Overview
Background
Emeritus Professor Mark Smithers is a surgical oncologist who specialises in surgery for oesophago-gastric diseases, melanoma, advanced skin cancer and soft tissue sarcoma. He was the Director of the Upper GI and Soft Tissue Unit at the Princess Alexandra Hospital, in Brisbane, Australia from 1998 - 2023. Commencing his academic career with the University of Queensland in 1987, he progressed to be the Mayne Chair in Surgery and head of the Academy of Surgery. He is the second University of Queensland Medical graduate to be appointed to this role. His research has been focussed on the development and assessment of outcomes from minimally invasive upper GI surgery, and trials assessing the role of perioperative multidisciplinary therapy for esophageal and gastric cancer. As well he has led, or been involved with, clinical trials from phase I to III, for all stages of melanoma through his role as the Chair of the Queensland Melanoma Project. More recently he has been involved with the assessment of access to, and outcomes from, surgery for cancer in Queensland, Australia.
He has overseen the administration and development of the surgery curriculum, and the teaching, in the Academy of Surgery, in the UQ Faculty of Medicine. He was on a number of committees relevant to the implementation of the UQ MD design course. He has held various leadership and committee roles with the Royal Australasian College of Surgeons, as well as leadership roles, including the Presidency, in the Australian and New Zealand Oesophago Gastric Surgeons Association. He has also been on the committees of international organisations related to oesophageal and gastric surgery. He has published 250 articles, eight book chapters, and has been on the editorial board of a number of surgical journals.
He has been recognised for his clinical and academic roles by the award of Member of the Order of Australia (AM). The citation reads, "for service to medicine in the fields of gastro-intestinal and melanoma surgery, to medical education and to professional organisations". The Royal Australasian College of Surgeons awarded him the Sir Hugh Devine medal, for services to surgery and the community. This is the College’s highest honour. Internationally, he has been awarded an honorary fellowship of the Royal College of Surgeons of Edinburgh and recently, in the United States, he was elected as an Honarary Fellow of the American Surgical Association.
Availability
- Professor Mark Smithers is:
- Not available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
- Honorary Fellow, American Surgical Association, American Surgical Association
- Fellow, Royal Australasian College of Surgeons, Royal Australasian College of Surgeons
- Fellow, Royal College of Surgeons of Edinburgh, Royal College of Surgeons of Edinburgh
- Fellow, Royal College of Surgeons of England, Royal College of Surgeons of England
Research interests
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Cutaneous Melanoma
epidemiology, public health issues and management of all stages
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Management of Oesophageal and Gastric Cancer
Investigation and management of benign and malignant diseases of the oesophagus and the stomach.
Works
Search Professor Mark Smithers’s works on UQ eSpace
2024
Journal Article
Complications and adverse events in lymphadenectomy of the inguinal area: worldwide expert consensus
Sotelo, René, Sayegh, Aref S., Medina, Luis G., Perez, Laura C., La Riva, Anibal, Eppler, Michael B., Gaona, José, Tobias-Machado, Marcos, Spiess, Philippe E., Pettaway, Curtis A., Lima Pompeo, Antonio Carlos, Lima Mattos, Pablo Aloisio, Wilson, Timothy G., Villoldo, Gustavo M., Chung, Eric, Samaniego, Aldo, Ornellas, Antonio Augusto, Pinheiro, Vladimir, Brazão, Eder S., Subira-Rios, David, Koifman, Leandro, Zequi, Stênio de Cassio, Pontillo Z, Humberto M., Rodrigues Calixto, José de Ribamar, Campos Silva, Rafael, Smithers, B. Mark, Garzon, Simone, Haase, Oliver, Sommariva, Antonio ... Cacciamani, Giovanni E. (2024). Complications and adverse events in lymphadenectomy of the inguinal area: worldwide expert consensus. BJS Open, 8 (4) zrae056, 1-8. doi: 10.1093/bjsopen/zrae056
2024
Journal Article
Lymphatic expression of the proliferation marker Ki67 is linked to sentinel node positivity, recurrence and mortality in primary cutaneous melanoma
Tan, Samuel X., Chong, Sharene, Rowe, Casey, Galbraith, Jack, Dight, James, Zhou, Chenhao, Malt, Maryrose, Smithers, Bernard Mark and Khosrotehrani, Kiarash (2024). Lymphatic expression of the proliferation marker Ki67 is linked to sentinel node positivity, recurrence and mortality in primary cutaneous melanoma. Experimental Dermatology, 33 (3) e15041, 1-7. doi: 10.1111/exd.15041
2024
Journal Article
iCare – a self-directed, interactive online program to improve health and wellbeing for people living with upper gastrointestinal or hepato-pancreato-biliary cancers, and their informal carers: the study protocol for a Phase II randomised controlled trial
Livingston, Patricia M., Winter, Natalie, Ugalde, Anna, Orellana, Liliana, Mikocka-Walus, Antonina, Jefford, Michael, Zalcberg, John, Orford, Neil, Hutchinson, Alison M., Barbour, Andrew, Kiss, Nicole, Smithers, Bernard Mark, Watson, David I., McCaffrey, Nikki and White, Victoria (2024). iCare – a self-directed, interactive online program to improve health and wellbeing for people living with upper gastrointestinal or hepato-pancreato-biliary cancers, and their informal carers: the study protocol for a Phase II randomised controlled trial. BMC Cancer, 24 (1) 144. doi: 10.1186/s12885-024-11861-2
2024
Journal Article
Novel Textbook Outcomes following emergency laparotomy: Delphi exercise
Naumann, David N., Bhangu, Aneel, Brooks, Adam, Martin, Matthew, Cotton, Bryan A., Khan, Mansoor, Midwinter, Mark J., Pearce, Lyndsay, Bowley, Douglas M., Holcomb, John B., Griffiths, Ewen A., Smithers, Mark (BEACON Collaborative group member) and BEACON Collaborative (2024). Novel Textbook Outcomes following emergency laparotomy: Delphi exercise. BJS Open, 8 (1) zrad145. doi: 10.1093/bjsopen/zrad145
2024
Journal Article
Automated scoring of tumour infiltrating lymphocytes informs risk of death from thin melanoma: a nested case-case study
Tan, Samuel X., Aung, Thazin N., Claeson, Magdalena, Acs, Balazs, Zhou, Chenhao, Brown, Susan, Lambie, Duncan, Baade, Peter D., Pandeya, Nirmala, Soyer, H. Peter, Smithers, B. Mark, Whiteman, David C., Rimm, David L. and Khosrotehrani, Kiarash (2024). Automated scoring of tumour infiltrating lymphocytes informs risk of death from thin melanoma: a nested case-case study. Journal of the American Academy of Dermatology, 90 (1), 179-182. doi: 10.1016/j.jaad.2023.09.026
2023
Journal Article
pSTAT5 is associated with improved survival in patients with thick or ulcerated primary cutaneous melanoma
Tan, Samuel X., Chong, Sharene, Rowe, Casey, Claeson, Magdalena, Dight, James, Zhou, Chenhao, Rodero, Mathieu P., Malt, Maryrose, Smithers, B. Mark, Green, Adele C. and Khosrotehrani, Kiarash (2023). pSTAT5 is associated with improved survival in patients with thick or ulcerated primary cutaneous melanoma. Melanoma Research, 33 (6), 506-513. doi: 10.1097/cmr.0000000000000915
2023
Journal Article
PHYSIO+++: protocol for a pilot randomised controlled trial assessing the feasibility of physiotherapist-led non-invasive ventilation for patients with hypoxaemia following abdominal surgery
Hackett, Claire, Denehy, Linda, Kruger, Peter, Ripley, Nina, Reid, Natasha, Smithers, B. Mark, Walker, Rachel M., Hope, Louise and Boden, Ianthe (2023). PHYSIO+++: protocol for a pilot randomised controlled trial assessing the feasibility of physiotherapist-led non-invasive ventilation for patients with hypoxaemia following abdominal surgery. BMJ Open, 13 (12) e078175, 1-10. doi: 10.1136/bmjopen-2023-078175
2023
Journal Article
Prognosis of naevoid melanomas
Cook, Martin G., Grant, Megan, Sylvestre, Yvonne, Akhras, Victoria, Khosrotehrani, Kiarash, Hughes, Maria Celia B, Malt, Maryrose, Smithers, B. Mark, Massi, Daniela, De Giorgi, Vincenzo, Marais, Richard and Green, Adele C. (2023). Prognosis of naevoid melanomas. Pathology - Research and Practice, 251 154881, 154881. doi: 10.1016/j.prp.2023.154881
2023
Journal Article
ctDNA: a promising biomarker for predicting recurrence in BRAF-negative melanoma patients
Aoude, Lauren G., Brosda, Sandra, Ng, Jessica, Lonie, James M., Belle, Clemence J., Patel, Kalpana, Koufariotis, Lambros T., Wood, Scott, Atkinson, Victoria, Smithers, B. Mark, Pearson, John V., Waddell, Nicola, Barbour, Andrew P. and Bonazzi, Vanessa F. (2023). ctDNA: a promising biomarker for predicting recurrence in BRAF-negative melanoma patients. Journal of Molecular Diagnostics, 25 (10), 771-781. doi: 10.1016/j.jmoldx.2023.06.014
2023
Conference Publication
Gastric filling in neoadjuvant chemoradiotherapy for oesophageal cancer
Hwang, Yang, Chen, Beini, Mai, Tao, Lee, Dominique, Thomson, Iain, Smithers, Mark and Frankel, Adam (2023). Gastric filling in neoadjuvant chemoradiotherapy for oesophageal cancer. 19th ISDE World Congress for Esophageal Diseases, Toronto, ON, Canada, 8-10 September 2023. Los Angeles, CA, United States: John Wiley & Sons. doi: 10.1093/dote/doad052.183
2023
Journal Article
Massive mixed epithelial-stromal tumour of seminal vesicle requiring challenging abdominoperineal resection: a case report and review of literature
Yu, Zirong, Choy, Kay Tai, Ong, Ferdinand, Williams, Evan, Naidu, Sanjeev, Smithers, Bernard M., Gurung, Anjan and Lutton, Nicholas (2023). Massive mixed epithelial-stromal tumour of seminal vesicle requiring challenging abdominoperineal resection: a case report and review of literature. Journal of Surgical Case Reports, 2023 (8) rjad490, 1-3. doi: 10.1093/jscr/rjad490
2023
Journal Article
Individual participant data network meta-analysis of neoadjuvant chemotherapy or chemoradiotherapy in esophageal or gastroesophageal junction carcinoma
Faron, Matthieu, Cheugoua-Zanetsie, Maurice, Tierney, Jayne, Thirion, Pierre, Nankivell, Matthew, Winter, Kathryn, Yang, Hong, Shapiro, Joel, Vernerey, Dewi, Smithers, B. Mark, Walsh, Thomas, Piessen, Guillaume, Nilsson, Magnus, Boonstra, Jurjen, Ychou, Marc, Law, Simon, Cunningham, David, de Vathaire, Florent, Stahl, Michael, Urba, Susan, Valmasoni, Michele, Williaume, Danièle, Thomas, Janine, Lordick, Florian, Tepper, Joel, Roth, Jack, Gebski, Val, Burmeister, Bryan, Paoletti, Xavier ... on behalf of the MANATEC-02 Collaborative Group (2023). Individual participant data network meta-analysis of neoadjuvant chemotherapy or chemoradiotherapy in esophageal or gastroesophageal junction carcinoma. Journal of Clinical Oncology, 41 (28) jco2202279, 4535-4547. doi: 10.1200/jco.22.02279
2023
Journal Article
Multi-omic features of oesophageal adenocarcinoma in patients treated with preoperative neoadjuvant therapy
M. Naeini, Marjan, Newell, Felicity, Aoude, Lauren G., Bonazzi, Vanessa F., Patel, Kalpana, Lampe, Guy, Koufariotis, Lambros T., Lakis, Vanessa, Addala, Venkateswar, Kondrashova, Olga, Johnston, Rebecca L., Sharma, Sowmya, Brosda, Sandra, Holmes, Oliver, Leonard, Conrad, Wood, Scott, Xu, Qinying, Thomas, Janine, Walpole, Euan, Tao Mai, G., Ackland, Stephen P., Martin, Jarad, Burge, Matthew, Finch, Robert, Karapetis, Christos S., Shannon, Jenny, Nott, Louise, Bohmer, Robert, Wilson, Kate ... Waddell, Nicola (2023). Multi-omic features of oesophageal adenocarcinoma in patients treated with preoperative neoadjuvant therapy. Nature Communications, 14 (1) 3155, 3155. doi: 10.1038/s41467-023-38891-x
2023
Journal Article
Quality indicators in surgery for cancer: not just the operation
Smithers, B. Mark (2023). Quality indicators in surgery for cancer: not just the operation. ANZ Journal of Surgery, 93 (7-8), 1765-1767. doi: 10.1111/ans.18516
2023
Journal Article
The association between <scp>BRAF‐V600E</scp> mutations and death from thin (≤1.00 mm) melanomas: a nested case‐case study from Queensland, Australia
Claeson, M., Tan, S. X., Lambie, D., Brown, S., Walsh, M. D., Baade, P. D., Pandeya, N., Whitehead, K. J., Soyer, H. P., Smithers, B. M., Whiteman, D. C. and Khosrotehrani, K. (2023). The association between BRAF‐V600E mutations and death from thin (≤1.00 mm) melanomas: a nested case‐case study from Queensland, Australia. Journal of the European Academy of Dermatology and Venereology, 37 (9), e1168-e1172. doi: 10.1111/jdv.19173
2023
Journal Article
Regarding: predicting regional lymph node recurrence in the modern age of tumor-positive sentinel node melanoma
Thompson, John F., Hyngstrom, John, Caracò, Corrado, Zager, Jonathan S., Jahkola, Tiina, Bowles, Tawnya L., Pennacchioli, Elisabetta, Hoekstra, Harald J., Moncrieff, Marc, Ingvar, Christian, van Akkooi, Alexander, Sabel, Michael S., Levine, Edward A., Henderson, Michael, Dummer, Reinhard, Rossi, Carlo Riccardo, Kane, John M., Trocha, Steven, Wright, Frances, Byrd, David R., Matter, Maurice, MacKenzie-Ross, Alastair, Kelley, Mark C., Terheyden, Patrick, Huston, Tara L., Wayne, Jeffrey D., Neuman, Heather, Smithers, B. Mark, Desai, Darius ... Faries, Mark B. (2023). Regarding: predicting regional lymph node recurrence in the modern age of tumor-positive sentinel node melanoma. Annals of Surgical Oncology, 30 (7), 4359-4360. doi: 10.1245/s10434-023-13570-9
2023
Conference Publication
Automated assessment of tumor infiltrating lymphocytes informs mortality in thin melanoma
Tan, S. X., Aung, T. Nwe, Claeson, M., Zhou, C., Brown, S., Acs, B., Lambie, D., Baade, P., Pandeya, N., Soyer, H., Smithers, B., Whiteman, D., Rimm, D. and Khosrotehrani, K. (2023). Automated assessment of tumor infiltrating lymphocytes informs mortality in thin melanoma. 1st International Societies for Investigative Dermatology Meeting, Tokyo, Japan, 12 - 13 May 2023. Oxford, United Kingdom: Elsevier.
2023
Journal Article
Trends and patterns of care of sentinel node biopsy in cutaneous melanoma: a population‐based study in Queensland
Wong, Jessica, Moore, Julie, Soyer, H. Peter, Mar, Victoria and Smithers, B. Mark (2023). Trends and patterns of care of sentinel node biopsy in cutaneous melanoma: a population‐based study in Queensland. ANZ Journal of Surgery, 93 (9), 2172-2179. doi: 10.1111/ans.18372
2023
Conference Publication
Surgery and radiotherapy can successfully salvage isolated lymph node field recurrence after lymphadenectomy in patients with melanoma
Henderson, Michael A., Gyorki, David, Burmeister, Bryan, Fisher, Richard, Di Julio, Juliana, Smithers, Mark, Hong, Angela, Shannon, Kerwin, Scolyer, Richard A., Carruthers, Scott, Coventry, Brendon, Babington, Scott, Duprat, Joao, Hoekstra, Harald and Thompson, John (2023). Surgery and radiotherapy can successfully salvage isolated lymph node field recurrence after lymphadenectomy in patients with melanoma. Annual International Conference of the Society-of-Surgical-Oncology (SSO) on Surgical Cancer Care, Boston, MA United States, 22-25 March 2023. New York, NY United States: Springer. doi: 10.1245/s10434-023-13332-7
2023
Journal Article
Textbook outcomes for oesophagectomy: A valid composite measure assessment tool for surgical performance in a specialist unit
Wu, Michael Yulong, McGregor, Richard J., Scott, Justin, Smithers, B. Mark, Thomas, Janine, Frankel, Adam, Barbour, Andrew and Thomson, Iain (2023). Textbook outcomes for oesophagectomy: A valid composite measure assessment tool for surgical performance in a specialist unit. European Journal of Surgical Oncology, 49 (9) 106897, 106897. doi: 10.1016/j.ejso.2023.03.233
Funding
Current funding
Supervision
Availability
- Professor Mark Smithers is:
- Not available for supervision
Supervision history
Current supervision
-
Master Philosophy
Assessment of the impact of treating service characteristics on surgical and oncological outcomes for patients with Retroperitoneal and Inguinal Sarcomas in Queensland
Principal Advisor
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Master Philosophy
Factors Influencing Anastomotic Complications after Oesophagectomy
Associate Advisor
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Doctor Philosophy
New tools for the multi-modal evaluation of pancreatic cancer and its precursor neoplasms.
Associate Advisor
Other advisors: Dr David Cavallucci
Completed supervision
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2020
Master Philosophy
An assessment of the impacts of centralising complex upper-gastrointestinal surgery in Queensland
Principal Advisor
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2024
Master Philosophy
In vivo Magnetic Resonance Spectroscopy (MRS) with 2-Dimensional (2D) COrrelated Spectroscopy (COSY) applied to breast cancer
Associate Advisor
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2020
Doctor Philosophy
Natural history of high-risk cutaneous primary melanoma and risk factors for disease progression
Associate Advisor
Other advisors: Professor Kiarash Khosrotehrani
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2020
Doctor Philosophy
An evaluation of the role of locoregional treatments for the management of in-transit melanoma metastases
Associate Advisor
Other advisors: Professor Peter Soyer
Media
Enquiries
Contact Professor Mark Smithers directly for media enquiries about:
- Advanced endoscopic surgery
- Cancer surgery
- Endoscopic surgery
- General surgery
- Melanoma
- Surgery - cancer
- Surgery - oesophageal, gastric cancer
- Surgery - upper GI
- Upper GI surgery
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