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Professor Mark Smithers
Professor

Mark Smithers

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Overview

Background

Emeritus Professor Mark Smithers is a surgical oncologist who specialises in surgery for oesophago-gastric diseases, melanoma, advanced skin cancer and soft tissue sarcoma. He was the Director of the Upper GI and Soft Tissue Unit at the Princess Alexandra Hospital, in Brisbane, Australia from 1998 - 2023. Commencing his academic career with the University of Queensland in 1987, he progressed to be the Mayne Chair in Surgery and head of the Academy of Surgery. He is the second University of Queensland Medical graduate to be appointed to this role. His research has been focussed on the development and assessment of outcomes from minimally invasive upper GI surgery, and trials assessing the role of perioperative multidisciplinary therapy for esophageal and gastric cancer. As well he has led, or been involved with, clinical trials from phase I to III, for all stages of melanoma through his role as the Chair of the Queensland Melanoma Project. More recently he has been involved with the assessment of access to, and outcomes from, surgery for cancer in Queensland, Australia.

He has overseen the administration and development of the surgery curriculum, and the teaching, in the Academy of Surgery, in the UQ Faculty of Medicine. He was on a number of committees relevant to the implementation of the UQ MD design course. He has held various leadership and committee roles with the Royal Australasian College of Surgeons, as well as leadership roles, including the Presidency, in the Australian and New Zealand Oesophago Gastric Surgeons Association. He has also been on the committees of international organisations related to oesophageal and gastric surgery. He has published 250 articles, eight book chapters, and has been on the editorial board of a number of surgical journals.

He has been recognised for his clinical and academic roles by the award of Member of the Order of Australia (AM). The citation reads, "for service to medicine in the fields of gastro-intestinal and melanoma surgery, to medical education and to professional organisations". The Royal Australasian College of Surgeons awarded him the Sir Hugh Devine medal, for services to surgery and the community. This is the College’s highest honour. Internationally, he has been awarded an honorary fellowship of the Royal College of Surgeons of Edinburgh and recently, in the United States, he was elected as an Honarary Fellow of the American Surgical Association.

Availability

Professor Mark Smithers is:
Not available for supervision
Media expert

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Honorary Fellow, American Surgical Association, American Surgical Association
  • Fellow, Royal Australasian College of Surgeons, Royal Australasian College of Surgeons
  • Fellow, Royal College of Surgeons of Edinburgh, Royal College of Surgeons of Edinburgh
  • Fellow, Royal College of Surgeons of England, Royal College of Surgeons of England

Research interests

  • Cutaneous Melanoma

    epidemiology, public health issues and management of all stages

  • Management of Oesophageal and Gastric Cancer

    Investigation and management of benign and malignant diseases of the oesophagus and the stomach.

Works

Search Professor Mark Smithers’s works on UQ eSpace

414 works between 1983 and 2025

221 - 240 of 414 works

2014

Conference Publication

Melanoma brain metastases: the impact of nodal disease

Jackson, James E., Burmeister, Bryan H., Burmeister, Elizabeth A., Foote, Matthew C., Thomas, Janine M., Meakin, Janelle A. and Smithers, B. Mark (2014). Melanoma brain metastases: the impact of nodal disease. 54th Annual Scientific Meeting of the American-Society-for-Radiation-Oncology (ASTRO), Boston, MA United States, 28-31 October 2012. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/s10585-013-9611-8

Melanoma brain metastases: the impact of nodal disease

2014

Journal Article

Treatment results of curative gastric resection from a specialist Australian unit: Low volume with satisfactory outcomes

Thomson I.G., Gotley D.C., Barbour A.P., Martin I., Jayasuria N., Thomas J. and Smithers B.M. (2014). Treatment results of curative gastric resection from a specialist Australian unit: Low volume with satisfactory outcomes. Gastric Cancer, 17 (1), 152-160. doi: 10.1007/s10120-013-0240-3

Treatment results of curative gastric resection from a specialist Australian unit: Low volume with satisfactory outcomes

2014

Journal Article

Changeable naevi in people at high risk for melanoma

Abbott, Nicola C. D., Pandeya, Nirmala, Ong, Natalie, McClenahan, Phil, Smithers, B. Mark, Green, Adele and Soyer, H. Peter (2014). Changeable naevi in people at high risk for melanoma. Australasian Journal of Dermatology, 56 (1), 14-18. doi: 10.1111/ajd.12181

Changeable naevi in people at high risk for melanoma

2014

Conference Publication

Randomized, double-blind phase II trial of NY-ESO-1 ISCOMATRIX vaccine and ISCOMATRIX adjuvant alone in patients with resected stage IIc, III, or IV malignant melanoma.

Cebon, Jonathan S., McArthur, Grant A., Chen, Weisan, Davis, Ian D., Gore, Martin Eric, Thompson, John F., Millward, Michael, Findlay, Michael P. N., Dunbar, Rod, Ottensmeier, Christian H. H., Venhaus, Ralph Rudolph, Nathan, Paul D., Dalgleish, Angus George, Cerundolo, Vincenzo, Maraskovsky, Eugene, Hopkins, Wendie, Marsden, Jeremy, Smithers, B. Mark, Hersey, Peter and Evans, T. R. Jeffry (2014). Randomized, double-blind phase II trial of NY-ESO-1 ISCOMATRIX vaccine and ISCOMATRIX adjuvant alone in patients with resected stage IIc, III, or IV malignant melanoma.. 50th Annual Meeting of the American Society of Clinical Oncology, Chicago, Illinois, 30 May - 3 June 2014 . Alexandria, VA, United States: American Society of Clinical Oncology.

Randomized, double-blind phase II trial of NY-ESO-1 ISCOMATRIX vaccine and ISCOMATRIX adjuvant alone in patients with resected stage IIc, III, or IV malignant melanoma.

2013

Journal Article

Patients undergoing lymphadenectomy for Stage III melanomas of known or unknown primary site do not differ in outcome

Hughes, Maria Celia, Wright, Annaliesa, Barbour, Andrew, Thomas, Janine, Smithers, B. Mark, Green, Adele C. and Khosrotehrani, Kiarash (2013). Patients undergoing lymphadenectomy for Stage III melanomas of known or unknown primary site do not differ in outcome. International Journal of Cancer, 133 (12), 3000-3007. doi: 10.1002/ijc.28318

Patients undergoing lymphadenectomy for Stage III melanomas of known or unknown primary site do not differ in outcome

2013

Conference Publication

The Volume-Outcome Relationship in Cancer Surgery - Do Rural Patients Have a Choice?

Smithers, Mark, Zarate, Dannie, Harden, Hazel, Colquist, Shoni and Walpole, Euan (2013). The Volume-Outcome Relationship in Cancer Surgery - Do Rural Patients Have a Choice?. HOBOKEN: WILEY-BLACKWELL.

The Volume-Outcome Relationship in Cancer Surgery - Do Rural Patients Have a Choice?

2013

Journal Article

Stage III melanoma in the axilla: patterns of regional recurrence after surgery with and without adjuvant radiation therapy

Pinkham, Mark B., Foote, Matthew C., Burmeister, Elizabeth, Thomas, Janine, Meakin, Janelle, Smithers, B. Mark and Burmeister, Bryan H. (2013). Stage III melanoma in the axilla: patterns of regional recurrence after surgery with and without adjuvant radiation therapy. International Journal of Radiation: Oncology - Biology - Physics, 86 (4), 702-708. doi: 10.1016/j.ijrobp.2013.03.019

Stage III melanoma in the axilla: patterns of regional recurrence after surgery with and without adjuvant radiation therapy

2013

Conference Publication

Australian Multi-Center Study of Isolated Limb Infusion Chemotherapy for Melanoma: Experience Outside of the Sydney Melanoma Unit

Kroon, H., Coventry, B., Giles, M., Henderson, M., Serpell, J. and Smithers, M. (2013). Australian Multi-Center Study of Isolated Limb Infusion Chemotherapy for Melanoma: Experience Outside of the Sydney Melanoma Unit. HOBOKEN: WILEY-BLACKWELL.

Australian Multi-Center Study of Isolated Limb Infusion Chemotherapy for Melanoma: Experience Outside of the Sydney Melanoma Unit

2013

Journal Article

Surgery and the management of cutaneous melanoma

Allan, C. and Smithers, B. M. (2013). Surgery and the management of cutaneous melanoma. British Journal of Surgery, 100 (3), 313-315. doi: 10.1002/bjs.9054

Surgery and the management of cutaneous melanoma

2013

Conference Publication

Survival and recurrence outcome in patients with melanomas of unknown primary invading lymph nodes

Wright, A., Hughes, M., Siskind, V., Smithers, M., Thomas, J., Green, A. and Khosrotehrani, K. (2013). Survival and recurrence outcome in patients with melanomas of unknown primary invading lymph nodes. The Australasian College of Dermatologists 46th Annual Scientific Meeting, Sydney, NSW Australia, 19 – 22 May 2013. Richmond, VIC Australia: Wiley-Blackwell. doi: 10.1111/ajd.12051

Survival and recurrence outcome in patients with melanomas of unknown primary invading lymph nodes

2013

Conference Publication

Adjuvant radiotherapy after lymphadenectomy in melanoma patients: Final results of an intergroup randomized trial (ANZMTG 0.1.02/TROG 02.01)

Henderson, Michael A., Burmeister, Bryan, Ainslie, Jill, Fisher, Richard, Di Iulio, Julianna, Smithers, Bernard Mark, Hong, Angela, Shannon, Kerwin F., Scolyer, Richard A., Carruthers, Scott, Coventry, Brendon J., Babington, Scott, Duprat, Joao, Hoekstra, Harald J. and Thompson, John F. (2013). Adjuvant radiotherapy after lymphadenectomy in melanoma patients: Final results of an intergroup randomized trial (ANZMTG 0.1.02/TROG 02.01). 49th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Chicago IL United States, May 31-Jun 04, 2013. United States: American Society of Clinical Oncology.

Adjuvant radiotherapy after lymphadenectomy in melanoma patients: Final results of an intergroup randomized trial (ANZMTG 0.1.02/TROG 02.01)

2013

Journal Article

Neoadjuvant Chemotherapy or Chemoradiotherapy for Locally Advanced Esophageal Cancer

Smithers, B. Mark and Thomson, Iain (2013). Neoadjuvant Chemotherapy or Chemoradiotherapy for Locally Advanced Esophageal Cancer. Thoracic Surgery Clinics, 23 (4), 509-523. doi: 10.1016/j.thorsurg.2013.07.005

Neoadjuvant Chemotherapy or Chemoradiotherapy for Locally Advanced Esophageal Cancer

2013

Conference Publication

Locoregional disease control in metastatic melanoma: Exploratory analysis from phase 2 testing of intralesional rose bengal

Agarwala, S., Thompson, J. F., Smithers, B. M., Ross, M. I., Coventry, B. J., Minor, D. R., Scoggins, C. R., Singer, J. M. and Wachter, E. A. (2013). Locoregional disease control in metastatic melanoma: Exploratory analysis from phase 2 testing of intralesional rose bengal. 17th ECCO / 38th ESMO / 32nd ESTRO European Cancer Congress on Reinforcing Multidisciplinarity, Amsterdam Netherlands, Sep 27-Oct 01, 2013. Oxford United Kingdom: Pergamon. doi: 10.1016/S0959-8049(13)70065-0

Locoregional disease control in metastatic melanoma: Exploratory analysis from phase 2 testing of intralesional rose bengal

2013

Journal Article

Impact of postoperative morbidity on long-term survival after oesophagectomy

Hii, M. W., Smithers, B. M., Gotley, D. C., Thomas, J. M., Thomson, I., Martin, I. and Barbour, A. P. (2013). Impact of postoperative morbidity on long-term survival after oesophagectomy. British Journal of Surgery, 100 (1), 95-104. doi: 10.1002/bjs.8973

Impact of postoperative morbidity on long-term survival after oesophagectomy

2013

Conference Publication

Pilot multi-marker analysis to evaluate prognosis in stage Ib and II melanomas

Rowe, C. J., Rodero, M., Malt, M., Smithers, M., Green, A. and Khosrotehrani, K. (2013). Pilot multi-marker analysis to evaluate prognosis in stage Ib and II melanomas. The Australasian College of Dermatologists 46th Annual Scientific Meeting, Sydney, NSW Australia, 19 – 22 May 2013. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12051

Pilot multi-marker analysis to evaluate prognosis in stage Ib and II melanomas

2013

Book Chapter

Esophagus carcinoma surveillance counter: Australia

Smithers, Bernard Mark, Thomas, Janine M. and Burmeister, Bryan H. (2013). Esophagus carcinoma surveillance counter: Australia. Patient Surveillance after Cancer Treatment. (pp. 97-100) edited by Frank Johnson, Yoshihiko Maehara, George P. Browman, Julie A. Margenthaler, Riccardo A. Audisio, John F. Thompson, David Y. Johnson, Craig C. Earle and Katerine S. Virgo. New York, United States: Humana Press. doi: 10.1007/978-1-60327-969-7_17

Esophagus carcinoma surveillance counter: Australia

2013

Conference Publication

Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy of autoimmune disease

Burton, B. R., Britton, G. J., Fang, H., Verhagen, J., Smithers, B., Sabatos-Peyton, C. A., Carney, L. J., Gough, J., Strobel, S. and Wraith, C. (2013). Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy of autoimmune disease. Annual Congress of the British-Society-for-Immunology, Liverpool England, Dec 02-05, 2013. West Sussex United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/imm.12217

Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy of autoimmune disease

2012

Journal Article

Prevalence and determinants of frequent gastroesophageal reflux symptoms in the Australian community

Pandeya, N., Green, A. C., Whiteman, D. C., The Australian Cancer Study and Smithers, B. M. (2012). Prevalence and determinants of frequent gastroesophageal reflux symptoms in the Australian community. Diseases of the Esophagus, 25 (7), 573-583. doi: 10.1111/j.1442-2050.2011.01287.x

Prevalence and determinants of frequent gastroesophageal reflux symptoms in the Australian community

2012

Journal Article

Modeling the cost-effectiveness of strategies for treating esophageal adenocarcinoma and high-grade dysplasia

Gordon, Louisa G., Hirst, Nicholas G., Mayne, George C., Watson, David I., Bright, Timothy, Cai, Wang, Barbour, Andrew P., Smithers, Bernard M., Whiteman, David C. and Eckermann, Simon (2012). Modeling the cost-effectiveness of strategies for treating esophageal adenocarcinoma and high-grade dysplasia. Journal of Gastrointestinal Surgery, 16 (8), 1451-1461. doi: 10.1007/s11605-012-1911-9

Modeling the cost-effectiveness of strategies for treating esophageal adenocarcinoma and high-grade dysplasia

2012

Journal Article

Metastasectomy for distant metastatic melanoma: analysis of data from the first multicenter selective lymphadenectomy trial (MSLT-I)

Howard, J. Harrison, Thompson, John F., Mozzillo, Nicola, Nieweg, Omgo E., Hoekstra, Harald J., Roses, Daniel F., Sondak, Vernon K., Reintgen, Douglas S., Kashani-Sabet, Mohammed, Karakousis, Constantine P., Coventry, Brendon J., Kraybill, William G., Smithers, B. Mark, Elashoff, Robert, Stern, Stacey L., Cochran, Alistair J., Faries, Mark B. and Morton, Donald L. (2012). Metastasectomy for distant metastatic melanoma: analysis of data from the first multicenter selective lymphadenectomy trial (MSLT-I). Annals of Surgical Oncology, 19 (8), 2547-2555. doi: 10.1245/s10434-012-2398-z

Metastasectomy for distant metastatic melanoma: analysis of data from the first multicenter selective lymphadenectomy trial (MSLT-I)

Funding

Current funding

  • 2024 - 2025
    Optimising the Diagnosis and Management of Unilateral Primary Aldosteronism (MSH SERTA Grant led by Metro South HHS)
    Metro South Hospital and Health Service
    Open grant
  • 2023 - 2026
    iCare - An interactive online portal to improve health and wellbeing for people living with complex cancers, and their informal carers: a Phase II randomised controlled trial (Ex led Deakin MRFF CTA)
    Deakin University
    Open grant
  • 2021 - 2026
    AGITG TOP GEAR: A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer (CTCS: led by USyd)
    University of Sydney
    Open grant
  • 2019 - 2026
    A Randomised Phase II Trial of Adjuvant Avelumab in Patients with Early Stage Merkel Cell Carcinoma
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2019 - 2025
    Melanoma Margins Trial II - A Phase III, Multi-centre Randomised Controlled Trial Investigating 1cm v 2cm Wide Surgical Excision Margins.. (NHMRC Project Grant led by the University of Melbourne).
    University of Melbourne
    Open grant

Past funding

  • 2021 - 2024
    Advanced technological approach to predicting survival in patients diagnosed with locally invasive cutaneous melanoma
    Cancer Council Queensland
    Open grant
  • 2021 - 2024
    Establishing Australia's First Familial Melanoma Clinic (MSH RSS SERTA Program Grant led by Metro South Hospital and Health Service)
    Metro South Hospital and Health Service
    Open grant
  • 2020 - 2021
    Cancer Evolution Biobank
    PA Research Foundation
    Open grant
  • 2017 - 2019
    Predictors of mortality in thin melanomas
    Cancer Council Queensland
    Open grant
  • 2013 - 2015
    To identify and assess markers of prognosis, response and resistance to therapy in patients with Stage III metastatic melanoma
    Cancer Bequest Fund
    Open grant
  • 2011
    DOCetaxel with or without radiation Therapy for resectable Oesophageal adenocarcinoma based on early PET Response to induction chemotherapy (DOCTOR)
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Effects of nevogenesis susceptibility genes and phenotypic correlation with dermoscopic characteristics of nevi
    NHMRC Project Grant
    Open grant
  • 2010 - 2014
    Comparison of pre- and perioperative immunonutrition in patients undergoing surgical resection of oesophageal cancer (NHMRC Project Grant administered by the University of Adelaide)
    University of Adelaide
    Open grant
  • 2001 - 2002
    The epidemiology of oesophageal cancer: Risk and molecular markers
    Queensland Cancer Fund
    Open grant
  • 2000
    The role of TAP and MHC class I expression in the response to melanoma immunotherapy using autologous dendritic cells
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1999 - 2000
    A phase II clinical trial in patients with metastatic melanoma comparing autologous dendritic cells pulsed with autologous tumour peptides and melanoma associated peptides linked to the endoplasmic re
    Queensland Cancer Fund
    Open grant
  • 1998
    A Phase I/II Clinical Trial to Test Tumour Vaccines Comprising with Protein or Autologous Tumour Antigen Autologous Dandritic Cells Generated in a Closed Bag System Pulsed
    Mayne Bequest Fund
    Open grant
  • 1998
    Isolated limb infusion of melphalan and microdialysis technique in treatment of recurrent malignant melanoma
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1998 - 2000
    Treatment of Recurrent Malignant Melanoma by Limb Infusion of Cytotoxic Drugs and Other Techniques
    NHMRC Project Grant
    Open grant
  • 1997 - 1998
    Pharmacokinetics of tumour necrosis factor (TNF) in isolated rat hindlimb perfusions and infusions related to melanoma therapy
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1996 - 1997
    Targeting and monitoring drug delivery in specific tissues using iontophoresis and microdialysis
    Quality Funds Round 3
    Open grant
  • 1995 - 1997
    Pharmacokinetics of melphalan in isolated limb perfusion and infusion
    Queensland Cancer Fund
    Open grant

Supervision

Availability

Professor Mark Smithers is:
Not available for supervision

Supervision history

Current supervision

  • Master Philosophy

    Assessment of the impact of treating service characteristics on surgical and oncological outcomes for patients with Retroperitoneal and Inguinal Sarcomas in Queensland

    Principal Advisor

    Other advisors: Professor Andrew Barbour

  • Master Philosophy

    Factors Influencing Anastomotic Complications after Oesophagectomy

    Associate Advisor

  • Doctor Philosophy

    New tools for the multi-modal evaluation of pancreatic cancer and its precursor neoplasms.

    Associate Advisor

    Other advisors: Dr David Cavallucci

Completed supervision

Media

Enquiries

Contact Professor Mark Smithers directly for media enquiries about:

  • Advanced endoscopic surgery
  • Cancer surgery
  • Endoscopic surgery
  • General surgery
  • Melanoma
  • Surgery - cancer
  • Surgery - oesophageal, gastric cancer
  • Surgery - upper GI
  • Upper GI surgery

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