A new G-protein coupled receptor target for conotoxins (2010-2012)
Abstract
Our aim is to characterise the interaction between conotoxins and the GABA(B) receptor, discover new conotoxins that target this receptor and design new ligands for related receptors that are also involved in nerve signalling. We will achieve this by undertaking structure/activity studies, screening venom extracts, mechanistic studies using receptor constructs and assays and functional studies in cell-based systems and native tissue. This will provide us with an intimate understanding of the effect of conotoxins on this novel receptor that will underpin the future development of new drug leads for treating neurological diseases including pain, anxiety, depression, epilepsy and drug addiction.
