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2025 Journal Article Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter pharmacokinetics study for Screening Antifungal Exposure in Intensive Care Units—the SAFE-ICU studyRoberts, Jason A., Sime, Fekade B., Lipman, Jeffrey, Hernández-Mitre, María Patricia, Baptista, João Pedro, Brüggemann, Roger J., Darvall, Jai, De Waele, Jan J., Dimopoulos, George, Lefrant, Jean-Yves, Mat Nor, Mohd Basri, Rello, Jordi, Seoane, Leonardo, Slavin, Monica A., Valkonen, Miia, Venditti, Mario, Ceccarelli, Giancarlo, Wong, Wai Tat, Zeitlinger, Markus and Roger, Claire (2025). Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter pharmacokinetics study for Screening Antifungal Exposure in Intensive Care Units—the SAFE-ICU study. Intensive Care Medicine, 51 (2), 1-16. doi: 10.1007/s00134-025-07793-5 |
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2025 Journal Article Safety, tolerability and pharmacokinetics of subcutaneous cefazolin as an alternative to intravenous administrationMurray, Fionnuala, Yoo, Okhee, Brophy-Williams, Samuel, Rawlins, Matthew, Wallis, Steven C., Roberts, Jason A., Raby, Edward, Salman, Sam and Manning, Laurens (2025). Safety, tolerability and pharmacokinetics of subcutaneous cefazolin as an alternative to intravenous administration. Journal of Antimicrobial Chemotherapy, 80 (2), 347-353. doi: 10.1093/jac/dkae397 |
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2025 Journal Article Is it a case of higher, the worse, or are beta-lactam antibiotics the innocent bystanders?Heffernan, Aaron J. and Roberts, Jason A. (2025). Is it a case of higher, the worse, or are beta-lactam antibiotics the innocent bystanders?. Journal of Critical Care, 85 154934, 154934. doi: 10.1016/j.jcrc.2024.154934 |
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2025 Journal Article Population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation—an ASAP ECMO studyAbdul-Aziz, Mohd H., Diehl, Arne, Liu, Xin, Cheng, Vesa, Corley, Amanda, Gilder, Eileen, Levkovich, Bianca, McGuinness, Shay, Ordonez, Jenny, Parke, Rachael, Pellegrino, Vincent, Wallis, Steven C., Fraser, John F., Shekar, Kiran and Roberts, Jason A. (2025). Population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation—an ASAP ECMO study. Antimicrobial Agents and Chemotherapy, 69 (2) e0143524, 1-15. doi: 10.1128/aac.01435-24 |
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2025 Journal Article Ceftriaxone population pharmacokinetics in plasma and cerebrospinal fluid of neurocritical care patientsKumta, Nilesh, Heffernan, Aaron J., Liu, Xin, Parker, Suzanne L., Cotta, Menino Osbert, Wallis, Steven C., Livermore, Amelia, Starr, Therese, Wai, Wong Tat, Joynt, Gavin M., Lipman, Jeffrey and Roberts, Jason A. (2025). Ceftriaxone population pharmacokinetics in plasma and cerebrospinal fluid of neurocritical care patients. International Journal of Antimicrobial Agents, 65 (5) 107461, 107461-5. doi: 10.1016/j.ijantimicag.2025.107461 |
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2025 Journal Article 211. Defining Optimal Sampling Times for Cefepime Therapeutic Drug Monitoring in Clinical PracticeRhodes, Nathaniel J, Smith, Brandon, Shields, Ryan K, Pan, Samantha, Weslander, Erin, Galvin, Shannon, Hughes, Jasmine, Hughes, Maria-Stephanie, Sime, Fekade B, Roberts, Jason A, Kiel, Patrick J, Neely, Michael N and Scheetz, Marc H (2025). 211. Defining Optimal Sampling Times for Cefepime Therapeutic Drug Monitoring in Clinical Practice. Open Forum Infectious Diseases, 12 (Supplement_1). doi: 10.1093/ofid/ofae631.069 |
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2025 Journal Article Evaluation of ampicillin plus ceftobiprole combination therapy in treating Enterococcus faecalis infective endocarditis and bloodstream infectionGiuliano, Simone, Angelini, Jacopo, Campanile, Floriana, Conti, Paola, Flammini, Sarah, Pagotto, Alberto, Sbrana, Francesco, Martini, Luca, D'Elia, Denise, Abdul-Aziz, Mohd H., Cotta, Menino O., Roberts, Jason A., Bonomo, Robert A. and Tascini, Carlo (2025). Evaluation of ampicillin plus ceftobiprole combination therapy in treating Enterococcus faecalis infective endocarditis and bloodstream infection. Scientific Reports, 15 (1) 3519, 1-16. doi: 10.1038/s41598-025-87512-8 |
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2025 Journal Article A pharmacokinetic/pharmacodynamic analysis of intravenous tranexamic acid in adult patients undergoing elective total hip arthroplasty (ORACLE)Gurunathan, Usha, Medcalf, Robert L., Chiang, Lily, Liu, Zikou, Liu, Xin, Keragala, Charithani B., Hernandez-Mitre, Maria Patricia, Brady, Paul, Wallis, Steven C., Roberts, Jason A., Mullany, Daniel, Nandurkar, Harshal, Eley, Victoria and Parker, Suzanne L. (2025). A pharmacokinetic/pharmacodynamic analysis of intravenous tranexamic acid in adult patients undergoing elective total hip arthroplasty (ORACLE). British Journal of Anaesthesia. doi: 10.1016/j.bja.2024.12.004 |
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2025 Journal Article Dosing optimisation of intravenous lidocaine in patients with class 1–3 obesity by population pharmacokinetic analysisTognolini, Angela R., Liu, Xin, Pandey, Saurabh, Roberts, Jason A., Wallis, Steven C., Jackson, Dwane and Eley, Victoria A. (2025). Dosing optimisation of intravenous lidocaine in patients with class 1–3 obesity by population pharmacokinetic analysis. Anaesthesia, 80 (5), 511-521. doi: 10.1111/anae.16531 |
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2025 Journal Article Erratum to ‘TMPRSS2 inhibitors for the treatment of COVID-19 in adults: a systematic review and meta-analysis of randomized clinical trials of nafamostat and camostat mesylate’ [Clin Microbiol Infect (30) (2024) 743–754, (S1198743X24000557), (10.1016/j.cmi.2024.01.029)]Hernández-Mitre, María Patricia, Morpeth, Susan C., Venkatesh, Balasubramanian, Hills, Thomas E., Davis, Joshua, Mahar, Robert K., McPhee, Grace, Jones, Mark, Totterdell, James, Tong, Steven Y.C. and Roberts, Jason A. (2025). Erratum to ‘TMPRSS2 inhibitors for the treatment of COVID-19 in adults: a systematic review and meta-analysis of randomized clinical trials of nafamostat and camostat mesylate’ [Clin Microbiol Infect (30) (2024) 743–754, (S1198743X24000557), (10.1016/j.cmi.2024.01.029)]. Clinical Microbiology and Infection, 31 (1) 141, 141-141. doi: 10.1016/j.cmi.2024.08.005 |
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2025 Journal Article Rezafungin acetate for the treatment of candidemia and invasive candidiasis: a pharmacokinetic evaluationBassetti, Matteo, Stewart, Adam, Bartalucci, Claudia, Vena, Antonio, Giacobbe, Daniele Roberto and Roberts, Jason (2025). Rezafungin acetate for the treatment of candidemia and invasive candidiasis: a pharmacokinetic evaluation. Expert Opinion On Drug Metabolism and Toxicology, 21 (2), 125-132. doi: 10.1080/17425255.2024.2424899 |
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2025 Journal Article Development of Methods to Produce SARS CoV-2 Virus-Like Particles at ScaleEdeling, Melissa A., Earnest, Linda, Carrera Montoya, Julio, Yap, Ashley Huey Yiing, Mumford, Jamie, Roberts, Jason, Wong, Chinn Yi, Hans, Dhiraj, Grima, Joseph, Bisset, Nicole, Bodle, Jesse, Rockman, Steven and Torresi, Joseph (2025). Development of Methods to Produce SARS CoV-2 Virus-Like Particles at Scale. Biotechnology and Bioengineering, 122 (5), 1118-1129. doi: 10.1002/bit.28937 |
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2025 Journal Article The pharmacokinetics of antibiotics in patients with obesity: a systematic review and consensus guidelines for dose adjustmentsMärtson, Anne-Grete, Barber, Katie E, Crass, Ryan L, Hites, Maya, Kloft, Charlotte, Kuti, Joseph L, Nielsen, Elisabet I, Pai, Manjunath P, Zeitlinger, Markus, Roberts, Jason A and Tängdén, Thomas (2025). The pharmacokinetics of antibiotics in patients with obesity: a systematic review and consensus guidelines for dose adjustments. The Lancet Infectious Diseases (Pharmacology 31 1985). doi: 10.1016/S1473-3099(25)00155-0 |
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2025 Journal Article Evaluation of the stability of aciclovir in elastomeric infusion devices used for outpatient parenteral antimicrobial therapySime, Fekade Bruck, Wallis, Steven, Jamieson, Conor, Hills, Tim, Gilchrist, Mark, Santillo, Mark, Seaton, R Andrew, Drummond, Felicity and Roberts, Jason (2025). Evaluation of the stability of aciclovir in elastomeric infusion devices used for outpatient parenteral antimicrobial therapy. European Journal of Hospital Pharmacy, 32 (3), 272-277. doi: 10.1136/ejhpharm-2023-003784 |
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2025 Journal Article Safety, tolerability and pharmacokinetics of subcutaneous meropenem as an alternative to intravenous administrationMurray, Fionnuala, Yoo, Okhee, Brophy-Williams, Samuel, Rawlins, Matthew, Wallis, Steven C., Roberts, Jason A., Raby, Edward, Salman, Sam and Manning, Laurens (2025). Safety, tolerability and pharmacokinetics of subcutaneous meropenem as an alternative to intravenous administration. Journal of Antimicrobial Chemotherapy, 80 (1), 209-215. doi: 10.1093/jac/dkae398 |
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2025 Journal Article Nebulized aminoglycosides for ventilator-associated pneumonia: methodological considerations and lessons from experimental studiesRouby, Jean-Jacques, Xia, Jing, Dhanani, Jayesh, Bassi, Gianluigi Li, Monsel, Antoine, Torres, Antoni, Arvaniti, Kostoula, Assefi, Mona, Bassetti, Matteo, Blot, Stijn, Boisson, Matthieu, Bouglé, Adrien, Constantin, Jean-Michel, Dimopoulos, George, Dugernier, Jonathan, Dureau, Pauline, Ehrmann, Stephan, Felton, Timothy, Kollef, Marin, Koutsoukou, Antonia, Kyriakoudi, Anna, Laterre, Pierre-François, Leone, Marc, Lepère, Victoria, Liao, Xuelian, Mishra, Shakti Bedanta, Mimoz, Olivier, Nair, Girish B, Niederman, Michael ... Zhu, Ying-gang (2025). Nebulized aminoglycosides for ventilator-associated pneumonia: methodological considerations and lessons from experimental studies. Journal of Intensive Medicine, 5 (1), 12-22. doi: 10.1016/j.jointm.2024.07.006 |
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2024 Journal Article Prolonged vs intermittent infusions of β-lactam antibiotics-replyRoberts, Jason A., Devaux, Anthony and Abdul-Aziz, Mohd H. (2024). Prolonged vs intermittent infusions of β-lactam antibiotics-reply. JAMA-Journal of the American Medical Association, 333 (3), 259. doi: 10.1001/jama.2024.23728 |
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2024 Journal Article A pooled pharmacokinetic analysis for piperacillin/tazobactam across different patient populations: From premature infants to the elderlyKong, Daming, Roberts, Jason A., Lipman, Jeffrey, Taccone, Fabio Silvio, Cohen-Wolkowiez, Michael, Sime, Fekade B., Tsai, Danny, De Cock, Pieter A. J. G., Jaruratanasirikul, Sutep, Dhaese, Sofie A. M., Udy, Andrew A., Felton, Timothy W., Michelet, Robin, Thibault, Celine, Koomen, Jeroen V., Eleveld, Douglas J., Struys, Michel M. R. F., De Waele, Jan J., Colin, Pieter J., Damen, Caroline and PIP/TAZ Consortium (2024). A pooled pharmacokinetic analysis for piperacillin/tazobactam across different patient populations: From premature infants to the elderly. Clinical Pharmacokinetics, 64 (1) 769329, 107-126. doi: 10.1007/s40262-024-01460-6 |
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2024 Journal Article Population pharmacokinetics of piperacillin-tazobactam in the plasma and cerebrospinal fluid of critically ill patientsKumta, Nilesh, Heffernan, Aaron J., Cotta, Menino Osbert, Liu, Xin, Parker, Suzanne, Wallis, Steven, Livermore, Amelia, Starr, Therese, Wong, Wai Tat, Joynt, Gavin M., Lipman, Jeffrey and Roberts, Jason A. (2024). Population pharmacokinetics of piperacillin-tazobactam in the plasma and cerebrospinal fluid of critically ill patients. Antimicrobial Agents and Chemotherapy, 69 (2), e0060124. doi: 10.1128/aac.00601-24 |
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2024 Journal Article A systematic review and individual bacterial species level meta-analysis of in vitro studies on the efficacy of ceftazidime/avibactam combined with other antimicrobials against carbapenem-resistant Gram-negative bacteriaAssefa, Getnet M., Roberts, Jason A., Aslan, Abdullah T., Mohammed, Solomon A. and Sime, Fekade B. (2024). A systematic review and individual bacterial species level meta-analysis of in vitro studies on the efficacy of ceftazidime/avibactam combined with other antimicrobials against carbapenem-resistant Gram-negative bacteria. Journal of Antimicrobial Chemotherapy, 80 (2), 334-346. doi: 10.1093/jac/dkae451 |
