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Professor Mark Smithers
Professor

Mark Smithers

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Overview

Background

Emeritus Professor Mark Smithers is a surgical oncologist who specialises in surgery for oesophago-gastric diseases, melanoma, advanced skin cancer and soft tissue sarcoma. He was the Director of the Upper GI and Soft Tissue Unit at the Princess Alexandra Hospital, in Brisbane, Australia from 1998 - 2023. Commencing his academic career with the University of Queensland in 1987, he progressed to be the Mayne Chair in Surgery and head of the Academy of Surgery. He is the second University of Queensland Medical graduate to be appointed to this role. His research has been focussed on the development and assessment of outcomes from minimally invasive upper GI surgery, and trials assessing the role of perioperative multidisciplinary therapy for esophageal and gastric cancer. As well he has led, or been involved with, clinical trials from phase I to III, for all stages of melanoma through his role as the Chair of the Queensland Melanoma Project. More recently he has been involved with the assessment of access to, and outcomes from, surgery for cancer in Queensland, Australia.

He has overseen the administration and development of the surgery curriculum, and the teaching, in the Academy of Surgery, in the UQ Faculty of Medicine. He was on a number of committees relevant to the implementation of the UQ MD design course. He has held various leadership and committee roles with the Royal Australasian College of Surgeons, as well as leadership roles, including the Presidency, in the Australian and New Zealand Oesophago Gastric Surgeons Association. He has also been on the committees of international organisations related to oesophageal and gastric surgery. He has published 250 articles, eight book chapters, and has been on the editorial board of a number of surgical journals.

He has been recognised for his clinical and academic roles by the award of Member of the Order of Australia (AM). The citation reads, "for service to medicine in the fields of gastro-intestinal and melanoma surgery, to medical education and to professional organisations". The Royal Australasian College of Surgeons awarded him the Sir Hugh Devine medal, for services to surgery and the community. This is the College’s highest honour. Internationally, he has been awarded an honorary fellowship of the Royal College of Surgeons of Edinburgh and recently, in the United States, he was elected as an Honarary Fellow of the American Surgical Association.

Availability

Professor Mark Smithers is:
Not available for supervision
Media expert

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Honorary Fellow, American Surgical Association, American Surgical Association
  • Fellow, Royal Australasian College of Surgeons, Royal Australasian College of Surgeons
  • Fellow, Royal College of Surgeons of Edinburgh, Royal College of Surgeons of Edinburgh
  • Fellow, Royal College of Surgeons of England, Royal College of Surgeons of England

Research interests

  • Cutaneous Melanoma

    epidemiology, public health issues and management of all stages

  • Management of Oesophageal and Gastric Cancer

    Investigation and management of benign and malignant diseases of the oesophagus and the stomach.

Works

Search Professor Mark Smithers’s works on UQ eSpace

419 works between 1983 and 2025

21 - 40 of 419 works

2024

Journal Article

Complications and adverse events in lymphadenectomy of the inguinal area: worldwide expert consensus

Sotelo, René, Sayegh, Aref S., Medina, Luis G., Perez, Laura C., La Riva, Anibal, Eppler, Michael B., Gaona, José, Tobias-Machado, Marcos, Spiess, Philippe E., Pettaway, Curtis A., Lima Pompeo, Antonio Carlos, Lima Mattos, Pablo Aloisio, Wilson, Timothy G., Villoldo, Gustavo M., Chung, Eric, Samaniego, Aldo, Ornellas, Antonio Augusto, Pinheiro, Vladimir, Brazão, Eder S., Subira-Rios, David, Koifman, Leandro, Zequi, Stênio de Cassio, Pontillo Z, Humberto M., Rodrigues Calixto, José de Ribamar, Campos Silva, Rafael, Smithers, B. Mark, Garzon, Simone, Haase, Oliver, Sommariva, Antonio ... Cacciamani, Giovanni E. (2024). Complications and adverse events in lymphadenectomy of the inguinal area: worldwide expert consensus. BJS Open, 8 (4) zrae056, 1-8. doi: 10.1093/bjsopen/zrae056

Complications and adverse events in lymphadenectomy of the inguinal area: worldwide expert consensus

2024

Journal Article

Lymphatic expression of the proliferation marker Ki67 is linked to sentinel node positivity, recurrence and mortality in primary cutaneous melanoma

Tan, Samuel X., Chong, Sharene, Rowe, Casey, Galbraith, Jack, Dight, James, Zhou, Chenhao, Malt, Maryrose, Smithers, Bernard Mark and Khosrotehrani, Kiarash (2024). Lymphatic expression of the proliferation marker Ki67 is linked to sentinel node positivity, recurrence and mortality in primary cutaneous melanoma. Experimental Dermatology, 33 (3) e15041, 1-7. doi: 10.1111/exd.15041

Lymphatic expression of the proliferation marker Ki67 is linked to sentinel node positivity, recurrence and mortality in primary cutaneous melanoma

2024

Journal Article

iCare – a self-directed, interactive online program to improve health and wellbeing for people living with upper gastrointestinal or hepato-pancreato-biliary cancers, and their informal carers: the study protocol for a Phase II randomised controlled trial

Livingston, Patricia M., Winter, Natalie, Ugalde, Anna, Orellana, Liliana, Mikocka-Walus, Antonina, Jefford, Michael, Zalcberg, John, Orford, Neil, Hutchinson, Alison M., Barbour, Andrew, Kiss, Nicole, Smithers, Bernard Mark, Watson, David I., McCaffrey, Nikki and White, Victoria (2024). iCare – a self-directed, interactive online program to improve health and wellbeing for people living with upper gastrointestinal or hepato-pancreato-biliary cancers, and their informal carers: the study protocol for a Phase II randomised controlled trial. BMC Cancer, 24 (1) 144. doi: 10.1186/s12885-024-11861-2

iCare – a self-directed, interactive online program to improve health and wellbeing for people living with upper gastrointestinal or hepato-pancreato-biliary cancers, and their informal carers: the study protocol for a Phase II randomised controlled trial

2024

Journal Article

Novel Textbook Outcomes following emergency laparotomy: Delphi exercise

Naumann, David N., Bhangu, Aneel, Brooks, Adam, Martin, Matthew, Cotton, Bryan A., Khan, Mansoor, Midwinter, Mark J., Pearce, Lyndsay, Bowley, Douglas M., Holcomb, John B., Griffiths, Ewen A., Smithers, Mark (BEACON Collaborative group member) and BEACON Collaborative (2024). Novel Textbook Outcomes following emergency laparotomy: Delphi exercise. BJS Open, 8 (1) zrad145. doi: 10.1093/bjsopen/zrad145

Novel Textbook Outcomes following emergency laparotomy: Delphi exercise

2024

Journal Article

Automated scoring of tumour infiltrating lymphocytes informs risk of death from thin melanoma: a nested case-case study

Tan, Samuel X., Aung, Thazin N., Claeson, Magdalena, Acs, Balazs, Zhou, Chenhao, Brown, Susan, Lambie, Duncan, Baade, Peter D., Pandeya, Nirmala, Soyer, H. Peter, Smithers, B. Mark, Whiteman, David C., Rimm, David L. and Khosrotehrani, Kiarash (2024). Automated scoring of tumour infiltrating lymphocytes informs risk of death from thin melanoma: a nested case-case study. Journal of the American Academy of Dermatology, 90 (1), 179-182. doi: 10.1016/j.jaad.2023.09.026

Automated scoring of tumour infiltrating lymphocytes informs risk of death from thin melanoma: a nested case-case study

2023

Journal Article

pSTAT5 is associated with improved survival in patients with thick or ulcerated primary cutaneous melanoma

Tan, Samuel X., Chong, Sharene, Rowe, Casey, Claeson, Magdalena, Dight, James, Zhou, Chenhao, Rodero, Mathieu P., Malt, Maryrose, Smithers, B. Mark, Green, Adele C. and Khosrotehrani, Kiarash (2023). pSTAT5 is associated with improved survival in patients with thick or ulcerated primary cutaneous melanoma. Melanoma Research, 33 (6), 506-513. doi: 10.1097/cmr.0000000000000915

pSTAT5 is associated with improved survival in patients with thick or ulcerated primary cutaneous melanoma

2023

Journal Article

PHYSIO+++: protocol for a pilot randomised controlled trial assessing the feasibility of physiotherapist-led non-invasive ventilation for patients with hypoxaemia following abdominal surgery

Hackett, Claire, Denehy, Linda, Kruger, Peter, Ripley, Nina, Reid, Natasha, Smithers, B. Mark, Walker, Rachel M., Hope, Louise and Boden, Ianthe (2023). PHYSIO+++: protocol for a pilot randomised controlled trial assessing the feasibility of physiotherapist-led non-invasive ventilation for patients with hypoxaemia following abdominal surgery. BMJ Open, 13 (12) e078175, 1-10. doi: 10.1136/bmjopen-2023-078175

PHYSIO+++: protocol for a pilot randomised controlled trial assessing the feasibility of physiotherapist-led non-invasive ventilation for patients with hypoxaemia following abdominal surgery

2023

Journal Article

Prognosis of naevoid melanomas

Cook, Martin G., Grant, Megan, Sylvestre, Yvonne, Akhras, Victoria, Khosrotehrani, Kiarash, Hughes, Maria Celia B, Malt, Maryrose, Smithers, B. Mark, Massi, Daniela, De Giorgi, Vincenzo, Marais, Richard and Green, Adele C. (2023). Prognosis of naevoid melanomas. Pathology - Research and Practice, 251 154881, 154881. doi: 10.1016/j.prp.2023.154881

Prognosis of naevoid melanomas

2023

Journal Article

ctDNA: a promising biomarker for predicting recurrence in BRAF-negative melanoma patients

Aoude, Lauren G., Brosda, Sandra, Ng, Jessica, Lonie, James M., Belle, Clemence J., Patel, Kalpana, Koufariotis, Lambros T., Wood, Scott, Atkinson, Victoria, Smithers, B. Mark, Pearson, John V., Waddell, Nicola, Barbour, Andrew P. and Bonazzi, Vanessa F. (2023). ctDNA: a promising biomarker for predicting recurrence in BRAF-negative melanoma patients. Journal of Molecular Diagnostics, 25 (10), 771-781. doi: 10.1016/j.jmoldx.2023.06.014

ctDNA: a promising biomarker for predicting recurrence in BRAF-negative melanoma patients

2023

Conference Publication

Gastric filling in neoadjuvant chemoradiotherapy for oesophageal cancer

Hwang, Yang, Chen, Beini, Mai, Tao, Lee, Dominique, Thomson, Iain, Smithers, Mark and Frankel, Adam (2023). Gastric filling in neoadjuvant chemoradiotherapy for oesophageal cancer. 19th ISDE World Congress for Esophageal Diseases, Toronto, ON, Canada, 8-10 September 2023. Los Angeles, CA, United States: John Wiley & Sons. doi: 10.1093/dote/doad052.183

Gastric filling in neoadjuvant chemoradiotherapy for oesophageal cancer

2023

Journal Article

Massive mixed epithelial-stromal tumour of seminal vesicle requiring challenging abdominoperineal resection: a case report and review of literature

Yu, Zirong, Choy, Kay Tai, Ong, Ferdinand, Williams, Evan, Naidu, Sanjeev, Smithers, Bernard M., Gurung, Anjan and Lutton, Nicholas (2023). Massive mixed epithelial-stromal tumour of seminal vesicle requiring challenging abdominoperineal resection: a case report and review of literature. Journal of Surgical Case Reports, 2023 (8) rjad490, 1-3. doi: 10.1093/jscr/rjad490

Massive mixed epithelial-stromal tumour of seminal vesicle requiring challenging abdominoperineal resection: a case report and review of literature

2023

Journal Article

Individual participant data network meta-analysis of neoadjuvant chemotherapy or chemoradiotherapy in esophageal or gastroesophageal junction carcinoma

Faron, Matthieu, Cheugoua-Zanetsie, Maurice, Tierney, Jayne, Thirion, Pierre, Nankivell, Matthew, Winter, Kathryn, Yang, Hong, Shapiro, Joel, Vernerey, Dewi, Smithers, B. Mark, Walsh, Thomas, Piessen, Guillaume, Nilsson, Magnus, Boonstra, Jurjen, Ychou, Marc, Law, Simon, Cunningham, David, de Vathaire, Florent, Stahl, Michael, Urba, Susan, Valmasoni, Michele, Williaume, Danièle, Thomas, Janine, Lordick, Florian, Tepper, Joel, Roth, Jack, Gebski, Val, Burmeister, Bryan, Paoletti, Xavier ... on behalf of the MANATEC-02 Collaborative Group (2023). Individual participant data network meta-analysis of neoadjuvant chemotherapy or chemoradiotherapy in esophageal or gastroesophageal junction carcinoma. Journal of Clinical Oncology, 41 (28) jco2202279, 4535-4547. doi: 10.1200/jco.22.02279

Individual participant data network meta-analysis of neoadjuvant chemotherapy or chemoradiotherapy in esophageal or gastroesophageal junction carcinoma

2023

Journal Article

Multi-omic features of oesophageal adenocarcinoma in patients treated with preoperative neoadjuvant therapy

M. Naeini, Marjan, Newell, Felicity, Aoude, Lauren G., Bonazzi, Vanessa F., Patel, Kalpana, Lampe, Guy, Koufariotis, Lambros T., Lakis, Vanessa, Addala, Venkateswar, Kondrashova, Olga, Johnston, Rebecca L., Sharma, Sowmya, Brosda, Sandra, Holmes, Oliver, Leonard, Conrad, Wood, Scott, Xu, Qinying, Thomas, Janine, Walpole, Euan, Tao Mai, G., Ackland, Stephen P., Martin, Jarad, Burge, Matthew, Finch, Robert, Karapetis, Christos S., Shannon, Jenny, Nott, Louise, Bohmer, Robert, Wilson, Kate ... Waddell, Nicola (2023). Multi-omic features of oesophageal adenocarcinoma in patients treated with preoperative neoadjuvant therapy. Nature Communications, 14 (1) 3155, 3155. doi: 10.1038/s41467-023-38891-x

Multi-omic features of oesophageal adenocarcinoma in patients treated with preoperative neoadjuvant therapy

2023

Journal Article

Quality indicators in surgery for cancer: not just the operation

Smithers, B. Mark (2023). Quality indicators in surgery for cancer: not just the operation. ANZ Journal of Surgery, 93 (7-8), 1765-1767. doi: 10.1111/ans.18516

Quality indicators in surgery for cancer: not just the operation

2023

Journal Article

The association between <scp>BRAF‐V600E</scp> mutations and death from thin (≤1.00 mm) melanomas: a nested case‐case study from Queensland, Australia

Claeson, M., Tan, S. X., Lambie, D., Brown, S., Walsh, M. D., Baade, P. D., Pandeya, N., Whitehead, K. J., Soyer, H. P., Smithers, B. M., Whiteman, D. C. and Khosrotehrani, K. (2023). The association between BRAF‐V600E mutations and death from thin (≤1.00 mm) melanomas: a nested case‐case study from Queensland, Australia. Journal of the European Academy of Dermatology and Venereology, 37 (9), e1168-e1172. doi: 10.1111/jdv.19173

The association between <scp>BRAF‐V600E</scp> mutations and death from thin (≤1.00 mm) melanomas: a nested case‐case study from Queensland, Australia

2023

Journal Article

Regarding: predicting regional lymph node recurrence in the modern age of tumor-positive sentinel node melanoma

Thompson, John F., Hyngstrom, John, Caracò, Corrado, Zager, Jonathan S., Jahkola, Tiina, Bowles, Tawnya L., Pennacchioli, Elisabetta, Hoekstra, Harald J., Moncrieff, Marc, Ingvar, Christian, van Akkooi, Alexander, Sabel, Michael S., Levine, Edward A., Henderson, Michael, Dummer, Reinhard, Rossi, Carlo Riccardo, Kane, John M., Trocha, Steven, Wright, Frances, Byrd, David R., Matter, Maurice, MacKenzie-Ross, Alastair, Kelley, Mark C., Terheyden, Patrick, Huston, Tara L., Wayne, Jeffrey D., Neuman, Heather, Smithers, B. Mark, Desai, Darius ... Faries, Mark B. (2023). Regarding: predicting regional lymph node recurrence in the modern age of tumor-positive sentinel node melanoma. Annals of Surgical Oncology, 30 (7), 4359-4360. doi: 10.1245/s10434-023-13570-9

Regarding: predicting regional lymph node recurrence in the modern age of tumor-positive sentinel node melanoma

2023

Conference Publication

Automated assessment of tumor infiltrating lymphocytes informs mortality in thin melanoma

Tan, S. X., Aung, T. Nwe, Claeson, M., Zhou, C., Brown, S., Acs, B., Lambie, D., Baade, P., Pandeya, N., Soyer, H., Smithers, B., Whiteman, D., Rimm, D. and Khosrotehrani, K. (2023). Automated assessment of tumor infiltrating lymphocytes informs mortality in thin melanoma. 1st International Societies for Investigative Dermatology Meeting, Tokyo, Japan, 12 - 13 May 2023. Oxford, United Kingdom: Elsevier.

Automated assessment of tumor infiltrating lymphocytes informs mortality in thin melanoma

2023

Journal Article

Trends and patterns of care of sentinel node biopsy in cutaneous melanoma: a population‐based study in Queensland

Wong, Jessica, Moore, Julie, Soyer, H. Peter, Mar, Victoria and Smithers, B. Mark (2023). Trends and patterns of care of sentinel node biopsy in cutaneous melanoma: a population‐based study in Queensland. ANZ Journal of Surgery, 93 (9), 2172-2179. doi: 10.1111/ans.18372

Trends and patterns of care of sentinel node biopsy in cutaneous melanoma: a population‐based study in Queensland

2023

Conference Publication

Surgery and radiotherapy can successfully salvage isolated lymph node field recurrence after lymphadenectomy in patients with melanoma

Henderson, Michael A., Gyorki, David, Burmeister, Bryan, Fisher, Richard, Di Julio, Juliana, Smithers, Mark, Hong, Angela, Shannon, Kerwin, Scolyer, Richard A., Carruthers, Scott, Coventry, Brendon, Babington, Scott, Duprat, Joao, Hoekstra, Harald and Thompson, John (2023). Surgery and radiotherapy can successfully salvage isolated lymph node field recurrence after lymphadenectomy in patients with melanoma. Annual International Conference of the Society-of-Surgical-Oncology (SSO) on Surgical Cancer Care, Boston, MA United States, 22-25 March 2023. New York, NY United States: Springer. doi: 10.1245/s10434-023-13332-7

Surgery and radiotherapy can successfully salvage isolated lymph node field recurrence after lymphadenectomy in patients with melanoma

2023

Journal Article

Textbook outcomes for oesophagectomy: A valid composite measure assessment tool for surgical performance in a specialist unit

Wu, Michael Yulong, McGregor, Richard J., Scott, Justin, Smithers, B. Mark, Thomas, Janine, Frankel, Adam, Barbour, Andrew and Thomson, Iain (2023). Textbook outcomes for oesophagectomy: A valid composite measure assessment tool for surgical performance in a specialist unit. European Journal of Surgical Oncology, 49 (9) 106897, 106897. doi: 10.1016/j.ejso.2023.03.233

Textbook outcomes for oesophagectomy: A valid composite measure assessment tool for surgical performance in a specialist unit

Funding

Current funding

  • 2024 - 2026
    Optimising the Diagnosis and Management of Unilateral Primary Aldosteronism
    Metro South Hospital and Health Service
    Open grant
  • 2021 - 2026
    AGITG TOP GEAR: A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer (CTCS: led by USyd)
    University of Sydney
    Open grant
  • 2019 - 2026
    A Randomised Phase II Trial of Adjuvant Avelumab in Patients with Early Stage Merkel Cell Carcinoma
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2019 - 2026
    Melanoma Margins Trial II - A Phase III, Multi-centre Randomised Controlled Trial Investigating 1cm v 2cm Wide Surgical Excision Margins.. (NHMRC Project Grant led by the University of Melbourne).
    University of Melbourne
    Open grant

Past funding

  • 2023 - 2026
    iCare - An interactive online portal to improve health and wellbeing for people living with complex cancers, and their informal carers: a Phase II randomised controlled trial (Ex led Deakin MRFF CTA)
    Deakin University
    Open grant
  • 2021 - 2024
    Advanced technological approach to predicting survival in patients diagnosed with locally invasive cutaneous melanoma
    Cancer Council Queensland
    Open grant
  • 2021 - 2024
    Establishing Australia's First Familial Melanoma Clinic (MSH RSS SERTA Program Grant led by Metro South Hospital and Health Service)
    Metro South Hospital and Health Service
    Open grant
  • 2020 - 2021
    Cancer Evolution Biobank
    PA Research Foundation
    Open grant
  • 2017 - 2019
    Predictors of mortality in thin melanomas
    Cancer Council Queensland
    Open grant
  • 2013 - 2015
    To identify and assess markers of prognosis, response and resistance to therapy in patients with Stage III metastatic melanoma
    Cancer Bequest Fund
    Open grant
  • 2011
    DOCetaxel with or without radiation Therapy for resectable Oesophageal adenocarcinoma based on early PET Response to induction chemotherapy (DOCTOR)
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Effects of nevogenesis susceptibility genes and phenotypic correlation with dermoscopic characteristics of nevi
    NHMRC Project Grant
    Open grant
  • 2010 - 2014
    Comparison of pre- and perioperative immunonutrition in patients undergoing surgical resection of oesophageal cancer (NHMRC Project Grant administered by the University of Adelaide)
    University of Adelaide
    Open grant
  • 2001 - 2002
    The epidemiology of oesophageal cancer: Risk and molecular markers
    Queensland Cancer Fund
    Open grant
  • 2000
    The role of TAP and MHC class I expression in the response to melanoma immunotherapy using autologous dendritic cells
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1999 - 2000
    A phase II clinical trial in patients with metastatic melanoma comparing autologous dendritic cells pulsed with autologous tumour peptides and melanoma associated peptides linked to the endoplasmic re
    Queensland Cancer Fund
    Open grant
  • 1998
    A Phase I/II Clinical Trial to Test Tumour Vaccines Comprising with Protein or Autologous Tumour Antigen Autologous Dandritic Cells Generated in a Closed Bag System Pulsed
    Mayne Bequest Fund
    Open grant
  • 1998
    Isolated limb infusion of melphalan and microdialysis technique in treatment of recurrent malignant melanoma
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1998 - 2000
    Treatment of Recurrent Malignant Melanoma by Limb Infusion of Cytotoxic Drugs and Other Techniques
    NHMRC Project Grant
    Open grant
  • 1997 - 1998
    Pharmacokinetics of tumour necrosis factor (TNF) in isolated rat hindlimb perfusions and infusions related to melanoma therapy
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1996 - 1997
    Targeting and monitoring drug delivery in specific tissues using iontophoresis and microdialysis
    Quality Funds Round 3
    Open grant
  • 1995 - 1997
    Pharmacokinetics of melphalan in isolated limb perfusion and infusion
    Queensland Cancer Fund
    Open grant

Supervision

Availability

Professor Mark Smithers is:
Not available for supervision

Supervision history

Current supervision

  • Master Philosophy

    Assessment of the impact of treating service characteristics on surgical and oncological outcomes for patients with Retroperitoneal and Inguinal Sarcomas in Queensland

    Principal Advisor

  • Master Philosophy

    Factors Influencing Anastomotic Complications after Oesophagectomy

    Associate Advisor

  • Doctor Philosophy

    New tools for the multi-modal evaluation of pancreatic cancer and its precursor neoplasms.

    Associate Advisor

    Other advisors: Dr David Cavallucci

Completed supervision

Media

Enquiries

Contact Professor Mark Smithers directly for media enquiries about:

  • Advanced endoscopic surgery
  • Cancer surgery
  • Endoscopic surgery
  • General surgery
  • Melanoma
  • Surgery - cancer
  • Surgery - oesophageal, gastric cancer
  • Surgery - upper GI
  • Upper GI surgery

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For help with finding experts, story ideas and media enquiries, contact our Media team:

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