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Professor Mark Smithers
Professor

Mark Smithers

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Overview

Background

Emeritus Professor Mark Smithers is a surgical oncologist who specialises in surgery for oesophago-gastric diseases, melanoma, advanced skin cancer and soft tissue sarcoma. He was the Director of the Upper GI and Soft Tissue Unit at the Princess Alexandra Hospital, in Brisbane, Australia from 1998 - 2023. Commencing his academic career with the University of Queensland in 1987, he progressed to be the Mayne Chair in Surgery and head of the Academy of Surgery. He is the second University of Queensland Medical graduate to be appointed to this role. His research has been focussed on the development and assessment of outcomes from minimally invasive upper GI surgery, and trials assessing the role of perioperative multidisciplinary therapy for esophageal and gastric cancer. As well he has led, or been involved with, clinical trials from phase I to III, for all stages of melanoma through his role as the Chair of the Queensland Melanoma Project. More recently he has been involved with the assessment of access to, and outcomes from, surgery for cancer in Queensland, Australia.

He has overseen the administration and development of the surgery curriculum, and the teaching, in the Academy of Surgery, in the UQ Faculty of Medicine. He was on a number of committees relevant to the implementation of the UQ MD design course. He has held various leadership and committee roles with the Royal Australasian College of Surgeons, as well as leadership roles, including the Presidency, in the Australian and New Zealand Oesophago Gastric Surgeons Association. He has also been on the committees of international organisations related to oesophageal and gastric surgery. He has published 250 articles, eight book chapters, and has been on the editorial board of a number of surgical journals.

He has been recognised for his clinical and academic roles by the award of Member of the Order of Australia (AM). The citation reads, "for service to medicine in the fields of gastro-intestinal and melanoma surgery, to medical education and to professional organisations". The Royal Australasian College of Surgeons awarded him the Sir Hugh Devine medal, for services to surgery and the community. This is the College’s highest honour. Internationally, he has been awarded an honorary fellowship of the Royal College of Surgeons of Edinburgh and recently, in the United States, he was elected as an Honarary Fellow of the American Surgical Association.

Availability

Professor Mark Smithers is:
Not available for supervision
Media expert

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Honorary Fellow, American Surgical Association, American Surgical Association
  • Fellow, Royal Australasian College of Surgeons, Royal Australasian College of Surgeons
  • Fellow, Royal College of Surgeons of Edinburgh, Royal College of Surgeons of Edinburgh
  • Fellow, Royal College of Surgeons of England, Royal College of Surgeons of England

Research interests

  • Cutaneous Melanoma

    epidemiology, public health issues and management of all stages

  • Management of Oesophageal and Gastric Cancer

    Investigation and management of benign and malignant diseases of the oesophagus and the stomach.

Works

Search Professor Mark Smithers’s works on UQ eSpace

414 works between 1983 and 2025

201 - 220 of 414 works

2015

Journal Article

Patterns of recurrence in patients with stage IIIB/C cutaneous melanoma of the head and neck following surgery with and without adjuvant radiation therapy: is isolated regional recurrence salvageable?

Barbour, Samantha, Smithers, B. Mark, Allan, Chris, Bayley, Gerard, Thomas, Janine, Foote, Matthew, Burmeister, Bryan and Barbour, Andrew P. (2015). Patterns of recurrence in patients with stage IIIB/C cutaneous melanoma of the head and neck following surgery with and without adjuvant radiation therapy: is isolated regional recurrence salvageable?. Annals of Surgical Oncology, 22 (12), 4052-4059. doi: 10.1245/s10434-014-4356-4

Patterns of recurrence in patients with stage IIIB/C cutaneous melanoma of the head and neck following surgery with and without adjuvant radiation therapy: is isolated regional recurrence salvageable?

2015

Conference Publication

Immune cell infiltrate subtypes inform on melanoma survival in stage Ib and II melanomas

Rowe, C., Tang, F., Rodero, M., Malt, M., Lambie, D., Smithers, M., Green, A. and Khosrotehrani, K. (2015). Immune cell infiltrate subtypes inform on melanoma survival in stage Ib and II melanomas. Australasian College of Dermatologists 48th Annual Scientific Meeting, Adelaide, Australia, 16 May 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12337

Immune cell infiltrate subtypes inform on melanoma survival in stage Ib and II melanomas

2015

Conference Publication

Treatment of oesophageal adenocarcinoma-what is the ideal? Results from a survey of Augis and Anzgosa members

Couper, G., Paterson-Brown, S. and Smithers, M. (2015). Treatment of oesophageal adenocarcinoma-what is the ideal? Results from a survey of Augis and Anzgosa members. 2nd Digestive Disorders Federation Conference, London, England, United Kingdom, Jun 22-25, 2015. London, United Kingdom: B M J Group. doi: 10.1136/gutjnl-2015-309861.598

Treatment of oesophageal adenocarcinoma-what is the ideal? Results from a survey of Augis and Anzgosa members

2015

Conference Publication

Complex cancer surgery for rare cancers: Volume-associated outcomes for patients undergoing pancreaticoduodenectomy in Queensland

Eden, Tania, Cossio, Danica, Dunn, Nathan, Colquist, Shoni, Guan, Tracey, Tran, Nancy and Smithers, Mark (2015). Complex cancer surgery for rare cancers: Volume-associated outcomes for patients undergoing pancreaticoduodenectomy in Queensland. COSA’s 42nd Annual Scientific Meeting. Rare Cancers: Common Goals, Hobart, Australia, 17–19 November 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/ajco.12432

Complex cancer surgery for rare cancers: Volume-associated outcomes for patients undergoing pancreaticoduodenectomy in Queensland

2015

Conference Publication

Changing Patterns of Pancreaticoduodenectomy Surgery in Queensland

Eden, Tania, Cossio, Danica, Dunn, Nathan, Colquist, Shoni, Guan, Tracey, Tran, Nancy and Smithers, Mark (2015). Changing Patterns of Pancreaticoduodenectomy Surgery in Queensland. COSA’s 42nd Annual Scientific Meeting. Rare Cancers: Common Goals, Hobart, Australia, 17–19 November, 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/ajco.12432

Changing Patterns of Pancreaticoduodenectomy Surgery in Queensland

2015

Conference Publication

Glutathione S-transferase P1 Ile105Val polymorphism: phenotypic characteristics and melanoma risk

Daley, G. M., Lee, K. J., Jagirdar, K., Smithers, B. M., Duffy, D. L., Sturm, R. A. and Soyer, H. P. (2015). Glutathione S-transferase P1 Ile105Val polymorphism: phenotypic characteristics and melanoma risk. 48th Annual Scientific Meeting of the Australasian College of Dermatologists, Adelaide SA, Australia, 16 May 2015. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12337

Glutathione S-transferase P1 Ile105Val polymorphism: phenotypic characteristics and melanoma risk

2014

Journal Article

Supportive care needs, anxiety, depression and quality of life amongst newly diagnosed patients with localised invasive cutaneous melanoma in Queensland, Australia

Beesley, Vanessa L., Smithers, B. Mark, Khosrotehrani, Kiarash, Khatun, Modsina, O'Rourke, Peter, Hughes, Maria Celia B., Malt, Maryrose K., Zonta, Mark J., Bayley, Gerard J., Barbour, Andrew P., Brown, Lee J., D'Arcy, Justin, Allan, Christopher and Green, Adèle C. (2014). Supportive care needs, anxiety, depression and quality of life amongst newly diagnosed patients with localised invasive cutaneous melanoma in Queensland, Australia. Psycho-Oncology, 24 (7), 763-770. doi: 10.1002/pon.3718

Supportive care needs, anxiety, depression and quality of life amongst newly diagnosed patients with localised invasive cutaneous melanoma in Queensland, Australia

2014

Journal Article

Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis

Nones, Katia, Waddell, Nicola, Wayte, Nicci, Patch, Ann-Marie, Bailey, Peter, Newell, Felicity, Holmes, Oliver, Fink, J. Lynn, Quinn, Michael C. J., Tang, Yue Hang, Lampe, Guy, Quek, Kelly, Loffler, Kelly A., Manning, Suzanne, Idrisoglu, Senel, Miller, David, Xu, Qinying, Waddell, Nick, Wilson, Peter J., Bruxner, Timothy J. C., Christ, Angelika N., Harliwong, Ivon, Nourse, Craig, Nourbakhsh, Ehsan, Anderson, Matthew, Kazakoff, Stephen, Leonard, Conrad, Wood, Scott, Simpson, Peter T. ... Barbour, Andrew P. (2014). Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis. Nature Communications, 5 (1) 6224, 5224.1-5224.9. doi: 10.1038/ncomms6224

Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis

2014

Journal Article

Phase 2 study of intralesional PV-10 in refractory metastatic melanoma

Thompson, John F., Agarwala, Sanjiv S., Smithers, B. Mark, Ross, Merrick I., Scoggins, Charles R., Coventry, Brendon J., Neuhaus, Susan J., Minor, David R., Singer, Jamie M. and Wachter, Eric A. (2014). Phase 2 study of intralesional PV-10 in refractory metastatic melanoma. Annals of Surgical Oncology, 22 (7), 2135-2142. doi: 10.1245/s10434-014-4169-5

Phase 2 study of intralesional PV-10 in refractory metastatic melanoma

2014

Journal Article

The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length

Iles, Mark M., Bishop, D. Timothy, Taylor, John C., Hayward, Nicholas K., Brossard, Myriam, Cust, Anne E., Dunning, Alison M., Lee, Jeffrey E., Moses, Eric K., Akslen, Lars A., AMFS Investigators, Andresen, Per A., Avril, Marie-Francoise, Azizi, Esther, Scarra, Giovanna Bianchi, Brown, Kevin M., Debniak, Tadeusz, Elder, David E., Friedman, Eitan, Ghiorzo, Paola, Gillanders, Elizabeth M., Goldstein, Alisa M., Gruis, Nelleke A., Hansson, Johan, Harland, Mark, Helsing, Per, Hocevar, Marko, Hoiom, Veronica, IBD investigators ... Visscher, Peter (2014). The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length. JNCI Journal of the National Cancer Institute, 106 (10) dju267. doi: 10.1093/jnci/dju267

The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length

2014

Journal Article

BRAF mutation status is an independent prognostic factor for resected stage IIIB and IIIC melanoma: implications for melanoma staging and adjuvant therapy

Barbour, Andrew P., Tang, Yue Hang, Armour, Nicola, Dutton-Regester, Ken, Krause, Lutz, Loffler, Kelly A., Lambie, Duncan, Burmeister, Bryan, Thomas, Janine, Smithers, B. Mark and Hayward, Nicholas K. (2014). BRAF mutation status is an independent prognostic factor for resected stage IIIB and IIIC melanoma: implications for melanoma staging and adjuvant therapy. European Journal of Cancer, 50 (15), 2668-2676. doi: 10.1016/j.ejca.2014.06.009

BRAF mutation status is an independent prognostic factor for resected stage IIIB and IIIC melanoma: implications for melanoma staging and adjuvant therapy

2014

Journal Article

Coping with esophageal cancer approaches worldwide

Cotton, Richard G. H., Langer, Rupert, Leong, Trevor, Martinek, Jan, Sewram, Vikash, Smithers, Mark, Swanson, Paul E., Qiao, You-Lin, Udagawa, Harushi, Ueno, Masaki, Wang, Meng, Wei, Wen-Qiang and White, Russell E. (2014). Coping with esophageal cancer approaches worldwide. Annals of the New York Academy of Sciences, 1325 (1), 138-158. doi: 10.1111/nyas.12522

Coping with esophageal cancer approaches worldwide

2014

Journal Article

Controversies in the management of gastrointestinal stromal tumors

Yip, Desmond, Zalcberg, John, Ackland, Stephen, Barbour, Andrew P., Desai, Jayesh, Fox, Stephen, Kotasek, Dusan, McArthur, Grant and Smithers, B. Mark (2014). Controversies in the management of gastrointestinal stromal tumors. Asia-Pacific Journal of Clinical Oncology, 10 (3), 216-227. doi: 10.1111/ajco.12187

Controversies in the management of gastrointestinal stromal tumors

2014

Journal Article

Australian multi-center experience outside of the Sydney Melanoma Unit of isolated limb infusion chemotherapy for melanoma

Coventry, Brendon J., Kroon, Hidde M., Giles, Mitchell H., Henderson, Michael, Speakman, David, Wall, Mark, Barbour, Andrew, Serpell, Jonathan, Paddle, Paul, Coventry, Alexander G.J., Sullivan, Thomas and Smithers, B. Mark (2014). Australian multi-center experience outside of the Sydney Melanoma Unit of isolated limb infusion chemotherapy for melanoma. Journal of Surgical Oncology, 109 (8), 780-785. doi: 10.1002/jso.23590

Australian multi-center experience outside of the Sydney Melanoma Unit of isolated limb infusion chemotherapy for melanoma

2014

Conference Publication

Efficacy of intralesional Rose Bengal in patients receiving injection of all existing melanoma in phase II study PV-10-MM-02.

Agarwala, Sanjiv S., Thompson, John F., Smithers, B. Mark, Ross, Merrick I., Scoggins, Charles Raben, Coventry, Brendon J., Neuhaus, Susan J., Minor, David R., Singer, Jamie M. and Wachter, Eric Andrew (2014). Efficacy of intralesional Rose Bengal in patients receiving injection of all existing melanoma in phase II study PV-10-MM-02.. 50th Annual Meeting of the American-Society-of-Clinical-Oncology, Chicago Il, May 30-Jun 03, 2014. ALEXANDRIA: AMER SOC CLINICAL ONCOLOGY.

Efficacy of intralesional Rose Bengal in patients receiving injection of all existing melanoma in phase II study PV-10-MM-02.

2014

Journal Article

Nomograms to predict recurrence and survival in stage IIIB and IIIC melanoma after therapeutic lymphadenectomy

Khosrotehrani, Kiarash, van der Ploeg, Augustinus P.T., Siskind,Victor, Hughes, Maria Celia, Wright, Annaliesa, Thomas, Janine, Barbour, Andrew, Allan, Christopher, Bayley, Gerard, Eggermont, Alexander, Verhoef, Cornelis, Smithers, B. Mark and Green, Adele C. (2014). Nomograms to predict recurrence and survival in stage IIIB and IIIC melanoma after therapeutic lymphadenectomy. European Journal of Cancer, 50 (7), 1301-1309. doi: 10.1016/j.ejca.2014.02.010

Nomograms to predict recurrence and survival in stage IIIB and IIIC melanoma after therapeutic lymphadenectomy

2014

Journal Article

Genome-wide analysis of esophageal adenocarcinoma yields specific copy number aberrations that correlate with prognosis

Frankel, Adam, Armour, Nicola, Nancarrow, Derek, Krause, Lutz, Hayward, Nicholas, Lampe, Guy, Smithers, B. Mark and Barbour, Andrew (2014). Genome-wide analysis of esophageal adenocarcinoma yields specific copy number aberrations that correlate with prognosis. Genes Chromosomes and Cancer, 53 (4), 324-338. doi: 10.1002/gcc.22143

Genome-wide analysis of esophageal adenocarcinoma yields specific copy number aberrations that correlate with prognosis

2014

Journal Article

Final trial report of sentinel-node biopsy versus nodal observation in melanoma

Morton, D. L., Thompson, J. F., Cochran, A. J., Mozzillo, N., Nieweg, O. E., Roses, D. F., Hoekstra, H. J., Karakousis, C. P., Puleo, C. A., Coventry, B. J., Kashani-Sabet, M., Smithers, B. M., Paul, E., Kraybill ,W. G., McKinnon, J. G., Wang, H.-J., Elashoff, R. and Faries, M. B. (2014). Final trial report of sentinel-node biopsy versus nodal observation in melanoma. New England Journal of Medicine, 370 (7), 599-609. doi: 10.1056/NEJMoa1310460

Final trial report of sentinel-node biopsy versus nodal observation in melanoma

2014

Journal Article

Changeable naevi in people at high risk for melanoma

Abbott, Nicola C. D., Pandeya, Nirmala, Ong, Natalie, McClenahan, Phil, Smithers, B. Mark, Green, Adele and Soyer, H. Peter (2014). Changeable naevi in people at high risk for melanoma. Australasian Journal of Dermatology, 56 (1), 14-18. doi: 10.1111/ajd.12181

Changeable naevi in people at high risk for melanoma

2014

Conference Publication

Randomized, double-blind phase II trial of NY-ESO-1 ISCOMATRIX vaccine and ISCOMATRIX adjuvant alone in patients with resected stage IIc, III, or IV malignant melanoma.

Cebon, Jonathan S., McArthur, Grant A., Chen, Weisan, Davis, Ian D., Gore, Martin Eric, Thompson, John F., Millward, Michael, Findlay, Michael P. N., Dunbar, Rod, Ottensmeier, Christian H. H., Venhaus, Ralph Rudolph, Nathan, Paul D., Dalgleish, Angus George, Cerundolo, Vincenzo, Maraskovsky, Eugene, Hopkins, Wendie, Marsden, Jeremy, Smithers, B. Mark, Hersey, Peter and Evans, T. R. Jeffry (2014). Randomized, double-blind phase II trial of NY-ESO-1 ISCOMATRIX vaccine and ISCOMATRIX adjuvant alone in patients with resected stage IIc, III, or IV malignant melanoma.. 50th Annual Meeting of the American Society of Clinical Oncology, Chicago, Illinois, 30 May - 3 June 2014 . Alexandria, VA, United States: American Society of Clinical Oncology.

Randomized, double-blind phase II trial of NY-ESO-1 ISCOMATRIX vaccine and ISCOMATRIX adjuvant alone in patients with resected stage IIc, III, or IV malignant melanoma.

Funding

Current funding

  • 2024 - 2025
    Optimising the Diagnosis and Management of Unilateral Primary Aldosteronism (MSH SERTA Grant led by Metro South HHS)
    Metro South Hospital and Health Service
    Open grant
  • 2023 - 2026
    iCare - An interactive online portal to improve health and wellbeing for people living with complex cancers, and their informal carers: a Phase II randomised controlled trial (Ex led Deakin MRFF CTA)
    Deakin University
    Open grant
  • 2021 - 2026
    AGITG TOP GEAR: A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer (CTCS: led by USyd)
    University of Sydney
    Open grant
  • 2019 - 2026
    A Randomised Phase II Trial of Adjuvant Avelumab in Patients with Early Stage Merkel Cell Carcinoma
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2019 - 2025
    Melanoma Margins Trial II - A Phase III, Multi-centre Randomised Controlled Trial Investigating 1cm v 2cm Wide Surgical Excision Margins.. (NHMRC Project Grant led by the University of Melbourne).
    University of Melbourne
    Open grant

Past funding

  • 2021 - 2024
    Advanced technological approach to predicting survival in patients diagnosed with locally invasive cutaneous melanoma
    Cancer Council Queensland
    Open grant
  • 2021 - 2024
    Establishing Australia's First Familial Melanoma Clinic (MSH RSS SERTA Program Grant led by Metro South Hospital and Health Service)
    Metro South Hospital and Health Service
    Open grant
  • 2020 - 2021
    Cancer Evolution Biobank
    PA Research Foundation
    Open grant
  • 2017 - 2019
    Predictors of mortality in thin melanomas
    Cancer Council Queensland
    Open grant
  • 2013 - 2015
    To identify and assess markers of prognosis, response and resistance to therapy in patients with Stage III metastatic melanoma
    Cancer Bequest Fund
    Open grant
  • 2011
    DOCetaxel with or without radiation Therapy for resectable Oesophageal adenocarcinoma based on early PET Response to induction chemotherapy (DOCTOR)
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Effects of nevogenesis susceptibility genes and phenotypic correlation with dermoscopic characteristics of nevi
    NHMRC Project Grant
    Open grant
  • 2010 - 2014
    Comparison of pre- and perioperative immunonutrition in patients undergoing surgical resection of oesophageal cancer (NHMRC Project Grant administered by the University of Adelaide)
    University of Adelaide
    Open grant
  • 2001 - 2002
    The epidemiology of oesophageal cancer: Risk and molecular markers
    Queensland Cancer Fund
    Open grant
  • 2000
    The role of TAP and MHC class I expression in the response to melanoma immunotherapy using autologous dendritic cells
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1999 - 2000
    A phase II clinical trial in patients with metastatic melanoma comparing autologous dendritic cells pulsed with autologous tumour peptides and melanoma associated peptides linked to the endoplasmic re
    Queensland Cancer Fund
    Open grant
  • 1998
    A Phase I/II Clinical Trial to Test Tumour Vaccines Comprising with Protein or Autologous Tumour Antigen Autologous Dandritic Cells Generated in a Closed Bag System Pulsed
    Mayne Bequest Fund
    Open grant
  • 1998
    Isolated limb infusion of melphalan and microdialysis technique in treatment of recurrent malignant melanoma
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1998 - 2000
    Treatment of Recurrent Malignant Melanoma by Limb Infusion of Cytotoxic Drugs and Other Techniques
    NHMRC Project Grant
    Open grant
  • 1997 - 1998
    Pharmacokinetics of tumour necrosis factor (TNF) in isolated rat hindlimb perfusions and infusions related to melanoma therapy
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1996 - 1997
    Targeting and monitoring drug delivery in specific tissues using iontophoresis and microdialysis
    Quality Funds Round 3
    Open grant
  • 1995 - 1997
    Pharmacokinetics of melphalan in isolated limb perfusion and infusion
    Queensland Cancer Fund
    Open grant

Supervision

Availability

Professor Mark Smithers is:
Not available for supervision

Supervision history

Current supervision

  • Master Philosophy

    Assessment of the impact of treating service characteristics on surgical and oncological outcomes for patients with Retroperitoneal and Inguinal Sarcomas in Queensland

    Principal Advisor

    Other advisors: Professor Andrew Barbour

  • Master Philosophy

    Factors Influencing Anastomotic Complications after Oesophagectomy

    Associate Advisor

  • Doctor Philosophy

    New tools for the multi-modal evaluation of pancreatic cancer and its precursor neoplasms.

    Associate Advisor

    Other advisors: Dr David Cavallucci

Completed supervision

Media

Enquiries

Contact Professor Mark Smithers directly for media enquiries about:

  • Advanced endoscopic surgery
  • Cancer surgery
  • Endoscopic surgery
  • General surgery
  • Melanoma
  • Surgery - cancer
  • Surgery - oesophageal, gastric cancer
  • Surgery - upper GI
  • Upper GI surgery

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