Overview
Background
John-Paul Tung is a Senior Research Fellow at Australian Red Cross Lifeblood (Lifeblood). He leads a program of research focused on the changes that occur in blood in between collection and transfusion, as well as how these changes might impact transfused patients. Particular focuses are on transfusion-related acute lung inujry (TRALI), transfusion-associated circulatory overload (TACO), and extracellular vesicles. He leads a research team of five Senior Research Assistants and three Research Assistants. He also supervises several PhD and Masters students. He holds an Honorary Senior Research Fellow position with the Faculty of Medicine at UQ. He also holds an adjunct Associate Professor position with the University of the Sunshine Coast and an adjunct Senior Lecturer position with QUT. He is also a former Secretary and Council Member of the International Society of Blood Transfusion's Young Professionals Council.
John-Paul completed a Bachelor of Science at UQ in 1999, after which he worked as a Scientist in nucleic acid testing in Brisbane, Melbourne and London. After returning to Brisbane, he commenced work as a Research Scientist with Lifeblood (formerly the Blood Service) in 2007. John-Paul then commenced a PhD with UQ and Prince Charles Hospital's Critical Care Research Group in 2008. His PhD, conferred in 2012, invovled the development of the first large animal model of TRALI using sheep, and resulted in several awards including best paper prizes from the International Society of Blood Transfusion and the Prince Charles Hospital as well as other awards from the Australian and New Zealand Society of Blood Transfusion and the British Blood Transfusion Society.
Availability
- Dr John-Paul Tung is:
- Available for supervision
Research impacts
As well as internal Lifeblood research project funding, John-Paul has been an investigator on over 20 competitive external grants worth over $7.5 million, including from the NHMRC, the ARC, and the Emergency Medicine Foundation. John-Paul has published over 40 papers including in American Journal of Respiratory and Critical Care Medicine (JIF 30.5), Intensive Care Medicine (JIF 17.4), Critical Care (JIF 9.1), and Blood Reviews (JIF 8.3). He has presented at international and national conferences, inculding invited presenations at the International Society of Blood Transfusion Congress, the Royal College of Pathologists Association Pathology Update, and the Brazilian Congress of Hematology, Hemotherapy, and Cellular Therapy. He has supervised over 20 research students including three PhD completions, two Masters completions, and eight Honours completions. He has several on-going academic and clincal collaborations including with the the Royal Brisbane and Women's Hospital, the Prince Charles Hospital, the Australian Defence Force, and the Baker Institute.
Works
Search Professor John-Paul Tung’s works on UQ eSpace
2024
Journal Article
Proteomic characterization of transfusable blood components: fresh frozen plasma, cryoprecipitate, and derived extracellular vesicles via data-independent mass spectrometry
Hwang, Ji Hui, Lai, Andrew, Tung, John-Paul, Harkin, Damien G., Flower, Robert L. and Pecheniuk, Natalie M. (2024). Proteomic characterization of transfusable blood components: fresh frozen plasma, cryoprecipitate, and derived extracellular vesicles via data-independent mass spectrometry. Journal of Proteome Research, 23 (10), 4508-4522. doi: 10.1021/acs.jproteome.4c00417
2024
Journal Article
Effects of red blood cell transfusion on patients undergoing cardiac surgery in Queensland – a retrospective cohort study
Obonyo, Nchafatso. G., Dhanapathy, Vikash, White, Nicole, Sela, Declan P., Rachakonda, Reema H., Tunbridge, Matthew, Sim, Beatrice, Teo, Derek, Nadeem, Zohaib, See Hoe, Louise E., Bassi, Gianluigi Li, Fanning, Jonathon P., Tung, John-Paul, Suen, Jacky Y. and Fraser, John F. (2024). Effects of red blood cell transfusion on patients undergoing cardiac surgery in Queensland – a retrospective cohort study. Journal of Cardiothoracic Surgery, 19 (1) 475. doi: 10.1186/s13019-024-02974-7
2024
Journal Article
Characterization of novel Rh variant (CETW) associated with haemolytic disease of fetus and newborn using recombinant technology
Zhao, Shen, Radenkovic, Filip, Flower, Robert, Zacchi, Lucia, Jones, Martina, Wilson, Brett, Liew, Yew Wah, Tung, John-Paul and Hyland, Catherine (2024). Characterization of novel Rh variant (CETW) associated with haemolytic disease of fetus and newborn using recombinant technology. Pathology, 56 (Supplement 1), S100-S100. doi: 10.1016/j.pathol.2023.12.336
2024
Journal Article
Extracellular vesicles in fresh frozen plasma and cryoprecipitate: Impact on in vitro endothelial cell viability
Hwang, Ji Hui, Tung, John-Paul, Harkin, Damien G., Flower, Robert L. and Pecheniuk, Natalie M. (2024). Extracellular vesicles in fresh frozen plasma and cryoprecipitate: Impact on in vitro endothelial cell viability. Transfusion, 64 (9), 1709-1718. doi: 10.1111/trf.17959
2023
Journal Article
Intraoperative cell salvage: The impact on immune cell numbers
Roets, Michelle, Sturgess, David, Tran, Thu, Obeysekera, Maheshi, Perros, Alexis, Tung, John-Paul, Flower, Robert, van Zundert, Andre and Dean, Melinda (2023). Intraoperative cell salvage: The impact on immune cell numbers. PLoS One, 18 (8) e0289177, 1-19. doi: 10.1371/journal.pone.0289177
2023
Journal Article
Investigation of the effect of pre‐analytical factors on particle concentration and size in cryoprecipitate using nanoparticle tracking analysis
Hwang, Ji Hui, Tung, John‐Paul, Harkin, Damien G., Flower, Robert L. and Pecheniuk, Natalie M. (2023). Investigation of the effect of pre‐analytical factors on particle concentration and size in cryoprecipitate using nanoparticle tracking analysis. Transfusion Medicine, 33 (5), 398-402. doi: 10.1111/tme.12986
2023
Journal Article
Effects of transfusing older red blood cells and platelets on obstetric patient outcomes: a retrospective cohort study
Obonyo, Nchafatso G., Lu, Lawrence Y., White, Nicole M., Sela, Declan P., Rachakonda, Reema H., Teo, Derek, Tunbridge, Matthew, Sim, Beatrice, See Hoe, Louise E., Fanning, Jonathon P., Tung, John‐Paul, McKnoulty, Matthew, Bassi, Gianluigi Li, Suen, Jacky Y. and Fraser, John F. (2023). Effects of transfusing older red blood cells and platelets on obstetric patient outcomes: a retrospective cohort study. International Journal of Gynecology and Obstetrics, 164 (1), 184-191. doi: 10.1002/ijgo.14997
2023
Conference Publication
Effects of Red Blood Cell Transfusion on Patients Undergoing Cardiac Surgery in Queensland—A Retrospective Cohort Study
Dhanapathy, V., Obonyo, N., White, N., Sela, D., Rachakonda, R., Tunbridge, M., Sim, B., Teo, D., Hoe, L. See, Fanning, J., Tung, J., Suen, J. and Fraser, J. (2023). Effects of Red Blood Cell Transfusion on Patients Undergoing Cardiac Surgery in Queensland—A Retrospective Cohort Study. 71st Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Adelaide, SA Australia, 3-6 August 2023. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2023.06.458
2023
Conference Publication
Proposal of a reliable scoring system for the histological assessment of multiorgan injury in large animal models of ischaemia and shock
Palmieri, C., See Hoe, L., Dyer, W., Heinsar, S., Rozencwaig, S., Tung, J.P., Bartnikowski, N., Passmore, M., Bouquet, M., Hislop, K., Wilson, E., Li Bassi, g., Mcgiffin, D., Suen, J. and Fraser, J. (2023). Proposal of a reliable scoring system for the histological assessment of multiorgan injury in large animal models of ischaemia and shock. 2022 Annual Congress of the European Society of Veterinary Pathology and European College of Veterinary Pathologists, Athens, Greece, 7 - 10 September 2022. London, United Kingdom: Elsevier. doi: 10.1016/j.jcpa.2023.03.059
2023
Journal Article
Next generation sequencing to identify iron status and individualise blood donors' experience
Jacko, Georgina, Sivakaanthan, Aarany, Obeysekera, Maheshi, Welvaert, Marijke, Viennet, Elvina, Hyland, Catherine, Tung, John-Paul, Perros, Alexis J, Flower, Robert L and Roulis, Eileen (2023). Next generation sequencing to identify iron status and individualise blood donors' experience. Blood transfusion = Trasfusione del sangue, 21 (6), 463-471. doi: 10.2450/BloodTransfus.499
2023
Journal Article
The impact of revised definitions for transfusion‐associated circulatory overload and transfusion‐related acute lung injury on haemovigilance reporting
Yuan, Yin, Dennington, Peta M., Daly, James, Baidya, Shoma and Tung, John‐Paul (2023). The impact of revised definitions for transfusion‐associated circulatory overload and transfusion‐related acute lung injury on haemovigilance reporting. Vox Sanguinis, 118 (3), 199-206. doi: 10.1111/vox.13402
2023
Conference Publication
Donor variability affects the outcome for the monocyte monolayer assay (MMA)
Tran, Thu V., Powley, Tanya, Tung, John-Paul, Flower, Robert L. and Dean, Melinda M. (2023). Donor variability affects the outcome for the monocyte monolayer assay (MMA). Pathology Update 2023, Melbourne, VIC Australia, 24-26 February 2023. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.pathol.2022.12.329
2023
Conference Publication
Molecular typing to personalise donor donation frequency
Flower, Robert L., Perros, Alexis J., Jacko, Georgina, Welvaert, Marijke, Viennet, Elvina, Hyland, Catherine, Tung, John-Paul and Roulis, Eileen (2023). Molecular typing to personalise donor donation frequency. Pathology Update 2023, Melbourne, VIC Australia, 24-26 February 2023. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.pathol.2022.12.304
2023
Journal Article
Limited potential of sheep as a large animal to model transfusion-related acute lung injury mediated by antibodies against human neutrophil antigen 3a
Radenkovic, Filip, Burton, Mark, Hassell, Penny, Chiaretti, Sara, Bui, Xuan, Zhao, Shen, Jones, Martina, Flower, Robert and Tung, John-Paul (2023). Limited potential of sheep as a large animal to model transfusion-related acute lung injury mediated by antibodies against human neutrophil antigen 3a. Annals of Blood, 9, 26. doi: 10.21037/aob-23-57
2022
Journal Article
Transfusion-related acute lung injury (TRALI): a retrospective review of reported cases in Queensland, Australia over 20 years
Sivakaanthan, Aarany, Swain, Fiona, Pahn, Gail, Goodison, Kathryn, Gutta, Naadir, Holdsworth, Rhonda, Baidya, Shoma and Tung, John-Paul (2022). Transfusion-related acute lung injury (TRALI): a retrospective review of reported cases in Queensland, Australia over 20 years. Blood transfusion, 20 (6), 454-464. doi: 10.2450/2022.0020-22
2022
Journal Article
Human neutrophil antigen 3 genotype impacts neutrophil-mediated endothelial cell cytotoxicity in a two-event model of TRALI
Chiaretti, Sara, Burton, Mark, Hassel, Penny, Radenkovic, Filip, Devikashri, Nilam, Sultana, Annette J, Temple, Fergal T, Dean, Melinda M and Tung, John-Paul (2022). Human neutrophil antigen 3 genotype impacts neutrophil-mediated endothelial cell cytotoxicity in a two-event model of TRALI. Blood transfusion, 20 (6), 465-474. doi: 10.2450/2022.0013-22
2022
Journal Article
Transfusion-related acute lung injury (TRALI): potential pathways of development, strategies for prevention and treatment, and future research directions
Tung, John-Paul, Chiaretti, Sara, Dean, Melinda M., Sultana, Annette J., Reade, Michael C. and Fung, Yoke Lin (2022). Transfusion-related acute lung injury (TRALI): potential pathways of development, strategies for prevention and treatment, and future research directions. Blood Reviews, 53 100926, 100926. doi: 10.1016/j.blre.2021.100926
2022
Journal Article
Psychological impact of the COVID-19 pandemic on young professionals in blood banks and transfusion services: A global cross-sectional survey
Al-Riyami, Arwa Z., Masser, Barbara, Herczenik, Eszter, Arora, Satyam, Boateng, Lilian Antwi, Dinardo, Carla Luana, Hutchinson, Tyler, Ji, Yanli, Langi Sasongko, Syeldy, Tung, John-Paul and Panchatcharam, Sathiya Murthi (2022). Psychological impact of the COVID-19 pandemic on young professionals in blood banks and transfusion services: A global cross-sectional survey. Vox Sanguinis, 117 (5), 685-692. doi: 10.1111/vox.13236
2022
Journal Article
Recovery of organ-specific tissue oxygen delivery at restrictive transfusion thresholds after fluid treatment in ovine haemorrhagic shock
Dyer, Wayne B., Simonova, Gabriela, Chiaretti, Sara, Bouquet, Mahe, Wellburn, Rebecca, Heinsar, Silver, Ainola, Carmen, Wildi, Karin, Sato, Kei, Livingstone, Samantha, Suen, Jacky Y., Irving, David O., Tung, John-Paul, li Bassi, Gianluigi and Fraser, John F. (2022). Recovery of organ-specific tissue oxygen delivery at restrictive transfusion thresholds after fluid treatment in ovine haemorrhagic shock. Intensive Care Medicine Experimental, 10 (1) 12, 12. doi: 10.1186/s40635-022-00439-6
2021
Journal Article
A clinically relevant sheep model of orthotopic heart transplantation 24 h after donor brainstem death
See Hoe, Louise E., Wildi, Karin, Obonyo, Nchafatso G., Bartnikowski, Nicole, McDonald, Charles, Sato, Kei, Heinsar, Silver, Engkilde-Pedersen, Sanne, Diab, Sara, Passmore, Margaret R., Wells, Matthew A., Boon, Ai-Ching, Esguerra, Arlanna, Platts, David G., James, Lynnette, Bouquet, Mahe, Hyslop, Kieran, Shuker, Tristan, Ainola, Carmen, Colombo, Sebastiano M., Wilson, Emily S., Millar, Jonathan E., Malfertheiner, Maximillian V., Reid, Janice D., O’Neill, Hollier, Livingstone, Samantha, Abbate, Gabriella, Sato, Noriko, He, Ting ... Fraser, John F. (2021). A clinically relevant sheep model of orthotopic heart transplantation 24 h after donor brainstem death. Intensive Care Medicine Experimental, 9 (1) 60, 1-24. doi: 10.1186/s40635-021-00425-4
Funding
Past funding
Supervision
Availability
- Dr John-Paul Tung is:
- Available for supervision
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Supervision history
Completed supervision
-
2020
Doctor Philosophy
Characterisation of immune responses to standard stored and cryopreserved blood components in sheep in vitro models of transfusion
Principal Advisor
Other advisors: Professor Michael Reade
-
2023
Doctor Philosophy
The role of the endothelial glycocalyx in severe trauma
Associate Advisor
Other advisors: Professor Michael Reade
-
2019
Doctor Philosophy
A Translational Approach to Potential Toxicity of Stored Blood Components
Associate Advisor
Other advisors: Dr Jacky Suen, Professor John Fraser
Media
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