Overview
Background
Dr Pranesh Padmanabhan, an NHMRC Emerging Leadership (Level 2) Fellow and Senior Research Fellow, heads the Molecular and Systems Medicine Group at the School of Biomedical Sciences and Queensland Brain Institute. His group combines mathematical modelling and quantitative imaging techniques to uncover pathomechanisms of several infectious and neurodegenerative diseases, aiming to develop and optimise treatments.
Dr. Padmanabhan began his research career as a chemical engineering PhD student in Prof. Narendra Dixit’s lab at the Indian Institute of Science. He focused on hepatitis C virus infection, innate immunity, and treatment optimisation through mathematical modelling. He received the Kuloor Memorial Medal for the best PhD thesis. In 2015, he secured a competitive three-year University of Queensland postdoctoral fellowship, joining the Queensland Brain Institute to work with Profs. Geoffrey Goodhill, Frederic Meunier, and Jürgen Götz, integrating computational modelling and molecular imaging approaches to address basic and translation neuroscience problems.
Throughout his career, Dr. Padmanabhan has secured over $2.6M in grant funding as the lead chief investigator and published in top-ranking journals, including Nature Computational Science, Nature Aging, Nature Reviews Neuroscience, Nature Reviews Neurology, Nature Communications, PNAS, EMBO Journal, Journal of Cell Biology, eLife, and PLoS Computational Biology.
Availability
- Dr Pranesh Padmanabhan is:
- Available for supervision
Qualifications
- Doctor of Philosophy, Indian Institute of Science
Works
Search Professor Pranesh Padmanabhan’s works on UQ eSpace
2022
Journal Article
Mechanistic models of COVID-19: insights into disease progression, vaccines, and therapeutics
Desikan, Rajat, Padmanabhan, Pranesh, Kierzek, Andrzej M. and van der Graaf, Piet H. (2022). Mechanistic models of COVID-19: insights into disease progression, vaccines, and therapeutics. International Journal of Antimicrobial Agents, 60 (1) 106606, 106606. doi: 10.1016/j.ijantimicag.2022.106606
2021
Journal Article
Increased B cell selection stringency in germinal centers can explain improved COVID-19 vaccine efficacies with low dose prime or delayed boost
Garg, Amar K., Mittal, Soumya, Padmanabhan, Pranesh, Desikan, Rajat and Dixit, Narendra M. (2021). Increased B cell selection stringency in germinal centers can explain improved COVID-19 vaccine efficacies with low dose prime or delayed boost. Frontiers in Immunology, 12 776933, 776933. doi: 10.3389/fimmu.2021.776933
2021
Other Outputs
Low dose prime and delayed boost can improve COVID-19 vaccine efficacies by increasing B cell selection stringency in germinal centres
Garg, Amar K., Mittal, Soumya, Padmanabhan, Pranesh, Desikan, Rajat and Dixit, Narendra M. (2021). Low dose prime and delayed boost can improve COVID-19 vaccine efficacies by increasing B cell selection stringency in germinal centres. doi: 10.1101/2021.09.08.21263248
2021
Other Outputs
Modelling the population-level protection conferred by COVID-19 vaccination
Padmanabhan, Pranesh, Desikan, Rajat and Dixit, Narendra M. (2021). Modelling the population-level protection conferred by COVID-19 vaccination. doi: 10.1101/2021.03.16.21253742
2020
Journal Article
Modular transient nanoclustering of activated β2-adrenergic receptors revealed by single-molecule tracking of conformation-specific nanobodies
Gormal, Rachel S., Padmanabhan, Pranesh, Kasula, Ravikiran, Bademosi, Adekunle T., Coakley, Sean, Giacomotto, Jean, Blum, Ailisa, Joensuu, Merja, Wallis, Tristan P., Lo, Harriet P., Budnar, Srikanth, Rae, James, Ferguson, Charles, Bastiani, Michele, Thomas, Walter G., Pardon, Els, Steyaert, Jan, Yap, Alpha S., Goodhill, Geoffrey J., Hilliard, Massimo A., Parton, Robert G. and Meunier, Frédéric A. (2020). Modular transient nanoclustering of activated β2-adrenergic receptors revealed by single-molecule tracking of conformation-specific nanobodies. Proceedings of the National Academy of Sciences of the United States of America, 117 (48), 30476-30487. doi: 10.1073/pnas.2007443117
2020
Other Outputs
The quantitative landscape of the neutralizing antibody response to SARS-CoV-2
Padmanabhan, Pranesh, Desikan, Rajat and Dixit, Narendra M. (2020). The quantitative landscape of the neutralizing antibody response to SARS-CoV-2. doi: 10.1101/2020.09.25.20201996
2020
Journal Article
Radial contractility of actomyosin rings facilitates axonal trafficking and structural stability
Wang, Tong, Li, Wei, Martin, Sally, Papadopulos, Andreas, Joensuu, Merja, Liu, Chunxia, Jiang, Anmin, Shamsollahi, Golnoosh, Amor, Rumelo, Lanoue, Vanessa, Padmanabhan, Pranesh and Meunier, Frédéric A. (2020). Radial contractility of actomyosin rings facilitates axonal trafficking and structural stability. Journal of Cell Biology, 219 (5) e201902001, 1-S7. doi: 10.1083/jcb.201902001
2020
Journal Article
Opening of smaller toxin pores by lipid micelle formation
Desikan, Rajat, Padmanabhan, Pranesh and Ganapathy Ayappa, K. (2020). Opening of smaller toxin pores by lipid micelle formation. Proceedings of the National Academy of Sciences of the United States of America, 117 (10), 5107-5108. doi: 10.1073/pnas.1921467117
2020
Book Chapter
Single-molecule imaging of recycling synaptic vesicles in live neurons
Joensuu, Merja, Martínez-Mármol, Ramon, Mollazade, Mahdie, Padmanabhan, Pranesh and Meunier, Frédéric A. (2020). Single-molecule imaging of recycling synaptic vesicles in live neurons. Single molecule microscopy in neurobiology. (pp. 81-114) edited by Nobuhiko Yamamoto and Yasushi Okada. New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-0532-5_5
2020
Book Chapter
Bistability in virus–host interaction networks underlies the success of hepatitis C treatments
Padmanabhan, Pranesh, Raja, Rubesh and Dixit, Narendra M. (2020). Bistability in virus–host interaction networks underlies the success of hepatitis C treatments. Phenotypic switching: implications in biology and medicine. (pp. 131-156) edited by Herbert Levine, Mohit Kumar Jolly, Prakash Kulkarni and Vidyanand Nanjundiah. London, United Kingdom: Academic Press. doi: 10.1016/b978-0-12-817996-3.00024-4
2019
Journal Article
Need for speed: Super-resolving the dynamic nanoclustering of syntaxin-1 at exocytic fusion sites
Padmanabhan, Pranesh, Bademosi, Adekunle T., Kasula, Ravikiran, Lauwers, Elsa, Verstreken, Patrik and Meunier, Frédéric A. (2019). Need for speed: Super-resolving the dynamic nanoclustering of syntaxin-1 at exocytic fusion sites. Neuropharmacology, 169 107554, 107554. doi: 10.1016/j.neuropharm.2019.02.036
2019
Journal Article
VAMP2 Binding to Munc18-1 Domain 3a Controls the Nanoscale Reorganization of the Plasma Membrane and Vesicle Interface During Vesicular Priming
Kasula, Ravikiran, Blum, Ailisa, Salla-Martret, Merce, Chai, Ye Jin, Jiang, Anmin, Wallis, Tristan P., Gormal, Rachel S., Brouillet, Julie Z., Padmanabhan, Pranesh, Weeratunga, Saroja K., Livingstone, Emma K., Mollazade, Mahdie, Joensuu, Merja, Martínez-Mármol, Ramón, Collins, Brett M. and Meunier, Frederic (2019). VAMP2 Binding to Munc18-1 Domain 3a Controls the Nanoscale Reorganization of the Plasma Membrane and Vesicle Interface During Vesicular Priming. SSRN Electronic Journal. doi: 10.2139/ssrn.3362260
2018
Journal Article
Modelling how responsiveness to interferon improves interferon-free treatment of hepatitis C virus infection
Venugopal, Vishnu, Padmanabhan, Pranesh, Raja, Rubesh and Dixit, Narendra M (2018). Modelling how responsiveness to interferon improves interferon-free treatment of hepatitis C virus infection. PLoS Computational Biology, 14 (7) e1006335, e1006335. doi: 10.1371/journal.pcbi.1006335
2018
Conference Publication
Super-resolving botulinum neurotoxin type A molecules: from surface landing to internalization in synaptic vesicles
Joensuu, Merja, Blum, Ailisa, Mollazade, Mahdie, Lanoue, Vanessa, Padmanabhan, Pranesh, Small, Christopher, Mahrhold, Stefan, Krez, Nadja, Rummel, Andreas and Meunier, Frederic A. (2018). Super-resolving botulinum neurotoxin type A molecules: from surface landing to internalization in synaptic vesicles. TOXINS 2019: Basic Science and Clinical Aspects of Botulinum and Other Neurotoxins, Copenhagen, Denmark, 16-19 January 2019. Kidlington, Oxford, United Kingdom: Pergamon Press. doi: 10.1016/j.toxicon.2018.11.122
2017
Journal Article
Visualizing endocytic recycling and trafficking in live neurons by subdiffractional tracking of internalized molecules
Joensuu, Merja, Martinez-Marmol, Ramon, Padmanabhan, Pranesh, Glass, Nick R., Durisic, Nela, Pelekanos, Matthew, Mollazade, Mahdie, Balistreri, Giuseppe, Amor, Rumelo, Cooper-White, Justin J., Goodhill, Geoffrey J. and Meunier, Frederic A. (2017). Visualizing endocytic recycling and trafficking in live neurons by subdiffractional tracking of internalized molecules. Nature Protocols, 12 (12), 2590-2622. doi: 10.1038/nprot.2017.116
2017
Journal Article
Erratum: In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters
Bademosi, Adekunle T., Lauwers, Elsa, Padmanabhan, Pranesh, Odierna, Lorenzo, Chai, Ye Jin, Papadopulos, Andreas, Goodhill, Geoffrey J., Verstreken, Patrik, van Swinderen, Bruno and Meunier, Frédéric A (2017). Erratum: In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters. Nature Communications, 8 (1) 14492. doi: 10.1038/ncomms14492
2016
Journal Article
In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters
Bademosi, Adekunle T., Lauwers, Elsa, Padmanabhan, Pranesh, Odierna, Lorenzo, Chai, Ye Jin, Papadopulos, Andreas, Goodhill, Geoffrey J., Verstreken, Patrik, Van Swinderen, Bruno and Meunier, Frederic A. (2016). In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters. Nature Communications, 7 (1) 13660, 13660. doi: 10.1038/ncomms13660
2016
Journal Article
Subdiffractional tracking of internalized molecules reveals heterogeneous motion states of synaptic vesicles
Joensuu, Merja, Padmanabhan, Pranesh, Durisic, Nela, Bademosi, Adekunle T. D., Cooper-Williams, Elizabeth, Morrow, Isabel C., Harper, Callista B., Jung, WooRam, Parton, Robert G., Goodhill, Geoffrey J., Papadopulos, Andreas and Meunier, Frederic A. (2016). Subdiffractional tracking of internalized molecules reveals heterogeneous motion states of synaptic vesicles. Journal of Cell Biology, 215 (2), 277-292. doi: 10.1083/jcb.201604001
2016
Book Chapter
Models of viral population dynamics
Padmanabhan, Pranesh and Dixit, Narendra M. (2016). Models of viral population dynamics. Quasispecies: from theory to experimental systems. (pp. 277-302) edited by Domingo, Esteban and Schuster, Peter. Cham, Switzerland: Springer International Publishing. doi: 10.1007/82_2015_458
2015
Journal Article
Modeling Suggests a Mechanism of Synergy between Hepatitis C Virus Entry Inhibitors and Drugs of Other Classes
Padmanabhan, P. and Dixit, N.M. (2015). Modeling Suggests a Mechanism of Synergy between Hepatitis C Virus Entry Inhibitors and Drugs of Other Classes. CPT: Pharmacometrics and Systems Pharmacology, 4 (8), 445-453. doi: 10.1002/psp4.12005
Supervision
Availability
- Dr Pranesh Padmanabhan is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Understanding pathomechanisms in Alzheimer's disease
Principal Advisor
Other advisors: Professor Trent Woodruff
-
Doctor Philosophy
In vitro microscopy studies into the organization and dynamics of key proteins that form the blood-brain barrier in physiological and pathological ageing and in response to therapeutic ultrasound
Principal Advisor
Other advisors: Dr Gerhard Leinenga, Professor Jurgen Götz
-
Doctor Philosophy
Investigating the cellular and molecular bioeffects of ultrasound and microbubble treatment using advanced imaging approaches
Principal Advisor
Other advisors: Dr Gerhard Leinenga, Professor Jurgen Götz
Completed supervision
-
2023
Doctor Philosophy
Molecular and cellular studies of neurodegenerative disease and neuronal protein synthesis
Associate Advisor
Other advisors: Dr Juan Polanco, Professor Jurgen Götz
Media
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