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2022

Journal Article

Isolation and culture of pure adult mouse microglia and astrocytes for in vitro characterization and analyses

Milner, Mark T., Lawrence, Grace M. E. P., Holley, Caroline L., Bodea, Liviu-Gabriel, Götz, Jürgen, Burgener, Sabrina S. and Schroder, Kate (2022). Isolation and culture of pure adult mouse microglia and astrocytes for in vitro characterization and analyses. STAR Protocols, 3 (2) 101295, 1-16. doi: 10.1016/j.xpro.2022.101295

Isolation and culture of pure adult mouse microglia and astrocytes for in vitro characterization and analyses

2022

Journal Article

Ultrasound-mediated bioeffects in senescent mice and Alzheimer’s mouse models

Balbi, Matilde, Blackmore, Daniel G., Padmanabhan, Pranesh and Götz, Jürgen (2022). Ultrasound-mediated bioeffects in senescent mice and Alzheimer’s mouse models. Brain Sciences, 12 (6) 775, 1-12. doi: 10.3390/brainsci12060775

Ultrasound-mediated bioeffects in senescent mice and Alzheimer’s mouse models

2022

Journal Article

Transcriptional signature in microglia isolated from an Alzheimer's disease mouse model treated with scanning ultrasound

Leinenga, Gerhard, Bodea, Liviu‐Gabriel, Schröder, Jan, Sun, Giuzhi, Zhou, Yichen, Song, Jae, Grubman, Alexandra, Polo, Jose M. and Götz, Jürgen (2022). Transcriptional signature in microglia isolated from an Alzheimer's disease mouse model treated with scanning ultrasound. Bioengineering & Translational Medicine, 8 (1) e10329, e10329. doi: 10.1002/btm2.10329

Transcriptional signature in microglia isolated from an Alzheimer's disease mouse model treated with scanning ultrasound

2022

Journal Article

Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model

Chen, Liyu, Sutharsan, Ratneswary, Lee, Jonathan LF, Cruz, Esteban, Asnicar, Blaise, Palliyaguru, Tishila, Wasielewska, Joanna M, Gaudin, Arnaud, Song, Jae, Leinenga, Gerhard and Götz, Jürgen (2022). Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model. Theranostics, 12 (5), 1952-1970. doi: 10.7150/thno.65539

Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model

2022

Journal Article

A sporadic Alzheimer’s blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies

Wasielewska, Joanna M., Chaves, Juliana C.S., Johnston, Rebecca L., Milton, Laura A., Hernández, Damián, Chen, Liyu, Song, Jae, Lee, Wendy, Leinenga, Gerhard, Nisbet, Rebecca M., Pébay, Alice, Götz, Jürgen, White, Anthony R. and Oikari, Lotta E. (2022). A sporadic Alzheimer’s blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies. Theranostics, 12 (16), 6826-6847. doi: 10.7150/thno.72685

A sporadic Alzheimer’s blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies

2021

Journal Article

Super-resolution microscopy: a closer look at synaptic dysfunction in Alzheimer disease

Padmanabhan, Pranesh, Kneynsberg, Andrew and Götz, Jürgen (2021). Super-resolution microscopy: a closer look at synaptic dysfunction in Alzheimer disease. Nature Reviews Neuroscience, 22 (12), 723-740. doi: 10.1038/s41583-021-00531-y

Super-resolution microscopy: a closer look at synaptic dysfunction in Alzheimer disease

2021

Journal Article

Therapeutic ultrasound as a treatment modality for physiological and pathological ageing including Alzheimer’s disease

Götz, Jürgen, Richter-Stretton, Gina and Cruz, Esteban (2021). Therapeutic ultrasound as a treatment modality for physiological and pathological ageing including Alzheimer’s disease. Pharmaceutics, 13 (7) 1002, 1002. doi: 10.3390/pharmaceutics13071002

Therapeutic ultrasound as a treatment modality for physiological and pathological ageing including Alzheimer’s disease

2021

Journal Article

Exosomal and vesicle-free tau seeds - propagation and convergence in endolysosomal permeabilization

Polanco, Juan Carlos and Götz, Jürgen (2021). Exosomal and vesicle-free tau seeds - propagation and convergence in endolysosomal permeabilization. The FEBS Journal, 289 (22) febs.16055, 6891-6907. doi: 10.1111/febs.16055

Exosomal and vesicle-free tau seeds - propagation and convergence in endolysosomal permeabilization

2021

Journal Article

Altered ribosomal function and protein synthesis caused by tau

Evans, Harrison Tudor, Taylor, Deonne, Kneynsberg, Andrew, Bodea, Liviu-Gabriel and Götz, Jürgen (2021). Altered ribosomal function and protein synthesis caused by tau. Acta Neuropathologica Communications, 9 (1) 110, 110. doi: 10.1186/s40478-021-01208-4

Altered ribosomal function and protein synthesis caused by tau

2021

Journal Article

PINK1 and parkin shape the organism-wide distribution of a deleterious mitochondrial genome

Ahier, Arnaud, Dai, Chuan-Yang, Kirmes, Ina, Cummins, Nadia, Hung, Grace Ching Ching, Götz, Jürgen and Zuryn, Steven (2021). PINK1 and parkin shape the organism-wide distribution of a deleterious mitochondrial genome. Cell Reports, 35 (9) 109203, 109203. doi: 10.1016/j.celrep.2021.109203

PINK1 and parkin shape the organism-wide distribution of a deleterious mitochondrial genome

2021

Journal Article

Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney

Sexton, Claire E, Anstey, Kaarin J, Baldacci, Filippo, Barnum, C J, Barron, Anna M, Blennow, Kaj, Brodaty, Henry, Burnham, Samantha, Elahi, Fanny M, Götz, Jürgen, Jeon, Yun-Hee, Koronyo-Hamaoui, Maya, Landau, Susan M, Lautenschlager, Nicola T, Laws, Simon M, Lipnicki, Darren M, Lu, Hanzhang, Masters, Colin L, Moyle, Wendy, Nakamura, Akinori, Pasinetti, Giulio Maria, Rao, Naren, Rowe, Christopher, Sachdev, Perminder S, Schofield, Peter R, Sigurdsson, Einar M, Smith, Kate, Srikanth, Velandai, Szoeke, Cassandra ... Carrillo, Maria C (2021). Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney. Alzheimer's & dementia : the journal of the Alzheimer's Association, 18 (1) alz.12380, 178-190. doi: 10.1002/alz.12380

Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney

2021

Journal Article

Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling

Blackmore, Daniel G., Turpin, Fabrice, Palliyaguru, Tishila, Evans, Harrison T., Chicoteau, Antony, Lee, Wendy, Pelekanos, Matthew, Nguyen, Nghia, Song, Jae, Sullivan, Robert K. P., Sah, Pankaj, Bartlett, Perry F. and Götz, Jürgen (2021). Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling. Molecular Psychiatry, 26 (11), 6975-6991. doi: 10.1038/s41380-021-01129-7

Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling

2021

Journal Article

A comparative study of the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in the APP23 mouse model of Alzheimer disease

Leinenga, Gerhard, Koh, Wee Kiat and Götz, Jürgen (2021). A comparative study of the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in the APP23 mouse model of Alzheimer disease. Alzheimer's Research and Therapy, 13 (1) 76, 1-14. doi: 10.1186/s13195-021-00809-4

A comparative study of the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in the APP23 mouse model of Alzheimer disease

2021

Journal Article

De novo proteomic methods for examining the molecular mechanisms underpinning long-term memory

Evans, Harrison Tudor, Blackmore, Daniel, Goetz, Juergen and Bodea, Liviu-Gabriel (2021). De novo proteomic methods for examining the molecular mechanisms underpinning long-term memory. Brain Research Bulletin, 169, 94-103. doi: 10.1016/j.brainresbull.2020.12.015

De novo proteomic methods for examining the molecular mechanisms underpinning long-term memory

2021

Journal Article

Tau antibody isotype induces differential effects following passive immunisation of tau transgenic mice

Bajracharya, Rinie, Brici, David, Bodea, Liviu-Gabriel, Janowicz, Phillip W., Götz, Jürgen and Nisbet, Rebecca M. (2021). Tau antibody isotype induces differential effects following passive immunisation of tau transgenic mice. Acta Neuropathologica Communications, 9 (1) 42, 1-13. doi: 10.1186/s40478-021-01147-0

Tau antibody isotype induces differential effects following passive immunisation of tau transgenic mice

2021

Journal Article

The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer’s disease

Milner, Mark T, Maddugoda, Madhavi, Götz, Jürgen, Burgener, Sabrina S and Schroder, Kate (2021). The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer’s disease. Current Opinion in Immunology, 68, 116-124. doi: 10.1016/j.coi.2020.10.011

The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer’s disease

2021

Journal Article

Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol

Polanco, Juan Carlos, Hand, Gabriel Rhys, Briner, Adam, Li, Chuanzhou and Götz, Jürgen (2021). Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol. Acta Neuropathologica, 141 (2), 235-256. doi: 10.1007/s00401-020-02254-3

Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol

2020

Journal Article

Role for caveolin-mediated transcytosis in facilitating transport of large cargoes into the brain via ultrasound

Pandit, Rucha, Koh, Wee Kiat, Sullivan, Robert K.P., Palliyaguru, Tishila, Parton, Robert G. and Götz, Jürgen (2020). Role for caveolin-mediated transcytosis in facilitating transport of large cargoes into the brain via ultrasound. Journal of Controlled Release, 327, 667-675. doi: 10.1016/j.jconrel.2020.09.015

Role for caveolin-mediated transcytosis in facilitating transport of large cargoes into the brain via ultrasound

2020

Journal Article

Fyn kinase controls tau aggregation in vivo

Briner, Adam, Götz, Jürgen and Polanco, Juan Carlos (2020). Fyn kinase controls tau aggregation in vivo. Cell Reports, 32 (7) 108045, 108045. doi: 10.1016/j.celrep.2020.108045

Fyn kinase controls tau aggregation in vivo

2020

Journal Article

Delivery of antibodies into the brain using focused scanning ultrasound

Leinenga, Gerhard, Bodea, Liviu-Gabriel, Koh, Wee Kiat, Nisbet, Rebecca M. and Götz, Jürgen (2020). Delivery of antibodies into the brain using focused scanning ultrasound. Journal of Visualized Experiments, 2020 (161) e61372, 1-13. doi: 10.3791/61372

Delivery of antibodies into the brain using focused scanning ultrasound