Associate Professor Richard Clark
Associate Professor

Richard Clark

Email: 
Phone: 
+61 7 336 51527

Background

Dr Clark is an Associate Professor at the School of Biomedical Sciences where he is Head of the Peptide Chemical Biology Lab. He completed his PhD in 2000 at the UQ Chemistry Department studying marine natural products chemistry and chemical ecology with Prof. Mary Garson. He then shifted his research focus towards peptide chemistry, structural biology and drug design when he was recruited to the lab of Prof. David Craik at the IMB. His current research focus is the development of technologies to stabilise peptide therapeutics and the elucidation of the structure/function activity of bioactive peptides.

Availability

Associate Professor Richard Clark is:
Available for supervision

Fields of research

Biological Sciences Medicinal and biomolecular chemistry Pharmacology and pharmaceutical sciences

Qualifications

  • Bachelor (Honours) of Science (Advanced), University of Tasmania
  • Doctor of Philosophy, The University of Queensland

Search Professor Richard Clark’s works on UQ eSpace

168 works between 1998 and 2025
All (168) Journal Article (122) Book Chapter (5) Conference Publication (40) Other Outputs (1)

141 - 160 of 168 works

2005

Journal Article

Disulfide bond mutagenesis and the structure and function of the head-to-tail macrocyclic trypsin inhibitor SFTI-1

Korsinczky, M. L. J., Clark, R. J. and Craik, D. J. (2005). Disulfide bond mutagenesis and the structure and function of the head-to-tail macrocyclic trypsin inhibitor SFTI-1. Biochemistry, 44 (4), 1145-1153. doi: 10.1021/bi048297r

Disulfide bond mutagenesis and the structure and function of the head-to-tail macrocyclic trypsin inhibitor SFTI-1

2005

Book Chapter

Structure-based drug design and NMR-based screening

Craik, D. J. and Clark, R. J. (2005). Structure-based drug design and NMR-based screening. Encyclopdeia of Molecular Cell Biology and Molecular Medicine. (pp. 517-605) edited by Robert A Meyers. Germany: Wiley-VCH.

Structure-based drug design and NMR-based screening

2004

Conference Publication

A novel threaded ring structure for the antimicrobial peptide microcin J25

Craik, D. J., Rosengren, K. J., Clark, R. J., Daly, N. L. and Goransson, U. (2004). A novel threaded ring structure for the antimicrobial peptide microcin J25. 3rd International and 28th European Peptide Symposium, Prague, Czech Republic, 5–10 September 2004. West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.617

A novel threaded ring structure for the antimicrobial peptide microcin J25

2004

Conference Publication

Design, Synthesis and Structural Studies of Cyclic Alpha-Conotoxins

Clark, RJ, Dempster, L, Daly, NL, Rosengren, KJ and Craik, DJ (2004). Design, Synthesis and Structural Studies of Cyclic Alpha-Conotoxins. CHICHESTER: JOHN WILEY & SONS LTD.

Design, Synthesis and Structural Studies of Cyclic Alpha-Conotoxins

2004

Conference Publication

Cyclotides: Novel Peptidic Pesticides for Plant Protection

Plan, MR, Goransson, U, Rosengren, KJ, Clark, RJ, Daly, NL, Evert, P, Chen, C, Cagauan, AG and Craik, DJ (2004). Cyclotides: Novel Peptidic Pesticides for Plant Protection. CHICHESTER: JOHN WILEY & SONS LTD.

Cyclotides: Novel Peptidic Pesticides for Plant Protection

2004

Journal Article

Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins

Dutton, J. L., Renda, R. F., Waine, C., Clark, R. J., Daly, N. L., Jennings, C. V., Anderson, M. A. and Craik, D. J. (2004). Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins. Journal of Biological Chemistry, 279 (45), 46858-46867. doi: 10.1074/jbc.M407421200

Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins

2003

Conference Publication

Probing nucleotide dissociation from myosin in vitro using microgram quantities of myosin

Clark, Richard J., Nyitrai, Miklós, Webb, Martin R. and Geeves, Michael A. (2003). Probing nucleotide dissociation from myosin in vitro using microgram quantities of myosin.

Probing nucleotide dissociation from myosin in vitro using microgram quantities of myosin

2003

Journal Article

Disulfide folding pathways of cystine knot proteins: Tying the knot within the circular backbone of the cyclotides

Daly, N. L., Clark, R. J. and Craik, D. J. (2003). Disulfide folding pathways of cystine knot proteins: Tying the knot within the circular backbone of the cyclotides. The Journal of Biological Chemistry, 278 (8), 6314-6322. doi: 10.1074/jbc.M210492200

Disulfide folding pathways of cystine knot proteins: Tying the knot within the circular backbone of the cyclotides

2003

Journal Article

Structure-function studies of the plant cyclotides: the role of a circular protein backbone

Craik, David J., Barry, Daniel G., Clark, Richard J., Daly, Norelle L. and Sando, Lillian (2003). Structure-function studies of the plant cyclotides: the role of a circular protein backbone. Journal of Toxicology: Toxin Reviews, 22 (4), 555-576. doi: 10.1081/TXR-120026914

Structure-function studies of the plant cyclotides: the role of a circular protein backbone

2003

Journal Article

Linearization of a naturally occurring circular protein maintains structure but eliminates hemolytic activity

Barry, D. G., Daly, N. L., Clark, R. J., Sando, L. and Craik, D. J. (2003). Linearization of a naturally occurring circular protein maintains structure but eliminates hemolytic activity. Biochemistry, 42 (22), 6688-6695. doi: 10.1021/bi027323n

Linearization of a naturally occurring circular protein maintains structure but eliminates hemolytic activity

2003

Journal Article

Diversity in the disulfide folding pathways of cystine knot peptides

Daly, N. L., Clark, R. J., Goransson, U. and Craik, D. J. (2003). Diversity in the disulfide folding pathways of cystine knot peptides. Letters in Peptide Science, 10 (5-6), 523-531. doi: 10.1007/BF02442584

Diversity in the disulfide folding pathways of cystine knot peptides

2003

Journal Article

Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone

Rosengren, K. J., Clark, R. J., Daly, N. L., Goransson, U., Jones, A. and Craik, D. J. (2003). Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone. Journal of the American Chemical Society, 125 (41), 12464-12474. doi: 10.1021/JA0367703

Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone

2003

Book Chapter

NMR and Drug Discovery

Craik, D. J. and Clark, R. J. (2003). NMR and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery, Vol 1, Drug Discovery. (pp. 507-582) edited by Donald J Abraham. USA: John Wiley & Sons. doi: 10.1002/0471266949.bmc011

NMR and Drug Discovery

2003

Journal Article

Structure-function studies of the plant cyclotides: The role of a circular protein backbone

Craik, David J., Barry, Daniel G., Clark, Richard J., Daly, Norelle L. and Sando, Lillian (2003). Structure-function studies of the plant cyclotides: The role of a circular protein backbone. Toxin Reviews, 22 (4), 555-576. doi: 10.1081/TXR-120026914

Structure-function studies of the plant cyclotides: The role of a circular protein backbone

2002

Journal Article

A sponge allelochemical induces ascidian settlement but inhibits metamorphosis

Green, K. M., Russell, B. D., Clark, R. J., Jones, M. K ., Garson, M. J., Skilleter, G. A. and Degnan, B. M. (2002). A sponge allelochemical induces ascidian settlement but inhibits metamorphosis. Marine Biology, 140 (2), 355-363. doi: 10.1007/s002270100698

A sponge allelochemical induces ascidian settlement but inhibits metamorphosis

2002

Conference Publication

Sponge allelochemical induces ascidian development but inhibits metamorphosis

Green, K., Russell, B. D., Clark, R., Jones, M. K., Skilleter, G. A., Garson, M. J. and Degnan, B. M. (2002). Sponge allelochemical induces ascidian development but inhibits metamorphosis. 23rd International Conference on Natural Products, Italy, July, 2002.

Sponge allelochemical induces ascidian development but inhibits metamorphosis

2001

Journal Article

Discovery and structures of the cyclotides: novel macrocyclic peptides from plants

Craik, David J., Anderson, Marilyn A., Barry, Daniel G., Clark, Richard J., Daly, Norelle L., Jennings, Cameron V. and Mulvenna, Jason P. (2001). Discovery and structures of the cyclotides: novel macrocyclic peptides from plants. Letters in Peptide Science, 8 (3-5), 119-128. doi: 10.1007/BF02446507

Discovery and structures of the cyclotides: novel macrocyclic peptides from plants

2001

Journal Article

Antifungal alkyl amino alcohols from the tropical marine sponge Haliclona n. sp.

Clark, R. J., Garson, M. J. and Hooper, J. N. A. (2001). Antifungal alkyl amino alcohols from the tropical marine sponge Haliclona n. sp.. Journal of Natural Products, 64 (12), 1568-1571. doi: 10.1021/np010246x

Antifungal alkyl amino alcohols from the tropical marine sponge Haliclona n. sp.

2001

Conference Publication

Sponge allelochemical induces ascidian development but inhibits metamorphosis

Clark, R. J., Degnan, B. M., Garson, M. J., Green, K. M., Jones, M. K., Russell, B. D. and Skilleter, G. A. (2001). Sponge allelochemical induces ascidian development but inhibits metamorphosis. The World Chemistry Congress 2001, Brisbane, Australia, 106 July 2001.

Sponge allelochemical induces ascidian development but inhibits metamorphosis

2001

Conference Publication

Sponge alleleochemical induces ascidian settlement but inhibits metamorphosis

Green, K., Russell, B. D., Clark, R. J., Jones, M. K., Skilleter, G. A., Garson, M. J. and Degnan, B. M. (2001). Sponge alleleochemical induces ascidian settlement but inhibits metamorphosis. 3rd IUPAC International Conference on Biodiversity, Turkey, 2001. Antalya, Turkey:

Sponge alleleochemical induces ascidian settlement but inhibits metamorphosis

Current funding

  • 2024 - 2027
    Preclinical development of complement C5a receptor 2 modulators for motor neuron disease
    Cure for MND Foundation - Drug Development Grants
    Open grant
  • 2022 - 2026
    Making peptides orally bioavailable
    ARC Discovery Projects
    Open grant
  • 2022 - 2025
    Making peptide drugs orally bioavailable
    NHMRC IDEAS Grants
    Open grant
  • 2022 - 2025
    Novel long-acting and orally delivered conotoxin-based peptides with both analgesic efficacy and disease modifying potential
    NHMRC Development Grant
    Open grant

Past funding

  • 2022 - 2024
    Developing novel acid-sensing ion channel inhibitors as neuroprotective leads and diagnostic agents for multiple sclerosis
    Multiple Sclerosis Research Australia - Targeted Grant - Neurodegeneration
    Open grant
  • 2021 - 2023
    Complement C5aR1: A novel therapeutic target for brain cancer
    Brain Cancer Innovation Project Grants
    Open grant
  • 2020 - 2022
    Neuroprotective role of novel acid-sensing ion channel inhibitor in Multiple sclerosis (MS) disease
    Multiple Sclerosis Research Australia
    Open grant
  • 2020 - 2024
    Preclinical development of centrally active complement C3a receptor modulators as disease-modifying drugs for motor neuron disease
    Cure for MND Foundation - Drug Development Grants
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019
    Chemical Purification Network
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Multichannel peptide synthesiser to accelerate UQ's biodiscovery pipeline and peptide drug development programs
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    A Pharmacology Screening Facility to Accelerate Drug Discovery and Development
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2019
    Hormone transplant by alpha-2-macroglubulin: Novel roles in regulating hormone activity (NHMRC Project Grant led by the University of Sydney)
    University of Sydney
    Open grant
  • 2017 - 2021
    Preclinical Development of Complement C5aR Antagonists for the Treatment of Motor Neuron Disease
    NHMRC Development Grant
    Open grant
  • 2016 - 2017
    Development of complement C5aR1 antagonists for the treatment of motor neuron disease
    UQ Collaboration and Industry Engagement Fund - FirstLink
    Open grant
  • 2016
    Integrative blood coagulation research core facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Patch-clamp electrophysiology platform for drug and insecticide discovery
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Better treatments for chronic pain
    NHMRC Development Grant
    Open grant
  • 2012 - 2015
    Elucidating the mechanisms of alpha-conotoxin-induced calcium channel inhibition via G protein-coupled receptors (NHMRC project grant administered by Royal Melbourne Institute of Technology)
    Royal Melbourne Institute of Technology University
    Open grant
  • 2011 - 2012
    Elucidating the neuroprotective properties of alpha-conotoxins
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2011 - 2015
    Development of effective peptide-based drugs
    ARC Future Fellowships
    Open grant
  • 2011
    A Multi-Channel Fluorescence Plate Reader for Studying Receptor-Ligand Interactions
    NHMRC Equipment Grant
    Open grant
  • 2011
    Building UQ's analytical capacity in biomedical sciences
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2014
    Understanding the structure/function relationships of the iron regulatory peptide hepcidin
    NHMRC Project Grant
    Open grant
  • 2010 - 2012
    A new G-protein coupled receptor target for conotoxins
    ARC Discovery Projects
    Open grant
  • 2010 - 2012
    New peptide-based drugs for the treatment of neuropathic pain
    NHMRC Project Grant
    Open grant
  • 2010
    The development of peptides (mini-proteins) as drugs: improved purification capability
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009 - 2021
    Cone Shell snail venom research
    The Simon Axelsen Memorial Fund
    Open grant
  • 2008 - 2011
    NHMRC Career Development Award (Biomedical - Level 1): Development of effective peptide-based drugs
    NHMRC Career Development Award
    Open grant
  • 2008 - 2010
    Development of a novel orally active peptide for the treatment of pain
    NHMRC Development Grant
    Open grant
  • 2008 - 2010
    Discovery of novel cyclotides.
    Department of Innovation, Industry, Science and Research
    Open grant
  • 2007
    Exploring the therapeutic potential of a novel family of proteins
    Australian Academy of Science
    Open grant
  • 2007 - 2010
    Development of a generic strategy for the stabilisation of peptide-based therapeutics
    NHMRC Project Grant
    Open grant
  • 2007 - 2008
    Development of stable peptide-based drugs for the treatment of iron disorders
    UQ Early Career Researcher
    Open grant
  • 2007
    Molecular imprinting of circular proteins
    UQ Travel Grants Scheme
    Open grant
  • 2007 - 2010
    Novel peptides for the treatment of pain
    NHMRC Project Grant
    Open grant

Availability

Associate Professor Richard Clark is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

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