Overview
Background
Dr Pranesh Padmanabhan, an NHMRC Emerging Leadership (Level 2) Fellow and Senior Research Fellow, heads the Molecular and Systems Medicine Group at the School of Biomedical Sciences and Queensland Brain Institute. His group combines mathematical modelling and quantitative imaging techniques to uncover pathomechanisms of several infectious and neurodegenerative diseases, aiming to develop and optimise treatments.
Dr. Padmanabhan began his research career as a chemical engineering PhD student in Prof. Narendra Dixit’s lab at the Indian Institute of Science. He focused on hepatitis C virus infection, innate immunity, and treatment optimisation through mathematical modelling. He received the Kuloor Memorial Medal for the best PhD thesis. In 2015, he secured a competitive three-year University of Queensland postdoctoral fellowship, joining the Queensland Brain Institute to work with Profs. Geoffrey Goodhill, Frederic Meunier, and Jürgen Götz, integrating computational modelling and molecular imaging approaches to address basic and translation neuroscience problems.
Throughout his career, Dr. Padmanabhan has secured over $2.6M in grant funding as the lead chief investigator and published in top-ranking journals, including Nature Computational Science, Nature Aging, Nature Reviews Neuroscience, Nature Reviews Neurology, Nature Communications, PNAS, EMBO Journal, Journal of Cell Biology, eLife, and PLoS Computational Biology.
Availability
- Dr Pranesh Padmanabhan is:
- Available for supervision
Qualifications
- Doctor of Philosophy, Indian Institute of Science
Works
Search Professor Pranesh Padmanabhan’s works on UQ eSpace
Featured
2022
Journal Article
Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion
Padmanabhan, Pranesh, Kneynsberg, Andrew, Cruz, Esteban, Amor, Rumelo, Sibarita, Jean‐Baptiste and Götz, Jürgen (2022). Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion. The EMBO Journal, 41 (19) e111265, 1-16. doi: 10.15252/embj.2022111265
Featured
2022
Journal Article
Modeling how antibody responses may determine the efficacy of COVID-19 vaccines
Padmanabhan, Pranesh, Desikan, Rajat and Dixit, Narendra M. (2022). Modeling how antibody responses may determine the efficacy of COVID-19 vaccines. Nature Computational Science, 2 (2), 123-131. doi: 10.1038/s43588-022-00198-0
Featured
2021
Journal Article
Super-resolution microscopy: a closer look at synaptic dysfunction in Alzheimer disease
Padmanabhan, Pranesh, Kneynsberg, Andrew and Götz, Jürgen (2021). Super-resolution microscopy: a closer look at synaptic dysfunction in Alzheimer disease. Nature Reviews Neuroscience, 22 (12), 723-740. doi: 10.1038/s41583-021-00531-y
Featured
2020
Journal Article
Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection
Padmanabhan, Pranesh, Desikan, Rajat and Dixit, Narendra M. (2020). Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection. PLoS Computational Biology, 16 (12) e1008461, e1008461. doi: 10.1371/journal.pcbi.1008461
Featured
2019
Journal Article
Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines
Padmanabhan, Pranesh, Martínez-Mármol, Ramón, Xia, Di, Götz, Jürgen and Meunier, Frédéric A. (2019). Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines. eLife, 8 e45040. doi: 10.7554/elife.45040
Featured
2018
Journal Article
Axon growth regulation by a bistable molecular switch
Padmanabhan, Pranesh and Goodhill, Geoffrey J. (2018). Axon growth regulation by a bistable molecular switch. Proceedings of the Royal Society of London B: Biological Sciences, 285 (1877) 20172618, 20172618. doi: 10.1098/rspb.2017.2618
Featured
2017
Journal Article
Inhibitors of hepatitis C virus entry may be potent ingredients of optimal drug combinations
Padmanabhan, Pranesh and Dixit, Narendra M. (2017). Inhibitors of hepatitis C virus entry may be potent ingredients of optimal drug combinations. Proceedings of the National Academy of Sciences, 114 (23), E4524-E4526. doi: 10.1073/pnas.1704531114
Featured
2014
Journal Article
Emergent properties of the interferon-signalling network may underlie the success of hepatitis C treatment
Padmanabhan, Pranesh, Garaigorta, Urtzi and Dixit, Narendra M. (2014). Emergent properties of the interferon-signalling network may underlie the success of hepatitis C treatment. Nature Communications, 5 (1) 3872, 1-9. doi: 10.1038/ncomms4872
Featured
2011
Journal Article
Mathematical model of viral kinetics in vitro estimates the number of E2-CD81 complexes necessary for hepatitis C virus entry
Padmanabhan, Pranesh and Dixit, Narendra M. (2011). Mathematical model of viral kinetics in vitro estimates the number of E2-CD81 complexes necessary for hepatitis C virus entry. PLoS Computational Biology, 7 (12) e1002307, e1002307-e1002307. doi: 10.1371/journal.pcbi.1002307
2024
Journal Article
Improving cognition without clearing amyloid: effects of tau and ultrasound neuromodulation
Leinenga, Gerhard, Padmanabhan, Pranesh and Götz, Jürgen (2024). Improving cognition without clearing amyloid: effects of tau and ultrasound neuromodulation. Journal of Alzheimer's Disease, 100 (s1), S211-S222. doi: 10.3233/jad-240616
2024
Journal Article
Proteostasis as a fundamental principle of Tau immunotherapy
Cruz, Esteban, Nisbet, Rebecca M, Padmanabhan, Pranesh, van Waardenberg, Ashley J, Graham, Mark E, Nkajja, Godfrey, Tapaswi, Swara, Connor, Bradley J, Robinson, Phil and Götz, Jürgen (2024). Proteostasis as a fundamental principle of Tau immunotherapy. Brain. doi: 10.1093/brain/awae254
2024
Journal Article
Ultrasound and antibodies — a potentially powerful combination for Alzheimer disease therapy
Götz, Jürgen and Padmanabhan, Pranesh (2024). Ultrasound and antibodies — a potentially powerful combination for Alzheimer disease therapy. Nature Reviews Neurology, 20 (5) ARTN s41582-024-00943-1, 1-2. doi: 10.1038/s41582-024-00943-1
2024
Journal Article
Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells
Padmanabhan, Pranesh, Kneynsberg, Andrew, Cruz, Esteban, Briner, Adam and Götz, Jürgen (2024). Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells. Molecular Brain, 17 (1) 7, 7. doi: 10.1186/s13041-024-01078-6
2024
Journal Article
Multimodal evaluation of blood-brain barrier opening in mice in response to low-intensity ultrasound and a claudin-5 binder
Chen, Liyu, Song, Jae, Richter-Stretton, Gina, Lee, Wendy, Padmanabhan, Pranesh and Götz, Jürgen (2024). Multimodal evaluation of blood-brain barrier opening in mice in response to low-intensity ultrasound and a claudin-5 binder. Nanotheranostics, 8 (4), 427-441. doi: 10.7150/ntno.95146
2023
Journal Article
Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology
Aguado, Julio, Amarilla, Alberto A., Taherian Fard, Atefeh, Albornoz, Eduardo A., Tyshkovskiy, Alexander, Schwabenland, Marius, Chaggar, Harman K., Modhiran, Naphak, Gómez-Inclán, Cecilia, Javed, Ibrahim, Baradar, Alireza A., Liang, Benjamin, Peng, Lianli, Dharmaratne, Malindrie, Pietrogrande, Giovanni, Padmanabhan, Pranesh, Freney, Morgan E., Parry, Rhys, Sng, Julian D. J., Isaacs, Ariel, Khromykh, Alexander A., Valenzuela Nieto, Guillermo, Rojas-Fernandez, Alejandro, Davis, Thomas P., Prinz, Marco, Bengsch, Bertram, Gladyshev, Vadim N., Woodruff, Trent M., Mar, Jessica C. ... Wolvetang, Ernst J. (2023). Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology. Nature Aging, 3 (12), 1561-1575. doi: 10.1038/s43587-023-00519-6
2023
Journal Article
Modelling how increased Cathepsin B/L and decreased TMPRSS2 usage for cell entry by the SARS-CoV-2 Omicron variant may affect the efficacy and synergy of TMPRSS2 and Cathepsin B/L inhibitors
Padmanabhan, Pranesh and Dixit, Narendra M. (2023). Modelling how increased Cathepsin B/L and decreased TMPRSS2 usage for cell entry by the SARS-CoV-2 Omicron variant may affect the efficacy and synergy of TMPRSS2 and Cathepsin B/L inhibitors. Journal of Theoretical Biology, 572 111568, 111568. doi: 10.1016/j.jtbi.2023.111568
2023
Journal Article
Clinical relevance of animal models in aging-related dementia research
Padmanabhan, Pranesh and Götz, Jürgen (2023). Clinical relevance of animal models in aging-related dementia research. Nature Aging, 3 (5), 481-493. doi: 10.1038/s43587-023-00402-4
2022
Journal Article
Opportunities and challenges in delivering biologics for Alzheimer's disease by low-intensity ultrasound
Chen, Liyu, Cruz, Esteban, Oikari, Lotta E., Padmanabhan, Pranesh, Song, Jae and Götz, Jürgen (2022). Opportunities and challenges in delivering biologics for Alzheimer's disease by low-intensity ultrasound. Advanced Drug Delivery Reviews, 189 114517, 1-18. doi: 10.1016/j.addr.2022.114517
2022
Journal Article
Ultrasound-mediated bioeffects in senescent mice and Alzheimer’s mouse models
Balbi, Matilde, Blackmore, Daniel G., Padmanabhan, Pranesh and Götz, Jürgen (2022). Ultrasound-mediated bioeffects in senescent mice and Alzheimer’s mouse models. Brain Sciences, 12 (6) 775, 1-12. doi: 10.3390/brainsci12060775
2022
Journal Article
Mechanistic models of COVID-19: insights into disease progression, vaccines, and therapeutics
Desikan, Rajat, Padmanabhan, Pranesh, Kierzek, Andrzej M. and van der Graaf, Piet H. (2022). Mechanistic models of COVID-19: insights into disease progression, vaccines, and therapeutics. International Journal of Antimicrobial Agents, 60 (1) 106606, 106606. doi: 10.1016/j.ijantimicag.2022.106606
Supervision
Availability
- Dr Pranesh Padmanabhan is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
In vitro microscopy studies into the organization and dynamics of key proteins that form the blood-brain barrier in physiological and pathological ageing and in response to therapeutic ultrasound
Principal Advisor
Other advisors: Dr Gerhard Leinenga, Professor Jürgen Götz
Completed supervision
-
2023
Doctor Philosophy
Molecular and cellular studies of neurodegenerative disease and neuronal protein synthesis
Associate Advisor
Other advisors: Dr Juan Polanco, Professor Jürgen Götz
Media
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