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Dr Md Moniruzzaman
Dr

Md Moniruzzaman

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Overview

Background

Dr Moniruzzaman is working as a Senior Postdoctoral Research Fellow at the UQ Faculty of Medicine and PA Hospital of Metro South Health. His research focuses on the molecular pathobiology of inflammatory diseases, in particular, how mucosal epithelial cells and gut microbiota regulate immune function in the gastrointestinal (GI) tract and contribute to different diseases, including inflammatory bowel diseases (IBD) and functional GI symptoms called disorders of gut-brain interactions (DGBI). Dr Moniruzzaman received his PhD from The University of Queensland in 2020, where he studied how the interleukin(IL)-20 family of cytokines (IL-20, IL-22, and IL-24) regulate mucosal epithelial and immune function in inflammatory and infectious diseases, including ulcerative colitis (UC) and respiratory syncytial virus. After graduation, he received postdoctoral training in the IBD Lab at Mater Research Institute – UQ and Nanomedicine Lab at UQ School of Pharmacy, where he investigated the role of cannabinoid receptors in UC and colitis-associated colorectal cancer, development of cannabinoid formulations to treat UC, and involvement of autophagy gene Atg7 in 6-Thioguanin mediated protection from UC. He was awarded a highly competitive UQ Postdoctoral Research Fellowship (2021-2022) and UQ School of Pharmacy Strategic Grant (2022) to study cannabinoids and Atg7 in UC, Translational Research Institute LINC Grant (2023) to study cannabinoids in palliative care of patients with advanced cancer, and Metro South Health SERTA (2024-2025) to study non-antibiotic treatment of SI dysbiosis in patients with DGBI. His current work focuses on how small intestinal dysbiosis controls the mucosal immune microenvironment and contributes to the pathogenesis of DGBI, including irritable bowel syndrome (IBS), functional dyspepsia (FD), and gastroparesis.

Availability

Dr Md Moniruzzaman is:
Available for supervision

Qualifications

  • Bachelor (Honours) of Pharmacy, Stamford University Bangladesh
  • Masters (Research) of Pharmacy, Dongguk University
  • Doctoral (Research) of Biochemistry and Cell Biology, The University of Queensland

Research interests

  • Immune regulation in mucosal inflammation

    Intestinal epithelial cells produce various antimicrobial peptides and cytokines that contribute to immune regulation and barrier integrity. The gut microbiota also plays a critical role in mucosal immune regulation through its interaction with the immune system and helps shape its development and function. Dysbiosis, an imbalance in the gut microbial composition, can lead to impaired immune regulation and contribute to mucosal inflammation. Understanding the mechanisms of immune regulation in mucosal inflammation is crucial for developing therapeutic interventions. Targeting immune cells and microbiota and promoting barrier integrity are potential strategies for restoring immune balance and alleviating mucosal inflammation-related diseases.

  • Intestinal microbial dysbiosis in Disorders of Gut-Brain Interaction (DGBI)

    Gut-brain interactions refer to the bidirectional communication and connection between the gut (digestive system) and the brain (central nervous system). The gut-brain axis is a complex network involving various pathways and signalling mechanisms that facilitate communication between these two systems. The enteric nervous system, also known as the "second brain," is a network of neurons within the gut that can function independently and communicate with the central nervous system. The vagus nerve, a major nerve connecting the gut and the brain, plays a crucial role in transmitting signals and information between these two systems. Gut-brain interactions are involved in regulating a wide range of functions, including digestion, appetite, mood, stress response, and immune function. The gut microbiota, the collection of microorganisms residing in the gut, also influences gut-brain interactions through the production of neurotransmitters and other signalling molecules. However, any disturbance in communication could lead to a variety of symptoms and conditions, called disorders of gut-brain interaction (DGBI), which include motility disturbance, visceral hypersensitivity, altered mucosal and immune function, altered gut microbiota, and altered CNS processing. Therefore, understanding and studying gut-brain interactions is essential for gaining insights into various disorders and developing potential treatments.

Works

Search Professor Md Moniruzzaman’s works on UQ eSpace

55 works between 2014 and 2024

1 - 20 of 55 works

2024

Journal Article

Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis

Sajiir, Haressh, Keshvari, Sahar, Wong, Kuan Yau, Borg, Danielle J., Steyn, Frederik J., Fercher, Christian, Taylor, Karin, Taylor, Breten, Barnard, Ross T., Müller, Alexandra, Moniruzzaman, Md, Miller, Gregory, Wang, Ran, Fotheringham, Amelia, Schreiber, Veronika, Sheng, Yong Hua, Hancock, Janelle Louise, Loo, Dorothy, Burr, Lucy, Huynh, Tony, Lockett, Jack, Ramm, Grant A., Macdonald, Graeme A., Prins, Johannes B., McGuckin, Michael A. and Hasnain, Sumaira Z. (2024). Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis. Nature Communications, 15 (1) 4528, 4528. doi: 10.1038/s41467-024-48317-x

Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis

Featured

2024

Journal Article

Cannabidiol - help and hype in targeting mucosal diseases

Moniruzzaman, Md, Janjua, Taskeen Iqbal, Martin, Jennifer H., Begun, Jakob and Popat, Amirali (2024). Cannabidiol - help and hype in targeting mucosal diseases. Journal of Controlled Release, 365, 530-543. doi: 10.1016/j.jconrel.2023.11.010

Cannabidiol - help and hype in targeting mucosal diseases

Featured

2023

Journal Article

Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells

Moniruzzaman, Md, Rahman, M. Arifur, Wang, Ran, Wong, Kuan Yau, Chen, Alice C. -H., Mueller, Alexandra, Taylor, Steven, Harding, Alexa, Illankoon, Thishan, Wiid, Percival, Sajiir, Haressh, Schreiber, Veronika, Burr, Lucy D., McGuckin, Michael A., Phipps, Simon and Hasnain, Sumaira Z. (2023). Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells. The Journal of Experimental Medicine, 220 (11) e20230106. doi: 10.1084/jem.20230106

Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells

Featured

2023

Conference Publication

Enhancing the efficacy of cannabidiol using protein nanoparticles to treat inflammatory bowel disease

Moniruzzaman, M., Rewatkar, P., Begun, J. and Popat, A. (2023). Enhancing the efficacy of cannabidiol using protein nanoparticles to treat inflammatory bowel disease. 18th Congress of ECCO, Copenhagen, Denmark, 1-4 March 2023. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjac190.0167

Enhancing the efficacy of cannabidiol using protein nanoparticles to treat inflammatory bowel disease

Featured

2022

Journal Article

IL-20 activates ERK1/2 and suppresses splicing of X-box protein-1 in intestinal epithelial cells but does not improve pathology in acute or chronic models of colitis

Moniruzzaman, Md., Wong, Kuan Yau, Wang, Ran, Symon, Hamish, Mueller, Alexandra, Rahman, M. Arifur and Hasnain, Sumaira Z. (2022). IL-20 activates ERK1/2 and suppresses splicing of X-box protein-1 in intestinal epithelial cells but does not improve pathology in acute or chronic models of colitis. International Journal of Molecular Sciences, 24 (1) 174, 174. doi: 10.3390/ijms24010174

IL-20 activates ERK1/2 and suppresses splicing of X-box protein-1 in intestinal epithelial cells but does not improve pathology in acute or chronic models of colitis

Featured

2021

Journal Article

Facile synthesis of dendrimer like mesoporous silica nanoparticles to enhance targeted delivery of interleukin-22

Elshaer, Dana, Moniruzzaman, Md., Ong, Yi Theng, Qu, Zhi, Schreiber, Veronika, Begun, Jakob and Popat, Amirali (2021). Facile synthesis of dendrimer like mesoporous silica nanoparticles to enhance targeted delivery of interleukin-22. Biomaterials Science, 9 (22), 7402-7411. doi: 10.1039/d1bm01352a

Facile synthesis of dendrimer like mesoporous silica nanoparticles to enhance targeted delivery of interleukin-22

Featured

2021

Journal Article

Gut microbiota shape the inflammatory response in mice with an epithelial defect

Wang, Ran, Moniruzzaman, Md, Wong, Kuan Yau, Wiid, Percival, Harding, Alexa, Giri, Rabina, Tong, Wendy Hui, Creagh, Jackie, Begun, Jakob, McGuckin, Michael A. and Hasnain, Sumaira Z. (2021). Gut microbiota shape the inflammatory response in mice with an epithelial defect. Gut microbes, 13 (1), 1-18. doi: 10.1080/19490976.2021.1887720

Gut microbiota shape the inflammatory response in mice with an epithelial defect

Featured

2020

Journal Article

The leaves of Bougainvillea spectabilis suppressed inflammation and nociception in vivo through the modulation of glutamatergic, cGMP, and ATP-sensitive K+ channel pathways

Ferdous, Afia, Janta, Rabir Ahmed, Arpa, Rubaiya Nushin, Afroze, Mirola, Khan, Mala and Moniruzzaman, Md. (2020). The leaves of Bougainvillea spectabilis suppressed inflammation and nociception in vivo through the modulation of glutamatergic, cGMP, and ATP-sensitive K+ channel pathways. Journal of Ethnopharmacology, 261 113148, 113148. doi: 10.1016/j.jep.2020.113148

The leaves of Bougainvillea spectabilis suppressed inflammation and nociception in vivo through the modulation of glutamatergic, cGMP, and ATP-sensitive K+ channel pathways

2019

Journal Article

Interleukin (IL)-22 from IL-20 Subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway

Moniruzzaman, Md., Wang, Ran, Jeet, Varinder, McGuckin, Michael A. and Hasnain, Sumaira Z. (2019). Interleukin (IL)-22 from IL-20 Subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway. International Journal of Molecular Sciences, 20 (14) 3468, 3468. doi: 10.3390/ijms20143468

Interleukin (IL)-22 from IL-20 Subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway

2016

Journal Article

The ethyl acetate fraction from Physalis alkekengi inhibits LPS-induced pro-inflammatory mediators in BV2 cells and inflammatory pain in mice

Moniruzzaman, Md., Bose, Shambhunath, Kim, Young-Mi, Chin, Young-Won and Cho, Jungsook (2016). The ethyl acetate fraction from Physalis alkekengi inhibits LPS-induced pro-inflammatory mediators in BV2 cells and inflammatory pain in mice. Journal of Ethnopharmacology, 181, 26-36. doi: 10.1016/j.jep.2016.01.023

The ethyl acetate fraction from Physalis alkekengi inhibits LPS-induced pro-inflammatory mediators in BV2 cells and inflammatory pain in mice

2024

Journal Article

First assessment of trace metals in the intertidal zone of the world's longest continuous beach, Cox's Bazar, Bangladesh

Karmaker, Kowshik Das, Khan, Nasim, Akhtar, Umme Sarmeen, Moniruzzaman, Mohammad, Parvin, Afroza, Ghosh, Arnob, Saha, Badhan and Hossain, Md. Kamal (2024). First assessment of trace metals in the intertidal zone of the world's longest continuous beach, Cox's Bazar, Bangladesh. Marine Pollution Bulletin, 207 116928, 116928. doi: 10.1016/j.marpolbul.2024.116928

First assessment of trace metals in the intertidal zone of the world's longest continuous beach, Cox's Bazar, Bangladesh

2024

Conference Publication

Unveiling The Gut-brain Connectivity And Links With The Immune System: Utilising Self-reported Symptoms Or The Response To A Standardised Nutrient Challenge

Moniruzzaman, Md, Shah, Ayesha, Fairlie, Thomas, Noon, Ebony, Morrison, Mark, Talley, Nicholas J., Koloski, Natasha A., Jones, Michael P. and Holtmann, Gerald J. (2024). Unveiling The Gut-brain Connectivity And Links With The Immune System: Utilising Self-reported Symptoms Or The Response To A Standardised Nutrient Challenge. Digestive Disease Week (DDW) 2024, Washington, DC United States, 18-21 May 2024. Elsevier. doi: 10.1016/s0016-5085(24)01585-3

Unveiling The Gut-brain Connectivity And Links With The Immune System: Utilising Self-reported Symptoms Or The Response To A Standardised Nutrient Challenge

2024

Journal Article

Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Steinmetz, Jaimie D, Seeher, Katrin Maria, Schiess, Nicoline, Nichols, Emma, Cao, Bochen, Servili, Chiara, Cavallera, Vanessa, Cousin, Ewerton, Hagins, Hailey, Moberg, Madeline E, Mehlman, Max L, Abate, Yohannes Habtegiorgis, Abbas, Jaffar, Abbasi, Madineh Akram, Abbasian, Mohammadreza, Abbastabar, Hedayat, Abdelmasseh, Michael, Abdollahi, Mohammad, Abdollahi, Mozhan, Abdollahifar, Mohammad-Amin, Abd-Rabu, Rami, Abdulah, Deldar Morad, Abdullahi, Auwal, Abedi, Aidin, Abedi, Vida, Abeldaño Zuñiga, Roberto Ariel, Abidi, Hassan, Abiodun, Olumide, Aboagye, Richard Gyan ... Dua, Tarun (2024). Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet Neurology, 23 (4), 344-381. doi: 10.1016/s1474-4422(24)00038-3

Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

2023

Conference Publication

Small intestinal bacterial overgrowth in chronic liver disease: a systematic review and meta-analysis of case-control studies

Spannenburg, L., Shah, A., Thite, P., Fairlie, T., Moniruzzaman, M., Stuart, K. A., Koloski, N. A., Morrison, M., Jones, M. P. and Holtmann, G. J. (2023). Small intestinal bacterial overgrowth in chronic liver disease: a systematic review and meta-analysis of case-control studies. 31st United European Gastroenterology Week 2023, Copenhagen, Denmark, 14-17 October 2023. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/ueg2.1246

Small intestinal bacterial overgrowth in chronic liver disease: a systematic review and meta-analysis of case-control studies

2023

Journal Article

Exploring potential anti-inflammatory effects of medicinal cannabis

Gurgenci, Taylan, Kijanka, Gregor, Greer, Ristan, Huggett, Georgie, Good, Phillip, Moniruzzaman, Md and Hardy, Janet (2023). Exploring potential anti-inflammatory effects of medicinal cannabis. Supportive Care in Cancer, 31 (12) 629, 629. doi: 10.1007/s00520-023-08069-8

Exploring potential anti-inflammatory effects of medicinal cannabis

2023

Journal Article

Global, regional, and national burden of rheumatoid arthritis, 1990-2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021

GBD 2021 Rheumatoid Arthritis Collaborators and Moniruzzaman, Md (2023). Global, regional, and national burden of rheumatoid arthritis, 1990-2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. The Lancet. Rheumatology, 5 (10), e594-e610. doi: 10.1016/S2665-9913(23)00211-4

Global, regional, and national burden of rheumatoid arthritis, 1990-2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021

2023

Journal Article

Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019

GBD 2019 IMID Collaborators, Moni, Mohammad Ali, Moniruzzaman, Md and Pak, Anton (2023). Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019. EClinicalMedicine, 64 102193, 102193. doi: 10.1016/j.eclinm.2023.102193

Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019

2023

Conference Publication

Small intestinal bacterial overgrowth in chronic liver disease: A systematic review and meta-analysis of case-control studies

Spannenburg, L., Shah, A., Thite, P., Fairlie, T., Koloski, N., Moniruzzaman, M., Morrison, M., Jones, M. and Holtmann, G. (2023). Small intestinal bacterial overgrowth in chronic liver disease: A systematic review and meta-analysis of case-control studies. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2023, Brisbane, QLD Australia, 2-5 September 2023. Richmond, VIC Australia: John Wiley & Sons.

Small intestinal bacterial overgrowth in chronic liver disease: A systematic review and meta-analysis of case-control studies

2023

Conference Publication

Targeted interleukin-22 therapy improves glycemic control, steatohepatitis, and fibrosis in experimental models of metabolic dysfunction-associated steatohepatitis

Sajiir, H., Keshvari, S., Wong, K. Y., Borg, D., Mueller, A., Moniruzzaman, M., Wang, R., Fotheringham, A., Schreiber, V., Sheng, Y., Lockett, J., Ramm, G., Macdonald, G., Prins, J. B., Mcguckin, M. A. and Hasnain, S. Z. (2023). Targeted interleukin-22 therapy improves glycemic control, steatohepatitis, and fibrosis in experimental models of metabolic dysfunction-associated steatohepatitis. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2023, Brisbane, QLD, Australia, 2 - 5 September 2023. Richmond, VIC, Australia: John Wiley & Sons. doi: 10.1111/jgh.16288

Targeted interleukin-22 therapy improves glycemic control, steatohepatitis, and fibrosis in experimental models of metabolic dysfunction-associated steatohepatitis

2023

Journal Article

MUC13 cell surface mucin limits Salmonella Typhimurium infection by protecting the mucosal epithelial barrier

McGuckin, Michael A., Davies, Julie M., Felgner, Pascal, Wong, Kuan Yau, Giri, Rabina, He, Yaowu, Moniruzzaman, Md., Kryza, Thomas, Sajiir, Haressh, Hooper, John D., Florin, Timothy H., Begun, Jakob, Oussalah, Abderrahim, Hasnain, Sumaira Z., Hensel, Michael and Sheng, Yong H. (2023). MUC13 cell surface mucin limits Salmonella Typhimurium infection by protecting the mucosal epithelial barrier. Cellular and Molecular Gastroenterology and Hepatology, 16 (6), 985-1009. doi: 10.1016/j.jcmgh.2023.08.011

MUC13 cell surface mucin limits Salmonella Typhimurium infection by protecting the mucosal epithelial barrier

Funding

Current funding

  • 2023 - 2026
    Exploring potential anti-inflammatory effects of THC/CBD 1:20 medicinal cannabis product in patients with advanced cancer - Cann-inflamm (TRI-LINC project led by Mater Research)
    Mater Research Ltd
    Open grant

Supervision

Availability

Dr Md Moniruzzaman is:
Available for supervision

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Supervision history

Current supervision

Media

Enquiries

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