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2003

Journal Article

Morphine-3-glucuronide's neuro-excitatory effects are mediated via indirect activation of N-methyl-D-aspartic acid receptors: Mechanistic studies in embryonic cultured hippocampal neurones

Hemstapat, K., Monteith, G. R., Smith, D. and Smith, M. T. (2003). Morphine-3-glucuronide's neuro-excitatory effects are mediated via indirect activation of N-methyl-D-aspartic acid receptors: Mechanistic studies in embryonic cultured hippocampal neurones. Anesthesia & Analgesia, 97 (2), 494-505. doi: 10.1213/01.ANE.0000059225.40049.99

Morphine-3-glucuronide's neuro-excitatory effects are mediated via indirect activation of N-methyl-D-aspartic acid receptors: Mechanistic studies in embryonic cultured hippocampal neurones

2003

Journal Article

Managing diabetic neuropathy

Smith, M. T. (2003). Managing diabetic neuropathy. Australian Pharmacist, 22 (10), 782-787.

Managing diabetic neuropathy

2003

Journal Article

The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes

Wei, M., Ong, L., Smith, M. T., Ross, F. B., Schmid, K., Hoey, A., Burstow, D. J. and Brown, L. C. (2003). The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes. Heart, Lung and Circulation, 2003 (12), 44-50. doi: 10.1046/j.1444-2892.2003.00160.x

The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes

2003

Journal Article

The neuroexcitatory morphine metabolite, morphine-3-glucuronide (M3G), is not neurotoxic in primary cultures of either hippocampal or cerebellar granule neurones

Hemstapat, K., Smith, S. A., Monteith, G. R. and Smith, M. T. (2003). The neuroexcitatory morphine metabolite, morphine-3-glucuronide (M3G), is not neurotoxic in primary cultures of either hippocampal or cerebellar granule neurones. Pharmacology & Toxicology, 93 (4), 197-200. doi: 10.1034/j.1600-0773.2003.930408.x

The neuroexcitatory morphine metabolite, morphine-3-glucuronide (M3G), is not neurotoxic in primary cultures of either hippocampal or cerebellar granule neurones

2002

Journal Article

The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.

Smith, M. T., Cabot, P. J., Ross, F. B., Robertson, A. D. and Lewis, R. J. (2002). The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.. Pain, 96 (1-2), 119-127. doi: 10.1016/S0304-3959(01)00436-5

The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.

2001

Journal Article

Sex-related differences in antinociception and tolerance development following chronic intravenous infusion of morphine in the rat: modulatory role of testosterone via morphine clearance

South, Samantha M., Wright, Andrew W. E., Lau, Michael, Mather, Laurence E. and Smith, Maree T. (2001). Sex-related differences in antinociception and tolerance development following chronic intravenous infusion of morphine in the rat: modulatory role of testosterone via morphine clearance. Journal of Pharmacology and Experimental Therapeutics, 297 (1), 446-457.

Sex-related differences in antinociception and tolerance development following chronic intravenous infusion of morphine in the rat: modulatory role of testosterone via morphine clearance

2001

Journal Article

The role of morphine-6-glucuronide (M6G) in pain control

Smith, Maree T. and South, Samantha M. (2001). The role of morphine-6-glucuronide (M6G) in pain control. Pain Reviews, 8 (3-4), 171-191. doi: 10.1191/0968130201pr183ra

The role of morphine-6-glucuronide (M6G) in pain control

2001

Journal Article

Analgesic tolerance to opioids

South, S. M. and Smith, M. T. (2001). Analgesic tolerance to opioids. Pain: Clinical Updates, 9 (5), 1-4.

Analgesic tolerance to opioids

2001

Journal Article

Opioid analgesic prescribing and use - an audit of analgesic prescribing by general practitioners and The Multidisciplinary Pain Centre at Royal Brisbane Hospital

Nissen, L. M., Tett, S. E., Cramond, T., Williams, B. and Smith, M. T. (2001). Opioid analgesic prescribing and use - an audit of analgesic prescribing by general practitioners and The Multidisciplinary Pain Centre at Royal Brisbane Hospital. British Journal of Clinical Pharmacology, 52 (6), 693-698. doi: 10.1046/j.0306-5251.2001.01502.x

Opioid analgesic prescribing and use - an audit of analgesic prescribing by general practitioners and The Multidisciplinary Pain Centre at Royal Brisbane Hospital

2001

Journal Article

Hydromorphone-3-glucuronide - A more potent neuro-excitant than its structural analogue, morphine-3-glucuronide

Wright, AWE, Mather, LE and Smith, MT (2001). Hydromorphone-3-glucuronide - A more potent neuro-excitant than its structural analogue, morphine-3-glucuronide. Life Sciences, 69 (4), 409-420. doi: 10.1016/S0024-3205(01)01133-X

Hydromorphone-3-glucuronide - A more potent neuro-excitant than its structural analogue, morphine-3-glucuronide

2000

Journal Article

Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats

Ross, Fraser B., Wallis, Steven C. and Smith, Maree T. (2000). Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats. Pain, 84 (2-3), 421-428. doi: 10.1016/S0304-3959(99)00230-4

Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats

2000

Journal Article

Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat

Nielsen, C. K., Ross, F. B. and Smith, M. T. (2000). Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat. Journal of Pharmacology and Experimental Therapeutics, 295 (1), 91-99.

Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat

2000

Journal Article

Neuroexcitatory effects of morphine and hydromorphone: Evidence implicating the 3-glucuronide metabolites

Smith, MT (2000). Neuroexcitatory effects of morphine and hydromorphone: Evidence implicating the 3-glucuronide metabolites. Clinical and Experimental Pharmacology and Physiology, 27 (7), 524-528. doi: 10.1046/j.1440-1681.2000.03290.x

Neuroexcitatory effects of morphine and hydromorphone: Evidence implicating the 3-glucuronide metabolites

2000

Journal Article

Systemic coadministration of chloramphenicol with intravenous but not intracerebroventricular morphine markedly increases morphine antinociception and delays development of antinociceptive tolerance in rats

Smith, M. T., Nielsen, C. K., Lim-Fraser, M. Y. C., Wright, A. W. E. and Lau, M. (2000). Systemic coadministration of chloramphenicol with intravenous but not intracerebroventricular morphine markedly increases morphine antinociception and delays development of antinociceptive tolerance in rats. Drug Metabolism And Disposition, 28 (2), 236-244.

Systemic coadministration of chloramphenicol with intravenous but not intracerebroventricular morphine markedly increases morphine antinociception and delays development of antinociceptive tolerance in rats

1999

Journal Article

Brain region-specific studies of the excitatory behavioral effects of morphine-3-glucuronide

Halliday, Andrew J., Bartlett, Selena E., Colditz, Paul and Smith, Maree T. (1999). Brain region-specific studies of the excitatory behavioral effects of morphine-3-glucuronide. Life Sciences, 65 (2), 225-236. doi: 10.1016/S0024-3205(99)00239-8

Brain region-specific studies of the excitatory behavioral effects of morphine-3-glucuronide

1999

Journal Article

Cerebrospinal fluid and plasma concentrations of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in patients before and after initiation of intracerebroventricular morphine for cancer pain management

Smith, M. T., Wright, A. W., Williams, B., Stuart, G. and Cramond, T. R. (1999). Cerebrospinal fluid and plasma concentrations of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in patients before and after initiation of intracerebroventricular morphine for cancer pain management. Anesthesia and analgesia, 88 (1), 109-116. doi: 10.1097/00000539-199901000-00021

Cerebrospinal fluid and plasma concentrations of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in patients before and after initiation of intracerebroventricular morphine for cancer pain management

1999

Journal Article

Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis

Keates, HL, Cramond, T and Smith, MT (1999). Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis. Anesthesia and Analgesia, 89 (2), 409-415. doi: 10.1097/00000539-199908000-00030

Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis

1999

Journal Article

Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis

Keates, Helen L., Cramond, Teresa and Smith, Maree T. (1999). Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis. Anesthesia and Analgesia, 89 (2), 409-415.

Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis

1998

Journal Article

The excitatory behavioral and antianalgesic pharmacology of normorphine- 3-glucuronide after intracerebroventricular administration to rats

Smith, Gregg D. and Smith, Maree T. (1998). The excitatory behavioral and antianalgesic pharmacology of normorphine- 3-glucuronide after intracerebroventricular administration to rats. Journal of Pharmacology and Experimental Therapeutics, 285 (3), 1157-1162.

The excitatory behavioral and antianalgesic pharmacology of normorphine- 3-glucuronide after intracerebroventricular administration to rats

1998

Journal Article

Hydromorphone-3-glucuronide: Biochemical synthesis and preliminary pharmacological evaluation

Wright, AWE, Nocente, ML and Smith, MT (1998). Hydromorphone-3-glucuronide: Biochemical synthesis and preliminary pharmacological evaluation. Life Sciences, 63 (5), 401-411. doi: 10.1016/S0024-3205(98)00288-4

Hydromorphone-3-glucuronide: Biochemical synthesis and preliminary pharmacological evaluation