Development of effective peptide-based drugs (2011-2015)
Abstract
The study of endogenous human peptides and proteins and the isolation and characterisation of bioactive peptides from natural sources has generated huge interest in the development of these molecules for the treatment of a broad range of disease states. However, there are still a number of hurdles that need to be overcome before this source of promising drug leads fulfil their vast potential. One of the biggest challenges in the development of peptide and proteins as drugs is overcoming their poor biological stability. The broad aim of my research is to create potent and selective drug leads based on naturally occurring peptides and to develop novel strategies to stabilise these molecules so they are able to be effective therapeutics.
