Overview
Background
Dr Changkui Fu is currently an NHMRC Emerging Leadership Fellow in the Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland (UQ).
Dr Fu obtained his bachelor and PhD degrees in Chemistry from Tsinghua University China in 2010 and 2015 respectively. After that, he moved to the Centre of Advanced Macromolecular Design (CAMD) in the UNSW as a postdoctoral researcher working with Prof Cyrille Boyer to explore photo-induced polymerization technologies. In 2016, he relocated to AIBN, UQ as a postdoctoral research fellow in Prof Andrew Whittaker's group on developing advanced imaging agents. In 2018, He was awarded a UQ Development Fellowship to work on novel bioactive polymers. Following this, he was awarded an NHMRC Emerging Investigator Grant on studying Bio-Nano interaction.
Dr Fu's research focuses on the design and synthesis of novel polymers with well-defined molecular structures and sophisticated functionalities. These polymers are suitable for a range of advanced applications including controlled drug delivery and bioimaging. He has published a number of peer-reviewed articles in leading scientific journals including Macromolecules, ACS Macro Letter, Polymer Chemistry, Advanced Healthcare Materials, Chemical Communications, JACS, Angewandte Chemie and others, and been granted a patent. To date, these publications have received nearly 4000 citations in total with an h-index of 36.
Dr Fu is looking for HDRs to join his group with a focus on Polymer Science and Biomaterials.
Availability
- Dr Changkui Fu is:
- Available for supervision
Qualifications
- Bachelor, Tsinghua University
- Doctor of Philosophy, Tsinghua University
Research interests
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Synthetic polymer chemistry
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Biomedical polymers
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Protein conjugation
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Bio-Nano interactions
Works
Search Professor Changkui Fu’s works on UQ eSpace
2021
Journal Article
Eco‐friendly biomolecule‐nanomaterial hybrids as next‐generation agrochemicals for topical delivery
Li, Peng, Huang, Yun, Fu, Changkui, Jiang, Shang Xu, Peng, Wei, Jia, Yi, Peng, Hong, Zhang, Ping, Manzie, Narelle, Mitter, Neena and Xu, Zhi Ping (2021). Eco‐friendly biomolecule‐nanomaterial hybrids as next‐generation agrochemicals for topical delivery. EcoMat, 3 (5) eom2.12132, 1-19. doi: 10.1002/eom2.12132
2021
Journal Article
Inhibition of amyloid aggregation and toxicity with Janus iron oxide nanoparticles
Andrikopoulos, Nicholas, Song, Zhiyuan, Wan, Xulin, Douek, Alon M., Javed, Ibrahim, Fu, Changkui, Xing, Yanting, Xin, Fangyun, Li, Yuhuan, Kakinen, Aleksandr, Koppel, Kairi, Qiao, Ruirui, Whittaker, Andrew K., Kaslin, Jan, Davis, Thomas P., Song, Yang, Ding, Feng and Ke, Pu Chun (2021). Inhibition of amyloid aggregation and toxicity with Janus iron oxide nanoparticles. Chemistry of Materials, 33 (16) acs.chemmater.1c01947, 6484-6500. doi: 10.1021/acs.chemmater.1c01947
2021
Journal Article
Editorial: Design, Synthesis and Biomedical Applications of Functional Polymers
Fu, Changkui, Zhu, Chongyu, Synatschke, Christopher V. and Zhang, Xiaoyong (2021). Editorial: Design, Synthesis and Biomedical Applications of Functional Polymers. Frontiers in Chemistry, 9 681189, 681189. doi: 10.3389/fchem.2021.681189
2021
Journal Article
Photo-directing chemoepitaxy: the versatility of poly(aryl methacrylate) films in tuning block copolymer wetting
Zhao, Jiacheng, McCallum, Francis J., Yu, Ye, Fu, Changkui, Kaitz, Joshua A., Cameron, James F., Trefonas, Peter, Blakey, Idriss, Peng, Hui and Whittaker, Andrew K. (2021). Photo-directing chemoepitaxy: the versatility of poly(aryl methacrylate) films in tuning block copolymer wetting. Polymer Chemistry, 12 (21), 3201-3209. doi: 10.1039/d1py00501d
2021
Journal Article
Photo/thermal dual responses in aqueous-soluble copolymers containing 1-naphthyl methacrylate
Zhao, Jiacheng, Er, Gerald Tze Kwang, McCallum, Francis J., Wang, Sisi, Fu, Changkui, Kaitz, Joshua A., Cameron, James F., Trefonas, Peter, Blakey, Idriss, Peng, Hui and Whittaker, Andrew K. (2021). Photo/thermal dual responses in aqueous-soluble copolymers containing 1-naphthyl methacrylate. Macromolecules, 54 (10), 4860-4870. doi: 10.1021/acs.macromol.1c00297
2021
Journal Article
Amphiphilic perfluoropolyether copolymers for the effective removal of polyfluoroalkyl substances from aqueous environments
Tan, Xiao, Zhong, Jiexi, Fu, Changkui, Dang, Huy, Han, Yanxiao, Král, Petr, Guo, Jianhua, Yuan, Zhiguo, Peng, Hui, Zhang, Cheng and Whittaker, Andrew K. (2021). Amphiphilic perfluoropolyether copolymers for the effective removal of polyfluoroalkyl substances from aqueous environments. Macromolecules, 54 (7) acs.macromol.1c00096, 3447-3457. doi: 10.1021/acs.macromol.1c00096
2021
Journal Article
Antifouling surfaces enabled by surface grafting of highly hydrophilic sulfoxide polymer brushes
Xu, Xin, Huang, Xumin, Chang, Yixin, Yu, Ye, Zhao, Jiacheng, Isahak, Naatasha, Teng, Jisi, Qiao, Ruirui, Peng, Hui, Zhao, Chun-Xia, Davis, Thomas P., Fu, Changkui and Whittaker, Andrew K. (2021). Antifouling surfaces enabled by surface grafting of highly hydrophilic sulfoxide polymer brushes. Biomacromolecules, 22 (2), 330-339. doi: 10.1021/acs.biomac.0c01193
2021
Journal Article
Tuning the thermoresponsive properties of PEG-based fluorinated polymers and stimuli responsive drug release for switchable 19F magnetic resonance imaging
Usman, Adil, Zhang, Cheng, Zhao, Jiacheng, Peng, Hui, Kurniawan, Nyoman D., Fu, Changkui, Hill, David J. T. and Whittaker, Andrew K. (2021). Tuning the thermoresponsive properties of PEG-based fluorinated polymers and stimuli responsive drug release for switchable 19F magnetic resonance imaging. Polymer Chemistry, 12 (38), 5438-5448. doi: 10.1039/d1py00602a
2020
Journal Article
The impact of polymer size and cleavability on the intravenous pharmacokinetics of PEG-based hyperbranched polymers in rats
Marasini, Nirmal, Fu, Changkui, Fletcher, Nicholas L., Subasic, Christopher, Er, Gerald, Mardon, Karine, Thurecht, Kristofer J., Whittaker, Andrew K. and Kaminskas, Lisa M. (2020). The impact of polymer size and cleavability on the intravenous pharmacokinetics of PEG-based hyperbranched polymers in rats. Nanomaterials, 10 (12) 2452, 1-16. doi: 10.3390/nano10122452
2020
Journal Article
Use of microfluidics to fabricate bioerodable lipid hybrid nanoparticles containing hydromorphone or ketamine for the relief of intractable pain
Zhu, Minze, Whittaker, Andrew K., Jiang, Xingyu, Tang, Rupei, Li, Xuanyu, Xu, Weizhi, Fu, Changkui, Smith, Maree T. and Han, Felicity Y. (2020). Use of microfluidics to fabricate bioerodable lipid hybrid nanoparticles containing hydromorphone or ketamine for the relief of intractable pain. Pharmaceutical Research, 37 (10) 211, 1-12. doi: 10.1007/s11095-020-02939-0
2020
Journal Article
Functional polymers as metal-free magnetic resonance imaging contrast agents
Fu, Changkui, Yu, Ye, Xu, Xin, Wang, Qiaoyun, Chang, Yixin, Zhang, Cheng, Zhao, Jiacheng, Peng, Hui and Whittaker, Andrew K. (2020). Functional polymers as metal-free magnetic resonance imaging contrast agents. Progress in Polymer Science, 108 101286, 101286. doi: 10.1016/j.progpolymsci.2020.101286
2020
Journal Article
Biomimetic core-shell silica nanoparticles using a dual-functional peptide
Tengjisi, Hui, Yue, Yang, Guangze, Fu, Changkui, Liu, Yun and Zhao, Chun-Xia (2020). Biomimetic core-shell silica nanoparticles using a dual-functional peptide. Journal of Colloid and Interface Science, 581 (Pt A), 185-194. doi: 10.1016/j.jcis.2020.07.107
2020
Journal Article
Charge reversion simultaneously enhances tumor accumulation and cell uptake of layered double hydroxide nanohybrids for effective imaging and therapy
Liu, Jianping, Wu, Yilun, Fu, Changkui, Li, Bei, Li, Li, Zhang, Run, Xu, Tiefeng and Xu, Zhi Ping (2020). Charge reversion simultaneously enhances tumor accumulation and cell uptake of layered double hydroxide nanohybrids for effective imaging and therapy. Small, 16 (31) 2002115, e2002115. doi: 10.1002/smll.202002115
2020
Journal Article
Tuning of the aggregation behavior of fluorinated polymeric nanoparticles for improved therapeutic efficacy
Zhang, Cheng, Liu, Tianqing, Wang, Wenqian, Bell, Craig A., Han, Yanxiao, Fu, Changkui, Peng, Hui, Tan, Xiao, Král, Petr, Gaus, Katharina, Gooding, J. Justin and Whittaker, Andrew K. (2020). Tuning of the aggregation behavior of fluorinated polymeric nanoparticles for improved therapeutic efficacy. ACS Nano, 14 (6) acsnano.0c02954, 7425-7434. doi: 10.1021/acsnano.0c02954
2020
Journal Article
Proteins conjugated with sulfoxide-containing polymers show reduced macrophage cellular uptake and improved pharmacokinetics
Yu, Ye, Xu, Weizhi, Huang, Xumin, Xu, Xin, Qiao, Ruirui, Li, Yuhuan, Han, Felicity, Peng, Hui, Davis, Thomas P., Fu, Changkui and Whittaker, Andrew K. (2020). Proteins conjugated with sulfoxide-containing polymers show reduced macrophage cellular uptake and improved pharmacokinetics. ACS Macro Letters, 9 (6), 799-805. doi: 10.1021/acsmacrolett.0c00291
2020
Journal Article
Sulfoxide‐containing polymer‐coated nanoparticles demonstrate minimal protein fouling and improved blood circulation
Qiao, Ruirui, Fu, Changkui, Li, Yuhuan, Qi, Xiaole, Ni, Dalong, Nandakumar, Aparna, Siddiqui, Ghizal, Wang, Haiyan, Zhang, Zheng, Wu, Tingting, Zhong, Jian, Tang, Shi‐Yang, Pan, Shuaijun, Zhang, Cheng, Whittaker, Michael R., Engle, Jonathan W., Creek, Darren J., Caruso, Frank, Ke, Pu Chun, Cai, Weibo, Whittaker, Andrew K. and Davis, Thomas P. (2020). Sulfoxide‐containing polymer‐coated nanoparticles demonstrate minimal protein fouling and improved blood circulation. Advanced Science, 7 (13) 2000406, 2000406. doi: 10.1002/advs.202000406
2020
Journal Article
Low-fouling fluoropolymers for bioconjugation and in vivo tracking
Fu, Changkui, Demir, Baris, Alcantara, Sheilajen, Kumar, Vinod, Han, Felicity, Kelly, Hannah, Tan, Xiao, Yu, Ye, Xu, Weizhi, Zhao, Jiacheng, Zhang, Cheng, Peng, Hui, Boyer, Cyrille, Woodruff, Trent, Kent, Stephen, Searles, Debra and Whittaker, Andrew (2020). Low-fouling fluoropolymers for bioconjugation and in vivo tracking. Angewandte Chemie International Edition, 59 (12), 4729-4735. doi: 10.1002/anie.201914119
2020
Journal Article
Multimodal nanoprobe for pancreatic beta cell detection and amyloidosis mitigation
Xin, Fangyun, Li, Yuhuan, Fu, Changkui, Javed, Ibrahim, Huang, Xumin, Schaschkow, Anais, Ribeiro, Rita S. Garcia, Gurzov, Esteban N., Davis, Thomas P., Zhang, Xiaoling, Ke, Pu Chun and Qjao, Ruirui (2020). Multimodal nanoprobe for pancreatic beta cell detection and amyloidosis mitigation. Chemistry of Materials, 32 (3), 1080-1088. doi: 10.1021/acs.chemmater.9b03841
2020
Journal Article
Low‐fouling fluoropolymers for bioconjugation and in vivo tracking
Fu, Changkui, Demir, Baris, Alcantara, Sheilajen, Kumar, Vinod, Han, Felicity, Kelly, Hannah G., Tan, Xiao, Yu, Ye, Xu, Weizhi, Zhao, Jiacheng, Zhang, Cheng, Peng, Hui, Boyer, Cyrille, Woodruff, Trent M., Kent, Stephen J., Searles, Debra J. and Whittaker, Andrew K. (2020). Low‐fouling fluoropolymers for bioconjugation and in vivo tracking. Angewandte Chemie, 132 (12), 4759-4765. doi: 10.1002/ange.201914119
2019
Journal Article
Integrating fluorinated polymer and manganese‐layered double hydroxide nanoparticles as pH‐activated 19 F MRI agents for specific and sensitive detection of breast cancer
Zhang, Cheng, Li, Li, Han, Felicity Y., Yu, Xinying, Tan, Xiao, Fu, Changkui, Xu, Zhi Ping and Whittaker, Andrew K. (2019). Integrating fluorinated polymer and manganese‐layered double hydroxide nanoparticles as pH‐activated 19 F MRI agents for specific and sensitive detection of breast cancer. Small, 15 (36) 1902309, 1902309. doi: 10.1002/smll.201902309
Supervision
Availability
- Dr Changkui Fu is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Synthesis and application of advanced polymeric imaging agents
This project focuses on developing advanced polymers capable of inherent imaging property for high-resolution and highly sensitive imaging applications. In particular, we are interested in exploring synthetic polymers that can be used as high performance magnetic resonance imaging (MRI) contrast agents. Despite the popular use of metal-based MRI contrast agents such as gadolinium-chelates or iron oxide nanoparticles, safety concerns have been raised associated with the use of these metal-based contrast agents. The polymers developed in this project will provide outstanding candidates as metal-free MRI contrast agents, which would enable a variety of biomedical applications such as targeted imaging and therapy of many diseases. For more details, please read our recent papers (Polym. Chem., 2017, 8, 4585-4595; Macromolecules 2018, 51, 5875-5882; Angew.Chem. Int.Ed. 2020, 59, 4729 –4735).
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Design and synthesis of next-generation of antifouling polymers
Antifouling polymers play very important roles in many biomedical applications such as medical implants, drug delivery systems and targeted imaging and sensing. Polyethylene glycol (PEG) has been the most successful and popular antifouling polymer. Despite this, a number of limitations associated with use of PEG have emerged, with the apparent immunogenicity of PEG being the most striking and important as revealed by recent animal and clinical studies. The exact biological mechanism underpinning the immunogenicity of PEG is still not very clear. However, it is believed that the partial amphiphilic nature of PEG is largely responsible. Thus, this project aims to understand the origin of PEG immunogenicity, particularly from a perspective of the chemical nature of polymers, and correlate the antifouling performance of polymers to their structures to develop next-generation of antifouling polymers. For more details, please read our recent papers (Adv. Sci, 2020, 2000406; ACS Macro Lett. 2020, 9, 799–805; Angew.Chem. Int.Ed. 2020, 59, 4729 –4735).
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Develop new approaches for the delivery of protein therapeutics
Proteins are an important class of pharmaceuticals. There are 6 protein therapeutics out 10 best-selling drugs of 2018. Overcoming the limitations of many protein therapeutics such as low aqueous solubility and biological stability as well as possible immunogenicity to improve their bioavailability is a key to use them to treat human diseases. This project aims to developing new approaches for efficient and effective delivery of proteins by utilising advanced synthetic chemistry and biocompatible polymer materials. We pay particular attention to the pharmacokinetics and pharmacodynamics of the proteins formulated using our advanced approaches. For more details, please read our recent papers (ACS Macro Lett. 2020, 9, 799–805; Angew.Chem. Int.Ed. 2020, 59, 4729 –4735).
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We welcome motivated students with background on synthetic chemistry, polymer science, biomaterials, and pharmacy to join our research programs.
Supervision history
Current supervision
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Doctor Philosophy
Combinatorial Synthesis of Cationic Polymers for mRNA Delivery
Principal Advisor
Other advisors: Professor Andrew Whittaker
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Doctor Philosophy
Developing innovative protein-polymer conjugates for advanced treatment of diseases
Principal Advisor
Other advisors: Professor Andrew Whittaker, Dr Hui Peng
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Doctor Philosophy
Novel polymeric membranes for CO2 capture and electrical conversion
Associate Advisor
Other advisors: Dr Hui Peng, Associate Professor Jingwei Hou, Professor Andrew Whittaker
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Doctor Philosophy
Low fouling surfaces for Extracorporeal Membrane Oxygenation (ECMO) devices
Associate Advisor
Other advisors: Dr Hui Peng, Professor Andrew Whittaker
Completed supervision
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2024
Doctor Philosophy
Nanomaterials for Bioapplications: from Inorganic Nanoparticles to Polymeric Nanoparticles
Associate Advisor
Other advisors: Dr Hui Peng, Dr Gayathri Ediriweera, Professor Andrew Whittaker
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2024
Doctor Philosophy
Design, Synthesis and Evaluation of Perfluoropolyether (PFPE)-Containing Polymeric Devices for Efficient Removal of Per- and Polyfluoroalkyl Substances (PFAS) from Water Sources
Associate Advisor
Other advisors: Dr Hui Peng, Dr Cheng Zhang, Professor Andrew Whittaker
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2023
Doctor Philosophy
Intelligent Metal-Organic Frameworks Nanohybrids for Cancer Diagnosis and Therapy
Associate Advisor
Other advisors: Dr Hui Peng, Dr Gayathri Ediriweera, Professor Andrew Whittaker
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2022
Master Philosophy
Polymer-assisted Smart Iron Oxide Nanoparticles as Novel Magnetic Resonance Imaging Contrast Agents
Associate Advisor
Other advisors: Dr Ruirui Qiao
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2022
Doctor Philosophy
Dibromomaleimide-Based Conjugation Reactions for Self-Reporting Polymers
Associate Advisor
Other advisors: Dr Hui Peng, Professor Andrew Whittaker
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2022
Doctor Philosophy
Novel hydrogels for delivery of cancer drugs
Associate Advisor
Other advisors: Professor Andrew Whittaker, Professor Lisbeth Grondahl
Media
Enquiries
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