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2021 Journal Article Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosolPolanco, Juan Carlos, Hand, Gabriel Rhys, Briner, Adam, Li, Chuanzhou and Götz, Jürgen (2021). Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol. Acta Neuropathologica, 141 (2), 235-256. doi: 10.1007/s00401-020-02254-3 |
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2020 Journal Article Role for caveolin-mediated transcytosis in facilitating transport of large cargoes into the brain via ultrasoundPandit, Rucha, Koh, Wee Kiat, Sullivan, Robert K.P., Palliyaguru, Tishila, Parton, Robert G. and Götz, Jürgen (2020). Role for caveolin-mediated transcytosis in facilitating transport of large cargoes into the brain via ultrasound. Journal of Controlled Release, 327, 667-675. doi: 10.1016/j.jconrel.2020.09.015 |
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2020 Journal Article Fyn kinase controls tau aggregation in vivoBriner, Adam, Götz, Jürgen and Polanco, Juan Carlos (2020). Fyn kinase controls tau aggregation in vivo. Cell Reports, 32 (7) 108045, 108045. doi: 10.1016/j.celrep.2020.108045 |
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2020 Journal Article Delivery of antibodies into the brain using focused scanning ultrasoundLeinenga, Gerhard, Bodea, Liviu-Gabriel, Koh, Wee Kiat, Nisbet, Rebecca M. and Götz, Jürgen (2020). Delivery of antibodies into the brain using focused scanning ultrasound. Journal of Visualized Experiments, 2020 (161) e61372, 1-13. doi: 10.3791/61372 |
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2020 Journal Article Altered brain endothelial cell phenotype from a familial alzheimer mutation and its potential implications for amyloid clearance and drug deliveryOikari, Lotta E., Pandit, Rucha, Stewart, Romal, Cuní-López, Carla, Quek, Hazel, Sutharsan, Ratneswary, Rantanen, Laura M., Oksanen, Minna, Lehtonen, Sarka, de Boer, Carmela Maria, Polo, Jose M., Götz, Jürgen, Koistinaho, Jari and White, Anthony R. (2020). Altered brain endothelial cell phenotype from a familial alzheimer mutation and its potential implications for amyloid clearance and drug delivery. Stem Cell Reports, 14 (5), 924-939. doi: 10.1016/j.stemcr.2020.03.011 |
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2020 Journal Article PTEN activation contributes to neuronal and synaptic engulfment by microglia in tauopathyBenetatos, Joseph, Bennett, Rachel E., Evans, Harrison T., Ellis, Sevannah A., Hyman, Bradley T., Bodea, Liviu-Gabriel and Götz, Jürgen (2020). PTEN activation contributes to neuronal and synaptic engulfment by microglia in tauopathy. Acta Neuropathologica, 140 (1), 7-24. doi: 10.1007/s00401-020-02151-9 |
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2020 Journal Article Cell-specific non-canonical amino acid labelling identifies changes in the de novo proteome during memory formationEvans, Harrison Tudor, Bodea, Liviu-Gabriel and Götz, Jürgen (2020). Cell-specific non-canonical amino acid labelling identifies changes in the de novo proteome during memory formation. eLife, 9 e52990, e52990. doi: 10.7554/elife.52990 |
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2019 Journal Article The blood-brain barrier: physiology and strategies for drug deliveryPandit, Rucha, Chen, Liyu and Götz, Jürgen (2019). The blood-brain barrier: physiology and strategies for drug delivery. Advanced Drug Delivery Reviews, 165-166, 1-14. doi: 10.1016/j.addr.2019.11.009 |
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2019 Journal Article Scanning ultrasound in the absence of blood-brain barrier opening is not sufficient to clear β-amyloid plaques in the APP23 mouse model of Alzheimer's diseaseLeinenga, Gerhard, Koh, Wee Kiat and Götz, Jürgen (2019). Scanning ultrasound in the absence of blood-brain barrier opening is not sufficient to clear β-amyloid plaques in the APP23 mouse model of Alzheimer's disease. Brain Research Bulletin, 153, 8-14. doi: 10.1016/j.brainresbull.2019.08.002 |
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2019 Journal Article Mitochondria modulatory effects of new TSPO ligands in a cellular model of tauopathiesGrimm, Amandine, Lejri, Imane, Hallé, François, Schmitt, Martine, Götz, Jürgen, Bihel, Frederic and Eckert, Anne (2019). Mitochondria modulatory effects of new TSPO ligands in a cellular model of tauopathies. Journal of Neuroendocrinology, 32 (1) e12796, e12796. doi: 10.1111/jne.12796 |
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2019 Journal Article The search for improved animal models of Alzheimer's disease and novel strategies for therapeutic interventionLi, Chuanzhou, Briner, Adam and Götz, Jürgen (2019). The search for improved animal models of Alzheimer's disease and novel strategies for therapeutic intervention. Future Medicinal Chemistry, 11 (15), 1853-1857. doi: 10.4155/fmc-2019-0150 |
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2019 Journal Article Decreased synthesis of ribosomal proteins in tauopathy revealed by non‐canonical amino acid labellingEvans, Harrison Tudor, Benetatos, Joseph, van Roijen, Marloes, Bodea, Liviu‐Gabriel and Götz, Jürgen (2019). Decreased synthesis of ribosomal proteins in tauopathy revealed by non‐canonical amino acid labelling. The EMBO Journal, 38 (13) e101174, e101174. doi: 10.15252/embj.2018101174 |
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2019 Journal Article Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spinesPadmanabhan, Pranesh, Martínez-Mármol, Ramón, Xia, Di, Götz, Jürgen and Meunier, Frédéric A. (2019). Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines. eLife, 8 e45040. doi: 10.7554/elife.45040 |
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2019 Journal Article Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibodyJanowicz, Phillip W., Leinenga, Gerhard, Götz, Jürgen and Nisbet, Rebecca M. (2019). Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody. Scientific Reports, 9 (1) 9255, 9255. doi: 10.1038/s41598-019-45577-2 |
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2019 Journal Article Disease‐associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondriaCummins, Nadia, Tweedie, Andrea, Zuryn, Steven, Bertran‐Gonzalez, Jesus and Götz, Jürgen (2019). Disease‐associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria. The EMBO Journal, 38 (3) e99360, e99360. doi: 10.15252/embj.201899360 |
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2019 Journal Article Tauopathy in veterans with long-term posttraumatic stress disorder and traumatic brain injuryMohamed, Abdalla Z., Cumming, Paul, Götz, Jürgen and Nasrallah, Fatima (2019). Tauopathy in veterans with long-term posttraumatic stress disorder and traumatic brain injury. European Journal of Nuclear Medicine and Molecular Imaging, 46 (5), 1139-1151. doi: 10.1007/s00259-018-4241-7 |
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2019 Journal Article Molecular pathogenesis of the tauopathiesGötz, Jürgen, Halliday, Glenda and Nisbet, Rebecca M. (2019). Molecular pathogenesis of the tauopathies. Annual Review of Pathology: Mechanisms of Disease, 14 (1), 239-261. doi: 10.1146/annurev-pathmechdis-012418-012936 |
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2019 Book Chapter Experimental models of tauopathy – from mechanisms to therapiesGötz, Julika J. and Götz, Jürgen (2019). Experimental models of tauopathy – from mechanisms to therapies. Tau biology. (pp. 381-391) Singapore, Singapore: Springer. doi: 10.1007/978-981-32-9358-8_28 |
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2019 Journal Article Repeated ultrasound treatment of tau transgenic mice clears neuronal tau by autophagy and improves behavioral functionsPandit, Rucha, Leinenga, Gerhard and Gotz, Jurgen (2019). Repeated ultrasound treatment of tau transgenic mice clears neuronal tau by autophagy and improves behavioral functions. Theranostics, 9 (13), 3754-3767. doi: 10.7150/thno.34388 |
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2018 Journal Article Are you TORCing tau me? Amyloid‐β blocks the conversation between lysosomes and mitochondriaPolanco, Juan Carlos and Götz, Jürgen (2018). Are you TORCing tau me? Amyloid‐β blocks the conversation between lysosomes and mitochondria. The EMBO Journal, 37 (22) e100839, e100839. doi: 10.15252/embj.2018100839 |
