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2018 Journal Article Immune Cell Gene Signatures for Profiling the Microenvironment of Solid TumorsNirmal, Ajit J., Regan, Tim, Shih, Barbara B., Hume, David A., Sims, Andrew H. and Freeman, Tom C. (2018). Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors. Cancer Immunology Research, 6 (11), 1388-1400. doi: 10.1158/2326-6066.CIR-18-0342 |
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2018 Journal Article ADGRE1 (EMR1, F4/80) is a rapidly-evolving gene expressed in mammalian monocyte-macrophagesWaddell, Lindsey A., Lefevre, Lucas, Bush, Stephen J., Raper, Anna, Young, Rachel, Lisowski, Zofia M., McCulloch, Mary E.B., Muriuki, Charity, Sauter, Kristin A., Clark, Emily L., Irvine, Katharine M., Pridans, Clare, Hope, Jayne C. and Hume, David A. (2018). ADGRE1 (EMR1, F4/80) is a rapidly-evolving gene expressed in mammalian monocyte-macrophages. Frontiers in Immunology, 9 (OCT) 2246. doi: 10.3389/fimmu.2018.02246 |
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2018 Journal Article Pleiotropic impacts of macrophage and microglial deficiency on development in rats with targeted mutation of the Csf1r locusPridans, Clare, Raper, Anna, Davis, Gemma M., Alves, Joana, Sauter, Kristin A., Lefevre, Lucas, Regan, Tim, Meek, Stephen, Sutherland, Linda, Thomson, Alison J., Clohisey, Sara, Bush, Stephen J, Rojo, Rocío, Lisowski, Zofia M., Wallace, Robert, Grabert, Kathleen, Upton, Kyle R., Tsai, Yi Ting, Brown, Deborah, Smith, Lee B., Summers, Kim M., Mabbott, Neil A., Piccardo, Pedro, Cheeseman, Michael T., Burdon, Tom and Hume, David A. (2018). Pleiotropic impacts of macrophage and microglial deficiency on development in rats with targeted mutation of the Csf1r locus. Journal of Immunology, 201 (9), 2683-2699. doi: 10.4049/jimmunol.1701783 |
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2018 Journal Article Environmentally enriched pigs have transcriptional profiles consistent with neuroprotective effects and reduced microglial activityBrown, S. M., Bush, S. J., Summers, K. M., Hume, D. A. and Lawrence, A. B. (2018). Environmentally enriched pigs have transcriptional profiles consistent with neuroprotective effects and reduced microglial activity. Behavioural Brain Research, 350, 6-15. doi: 10.1016/j.bbr.2018.05.015 |
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2018 Journal Article The transcription factor ZEB2 is required to maintain the tissue-specific identities of macrophagesScott, Charlotte L., T'Jonck, Wouter, Martens, Liesbet, Todorov, Helena, Sichien, Dorine, Soen, Bieke, Bonnardel, Johnny, De Prijck, Sofie, Vandamme, Niels, Cannoodt, Robrecht, Saelens, Wouter, Vanneste, Bavo, Toussaint, Wendy, De Bleser, Pieter, Takahashi, Nozomi, Vandenabeele, Peter, Henri, Sandrine, Pridans, Clare, Hume, David A., Lambrecht, Bart N., De Baetselier, Patrick, Milling, Simon W. F., Van Ginderachter, Jo A., Malissen, Bernard, Berx, Geert, Beschin, Alain, Saeys, Yvan and Guilliams, Martin (2018). The transcription factor ZEB2 is required to maintain the tissue-specific identities of macrophages. Immunity, 49 (2), 312-+. doi: 10.1016/j.immuni.2018.07.004 |
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2018 Journal Article Combination of novel and public RNA-seq datasets to generate an mRNA expression atlas for the domestic chickenBush, Stephen J., Freem, Lucy, MacCallum, Amanda J., O'Dell, Jenny, Wu, Chunlei, Afrasiabi, Cyrus, Psifidi, Androniki, Stevens, Mark P., Smith, Jacqueline, Summers, Kim M. and Hume, David A. (2018). Combination of novel and public RNA-seq datasets to generate an mRNA expression atlas for the domestic chicken. BMC Genomics, 19 (1) 594. doi: 10.1186/s12864-018-4972-7 |
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2018 Journal Article Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftmentKaur, Simranpreet, Raggatt, Liza J., Millard, Susan M., Wu, Andy C., Batoon, Lena, Jacobsen, Rebecca N., Winkler, Ingrid G., MacDonald, Kelli P., Perkins, Andrew C., Hume, David A., Levesque, Jean-Pierre and Pettit, Allison R. (2018). Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment. Blood, 132 (7), 735-749. doi: 10.1182/blood-2018-01-829663 |
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2018 Journal Article Microbial diversity and community composition of caecal microbiota in commercial and indigenous Indian chickens determined using 16s rDNA amplicon sequencingPandit, Ramesh J., Hinsu, Ankit T., Patel, Namrata V., Koringa, Prakash G., Jakhesara, Subhash J., Thakkar, Jalpa R., Shah, Tejas M., Limon, Georgina, Psifidi, Androniki, Guitian, Javier, Hume, David A., Tomley, Fiona M., Rank, Dharamshibhai N., Raman, M., Tirumurugaan, K. G., Blake, Damer P. and Joshi, Chaitanya G. (2018). Microbial diversity and community composition of caecal microbiota in commercial and indigenous Indian chickens determined using 16s rDNA amplicon sequencing. Microbiome, 6 (1) 115. doi: 10.1186/s40168-018-0501-9 |
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2018 Journal Article Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenzaDunning, Jake, Blankley, Simon, Hoang, Long T., Cox, Mike, Graham, Christine M., James, Philip L., Bloom, Chloe I., Chaussabel, Damien, Banchereau, Jacques, Brett, Stephen J., Habibi, Maximillian S., Johnston, Sebastian L., Hansel, Trevor T., Levin, Mike, Thwaites, Ryan S., Warner, John O., Cookson, William O., Gazzard, Brian G., Hay, Alan, McCauley, John, Aylin, Paul, Ashby, Deborah, Barclay, Wendy S., Elderfield, Ruth A., Nadel, Simon, Herberg, Jethro A., Drumright, Lydia N., Garcia-Alvarez, Laura, Holmes, Alison H. ... Openshaw, Peter J. M. (2018). Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza. Nature Immunology, 19 (6), 625-635. doi: 10.1038/s41590-018-0111-5 |
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2018 Journal Article An update on equine postoperative ileus: definitions, pathophysiology and managementLisowski, Z. M., Pirie, R. S., Blikslager, A. T., Lefebvre, D., Hume, D. A. and Hudson, N. P. H. (2018). An update on equine postoperative ileus: definitions, pathophysiology and management. Equine Veterinary Journal, 50 (3), 292-303. doi: 10.1111/evj.12801 |
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2018 Journal Article Cross-species inference of long non-coding RNAs greatly expands the ruminant transcriptomeBush, Stephen J., Muriuki, Charity, McCulloch, Mary E. B., Farquhar, Iseabail L., Clark, Emily L. and Hume, David A. (2018). Cross-species inference of long non-coding RNAs greatly expands the ruminant transcriptome. Genetics Selection Evolution, 50 (1) 20. doi: 10.1186/s12711-018-0391-0 |
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2018 Journal Article The role of CSF1R-dependent macrophages in control of the intestinal stem-cell nicheSehgal, Anuj, Donaldson, David S., Pridans, Clare, Sauter, Kristin A., Hume, David A. and Mabbott, Neil A. (2018). The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche. Nature Communications, 9 (1) 1272, 1272. doi: 10.1038/s41467-018-03638-6 |
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2018 Journal Article The preterm labor associated ADAMTS2 gene is induced by glucocorticoidsJubb, Alasdair W., Hofer, Thomas P., Hume, David A. and Ziegler-Heitbrock, Loems (2018). The preterm labor associated ADAMTS2 gene is induced by glucocorticoids. American Journal of Obstetrics and Gynecology, 219 (1), 122-123. doi: 10.1016/j.ajog.2018.03.024 |
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2018 Journal Article Csf1r-mApple transgene expression and ligand binding in vivo reveal dynamics of CSF1R expression within the mononuclear phagocyte systemHawley, Catherine A., Rojo, Rocio, Raper, Anna, Sauter, Kristin A., Lisowski, Zofia M., Grabert, Kathleen, Bain, Calum C., Davis, Gemma M., Louwe, Pieter A., Ostrowski, Michael C., Hume, David A., Pridans, Clare and Jenkins, Stephen J. (2018). Csf1r-mApple transgene expression and ligand binding in vivo reveal dynamics of CSF1R expression within the mononuclear phagocyte system. Journal of Immunology, 200 (6), 2209-2223. doi: 10.4049/jimmunol.1701488 |
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2018 Journal Article Macrophage colony-stimulating factor increases hepatic macrophage content, liver growth, and lipid accumulation in neonatal ratsPridans, Clare, Sauter, Kristin A., Irvine, Katharine M., Davis, Gemma M., Lefevre, Lucas, Raper, Anna, Rojo, Rocio, Nirmal, Ajit J., Beard, Philippa, Cheeseman, Michael and Hume, David A. (2018). Macrophage colony-stimulating factor increases hepatic macrophage content, liver growth, and lipid accumulation in neonatal rats. American Journal of Physiology - Gastrointestinal and Liver Physiology, 314 (3), G388-G398. doi: 10.1152/ajpgi.00343.2017 |
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2018 Journal Article Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human diseaseBaillie, J. Kenneth, Bretherick, Andrew, Haley, Christopher S., Clohisey, Sara, Gray, Alan, Neyton, Lucile P. A., Barrett, Jeffrey, Stahl, Eli A., Tenesa, Albert, Andersson, Robin, Brown, J. Ben, Faulkner, Geoffrey J., Lizio, Marina, Schaefer, Ulf, Daub, Carsten, Itoh, Masayoshi, Kondo, Naoto, Lassmann, Timo, Kawai, Jun, IIBDGC Consortium, Mole, Damian, Bajic, Vladimir B., Heutink, Peter, Rehli, Michael, Kawaji, Hideya, Sandelin, Albin, Suzuki, Harukazu, Satsangi, Jack, Wells, Christine A. ... Hume, David A. (2018). Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease. PL o S Computational Biology, 14 (3) e1005934, e1005934. doi: 10.1371/journal.pcbi.1005934 |
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2018 Journal Article Effects of anti-inflammatory drugs on the expression of tryptophan-metabolism genes by human macrophagesRegan, Tim, Gill, Andrew C., Clohisey, Sara M., Barnett, Mark W., Pariante, Carmine M., Harrison, Neil A., Hume, David A., Bullmore, Edward T. and Freeman, Tom C. (2018). Effects of anti-inflammatory drugs on the expression of tryptophan-metabolism genes by human macrophages. Journal of Leukocyte Biology, 103 (4), 681-692. doi: 10.1002/JLB.3A0617-261R |
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2018 Journal Article Replicable and coupled changes in innate and adaptive immune gene expression in two case-control studies of blood microarrays in major depressive disorderLeday, Gwenaël G.R., Vértes, Petra E., Richardson, Sylvia, Greene, Jonathan R., Regan, Tim, Khan, Shahid, Henderson, Robbie, Freeman, Tom C., Pariante, Carmine M., Harrison, Neil A., Perry, V. Hugh, Drevets, Wayne C., Wittenberg, Gayle M., Bullmore, Edward T., MRC Immunopsychiatry Consortium, Bullmore, Edward, Vertes, Petra, Cardinal, Rudolf, Richardson, Sylvia, Leday, Gwenael, Freeman, Tom, Regan, Tim, Hume, David, Wu, Zhaozong, Pariante, Carmine, Cattaneo, Annamaria, Zunszain, Patricia, Borsini, Alessandra, Stewart, Robert ... Henderson, Robbie (2018). Replicable and coupled changes in innate and adaptive immune gene expression in two case-control studies of blood microarrays in major depressive disorder. Biological Psychiatry, 83 (1), 70-80. doi: 10.1016/j.biopsych.2017.01.021 |
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2018 Journal Article Species-specific transcriptional regulation of genes involved in nitric oxide production and arginine metabolism in macrophagesYoung, Rachel, Bush, Stephen J., Lefevre, Lucas, McCulloch, Mary E.B., Lisowski, Zofia M., Muriuki, Charity, Waddell, Lindsey A., Sauter, Kristin A., Pridans, Clare, Clark, Emily L. and Hume, David A. (2018). Species-specific transcriptional regulation of genes involved in nitric oxide production and arginine metabolism in macrophages. ImmunoHorizons, 2 (1), 27-37. doi: 10.4049/immunohorizons.1700073 |
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2017 Journal Article Glucocorticoid Receptor Binding Induces Rapid and Prolonged Large-Scale Chromatin Decompaction at Multiple Target LociJubb, Alasdair W., Boyle, Shelagh, Hume, David A. and Bickmore, Wendy A. (2017). Glucocorticoid Receptor Binding Induces Rapid and Prolonged Large-Scale Chromatin Decompaction at Multiple Target Loci. Cell Reports, 21 (11), 3022-3031. doi: 10.1016/j.celrep.2017.11.053 |
