Dr Simon de Veer
Dr

Simon de Veer

Email: 
Phone: 
+61 7 334 62021

Availability

Dr Simon de Veer is:
Available for supervision

Qualifications

  • Doctor of Philosophy, Queensland University of Technology

Search Professor Simon de Veer’s works on UQ eSpace

51 works between 2009 and 2024
All (51) Journal Article (46) Book Chapter (2) Conference Publication (3)

21 - 40 of 51 works

2019

Journal Article

Iterative optimization of the cyclic peptide SFTI-1 yields potent inhibitors of neutrophil proteinase 3

Tian, Sixin, Swedberg, Joakim E., Li, Choi Yi, Craik, David J. and de Veer, Simon J. (2019). Iterative optimization of the cyclic peptide SFTI-1 yields potent inhibitors of neutrophil proteinase 3. ACS Medicinal Chemistry Letters, 10 (8) acsmedchemlett.9b00253, 1234-1239. doi: 10.1021/acsmedchemlett.9b00253

Iterative optimization of the cyclic peptide SFTI-1 yields potent inhibitors of neutrophil proteinase 3

2019

Journal Article

KLK4 inhibition by cyclic and acyclic peptides: structural and dynamical insights into standard-mechanism protease inhibitors

Riley, Blake T., Ilyichova, Olga, de Veer, Simon J., Swedberg, Joakim E., Wilson, Emily, Hoke, David E., Harris, Jonathan M. and Buckle, Ashley M. (2019). KLK4 inhibition by cyclic and acyclic peptides: structural and dynamical insights into standard-mechanism protease inhibitors. Biochemistry, 58 (21), 2524-2533. doi: 10.1021/acs.biochem.9b00191

KLK4 inhibition by cyclic and acyclic peptides: structural and dynamical insights into standard-mechanism protease inhibitors

2019

Journal Article

Amino acid scanning at P5′ within the Bowman–Birk inhibitory loop reveals specificity trends for diverse serine proteases

Li, Choi Yi, de Veer, Simon J., White, Andrew M., Chen, Xingchen, Harris, Jonathan M., Swedberg, Joakim E. and Craik, David J. (2019). Amino acid scanning at P5′ within the Bowman–Birk inhibitory loop reveals specificity trends for diverse serine proteases. Journal of Medicinal Chemistry, 62 (7), 3696-3706. doi: 10.1021/acs.jmedchem.9b00211

Amino acid scanning at P5′ within the Bowman–Birk inhibitory loop reveals specificity trends for diverse serine proteases

2019

Journal Article

Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motif

Chen, Xingchen, Riley, Blake T., De Veer, Simon J., Hoke, David E., Van Haeften, Jessica, Leahy, Darren, Swedberg, Joakim E., Brattsand, Maria, Hartfield, Perry J., Buckle, Ashley M. and Harris, Jonathan M. (2019). Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motif. PLoS ONE, 14 (1) e0210842, e0210842. doi: 10.1371/journal.pone.0210842

Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motif

2019

Journal Article

Characterising the subsite specificity of urokinase-type plasminogen activator and tissue-type plasminogen activator using a sequence-defined peptide aldehyde library

Li, Choi Yi, de Veer, Simon J., Law, Ruby H. P., Whisstock, James C., Craik, David J. and Swedberg, Joakim E. (2019). Characterising the subsite specificity of urokinase-type plasminogen activator and tissue-type plasminogen activator using a sequence-defined peptide aldehyde library. ChemBioChem, 19 (1), 46-50. doi: 10.1002/cbic.201800395

Characterising the subsite specificity of urokinase-type plasminogen activator and tissue-type plasminogen activator using a sequence-defined peptide aldehyde library

2018

Journal Article

Potent, selective, and cell-penetrating inhibitors of Kallikrein-related peptidase 4 based on the cyclic peptide MCoTI-II

Swedberg, Joakim E., Ghani, Hafiza Abdul, Harris, Jonathan M., de Veer, Simon J. and Craik, David J. (2018). Potent, selective, and cell-penetrating inhibitors of Kallikrein-related peptidase 4 based on the cyclic peptide MCoTI-II. ACS Medicinal Chemistry Letters, 9 (12) acsmedchemlett.8b00422, 1258-1262. doi: 10.1021/acsmedchemlett.8b00422

Potent, selective, and cell-penetrating inhibitors of Kallikrein-related peptidase 4 based on the cyclic peptide MCoTI-II

2018

Journal Article

Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1

de Veer, Simon J., Li, Choi Yi, Swedberg, Joakim E., Schroeder, Christina I. and Craik, David J. (2018). Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1. European Journal of Medicinal Chemistry, 155, 695-704. doi: 10.1016/j.ejmech.2018.06.029

Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1

2017

Journal Article

Kallikrein-related peptidase 5 contributes to H3N2 influenza virus infection in human lungs

Magnen, Melia, Gueugnon, Fabien, Guillon, Antoine, Baranek, Thomas, Thibault, Virginie C., Petit-Courty, Agnes, de Veer, Simon J., Harris, Jonathan, Humbles, Alison A., Si-Tahar, Mustapha and Courty, Yves (2017). Kallikrein-related peptidase 5 contributes to H3N2 influenza virus infection in human lungs. Journal of Virology, 91 (16) e00421-17. doi: 10.1128/JVI.00421-17

Kallikrein-related peptidase 5 contributes to H3N2 influenza virus infection in human lungs

2017

Journal Article

Cyclotides as tools in chemical biology

de Veer, Simon J., Weidmann, Joachim and Craik, David J. (2017). Cyclotides as tools in chemical biology. Accounts of Chemical Research, 50 (7), 1557-1565. doi: 10.1021/acs.accounts.7b00157

Cyclotides as tools in chemical biology

2017

Journal Article

Selective substrates and inhibitors for kallikrein-related peptidase 7 (KLK7) shed light on KLK proteolytic activity in the stratum corneum

de Veer, Simon J., Furio, Laetitia, Swedberg, Joakim E., Munro, Christopher A., Brattsand, Maria, Clements, Judith A., Hovnanian, Alain and Harris, Jonathan M. (2017). Selective substrates and inhibitors for kallikrein-related peptidase 7 (KLK7) shed light on KLK proteolytic activity in the stratum corneum. The Journal of Investigative Dermatology, 137 (2), 430-439. doi: 10.1016/j.jid.2016.09.017

Selective substrates and inhibitors for kallikrein-related peptidase 7 (KLK7) shed light on KLK proteolytic activity in the stratum corneum

2017

Journal Article

Design of potent and selective cathepsin G inhibitors based on the sunflower trypsin inhibitor-1 scaffold

Swedberg, Joakim E., Li, Choi Yi, De Veer, Simon J., Wang, Conan K. and Craik, David J. (2017). Design of potent and selective cathepsin G inhibitors based on the sunflower trypsin inhibitor-1 scaffold. Journal of Medicinal Chemistry, 60 (2), 658-667. doi: 10.1021/acs.jmedchem.6b01509

Design of potent and selective cathepsin G inhibitors based on the sunflower trypsin inhibitor-1 scaffold

2017

Journal Article

Attenuated kallikrein-related peptidase activity disrupts desquamation and leads to stratum corneum thickening in human skin equivalent models

McGovern, J. A., Meinert, C., de Veer, S. J., Hollier, B. G., Parker, T. J. and Upton, Z. (2017). Attenuated kallikrein-related peptidase activity disrupts desquamation and leads to stratum corneum thickening in human skin equivalent models. British Journal of Dermatology, 176 (1), 145-158. doi: 10.1111/bjd.14879

Attenuated kallikrein-related peptidase activity disrupts desquamation and leads to stratum corneum thickening in human skin equivalent models

2017

Book Chapter

Naturally occurring disulfide-rich cyclic peptides from plants and animals: Synthesis and biosynthesis

de Veer, Simon J. and Craik, David J. (2017). Naturally occurring disulfide-rich cyclic peptides from plants and animals: Synthesis and biosynthesis. Chemical biology of natural products. (pp. 491-529) edited by David J. Newman, Gordon M. Cragg and Paul Grothaus. Boca Raton, FL United States: CRC Press. doi: 10.1201/9781315117089-14

Naturally occurring disulfide-rich cyclic peptides from plants and animals: Synthesis and biosynthesis

2016

Journal Article

Exploring the active site binding specificity of kallikrein-related peptidase 5 (KLK5) guides the design of new peptide substrates and inhibitors

De Veer, Simon J., Swedberg, Joakim E., Brattsand, Maria, Clements, Judith A. and Harris, Jonathan M. (2016). Exploring the active site binding specificity of kallikrein-related peptidase 5 (KLK5) guides the design of new peptide substrates and inhibitors. Biological Chemistry, 397 (12), 1237-1249. doi: 10.1515/hsz-2016-0112

Exploring the active site binding specificity of kallikrein-related peptidase 5 (KLK5) guides the design of new peptide substrates and inhibitors

2016

Journal Article

Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics

Riley, Blake T., Ilyichova, Olga, Costa, Mauricio G. S., Porebski, Benjamin T., De Veer, Simon J., Swedberg, Joakim E., Kass, Itamar, Harris, Jonathan M., Hoke, David E. and Buckle, Ashley M. (2016). Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics. Scientific Reports, 6 (1) 35385, 35385. doi: 10.1038/srep35385

Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics

2016

Journal Article

Substrate-guided design of selective FXIIa inhibitors based on the plant-derived Momordica cochinchinensis trypsin inhibitor-II (MCoTI-II) scaffold

Swedberg, Joakim E., Mahatmanto, Tunjung, Ghani, Hafiza Abdul, de Veer, Simon J., Schroeder, Christina I., Harris, Jonathan M. and Craik, David J. (2016). Substrate-guided design of selective FXIIa inhibitors based on the plant-derived Momordica cochinchinensis trypsin inhibitor-II (MCoTI-II) scaffold. Journal of Medicinal Chemistry, 59 (15), 7287-7292. doi: 10.1021/acs.jmedchem.6b00557

Substrate-guided design of selective FXIIa inhibitors based on the plant-derived Momordica cochinchinensis trypsin inhibitor-II (MCoTI-II) scaffold

2015

Journal Article

Improving the selectivity of engineered protease inhibitors: optimizing the P2 prime residue using a versatile cyclic peptide library

de Veer, Simon J., Wang, Conan, Harris, Jonathan M., Craik, David J. and Swedberg, Joakim E. (2015). Improving the selectivity of engineered protease inhibitors: optimizing the P2 prime residue using a versatile cyclic peptide library. Journal of Medicinal Chemistry, 58 (20), 8257-8268. doi: 10.1021/acs.jmedchem.5b01148

Improving the selectivity of engineered protease inhibitors: optimizing the P2 prime residue using a versatile cyclic peptide library

2015

Journal Article

Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition

de Veer, Simon J., Swedberg, Joakim E., Akcan, Muharrem, Rosengren, K. Johan, Brattsand, Maria, Craik, David J. and Harris, Jonathan M. (2015). Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition. Biochemical Journal, 469 (2), 243-253. doi: 10.1042/BJ20150412

Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition

2014

Conference Publication

Dominant and recessive Olmsted syndrome with erythromelalgia due to TRPV3 mutations

Duchatelet, S., de Veer, S., Guibbal, L., Freitag, S., Nitschke, P., Bole-Feysot, C., Bodemers, C. and Hovnanian, A. (2014). Dominant and recessive Olmsted syndrome with erythromelalgia due to TRPV3 mutations. 44th Annual Meeting of the European-Society-for-Dermatological-Research (ESDR), Copenhagen Denmark, Sep 10-13, 2014. NEW YORK: NATURE PUBLISHING GROUP.

Dominant and recessive Olmsted syndrome with erythromelalgia due to TRPV3 mutations

2014

Journal Article

Olmsted syndrome with erythromelalgia caused by recessive TRPV3 mutations

Duchatelet, S., Guibbal, L., de Veer, S., Fraitag, S., Nitschké, P., Zarhrate, M., Bodemer, C. and Hovnanian, A. (2014). Olmsted syndrome with erythromelalgia caused by recessive TRPV3 mutations. British Journal of Dermatology, 171 (3), 675-678. doi: 10.1111/bjd.12951

Olmsted syndrome with erythromelalgia caused by recessive TRPV3 mutations

Current funding

  • 2022 - 2024
    Developing FXIIa inhibitors as next-generation anticoagulants
    NHMRC Development Grant
    Open grant

Past funding

  • 2020 - 2022
    Peptide ligands as tools to decipher receptor biology
    NHMRC IDEAS Grants
    Open grant
  • 2019 - 2021
    Developing Factor XIIa inhibitors as new leads for preventing thrombosis
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Expanding the repertoire of immunomodulatory drugs: targeting the melanocortin system using engineered cyclic peptides
    NHMRC Early Career Fellowships
    Open grant

Availability

Dr Simon de Veer is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

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