Dr

Gerhard Leinenga

Email: 
Phone: 
+61 7 334 66326

Availability

Dr Gerhard Leinenga is:
Available for supervision

Fields of research

Animal neurobiology Behavioural neuroscience Biochemistry and cell biology Biological Sciences Biological psychology Cell neurochemistry Psychology Zoology

Qualifications

  • Bachelor of Science, The University of Queensland
  • Bachelor, The University of Queensland
  • Bachelor (Honours), The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Search Professor Gerhard Leinenga’s works on UQ eSpace

27 works between 2013 and 2024
All (27) Journal Article (19) Conference Publication (5) Other Outputs (3)

1 - 20 of 27 works

2024

Journal Article

Improving cognition without clearing amyloid: effects of tau and ultrasound neuromodulation

Leinenga, Gerhard, Padmanabhan, Pranesh and Götz, Jürgen (2024). Improving cognition without clearing amyloid: effects of tau and ultrasound neuromodulation. Journal of Alzheimer's Disease, 100 (s1), S211-S222. doi: 10.3233/jad-240616

Improving cognition without clearing amyloid: effects of tau and ultrasound neuromodulation

2024

Journal Article

Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction

Leinenga, Gerhard, To, Xuan Vinh, Bodea, Liviu-Gabriel, Yousef, Jumana, Richter-Stretton, Gina, Palliyaguru, Tishila, Chicoteau, Antony, Dagley, Laura, Nasrallah, Fatima and Götz, Jürgen (2024). Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction. Molecular Psychiatry, 29 (8), 1-16. doi: 10.1038/s41380-024-02509-5

Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction

2024

Other Outputs

Scanning ultrasound-mediated improvements in APP23 mice in vivo imaging

Leinenga, Gerhard, Richter-Stretton, Gina, To, Xuan Vinh and Götz, Jürgen (2024). Scanning ultrasound-mediated improvements in APP23 mice in vivo imaging. The University of Queensland. (Dataset) doi: 10.48610/0239687

Scanning ultrasound-mediated improvements in APP23 mice in vivo imaging

2023

Other Outputs

Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction

Leinenga, Gerhard, To, Xuan Vinh, Bodea, Liviu-Gabriel, Youse, Jumana, Richter-Stretton, Gina, Palliyaguru, Tishila, Chicoteau, Antony, Dagley, Laura, Nasrallah, Fatima and Götz, Jürgen (2023). Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction.

Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction

2022

Journal Article

Transcriptional signature in microglia isolated from an Alzheimer's disease mouse model treated with scanning ultrasound

Leinenga, Gerhard, Bodea, Liviu‐Gabriel, Schröder, Jan, Sun, Giuzhi, Zhou, Yichen, Song, Jae, Grubman, Alexandra, Polo, Jose M. and Götz, Jürgen (2022). Transcriptional signature in microglia isolated from an Alzheimer's disease mouse model treated with scanning ultrasound. Bioengineering & Translational Medicine, 8 (1) e10329, e10329. doi: 10.1002/btm2.10329

Transcriptional signature in microglia isolated from an Alzheimer's disease mouse model treated with scanning ultrasound

2022

Journal Article

Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model

Chen, Liyu, Sutharsan, Ratneswary, Lee, Jonathan LF, Cruz, Esteban, Asnicar, Blaise, Palliyaguru, Tishila, Wasielewska, Joanna M, Gaudin, Arnaud, Song, Jae, Leinenga, Gerhard and Götz, Jürgen (2022). Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model. Theranostics, 12 (5), 1952-1970. doi: 10.7150/thno.65539

Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model

2022

Journal Article

A sporadic Alzheimer’s blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies

Wasielewska, Joanna M., Chaves, Juliana C.S., Johnston, Rebecca L., Milton, Laura A., Hernández, Damián, Chen, Liyu, Song, Jae, Lee, Wendy, Leinenga, Gerhard, Nisbet, Rebecca M., Pébay, Alice, Götz, Jürgen, White, Anthony R. and Oikari, Lotta E. (2022). A sporadic Alzheimer’s blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies. Theranostics, 12 (16), 6826-6847. doi: 10.7150/thno.72685

A sporadic Alzheimer’s blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies

2021

Journal Article

A comparative study of the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in the APP23 mouse model of Alzheimer disease

Leinenga, Gerhard, Koh, Wee Kiat and Götz, Jürgen (2021). A comparative study of the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in the APP23 mouse model of Alzheimer disease. Alzheimer's Research and Therapy, 13 (1) 76, 1-14. doi: 10.1186/s13195-021-00809-4

A comparative study of the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in the APP23 mouse model of Alzheimer disease

2020

Journal Article

Delivery of antibodies into the brain using focused scanning ultrasound

Leinenga, Gerhard, Bodea, Liviu-Gabriel, Koh, Wee Kiat, Nisbet, Rebecca M. and Götz, Jürgen (2020). Delivery of antibodies into the brain using focused scanning ultrasound. Journal of Visualized Experiments, 2020 (161) e61372, 1-13. doi: 10.3791/61372

Delivery of antibodies into the brain using focused scanning ultrasound

2019

Journal Article

Scanning ultrasound in the absence of blood-brain barrier opening is not sufficient to clear β-amyloid plaques in the APP23 mouse model of Alzheimer's disease

Leinenga, Gerhard, Koh, Wee Kiat and Götz, Jürgen (2019). Scanning ultrasound in the absence of blood-brain barrier opening is not sufficient to clear β-amyloid plaques in the APP23 mouse model of Alzheimer's disease. Brain Research Bulletin, 153, 8-14. doi: 10.1016/j.brainresbull.2019.08.002

Scanning ultrasound in the absence of blood-brain barrier opening is not sufficient to clear β-amyloid plaques in the APP23 mouse model of Alzheimer's disease

2019

Journal Article

Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody

Janowicz, Phillip W., Leinenga, Gerhard, Götz, Jürgen and Nisbet, Rebecca M. (2019). Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody. Scientific Reports, 9 (1) 9255, 9255. doi: 10.1038/s41598-019-45577-2

Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody

2019

Journal Article

Repeated ultrasound treatment of tau transgenic mice clears neuronal tau by autophagy and improves behavioral functions

Pandit, Rucha, Leinenga, Gerhard and Gotz, Jurgen (2019). Repeated ultrasound treatment of tau transgenic mice clears neuronal tau by autophagy and improves behavioral functions. Theranostics, 9 (13), 3754-3767. doi: 10.7150/thno.34388

Repeated ultrasound treatment of tau transgenic mice clears neuronal tau by autophagy and improves behavioral functions

2018

Journal Article

Modeling ultrasound propagation through material of increasing geometrical complexity

Odabaee, Maryam, Odabaee, Mostafa, Pelekanos, Matthew, Leinenga, Gerhard and Götz, Jürgen (2018). Modeling ultrasound propagation through material of increasing geometrical complexity. Ultrasonics, 90, 52-62. doi: 10.1016/j.ultras.2018.05.014

Modeling ultrasound propagation through material of increasing geometrical complexity

2018

Journal Article

Safety and Efficacy of Scanning Ultrasound Treatment of Aged APP23 Mice

Leinenga, Gerhard and Gotz, Jurgen (2018). Safety and Efficacy of Scanning Ultrasound Treatment of Aged APP23 Mice. Frontiers in Neuroscience, 12 (FEB) 55, 1-10. doi: 10.3389/fnins.2018.00055

Safety and Efficacy of Scanning Ultrasound Treatment of Aged APP23 Mice

2018

Journal Article

Establishing sheep as an experimental species to validate ultrasound-mediated blood-brain barrier opening for potential therapeutic interventions

Pelekanos, Matthew, Leinenga, Gerhard, Odabaee, Mostafa, Odabaee, Maryam, Saifzadeh, Siamak, Steck, Roland and Götz, Jürgen (2018). Establishing sheep as an experimental species to validate ultrasound-mediated blood-brain barrier opening for potential therapeutic interventions. Theranostics, 8 (9), 2583-2602. doi: 10.7150/thno.22852

Establishing sheep as an experimental species to validate ultrasound-mediated blood-brain barrier opening for potential therapeutic interventions

2017

Journal Article

Ultrasound as a treatment modality for neurological diseases

Leinenga, Gerhard, Nisbet, Rebecca M. and Gotz, Jurgen (2017). Ultrasound as a treatment modality for neurological diseases. Medical Journal of Australia, 206 (11), 470-471. doi: 10.5694/mja16.01013

Ultrasound as a treatment modality for neurological diseases

2017

Journal Article

Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model

Nisbet, Rebecca M., Van der Jeugd, Ann, Leinenga, Gerhard, Evans, Harrison T., Janowicz, Phillip W. and Goetz, Juergen (2017). Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model. Brain, 140 (5), 1220-1230. doi: 10.1093/brain/awx052

Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model

2017

Other Outputs

Investigations of the effects of scanning focused ultrasound in mouse models of Alzheimer’s disease

Leinenga, Gerhard (2017). Investigations of the effects of scanning focused ultrasound in mouse models of Alzheimer’s disease. PhD Thesis, Queensland Brain Institute, The University of Queensland. doi: 10.14264/uql.2017.467

Investigations of the effects of scanning focused ultrasound in mouse models of Alzheimer’s disease

2016

Journal Article

Scanning ultrasound (SUS) causes no changes to neuronal excitability and prevents age-related reductions in hippocampal CA1 dendritic structure in wild-type mice

Hatch, Robert John, Leinenga, Gerhard and Götz, Jürgen (2016). Scanning ultrasound (SUS) causes no changes to neuronal excitability and prevents age-related reductions in hippocampal CA1 dendritic structure in wild-type mice. PloS One, 11 (10) e0164278, e0164278. doi: 10.1371/journal.pone.0164278

Scanning ultrasound (SUS) causes no changes to neuronal excitability and prevents age-related reductions in hippocampal CA1 dendritic structure in wild-type mice

2016

Journal Article

Ultrasound treatment of neurological diseases — current and emerging applications

Leinenga, Gerhard, Langton, Christian, Nisbet, Rebecca and Gotz, Jurgen (2016). Ultrasound treatment of neurological diseases — current and emerging applications. Nature Reviews Neurology, 12 (3), 161-174. doi: 10.1038/nrneurol.2016.13

Ultrasound treatment of neurological diseases — current and emerging applications

Availability

Dr Gerhard Leinenga is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    In vitro microscopy studies into the organization and dynamics of key proteins that form the blood-brain barrier in physiological and pathological ageing and in response to therapeutic ultrasound

    Associate Advisor

    Other advisors: Professor Jürgen Götz, Dr Pranesh Padmanabhan

Enquiries

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