund
    Open grant

Supervision

Availability

Professor Mark Smithers is:
Not available for supervision

Supervision history

Current supervision

  • Master Philosophy

    Assessment of the impact of treating service characteristics on surgical and oncological outcomes for patients with Retroperitoneal and Inguinal Sarcomas in Queensland

    Principal Advisor

    Other advisors: Professor Andrew Barbour

  • Doctor Philosophy

    New tools for the multi-modal evaluation of pancreatic cancer and its precursor neoplasms.

    Associate Advisor

    Other advisors: Dr David Cavallucci

  • Master Philosophy

    Factors Influencing Anastomotic Complications after Oesophagectomy

    Associate Advisor

Completed supervision

Media

Enquiries

Contact Professor Mark Smithers directly for media enquiries about:

  • Advanced endoscopic surgery
  • Cancer surgery
  • Endoscopic surgery
  • General surgery
  • Melanoma
  • Surgery - cancer
  • Surgery - oesophageal, gastric cancer
  • Surgery - upper GI
  • Upper GI surgery

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