
Overview
Background
Emeritus Professor Mark Smithers is a surgical oncologist who specialises in surgery for oesophago-gastric diseases, melanoma, advanced skin cancer and soft tissue sarcoma. He was the Director of the Upper GI and Soft Tissue Unit at the Princess Alexandra Hospital, in Brisbane, Australia from 1998 - 2023. Commencing his academic career with the University of Queensland in 1987, he progressed to be the Mayne Chair in Surgery and head of the Academy of Surgery. He is the second University of Queensland Medical graduate to be appointed to this role. His research has been focussed on the development and assessment of outcomes from minimally invasive upper GI surgery, and trials assessing the role of perioperative multidisciplinary therapy for esophageal and gastric cancer. As well he has led, or been involved with, clinical trials from phase I to III, for all stages of melanoma through his role as the Chair of the Queensland Melanoma Project. More recently he has been involved with the assessment of access to, and outcomes from, surgery for cancer in Queensland, Australia.
He has overseen the administration and development of the surgery curriculum, and the teaching, in the Academy of Surgery, in the UQ Faculty of Medicine. He was on a number of committees relevant to the implementation of the UQ MD design course. He has held various leadership and committee roles with the Royal Australasian College of Surgeons, as well as leadership roles, including the Presidency, in the Australian and New Zealand Oesophago Gastric Surgeons Association. He has also been on the committees of international organisations related to oesophageal and gastric surgery. He has published 250 articles, eight book chapters, and has been on the editorial board of a number of surgical journals.
He has been recognised for his clinical and academic roles by the award of Member of the Order of Australia (AM). The citation reads, "for service to medicine in the fields of gastro-intestinal and melanoma surgery, to medical education and to professional organisations". The Royal Australasian College of Surgeons awarded him the Sir Hugh Devine medal, for services to surgery and the community. This is the College’s highest honour. Internationally, he has been awarded an honorary fellowship of the Royal College of Surgeons of Edinburgh and recently, in the United States, he was elected as an Honarary Fellow of the American Surgical Association.
Availability
- Professor Mark Smithers is:
- Not available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
- Honorary Fellow, American Surgical Association, American Surgical Association
- Fellow, Royal Australasian College of Surgeons, Royal Australasian College of Surgeons
- Fellow, Royal College of Surgeons of Edinburgh, Royal College of Surgeons of Edinburgh
- Fellow, Royal College of Surgeons of England, Royal College of Surgeons of England
Research interests
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Cutaneous Melanoma
epidemiology, public health issues and management of all stages
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Management of Oesophageal and Gastric Cancer
Investigation and management of benign and malignant diseases of the oesophagus and the stomach.
Works
Search Professor Mark Smithers’s works on UQ eSpace
2018
Journal Article
Patterns of failure following dose-escalated chemoradiotherapy for fluorodeoxyglucose positron emission tomography staged squamous cell carcinoma of the oesophagus
Effeney, R., Shaw, T., Burmeister, B. H., Burmeister, E., Harvey, J., Mai, G. T., Thomas, J., Barbour, A. P., Smithers, B. M. and Pryor, D. I. (2018). Patterns of failure following dose-escalated chemoradiotherapy for fluorodeoxyglucose positron emission tomography staged squamous cell carcinoma of the oesophagus. Clinical Oncology, 30 (10), 642-649. doi: 10.1016/j.clon.2018.06.011
2018
Journal Article
MAGE-A3 immunotherapeutic as adjuvant therapy for patients with resected, MAGE-A3-positive, stage III melanoma (DERMA): a double-blind, randomised, placebo-controlled, phase 3 trial
Dreno, Brigitte, Thompson, John F., Smithers, Bernard Mark, Santinami, Mario, Jouary, Thomas, Gutzmer, Ralf, Levchenko, Evgeny, Rutkowski, Piotr, Grob, Jean-Jacques, Korovin, Sergii, Drucis, Kamil, Grange, Florent, Machet, Laurent, Hersey, Peter, Krajsova, Ivana, Testori, Alessandro, Conry, Robert, Guillot, Bernard, Kruit, Wim H. J., Demidov, Lev, Thompson, John A., Bondarenko, Igor, Jaroszek, Jaroslaw, Puig, Susana, Cinat, Gabriela, Hauschild, Axel, Goeman, Jelle J., van Houwelingen, Hans C., Ulloa-Montoya, Fernando ... Kirkwood, John M. (2018). MAGE-A3 immunotherapeutic as adjuvant therapy for patients with resected, MAGE-A3-positive, stage III melanoma (DERMA): a double-blind, randomised, placebo-controlled, phase 3 trial. The Lancet Oncology, 19 (7), 916-929. doi: 10.1016/S1470-2045(18)30254-7
2018
Journal Article
Neoadjuvant chemotherapy or chemoradiotherapy for adenocarcinoma of the esophagus
Visser, Els, Edholm, David, Smithers, B. Mark, Thomson, Iain G., Burmeister, Bryan H., Walpole, Euan T., Gotley, David C., Joubert, Warren L., Atkinson, Victoria, Mai, Tao, Thomas, Janine M. and Barbour, Andrew P. (2018). Neoadjuvant chemotherapy or chemoradiotherapy for adenocarcinoma of the esophagus. Journal of Surgical Oncology, 117 (8), 1687-1696. doi: 10.1002/jso.25089
2018
Journal Article
Clustering of prevention behaviours in patients with high-risk primary melanoma
Green, Adèle C., Hughes, Maria Celia B., von Schuckmann, Lena A., Khosrotehrani, Kiarash and Mark Smithers, B. (2018). Clustering of prevention behaviours in patients with high-risk primary melanoma. Psycho-Oncology, 27 (5), 1442-1449. doi: 10.1002/pon.4565
2018
Journal Article
Neoadjuvant therapy reduces cardiopulmunary function in patients undegoing oesophagectomy
Thomson, Iain G., Wallen, Matthew P., Hall, Adrian, Ferris, Rebekah, Gotley, David C., Barbour, Andrew P., Lee, Andrew, Thomas, Janine and Smithers, Bernard M. (2018). Neoadjuvant therapy reduces cardiopulmunary function in patients undegoing oesophagectomy. International Journal of Surgery, 53, 86-92. doi: 10.1016/j.ijsu.2018.03.030
2018
Journal Article
Intralesional PV-10 for the treatment of in-transit melanoma metastases-Results of a prospective, non-randomized, single center study
Read, Tavis A., Smith, Aaron, Thomas, Janine, David, Michael, Foote, Matthew, Wagels, Michael, Barbour, Andrew and Smithers, B. Mark (2018). Intralesional PV-10 for the treatment of in-transit melanoma metastases-Results of a prospective, non-randomized, single center study. Journal of Surgical Oncology, 117 (4), 579-587. doi: 10.1002/jso.24921
2018
Journal Article
Future-proofing academic surgery in Australia and New Zealand: the Annual RACS Joint Academic Meeting
Aitken, Sarah, Lee, James and Smithers, Mark (2018). Future-proofing academic surgery in Australia and New Zealand: the Annual RACS Joint Academic Meeting. ANZ Journal of Surgery , 88 (3), 130-131. doi: 10.1111/ans.14372
2018
Journal Article
An investigation into the nutritional status of patients receiving an Enhanced Recovery After Surgery (ERAS) protocol versus standard care following Oesophagectomy
Benton, Katie, Thomson, Iain, Isenring, Elisabeth, Mark Smithers, B. and Agarwal, Ekta (2018). An investigation into the nutritional status of patients receiving an Enhanced Recovery After Surgery (ERAS) protocol versus standard care following Oesophagectomy. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer, 26 (6), 1-6. doi: 10.1007/s00520-017-4038-4
2018
Conference Publication
Effect of a previous diagnosis of primary invasive melanoma on the progression of subsequent primary invasive melanoma
Chong, S., Green, A., Rowe, C., Malt, M., Brown, S., Smithers, M. and Khosrotehrani, K. (2018). Effect of a previous diagnosis of primary invasive melanoma on the progression of subsequent primary invasive melanoma. Australasian College of Dermatologists, 51st Annual Scientific Meeting, Gold Coast, QLD, Australia, 19-22 May 2018. Richmond, VIC, Australia: Wiley-Blackwell Publishing. doi: 10.1111/ajd.17_12815
2018
Conference Publication
Oncolytic immunotherapy with PV-10
Agarwala, Sanjiv, Smithers, B. Mark, Haushild, Axel, Ascierto, Paolo A. and Watcher, Eric (2018). Oncolytic immunotherapy with PV-10. Immunotherapy Bridge 2017, Naples, Italy, 29 November - 2 December 2017. London, United Kingdom: BioMed Central. doi: 10.1186/s12967-017-1352-z
2018
Conference Publication
Overview of melanoma genetics for dermatologists and results of a genetic analysis of multiple primary melanoma patients
MoMeniman, E., Sturm, R., Duffy, D., Jagirdar, K., Lee, K., Finnane, A., De'Ambrosis, B., Smithers, M. and Soyer, H. P. (2018). Overview of melanoma genetics for dermatologists and results of a genetic analysis of multiple primary melanoma patients. Australasian College of Dermatologists, 51st Annual Scientific Meeting, Gold Coast, Australia, 19–22 May 2018. Richmond, VIC, Australia: Wiley-Blackwell. doi: 10.1111/ajd.14_12815
2018
Book Chapter
Thoracoscopic and laparoscopic esophagectomy
Smithers, B. Mark, Thomson, Iain and Barbour, Andrew (2018). Thoracoscopic and laparoscopic esophagectomy. Operative thoracic surgery. (pp. 377-386) edited by Larry R. Kaiser, Sarah K. Thompson and Glyn G. Jamieson. Boca Raton, FL, United States: CRC Press. doi: 10.1201/9781315113777
2018
Conference Publication
Neoadjuvant therapy for esophageal adenocarcinoma: a propensity score-matched comparison of paclitaxel and carboplatin chemoradiotherapy with cisplatin and 5-fluoruracil-based chemo- or chemoradiotherapy
Barbour, A. P., Brosda, S., Wijnhoven, B., van Hootgem, S., Lanschot, J. J. B., Barbour, S., Lagarde, S., Krause, L., Pryor, D., Thomas, J., Walpole, E. T., van der Gaast, A. and Smithers, M. (2018). Neoadjuvant therapy for esophageal adenocarcinoma: a propensity score-matched comparison of paclitaxel and carboplatin chemoradiotherapy with cisplatin and 5-fluoruracil-based chemo- or chemoradiotherapy. 43rd ESMO Congress (ESMO), Munich, Germany, 19-23 October 2018. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/annonc/mdy282.015
2017
Journal Article
Benchmarking complications associated with esophagectomy
Low, Donald E., Kuppusamy, Madhan Kumar, Alderson, Derek, Cecconello, Ivan, Chang, Andrew C, Darling, Gail, Davies, Andrew, D'Journo, Xavier Benoit, Gisbertz, Suzanne S, Griffin, S Michael, Hardwick, Richard, Hoelscher, Arnulf, Hofstetter, Wayne, Jobe, Blair, Kitagawa, Yuko, Law, Simon, Mariette, Christophe, Maynard, Nick, Morse, Christopher R, Nafteux, Philippe, Pera, Manuel, Pramesh, C S, Puig, Sonia, Reynolds, John V, Schroeder, Wolfgang, Smithers, Mark and Wijnhoven, B P L (2017). Benchmarking complications associated with esophagectomy. Annals of surgery, 269 (2), 1-298. doi: 10.1097/SLA.0000000000002611
2017
Journal Article
Generational shift in melanoma incidence and mortality in Queensland, Australia, 1995-2014
Aitken, Joanne F, Youlden, Danny R, Baade, Peter D, Soyer, H Peter, Green, Adèle C and Smithers, B Mark (2017). Generational shift in melanoma incidence and mortality in Queensland, Australia, 1995-2014. International journal of cancer, 142 (8), 1528-1535. doi: 10.1002/ijc.31141
2017
Journal Article
Whither melanoma in Australia?
Smithers, B. Mark, Dunn, Jeff and Soyer, H. Peter (2017). Whither melanoma in Australia?. Medical Journal of Australia, 207 (8), 330-331. doi: 10.5694/mja17.00740
2017
Journal Article
Protocol for the TIDAL Melanoma Study: topical imiquimod or diphenylcyclopropenone for the management of cutaneous in-transit melanoma metastases-a phase II, single centre, randomised, pilot study
Read, Tavis, Webber, Scott, Thomas, Janine, Wagels, Michael, Schaider, Helmut, Soyer, H. Peter and Smithers, B. Mark (2017). Protocol for the TIDAL Melanoma Study: topical imiquimod or diphenylcyclopropenone for the management of cutaneous in-transit melanoma metastases-a phase II, single centre, randomised, pilot study. BMJ Open, 7 (10) e016816, 1-8. doi: 10.1136/bmjopen-2017-016816
2017
Journal Article
Associations of statins and diabetes with diagnosis of ulcerated cutaneous melanoma
von Schuckmann, Lena A., Smith, David, Hughes, Maria Celia B., Malt, Maryrose, van der Pols, Jolieke C., Khosrotehrani, Kiarash, Smithers, Bernard M. and Green, Adele C. (2017). Associations of statins and diabetes with diagnosis of ulcerated cutaneous melanoma. Journal of Investigative Dermatology, 137 (12), 2599-2605. doi: 10.1016/j.jid.2017.07.836
2017
Journal Article
Safety and Efficacy of Isolated Limb Infusion Chemotherapy for Advanced Locoregional Melanoma in Elderly Patients: An Australian Multicenter Study
Kroon, Hidde M., Coventry, Brendon J., Giles, Mitchell H., Henderson, Michael A., Speakman, David, Wall, Mark, Barbour, Andrew, Serpell, Jonathan, Paddle, Paul, Smithers, Bernard M. and Thompson, John F. (2017). Safety and Efficacy of Isolated Limb Infusion Chemotherapy for Advanced Locoregional Melanoma in Elderly Patients: An Australian Multicenter Study. Annals of Surgical Oncology, 24 (11), 3245-3251. doi: 10.1245/s10434-017-6046-5
2017
Journal Article
The impact of smoking on sentinel node metastasis of primary cutaneous melanoma
Jones, Maris S., Jones, Peter C., Stern, Stacey L., Elashoff, David, Hoon, Dave S. B., Thompson, John, Mozzillo, Nicola, Nieweg, Omgo E., Noyes, Dirk, Hoekstra, Harald J., Zager, Jonathan S., Roses, Daniel F., Testori, Alessandro, Coventry, Brendon J., Smithers, Mark B., Andtbacka, Robert, Agnese, Doreen, Schultz, Erwin, Hsueh, Eddy C., Kelley, Mark, Schneebaum, Schlomo, Jacobs, Lisa, Bowles, Tawnya, Kashani-Sabet, Mohammed, Johnson, Douglas and Faries, Mark B. (2017). The impact of smoking on sentinel node metastasis of primary cutaneous melanoma. Annals of Surgical Oncology, 24 (8), 2089-2094. doi: 10.1245/s10434-017-5775-9
Supervision
Availability
- Professor Mark Smithers is:
- Not available for supervision
Supervision history
Current supervision
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Master Philosophy
Trends in the regional nodal management of cutaneous melanoma.
Principal Advisor
Other advisors: Professor Peter Soyer
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Master Philosophy
Retroperitoneal sarcoma: Impact of the patterns of care on patient outcomes in Queensland.
Principal Advisor
Other advisors: Professor Andrew Barbour
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Master Philosophy
Factors Influencing Anastomotic Complications after Oesophagectomy
Associate Advisor
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Doctor Philosophy
Utilising the Multi-Disciplinary Resources at Tertiary Centres to Improve Outcomes from Pancreatic Cancer
Associate Advisor
Other advisors: Dr David Cavallucci
Completed supervision
-
2020
Master Philosophy
An assessment of the impacts of centralising complex upper-gastrointestinal surgery in Queensland
Principal Advisor
-
2024
Master Philosophy
In vivo Magnetic Resonance Spectroscopy (MRS) with 2-Dimensional (2D) COrrelated Spectroscopy (COSY) applied to breast cancer
Associate Advisor
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2020
Doctor Philosophy
Natural history of high-risk cutaneous primary melanoma and risk factors for disease progression
Associate Advisor
Other advisors: Professor Kiarash Khosrotehrani
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2020
Doctor Philosophy
An evaluation of the role of locoregional treatments for the management of in-transit melanoma metastases
Associate Advisor
Other advisors: Professor Peter Soyer, Associate Professor Helmut Schaider
Media
Enquiries
Contact Professor Mark Smithers directly for media enquiries about:
- Advanced endoscopic surgery
- Cancer surgery
- Endoscopic surgery
- General surgery
- Melanoma
- Surgery - cancer
- Surgery - oesophageal, gastric cancer
- Surgery - upper GI
- Upper GI surgery
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