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2024 Journal Article Improving cognition without clearing amyloid: effects of tau and ultrasound neuromodulationLeinenga, Gerhard, Padmanabhan, Pranesh and Götz, Jürgen (2024). Improving cognition without clearing amyloid: effects of tau and ultrasound neuromodulation. Journal of Alzheimer's Disease, 100 (s1), S211-S222. doi: 10.3233/jad-240616 |
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2024 Journal Article Proteostasis as a fundamental principle of Tau immunotherapyCruz, Esteban, Nisbet, Rebecca M, Padmanabhan, Pranesh, van Waardenberg, Ashley J, Graham, Mark E, Nkajja, Godfrey, Tapaswi, Swara, Connor, Bradley J, Robinson, Phil and Götz, Jürgen (2024). Proteostasis as a fundamental principle of Tau immunotherapy. Brain. doi: 10.1093/brain/awae254 |
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2024 Journal Article Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reductionLeinenga, Gerhard, To, Xuan Vinh, Bodea, Liviu-Gabriel, Yousef, Jumana, Richter-Stretton, Gina, Palliyaguru, Tishila, Chicoteau, Antony, Dagley, Laura, Nasrallah, Fatima and Götz, Jürgen (2024). Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction. Molecular Psychiatry, 29 (8), 1-16. doi: 10.1038/s41380-024-02509-5 |
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2024 Journal Article Ultrasound and antibodies — a potentially powerful combination for Alzheimer disease therapyGötz, Jürgen and Padmanabhan, Pranesh (2024). Ultrasound and antibodies — a potentially powerful combination for Alzheimer disease therapy. Nature Reviews Neurology, 20 (5) ARTN s41582-024-00943-1, 1-2. doi: 10.1038/s41582-024-00943-1 |
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2024 Journal Article Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cellsPadmanabhan, Pranesh, Kneynsberg, Andrew, Cruz, Esteban, Briner, Adam and Götz, Jürgen (2024). Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells. Molecular Brain, 17 (1) 7, 7. doi: 10.1186/s13041-024-01078-6 |
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2024 Journal Article Multimodal evaluation of blood-brain barrier opening in mice in response to low-intensity ultrasound and a claudin-5 binderChen, Liyu, Song, Jae, Richter-Stretton, Gina, Lee, Wendy, Padmanabhan, Pranesh and Götz, Jürgen (2024). Multimodal evaluation of blood-brain barrier opening in mice in response to low-intensity ultrasound and a claudin-5 binder. Nanotheranostics, 8 (4), 427-441. doi: 10.7150/ntno.95146 |
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2023 Journal Article Vascular senescence and leak are features of the early breakdown of the blood–brain barrier in Alzheimer’s disease modelsTing, Ka Ka, Coleman, Paul, Kim, Hani Jieun, Zhao, Yang, Mulangala, Jocelyne, Cheng, Ngan Ching, Li, Wan, Gunatilake, Dilini, Johnstone, Daniel M., Loo, Lipin, Neely, G. Gregory, Yang, Pengyi, Götz, Jürgen, Vadas, Mathew A. and Gamble, Jennifer R. (2023). Vascular senescence and leak are features of the early breakdown of the blood–brain barrier in Alzheimer’s disease models. GeroScience, 45 (6), 3307-3331. doi: 10.1007/s11357-023-00927-x |
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2023 Journal Article Three methods for examining the de novo proteome of microglia using BONCAT bioorthogonal labeling and FUNCAT click chemistryCarlisle, Alison Keolani, Götz, Jürgen and Bodea, Liviu-Gabriel (2023). Three methods for examining the de novo proteome of microglia using BONCAT bioorthogonal labeling and FUNCAT click chemistry. STAR Protocols, 4 (3) 102418, 102418. doi: 10.1016/j.xpro.2023.102418 |
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2023 Journal Article Break and accelerator—The mechanics of Tau (and amyloid) toxicityCruz, Esteban, Nisbet, Rebecca M. and Götz, Jürgen (2023). Break and accelerator—The mechanics of Tau (and amyloid) toxicity. Cytoskeleton, 81 (1), 24-29. doi: 10.1002/cm.21781 |
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2023 Journal Article ER‐mitochondria contacts and cholesterol metabolism are disrupted by disease‐associated tau proteinSzabo, Leonora, Cummins, Nadia, Paganetti, Paolo, Odermatt, Alex, Papassotiropoulos, Andreas, Karch, Celeste, Götz, Jürgen, Eckert, Anne and Grimm, Amandine (2023). ER‐mitochondria contacts and cholesterol metabolism are disrupted by disease‐associated tau protein. EMBO reports, 24 (8) e57499, 1-26. doi: 10.15252/embr.202357499 |
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2023 Journal Article Special issue on “Cytoskeletal proteins in health and neurodegenerative disease: Concepts and methods”Brandt, Roland and Götz, Jürgen (2023). Special issue on “Cytoskeletal proteins in health and neurodegenerative disease: Concepts and methods”. Brain Research Bulletin, 198, 50-52. doi: 10.1016/j.brainresbull.2023.04.007 |
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2023 Journal Article Clinical relevance of animal models in aging-related dementia researchPadmanabhan, Pranesh and Götz, Jürgen (2023). Clinical relevance of animal models in aging-related dementia research. Nature Aging, 3 (5), 481-493. doi: 10.1038/s43587-023-00402-4 |
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2023 Journal Article Ultrasound as a versatile tool for short- and long-term improvement and monitoring of brain functionBlackmore, Daniel G., Razansky, Daniel and Götz, Jürgen (2023). Ultrasound as a versatile tool for short- and long-term improvement and monitoring of brain function. Neuron, 111 (8), 1174-1190. doi: 10.1016/j.neuron.2023.02.018 |
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2023 Journal Article Tyrosine phosphatase STEP61 in human dementia and in animal models with amyloid and tau pathologyTaylor, Deonne, Kneynsberg, Andrew, van Roijen, Marloes and Götz, Jürgen (2023). Tyrosine phosphatase STEP61 in human dementia and in animal models with amyloid and tau pathology. Molecular Brain, 16 (1) 6, 6. doi: 10.1186/s13041-023-00994-3 |
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2022 Journal Article CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tauPolanco, Juan Carlos, Akimov, Yevhen, Fernandes, Avinash, Briner, Adam, Hand, Gabriel Rhys, van Roijen, Marloes, Balistreri, Giuseppe and Götz, Jürgen (2022). CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tau. Life Science Alliance, 6 (1) e202201689, 1-15. doi: 10.26508/lsa.202201689 |
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2022 Journal Article Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensatesMartínez-Mármol, Ramón, Small, Christopher, Jiang, Anmin, Palliyaguru, Tishila, Wallis, Tristan P., Gormal, Rachel S., Sibarita, Jean-Baptiste, Götz, Jürgen and Meunier, Frédéric A. (2022). Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensates. Molecular Psychiatry, 28 (2), 946-862. doi: 10.1038/s41380-022-01825-y |
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2022 Journal Article Opportunities and challenges in delivering biologics for Alzheimer's disease by low-intensity ultrasoundChen, Liyu, Cruz, Esteban, Oikari, Lotta E., Padmanabhan, Pranesh, Song, Jae and Götz, Jürgen (2022). Opportunities and challenges in delivering biologics for Alzheimer's disease by low-intensity ultrasound. Advanced Drug Delivery Reviews, 189 114517, 1-18. doi: 10.1016/j.addr.2022.114517 |
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2022 Journal Article Ultrasound-mediated delivery of novel tau-specific monoclonal antibody enhances brain uptake but not therapeutic efficacyBajracharya, Rinie, Cruz, Esteban, Götz, Jürgen and Nisbet, Rebecca M. (2022). Ultrasound-mediated delivery of novel tau-specific monoclonal antibody enhances brain uptake but not therapeutic efficacy. Journal of Controlled Release, 349, 634-648. doi: 10.1016/j.jconrel.2022.07.026 |
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2022 Journal Article Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletionPadmanabhan, Pranesh, Kneynsberg, Andrew, Cruz, Esteban, Amor, Rumelo, Sibarita, Jean‐Baptiste and Götz, Jürgen (2022). Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion. The EMBO Journal, 41 (19) e111265, 1-16. doi: 10.15252/embj.2022111265 |
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2022 Journal Article Isolation and culture of pure adult mouse microglia and astrocytes for in vitro characterization and analysesMilner, Mark T., Lawrence, Grace M. E. P., Holley, Caroline L., Bodea, Liviu-Gabriel, Götz, Jürgen, Burgener, Sabrina S. and Schroder, Kate (2022). Isolation and culture of pure adult mouse microglia and astrocytes for in vitro characterization and analyses. STAR Protocols, 3 (2) 101295, 1-16. doi: 10.1016/j.xpro.2022.101295 |
