Overview
Background
Dr Changkui Fu is currently an NHMRC Emerging Leadership Fellow in the Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland (UQ).
Dr Fu obtained his bachelor and PhD degrees in Chemistry from Tsinghua University China in 2010 and 2015 respectively. After that, he moved to the Centre of Advanced Macromolecular Design (CAMD) in the UNSW as a postdoctoral researcher working with Prof Cyrille Boyer to explore photo-induced polymerization technologies. In 2016, he relocated to AIBN, UQ as a postdoctoral research fellow in Prof Andrew Whittaker's group on developing advanced imaging agents. In 2018, He was awarded a UQ Development Fellowship to work on novel bioactive polymers. Following this, he was awarded an NHMRC Emerging Investigator Grant on studying Bio-Nano interaction.
Dr Fu's research focuses on the design and synthesis of novel polymers with well-defined molecular structures and sophisticated functionalities. These polymers are suitable for a range of advanced applications including controlled drug delivery and bioimaging. He has published a number of peer-reviewed articles in leading scientific journals including Macromolecules, ACS Macro Letter, Polymer Chemistry, Advanced Healthcare Materials, Chemical Communications, JACS, Angewandte Chemie and others, and been granted a patent. To date, these publications have received nearly 4000 citations in total with an h-index of 36.
Dr Fu is looking for HDRs to join his group with a focus on Polymer Science and Biomaterials.
Availability
- Dr Changkui Fu is:
- Available for supervision
Qualifications
- Bachelor, Tsinghua University
- Doctor of Philosophy, Tsinghua University
Research interests
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Synthetic polymer chemistry
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Biomedical polymers
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Protein conjugation
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Bio-Nano interactions
Works
Search Professor Changkui Fu’s works on UQ eSpace
2015
Journal Article
The power of one-pot: a hexa-component system containing π-π Stacking, Ugi reaction and RAFT polymerization for simple polymer conjugation on carbon nanotubes
Yang, Bin, Zhao, Yuan, Ren, Xu, Zhang, Xiaoyong, Fu, Changkui, Zhang, Yaling, Wei, Yen and Tao, Lei (2015). The power of one-pot: a hexa-component system containing π-π Stacking, Ugi reaction and RAFT polymerization for simple polymer conjugation on carbon nanotubes. Polymer Chemistry, 6 (4), 509-513. doi: 10.1039/c4py01323a
2015
Journal Article
Amphiphilic fluorescent copolymers via one-pot combination of chemoenzymatic transesterification and RAFT polymerization: synthesis, self-assembly and cell imaging
Huang, Zengfang, Zhang, Xiqi, Zhang, Xiaoyong, Fu, Changkui, Wang, Ke, Yuan, Jinying, Tao, Lei and Wei, Yen (2015). Amphiphilic fluorescent copolymers via one-pot combination of chemoenzymatic transesterification and RAFT polymerization: synthesis, self-assembly and cell imaging. Polymer Chemistry, 6 (4), 607-612. doi: 10.1039/c4py01421a
2015
Journal Article
Multicomponent polymerization system combining Hantzsch reaction and reversible addition - fragmentation chain transfer to efficiently synthesize well-defined poly(1,4-dihydropyridine)s
Zhang, Qingdong, Zhang, Yaling, Zhao, Yuan, Yang, Bin, Fu, Changkui, Wei, Yen and Tao, Lei (2015). Multicomponent polymerization system combining Hantzsch reaction and reversible addition - fragmentation chain transfer to efficiently synthesize well-defined poly(1,4-dihydropyridine)s. ACS Macro Letters, 4 (1), 128-132. doi: 10.1021/mz500734c
2014
Journal Article
Fluorescent PEGylation agent by a thiolactone-based one-pot reaction: a new strategy for theranostic combinations
Zhao, Yuan, Yang, Bin, Zhang, Yaling, Wang, Shiqi, Fu, Changkui, Wei, Yen and Tao, Lei (2014). Fluorescent PEGylation agent by a thiolactone-based one-pot reaction: a new strategy for theranostic combinations. Polymer Chemistry, 5 (23), 6656-6661. doi: 10.1039/c4py00995a
2014
Journal Article
Synthesis of multifunctional polymers through the ugi reaction for protein conjugation
Yang, Bin, Zhao, Yuan, Wang, Shiqi, Zhang, Yaling, Fu, Changkui, Wei, Yen and Tao, Lei (2014). Synthesis of multifunctional polymers through the ugi reaction for protein conjugation. Macromolecules, 47 (16), 5607-5612. doi: 10.1021/ma501385m
2014
Journal Article
From polymer sequence control to protein recognition: synthesis, self-assembly and lectin binding
Lu, Jiawei, Fu, Changkui, Wang, Shiqi, Tao, Lei, Yan, Litang, Haddleton, David M., Chen, Gaojian and Wei, Yen (2014). From polymer sequence control to protein recognition: synthesis, self-assembly and lectin binding. Macromolecules, 47 (14), 4676-4683. doi: 10.1021/ma500664u
2014
Journal Article
Combining enzymatic monomer transformation with photoinduced electron transfer - Reversible addition-fragmentation chain transfer for the synthesis of complex multiblock copolymers
Fu, Changkui, Xu, Jiangtao, Tao, Lei and Boyer, Cyrille (2014). Combining enzymatic monomer transformation with photoinduced electron transfer - Reversible addition-fragmentation chain transfer for the synthesis of complex multiblock copolymers. ACS Macro Letters, 3 (7), 633-638. doi: 10.1021/mz500245k
2014
Journal Article
Introducing mercaptoacetic acid locking imine reaction into polymer chemistry as a green click reaction
Zhao, Yuan, Yang, Bin, Zhu, Chongyu, Zhang, Yaling, Wang, Shiqi, Fu, Changkui, Wei, Yen and Tao, Lei (2014). Introducing mercaptoacetic acid locking imine reaction into polymer chemistry as a green click reaction. Polymer Chemistry, 5 (8), 2695-2699. doi: 10.1039/c4py00058g
2014
Journal Article
Introducing the Ugi reaction into polymer chemistry as a green click reaction to prepare middle-functional block copolymers
Yang, Bin, Zhao, Yuan, Fu, Changkui, Zhu, Chongyu, Zhang, Yaling, Wang, Shiqi, Wei, Yen and Tao, Lei (2014). Introducing the Ugi reaction into polymer chemistry as a green click reaction to prepare middle-functional block copolymers. Polymer Chemistry, 5 (8), 2704-2708. doi: 10.1039/c4py00001c
2014
Journal Article
Facile one-pot synthesis of new functional polymers through multicomponent systems
Wang, Shiqi, Fu, Changkui, Wei, Yen and Tao, Lei (2014). Facile one-pot synthesis of new functional polymers through multicomponent systems. Macromolecular Chemistry and Physics, 215 (6), 486-492. doi: 10.1002/macp.201300738
2014
Journal Article
Thermo and pH dual-responsive materials for controllable oil/water separation
Cao, Yingze, Liu, Na, Fu, Changkui, Li, Kan, Tao, Lei, Feng, Lin and Wei, Yen (2014). Thermo and pH dual-responsive materials for controllable oil/water separation. ACS Applied Materials and Interfaces, 6 (3), 2026-2030. doi: 10.1021/am405089m
2014
Journal Article
Exploration of multicomponent polymerization system
Wang, Shiqi, Fu, Changkui, Wei, Yen and Tao, Lei (2014). Exploration of multicomponent polymerization system. Progress in Chemistry, 26 (7), 1099-1106. doi: 10.7536/PC140110
2013
Journal Article
Synthesis of gradient copolymers by concurrent enzymatic monomer transformation and RAFT polymerization
Fu, Changkui, Yang, Bin, Zhu, Chongyu, Wang, Shiqi, Zhang, Yun, Wei, Yen and Tao, Lei (2013). Synthesis of gradient copolymers by concurrent enzymatic monomer transformation and RAFT polymerization. Polymer Chemistry, 4 (24), 5720-5725. doi: 10.1039/c3py00841j
2013
Journal Article
A new insight into the Biginelli reaction: the dawn of multicomponent click chemistry?
Zhu, Chongyu, Yang, Bin, Zhao, Yuan, Fu, Changkui, Tao, Lei and Wei, Yen (2013). A new insight into the Biginelli reaction: the dawn of multicomponent click chemistry?. Polymer Chemistry, 4 (21), 5395-5400. doi: 10.1039/c3py00553d
2013
Journal Article
Nonionic polymer cross-linked chitosan hydrogel: preparation and bioevaluation
Xu, Liangxin, Zhang, Xiaoyong, Zhu, Chongyu, Zhang, Yaling, Fu, Changkui, Yang, Bin, Tao, Lei and Wei, Yen (2013). Nonionic polymer cross-linked chitosan hydrogel: preparation and bioevaluation. Journal of Biomaterials Science - Polymer Edition, 24 (13), 1564-1574. doi: 10.1080/09205063.2013.781934
2013
Journal Article
A multicomponent polymerization system: click-chemoenzymatic-ATRP in one-pot for polymer synthesis
Zhang, Yun, Fu, Changkui, Zhu, Chongyu, Wang, Shiqi, Tao, Lei and Wei, Yen (2013). A multicomponent polymerization system: click-chemoenzymatic-ATRP in one-pot for polymer synthesis. Polymer Chemistry, 4 (3), 466-469. doi: 10.1039/c2py21039h
2013
Journal Article
Hierarchically porous chitosan-PEG-silica biohybrid: synthesis and rapid cell adsorption
Fu, Changkui, Wang, Shiqi, Feng, Lin, Liu, Xiaoqi, Ji, Yan, Tao, Lei, Li, Shuxi and Wei, Yen (2013). Hierarchically porous chitosan-PEG-silica biohybrid: synthesis and rapid cell adsorption. Advanced Healthcare Materials, 2 (2), 302-305. doi: 10.1002/adhm.201200166
2013
Journal Article
One-pot synthesis of optically active polymer via concurrent cooperation of enzymatic resolution and living radical polymerization
Fu, Changkui, Zhu, Chongyu, Wang, Shiqi, Liu, Honglei, Zhang, Yun, Guo, Hongchao, Tao, Lei and Wei, Yen (2013). One-pot synthesis of optically active polymer via concurrent cooperation of enzymatic resolution and living radical polymerization. Polymer Chemistry, 4 (2), 264-267. doi: 10.1039/c2py20875j
2012
Journal Article
One-pot cascade synthetic strategy: a smart combination of chemoenzymatic transesterification and raft polymerization
Wang, Shiqi, Fu, Changkui, Zhang, Yun, Tao, Lei, Li, Shuxi and Wei, Yen (2012). One-pot cascade synthetic strategy: a smart combination of chemoenzymatic transesterification and raft polymerization. ACS Macro Letters, 1 (10), 1224-1227. doi: 10.1021/mz300444w
2012
Journal Article
Combining chemoenzymatic monomer transformation with ATRP: a facile "one-pot" approach to functional polymers
Fu, Changkui, Tao, Lei, Zhang, Yun, Li, Shuxi and Wei, Yen (2012). Combining chemoenzymatic monomer transformation with ATRP: a facile "one-pot" approach to functional polymers. Chemical Communications, 48 (72), 9062-9064. doi: 10.1039/c2cc34633h
Supervision
Availability
- Dr Changkui Fu is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Synthesis and application of advanced polymeric imaging agents
This project focuses on developing advanced polymers capable of inherent imaging property for high-resolution and highly sensitive imaging applications. In particular, we are interested in exploring synthetic polymers that can be used as high performance magnetic resonance imaging (MRI) contrast agents. Despite the popular use of metal-based MRI contrast agents such as gadolinium-chelates or iron oxide nanoparticles, safety concerns have been raised associated with the use of these metal-based contrast agents. The polymers developed in this project will provide outstanding candidates as metal-free MRI contrast agents, which would enable a variety of biomedical applications such as targeted imaging and therapy of many diseases. For more details, please read our recent papers (Polym. Chem., 2017, 8, 4585-4595; Macromolecules 2018, 51, 5875-5882; Angew.Chem. Int.Ed. 2020, 59, 4729 –4735).
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Design and synthesis of next-generation of antifouling polymers
Antifouling polymers play very important roles in many biomedical applications such as medical implants, drug delivery systems and targeted imaging and sensing. Polyethylene glycol (PEG) has been the most successful and popular antifouling polymer. Despite this, a number of limitations associated with use of PEG have emerged, with the apparent immunogenicity of PEG being the most striking and important as revealed by recent animal and clinical studies. The exact biological mechanism underpinning the immunogenicity of PEG is still not very clear. However, it is believed that the partial amphiphilic nature of PEG is largely responsible. Thus, this project aims to understand the origin of PEG immunogenicity, particularly from a perspective of the chemical nature of polymers, and correlate the antifouling performance of polymers to their structures to develop next-generation of antifouling polymers. For more details, please read our recent papers (Adv. Sci, 2020, 2000406; ACS Macro Lett. 2020, 9, 799–805; Angew.Chem. Int.Ed. 2020, 59, 4729 –4735).
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Develop new approaches for the delivery of protein therapeutics
Proteins are an important class of pharmaceuticals. There are 6 protein therapeutics out 10 best-selling drugs of 2018. Overcoming the limitations of many protein therapeutics such as low aqueous solubility and biological stability as well as possible immunogenicity to improve their bioavailability is a key to use them to treat human diseases. This project aims to developing new approaches for efficient and effective delivery of proteins by utilising advanced synthetic chemistry and biocompatible polymer materials. We pay particular attention to the pharmacokinetics and pharmacodynamics of the proteins formulated using our advanced approaches. For more details, please read our recent papers (ACS Macro Lett. 2020, 9, 799–805; Angew.Chem. Int.Ed. 2020, 59, 4729 –4735).
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We welcome motivated students with background on synthetic chemistry, polymer science, biomaterials, and pharmacy to join our research programs.
Supervision history
Current supervision
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Doctor Philosophy
Developing innovative protein-polymer conjugates for advanced treatment of diseases
Principal Advisor
Other advisors: Professor Andrew Whittaker, Dr Hui Peng
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Doctor Philosophy
Combinatorial Synthesis of Cationic Polymers for mRNA Delivery
Principal Advisor
Other advisors: Professor Andrew Whittaker
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Doctor Philosophy
Low fouling surfaces for Extracorporeal Membrane Oxygenation (ECMO) devices
Associate Advisor
Other advisors: Dr Hui Peng, Professor Andrew Whittaker
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Doctor Philosophy
Novel polymeric membranes for CO2 capture and electrical conversion
Associate Advisor
Other advisors: Dr Hui Peng, Associate Professor Jingwei Hou, Professor Andrew Whittaker
Completed supervision
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2024
Doctor Philosophy
Nanomaterials for Bioapplications: from Inorganic Nanoparticles to Polymeric Nanoparticles
Associate Advisor
Other advisors: Dr Hui Peng, Dr Gayathri Ediriweera, Professor Andrew Whittaker
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2024
Doctor Philosophy
Design, Synthesis and Evaluation of Perfluoropolyether (PFPE)-Containing Polymeric Devices for Efficient Removal of Per- and Polyfluoroalkyl Substances (PFAS) from Water Sources
Associate Advisor
Other advisors: Dr Hui Peng, Dr Cheng Zhang, Professor Andrew Whittaker
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2023
Doctor Philosophy
Intelligent Metal-Organic Frameworks Nanohybrids for Cancer Diagnosis and Therapy
Associate Advisor
Other advisors: Dr Hui Peng, Dr Gayathri Ediriweera, Professor Andrew Whittaker
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2022
Master Philosophy
Polymer-assisted Smart Iron Oxide Nanoparticles as Novel Magnetic Resonance Imaging Contrast Agents
Associate Advisor
Other advisors: Dr Ruirui Qiao
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2022
Doctor Philosophy
Novel hydrogels for delivery of cancer drugs
Associate Advisor
Other advisors: Professor Andrew Whittaker, Professor Lisbeth Grondahl
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2022
Doctor Philosophy
Dibromomaleimide-Based Conjugation Reactions for Self-Reporting Polymers
Associate Advisor
Other advisors: Dr Hui Peng, Professor Andrew Whittaker
Media
Enquiries
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