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2024

Journal Article

Improving cognition without clearing amyloid: effects of tau and ultrasound neuromodulation

Leinenga, Gerhard, Padmanabhan, Pranesh and Götz, Jürgen (2024). Improving cognition without clearing amyloid: effects of tau and ultrasound neuromodulation. Journal of Alzheimer's Disease, 100 (s1), S211-S222. doi: 10.3233/jad-240616

Improving cognition without clearing amyloid: effects of tau and ultrasound neuromodulation

2024

Journal Article

Proteostasis as a fundamental principle of Tau immunotherapy

Cruz, Esteban, Nisbet, Rebecca M, Padmanabhan, Pranesh, van Waardenberg, Ashley J, Graham, Mark E, Nkajja, Godfrey, Tapaswi, Swara, Connor, Bradley J, Robinson, Phil and Götz, Jürgen (2024). Proteostasis as a fundamental principle of Tau immunotherapy. Brain, 148 (1), 168-184. doi: 10.1093/brain/awae254

Proteostasis as a fundamental principle of Tau immunotherapy

2024

Journal Article

Correction: Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction

Leinenga, Gerhard, To, Xuan Vinh, Bodea, Liviu-Gabriel, Yousef, Jumana, Richter-Stretton, Gina, Palliyaguru, Tishila, Chicoteau, Antony, Dagley, Laura, Nasrallah, Fatima and Götz, Jürgen (2024). Correction: Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction. Molecular Psychiatry, 29 (12), 3968-3970. doi: 10.1038/s41380-024-02616-3

Correction: Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction

2024

Journal Article

Ultrasound and antibodies — a potentially powerful combination for Alzheimer disease therapy

Götz, Jürgen and Padmanabhan, Pranesh (2024). Ultrasound and antibodies — a potentially powerful combination for Alzheimer disease therapy. Nature Reviews Neurology, 20 (5), 257-258. doi: 10.1038/s41582-024-00943-1

Ultrasound and antibodies — a potentially powerful combination for Alzheimer disease therapy

2024

Journal Article

Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction

Leinenga, Gerhard, To, Xuan Vinh, Bodea, Liviu-Gabriel, Yousef, Jumana, Richter-Stretton, Gina, Palliyaguru, Tishila, Chicoteau, Antony, Dagley, Laura, Nasrallah, Fatima and Götz, Jürgen (2024). Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction. Molecular Psychiatry, 29 (8), 1-16. doi: 10.1038/s41380-024-02509-5

Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction

2024

Journal Article

Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells

Padmanabhan, Pranesh, Kneynsberg, Andrew, Cruz, Esteban, Briner, Adam and Götz, Jürgen (2024). Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells. Molecular Brain, 17 (1) 7, 7. doi: 10.1186/s13041-024-01078-6

Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells

2024

Journal Article

Multimodal evaluation of blood-brain barrier opening in mice in response to low-intensity ultrasound and a claudin-5 binder

Chen, Liyu, Song, Jae, Richter-Stretton, Gina, Lee, Wendy, Padmanabhan, Pranesh and Götz, Jürgen (2024). Multimodal evaluation of blood-brain barrier opening in mice in response to low-intensity ultrasound and a claudin-5 binder. Nanotheranostics, 8 (4), 427-441. doi: 10.7150/ntno.95146

Multimodal evaluation of blood-brain barrier opening in mice in response to low-intensity ultrasound and a claudin-5 binder

2024

Other Outputs

Scanning ultrasound-mediated improvements in APP23 mice

Leinenga, Gerhard, Richter-Stretton, Gina, To, Xuan Vinh, Chicoteau, Antony, Lee, Wendy and Götz, Jürgen (2024). Scanning ultrasound-mediated improvements in APP23 mice. The University of Queensland. (Dataset) doi: 10.48610/2ca0cbe

Scanning ultrasound-mediated improvements in APP23 mice

2024

Other Outputs

Scanning ultrasound-mediated improvements in APP23 mice in vivo imaging

Leinenga, Gerhard, Richter-Stretton, Gina, To, Xuan Vinh and Götz, Jürgen (2024). Scanning ultrasound-mediated improvements in APP23 mice in vivo imaging. The University of Queensland. (Dataset) doi: 10.48610/0239687

Scanning ultrasound-mediated improvements in APP23 mice in vivo imaging

2023

Conference Publication

Neuronal targeting of tau using a mRNA‐encoded tau‐specific antibody fragment

Wongsodirdjo, Patricia, Caruso, Alayna C., Vella, Laura J., Hung, Ya Hui, Götz, Jürgen and Nisbet, Rebecca M. (2023). Neuronal targeting of tau using a mRNA‐encoded tau‐specific antibody fragment. Alzheimer’s Association International Conference AAIC 2023, Amsterdam, Netherlands, 16-20 July 2023. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1002/alz.082634

Neuronal targeting of tau using a mRNA‐encoded tau‐specific antibody fragment

2023

Journal Article

Vascular senescence and leak are features of the early breakdown of the blood–brain barrier in Alzheimer’s disease models

Ting, Ka Ka, Coleman, Paul, Kim, Hani Jieun, Zhao, Yang, Mulangala, Jocelyne, Cheng, Ngan Ching, Li, Wan, Gunatilake, Dilini, Johnstone, Daniel M., Loo, Lipin, Neely, G. Gregory, Yang, Pengyi, Götz, Jürgen, Vadas, Mathew A. and Gamble, Jennifer R. (2023). Vascular senescence and leak are features of the early breakdown of the blood–brain barrier in Alzheimer’s disease models. GeroScience, 45 (6), 3307-3331. doi: 10.1007/s11357-023-00927-x

Vascular senescence and leak are features of the early breakdown of the blood–brain barrier in Alzheimer’s disease models

2023

Journal Article

Three methods for examining the de novo proteome of microglia using BONCAT bioorthogonal labeling and FUNCAT click chemistry

Carlisle, Alison Keolani, Götz, Jürgen and Bodea, Liviu-Gabriel (2023). Three methods for examining the de novo proteome of microglia using BONCAT bioorthogonal labeling and FUNCAT click chemistry. STAR Protocols, 4 (3) 102418, 102418. doi: 10.1016/j.xpro.2023.102418

Three methods for examining the de novo proteome of microglia using BONCAT bioorthogonal labeling and FUNCAT click chemistry

2023

Journal Article

Break and accelerator—The mechanics of Tau (and amyloid) toxicity

Cruz, Esteban, Nisbet, Rebecca M. and Götz, Jürgen (2023). Break and accelerator—The mechanics of Tau (and amyloid) toxicity. Cytoskeleton, 81 (1), 24-29. doi: 10.1002/cm.21781

Break and accelerator—The mechanics of Tau (and amyloid) toxicity

2023

Journal Article

ER‐mitochondria contacts and cholesterol metabolism are disrupted by disease‐associated tau protein

Szabo, Leonora, Cummins, Nadia, Paganetti, Paolo, Odermatt, Alex, Papassotiropoulos, Andreas, Karch, Celeste, Götz, Jürgen, Eckert, Anne and Grimm, Amandine (2023). ER‐mitochondria contacts and cholesterol metabolism are disrupted by disease‐associated tau protein. EMBO reports, 24 (8) e57499, 1-26. doi: 10.15252/embr.202357499

ER‐mitochondria contacts and cholesterol metabolism are disrupted by disease‐associated tau protein

2023

Journal Article

Special issue on “Cytoskeletal proteins in health and neurodegenerative disease: Concepts and methods”

Brandt, Roland and Götz, Jürgen (2023). Special issue on “Cytoskeletal proteins in health and neurodegenerative disease: Concepts and methods”. Brain Research Bulletin, 198, 50-52. doi: 10.1016/j.brainresbull.2023.04.007

Special issue on “Cytoskeletal proteins in health and neurodegenerative disease: Concepts and methods”

2023

Journal Article

Clinical relevance of animal models in aging-related dementia research

Padmanabhan, Pranesh and Götz, Jürgen (2023). Clinical relevance of animal models in aging-related dementia research. Nature Aging, 3 (5), 481-493. doi: 10.1038/s43587-023-00402-4

Clinical relevance of animal models in aging-related dementia research

2023

Other Outputs

Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction

Leinenga, Gerhard, To, Xuan Vinh, Bodea, Liviu-Gabriel, Youse, Jumana, Richter-Stretton, Gina, Palliyaguru, Tishila, Chicoteau, Antony, Dagley, Laura, Nasrallah, Fatima and Götz, Jürgen (2023). Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction.

Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction

2023

Journal Article

Ultrasound as a versatile tool for short- and long-term improvement and monitoring of brain function

Blackmore, Daniel G., Razansky, Daniel and Götz, Jürgen (2023). Ultrasound as a versatile tool for short- and long-term improvement and monitoring of brain function. Neuron, 111 (8), 1174-1190. doi: 10.1016/j.neuron.2023.02.018

Ultrasound as a versatile tool for short- and long-term improvement and monitoring of brain function

2023

Journal Article

Tyrosine phosphatase STEP61 in human dementia and in animal models with amyloid and tau pathology

Taylor, Deonne, Kneynsberg, Andrew, van Roijen, Marloes and Götz, Jürgen (2023). Tyrosine phosphatase STEP61 in human dementia and in animal models with amyloid and tau pathology. Molecular Brain, 16 (1) 6, 6. doi: 10.1186/s13041-023-00994-3

Tyrosine phosphatase STEP61 in human dementia and in animal models with amyloid and tau pathology

2022

Journal Article

CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tau

Polanco, Juan Carlos, Akimov, Yevhen, Fernandes, Avinash, Briner, Adam, Hand, Gabriel Rhys, van Roijen, Marloes, Balistreri, Giuseppe and Götz, Jürgen (2022). CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tau. Life Science Alliance, 6 (1) e202201689, 1-15. doi: 10.26508/lsa.202201689

CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tau