
Overview
Background
Emeritus Professor Mark Smithers is a surgical oncologist who specialises in surgery for oesophago-gastric diseases, melanoma, advanced skin cancer and soft tissue sarcoma. He was the Director of the Upper GI and Soft Tissue Unit at the Princess Alexandra Hospital, in Brisbane, Australia from 1998 - 2023. Commencing his academic career with the University of Queensland in 1987, he progressed to be the Mayne Chair in Surgery and head of the Academy of Surgery. He is the second University of Queensland Medical graduate to be appointed to this role. His research has been focussed on the development and assessment of outcomes from minimally invasive upper GI surgery, and trials assessing the role of perioperative multidisciplinary therapy for esophageal and gastric cancer. As well he has led, or been involved with, clinical trials from phase I to III, for all stages of melanoma through his role as the Chair of the Queensland Melanoma Project. More recently he has been involved with the assessment of access to, and outcomes from, surgery for cancer in Queensland, Australia.
He has overseen the administration and development of the surgery curriculum, and the teaching, in the Academy of Surgery, in the UQ Faculty of Medicine. He was on a number of committees relevant to the implementation of the UQ MD design course. He has held various leadership and committee roles with the Royal Australasian College of Surgeons, as well as leadership roles, including the Presidency, in the Australian and New Zealand Oesophago Gastric Surgeons Association. He has also been on the committees of international organisations related to oesophageal and gastric surgery. He has published 250 articles, eight book chapters, and has been on the editorial board of a number of surgical journals.
He has been recognised for his clinical and academic roles by the award of Member of the Order of Australia (AM). The citation reads, "for service to medicine in the fields of gastro-intestinal and melanoma surgery, to medical education and to professional organisations". The Royal Australasian College of Surgeons awarded him the Sir Hugh Devine medal, for services to surgery and the community. This is the College’s highest honour. Internationally, he has been awarded an honorary fellowship of the Royal College of Surgeons of Edinburgh and recently, in the United States, he was elected as an Honarary Fellow of the American Surgical Association.
Availability
- Professor Mark Smithers is:
- Not available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
- Honorary Fellow, American Surgical Association, American Surgical Association
- Fellow, Royal Australasian College of Surgeons, Royal Australasian College of Surgeons
- Fellow, Royal College of Surgeons of Edinburgh, Royal College of Surgeons of Edinburgh
- Fellow, Royal College of Surgeons of England, Royal College of Surgeons of England
Research interests
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Cutaneous Melanoma
epidemiology, public health issues and management of all stages
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Management of Oesophageal and Gastric Cancer
Investigation and management of benign and malignant diseases of the oesophagus and the stomach.
Works
Search Professor Mark Smithers’s works on UQ eSpace
2015
Conference Publication
Complex cancer surgery for rare cancers: Volume-associated outcomes for patients undergoing pancreaticoduodenectomy in Queensland
Eden, Tania, Cossio, Danica, Dunn, Nathan, Colquist, Shoni, Guan, Tracey, Tran, Nancy and Smithers, Mark (2015). Complex cancer surgery for rare cancers: Volume-associated outcomes for patients undergoing pancreaticoduodenectomy in Queensland. COSA’s 42nd Annual Scientific Meeting. Rare Cancers: Common Goals, Hobart, Australia, 17–19 November 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/ajco.12432
2015
Conference Publication
Changing Patterns of Pancreaticoduodenectomy Surgery in Queensland
Eden, Tania, Cossio, Danica, Dunn, Nathan, Colquist, Shoni, Guan, Tracey, Tran, Nancy and Smithers, Mark (2015). Changing Patterns of Pancreaticoduodenectomy Surgery in Queensland. COSA’s 42nd Annual Scientific Meeting. Rare Cancers: Common Goals, Hobart, Australia, 17–19 November, 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/ajco.12432
2014
Journal Article
Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis
Nones, Katia, Waddell, Nicola, Wayte, Nicci, Patch, Ann-Marie, Bailey, Peter, Newell, Felicity, Holmes, Oliver, Fink, J. Lynn, Quinn, Michael C. J., Tang, Yue Hang, Lampe, Guy, Quek, Kelly, Loffler, Kelly A., Manning, Suzanne, Idrisoglu, Senel, Miller, David, Xu, Qinying, Waddell, Nick, Wilson, Peter J., Bruxner, Timothy J. C., Christ, Angelika N., Harliwong, Ivon, Nourse, Craig, Nourbakhsh, Ehsan, Anderson, Matthew, Kazakoff, Stephen, Leonard, Conrad, Wood, Scott, Simpson, Peter T. ... Barbour, Andrew P. (2014). Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis. Nature Communications, 5 (1) 6224, 5224.1-5224.9. doi: 10.1038/ncomms6224
2014
Journal Article
Supportive care needs, anxiety, depression and quality of life amongst newly diagnosed patients with localised invasive cutaneous melanoma in Queensland, Australia
Beesley, Vanessa L., Smithers, B. Mark, Khosrotehrani, Kiarash, Khatun, Modsina, O'Rourke, Peter, Hughes, Maria Celia B., Malt, Maryrose K., Zonta, Mark J., Bayley, Gerard J., Barbour, Andrew P., Brown, Lee J., D'Arcy, Justin, Allan, Christopher and Green, Adèle C. (2014). Supportive care needs, anxiety, depression and quality of life amongst newly diagnosed patients with localised invasive cutaneous melanoma in Queensland, Australia. Psycho-Oncology, 24 (7), 763-770. doi: 10.1002/pon.3718
2014
Journal Article
Phase 2 study of intralesional PV-10 in refractory metastatic melanoma
Thompson, John F., Agarwala, Sanjiv S., Smithers, B. Mark, Ross, Merrick I., Scoggins, Charles R., Coventry, Brendon J., Neuhaus, Susan J., Minor, David R., Singer, Jamie M. and Wachter, Eric A. (2014). Phase 2 study of intralesional PV-10 in refractory metastatic melanoma. Annals of Surgical Oncology, 22 (7), 2135-2142. doi: 10.1245/s10434-014-4169-5
2014
Journal Article
The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length
Iles, Mark M., Bishop, D. Timothy, Taylor, John C., Hayward, Nicholas K., Brossard, Myriam, Cust, Anne E., Dunning, Alison M., Lee, Jeffrey E., Moses, Eric K., Akslen, Lars A., AMFS Investigators, Andresen, Per A., Avril, Marie-Francoise, Azizi, Esther, Scarra, Giovanna Bianchi, Brown, Kevin M., Debniak, Tadeusz, Elder, David E., Friedman, Eitan, Ghiorzo, Paola, Gillanders, Elizabeth M., Goldstein, Alisa M., Gruis, Nelleke A., Hansson, Johan, Harland, Mark, Helsing, Per, Hocevar, Marko, Hoiom, Veronica, IBD investigators ... Visscher, Peter (2014). The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length. JNCI Journal of the National Cancer Institute, 106 (10) dju267. doi: 10.1093/jnci/dju267
2014
Journal Article
BRAF mutation status is an independent prognostic factor for resected stage IIIB and IIIC melanoma: implications for melanoma staging and adjuvant therapy
Barbour, Andrew P., Tang, Yue Hang, Armour, Nicola, Dutton-Regester, Ken, Krause, Lutz, Loffler, Kelly A., Lambie, Duncan, Burmeister, Bryan, Thomas, Janine, Smithers, B. Mark and Hayward, Nicholas K. (2014). BRAF mutation status is an independent prognostic factor for resected stage IIIB and IIIC melanoma: implications for melanoma staging and adjuvant therapy. European Journal of Cancer, 50 (15), 2668-2676. doi: 10.1016/j.ejca.2014.06.009
2014
Journal Article
Coping with esophageal cancer approaches worldwide
Cotton, Richard G. H., Langer, Rupert, Leong, Trevor, Martinek, Jan, Sewram, Vikash, Smithers, Mark, Swanson, Paul E., Qiao, You-Lin, Udagawa, Harushi, Ueno, Masaki, Wang, Meng, Wei, Wen-Qiang and White, Russell E. (2014). Coping with esophageal cancer approaches worldwide. Annals of the New York Academy of Sciences, 1325 (1), 138-158. doi: 10.1111/nyas.12522
2014
Journal Article
Controversies in the management of gastrointestinal stromal tumors
Yip, Desmond, Zalcberg, John, Ackland, Stephen, Barbour, Andrew P., Desai, Jayesh, Fox, Stephen, Kotasek, Dusan, McArthur, Grant and Smithers, B. Mark (2014). Controversies in the management of gastrointestinal stromal tumors. Asia-Pacific Journal of Clinical Oncology, 10 (3), 216-227. doi: 10.1111/ajco.12187
2014
Journal Article
Australian multi-center experience outside of the Sydney Melanoma Unit of isolated limb infusion chemotherapy for melanoma
Coventry, Brendon J., Kroon, Hidde M., Giles, Mitchell H., Henderson, Michael, Speakman, David, Wall, Mark, Barbour, Andrew, Serpell, Jonathan, Paddle, Paul, Coventry, Alexander G.J., Sullivan, Thomas and Smithers, B. Mark (2014). Australian multi-center experience outside of the Sydney Melanoma Unit of isolated limb infusion chemotherapy for melanoma. Journal of Surgical Oncology, 109 (8), 780-785. doi: 10.1002/jso.23590
2014
Conference Publication
Efficacy of intralesional Rose Bengal in patients receiving injection of all existing melanoma in phase II study PV-10-MM-02.
Agarwala, Sanjiv S., Thompson, John F., Smithers, B. Mark, Ross, Merrick I., Scoggins, Charles Raben, Coventry, Brendon J., Neuhaus, Susan J., Minor, David R., Singer, Jamie M. and Wachter, Eric Andrew (2014). Efficacy of intralesional Rose Bengal in patients receiving injection of all existing melanoma in phase II study PV-10-MM-02.. 50th Annual Meeting of the American-Society-of-Clinical-Oncology, Chicago Il, May 30-Jun 03, 2014. ALEXANDRIA: AMER SOC CLINICAL ONCOLOGY.
2014
Journal Article
Nomograms to predict recurrence and survival in stage IIIB and IIIC melanoma after therapeutic lymphadenectomy
Khosrotehrani, Kiarash, van der Ploeg, Augustinus P.T., Siskind,Victor, Hughes, Maria Celia, Wright, Annaliesa, Thomas, Janine, Barbour, Andrew, Allan, Christopher, Bayley, Gerard, Eggermont, Alexander, Verhoef, Cornelis, Smithers, B. Mark and Green, Adele C. (2014). Nomograms to predict recurrence and survival in stage IIIB and IIIC melanoma after therapeutic lymphadenectomy. European Journal of Cancer, 50 (7), 1301-1309. doi: 10.1016/j.ejca.2014.02.010
2014
Journal Article
Genome-wide analysis of esophageal adenocarcinoma yields specific copy number aberrations that correlate with prognosis
Frankel, Adam, Armour, Nicola, Nancarrow, Derek, Krause, Lutz, Hayward, Nicholas, Lampe, Guy, Smithers, B. Mark and Barbour, Andrew (2014). Genome-wide analysis of esophageal adenocarcinoma yields specific copy number aberrations that correlate with prognosis. Genes Chromosomes and Cancer, 53 (4), 324-338. doi: 10.1002/gcc.22143
2014
Journal Article
Final trial report of sentinel-node biopsy versus nodal observation in melanoma
Morton, D. L., Thompson, J. F., Cochran, A. J., Mozzillo, N., Nieweg, O. E., Roses, D. F., Hoekstra, H. J., Karakousis, C. P., Puleo, C. A., Coventry, B. J., Kashani-Sabet, M., Smithers, B. M., Paul, E., Kraybill ,W. G., McKinnon, J. G., Wang, H.-J., Elashoff, R. and Faries, M. B. (2014). Final trial report of sentinel-node biopsy versus nodal observation in melanoma. New England Journal of Medicine, 370 (7), 599-609. doi: 10.1056/NEJMoa1310460
2014
Conference Publication
Australian National Multi-Center Study of Isolated Limb Infusion Chemotherapy for Extremity Melanoma
Kroon, H. M., Coventry, B. J., Giles, M. H., Henderson, M., Smithers, B., Serpell, J. and Thompson, J. F. (2014). Australian National Multi-Center Study of Isolated Limb Infusion Chemotherapy for Extremity Melanoma. 67th Annual Cancer Symposium of the Society-of-Surgical-Oncology, Phoenix Az, Mar 12-15, 2014. New York, United States: Springer New York LLC. doi: 10.1245/s10434-013-3474-8
2014
Conference Publication
Subgroup Efficacy in Patients Receiving Intralesional Rose Bengal to All Existing Melanoma in Phase II Study Pv-10-Mm-02
Agarwala, S., Thompson, J. F., Smithers, B. M., Ross, M., Scoggins, C. R., Coventry, B. J., Neuhaus, S. J., Minor, D. R., Singer, J. M. and Wachter, E. (2014). Subgroup Efficacy in Patients Receiving Intralesional Rose Bengal to All Existing Melanoma in Phase II Study Pv-10-Mm-02. 39th European Society for Medical Oncology Congress (ESMO), Madrid, Spain, 26-30 September 2014. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/annonc/mdu344.36
2014
Journal Article
Treatment results of curative gastric resection from a specialist Australian unit: Low volume with satisfactory outcomes
Thomson I.G., Gotley D.C., Barbour A.P., Martin I., Jayasuria N., Thomas J. and Smithers B.M. (2014). Treatment results of curative gastric resection from a specialist Australian unit: Low volume with satisfactory outcomes. Gastric Cancer, 17 (1), 152-160. doi: 10.1007/s10120-013-0240-3
2014
Conference Publication
Melanoma brain metastases: the impact of nodal disease
Jackson, James E., Burmeister, Bryan H., Burmeister, Elizabeth A., Foote, Matthew C., Thomas, Janine M., Meakin, Janelle A. and Smithers, B. Mark (2014). Melanoma brain metastases: the impact of nodal disease. 54th Annual Scientific Meeting of the American-Society-for-Radiation-Oncology (ASTRO), Boston, MA United States, 28-31 October 2012. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/s10585-013-9611-8
2014
Journal Article
Changeable naevi in people at high risk for melanoma
Abbott, Nicola C. D., Pandeya, Nirmala, Ong, Natalie, McClenahan, Phil, Smithers, B. Mark, Green, Adele and Soyer, H. Peter (2014). Changeable naevi in people at high risk for melanoma. Australasian Journal of Dermatology, 56 (1), 14-18. doi: 10.1111/ajd.12181
2014
Conference Publication
Randomized, double-blind phase II trial of NY-ESO-1 ISCOMATRIX vaccine and ISCOMATRIX adjuvant alone in patients with resected stage IIc, III, or IV malignant melanoma.
Cebon, Jonathan S., McArthur, Grant A., Chen, Weisan, Davis, Ian D., Gore, Martin Eric, Thompson, John F., Millward, Michael, Findlay, Michael P. N., Dunbar, Rod, Ottensmeier, Christian H. H., Venhaus, Ralph Rudolph, Nathan, Paul D., Dalgleish, Angus George, Cerundolo, Vincenzo, Maraskovsky, Eugene, Hopkins, Wendie, Marsden, Jeremy, Smithers, B. Mark, Hersey, Peter and Evans, T. R. Jeffry (2014). Randomized, double-blind phase II trial of NY-ESO-1 ISCOMATRIX vaccine and ISCOMATRIX adjuvant alone in patients with resected stage IIc, III, or IV malignant melanoma.. 50th Annual Meeting of the American Society of Clinical Oncology, Chicago, Illinois, 30 May - 3 June 2014 . Alexandria, VA, United States: American Society of Clinical Oncology.
Supervision
Availability
- Professor Mark Smithers is:
- Not available for supervision
Supervision history
Current supervision
-
Master Philosophy
Retroperitoneal sarcoma: Impact of the patterns of care on patient outcomes in Queensland.
Principal Advisor
Other advisors: Professor Andrew Barbour
-
Master Philosophy
Trends in the regional nodal management of cutaneous melanoma.
Principal Advisor
Other advisors: Professor Peter Soyer
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Master Philosophy
Factors Influencing Anastomotic Complications after Oesophagectomy
Associate Advisor
-
Doctor Philosophy
Utilising the Multi-Disciplinary Resources at Tertiary Centres to Improve Outcomes from Pancreatic Cancer
Associate Advisor
Other advisors: Dr David Cavallucci
Completed supervision
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2020
Master Philosophy
An assessment of the impacts of centralising complex upper-gastrointestinal surgery in Queensland
Principal Advisor
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2024
Master Philosophy
In vivo Magnetic Resonance Spectroscopy (MRS) with 2-Dimensional (2D) COrrelated Spectroscopy (COSY) applied to breast cancer
Associate Advisor
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2020
Doctor Philosophy
Natural history of high-risk cutaneous primary melanoma and risk factors for disease progression
Associate Advisor
Other advisors: Professor Kiarash Khosrotehrani
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2020
Doctor Philosophy
An evaluation of the role of locoregional treatments for the management of in-transit melanoma metastases
Associate Advisor
Other advisors: Professor Peter Soyer, Associate Professor Helmut Schaider
Media
Enquiries
Contact Professor Mark Smithers directly for media enquiries about:
- Advanced endoscopic surgery
- Cancer surgery
- Endoscopic surgery
- General surgery
- Melanoma
- Surgery - cancer
- Surgery - oesophageal, gastric cancer
- Surgery - upper GI
- Upper GI surgery
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