
Overview
Background
Dr Moniruzzaman is working as a Senior Postdoctoral Research Fellow at the UQ Faculty of Medicine and PA Hospital of Metro South Health. His research focuses on the molecular pathobiology of inflammatory diseases, in particular, how mucosal epithelial cells and gut microbiota regulate immune function in the gastrointestinal (GI) tract and contribute to different diseases, including inflammatory bowel diseases (IBD) and functional GI symptoms called disorders of gut-brain interactions (DGBI). Dr Moniruzzaman received his PhD from The University of Queensland in 2020, where he studied how the interleukin(IL)-20 family of cytokines (IL-20, IL-22, and IL-24) regulate mucosal epithelial and immune function in inflammatory and infectious diseases, including ulcerative colitis (UC) and respiratory syncytial virus. After graduation, he received postdoctoral training in the IBD Lab at Mater Research Institute – UQ and Nanomedicine Lab at UQ School of Pharmacy, where he investigated the role of cannabinoid receptors in UC and colitis-associated colorectal cancer, development of cannabinoid formulations to treat UC, and involvement of autophagy gene Atg7 in 6-Thioguanin mediated protection from UC. He was awarded a highly competitive UQ Postdoctoral Research Fellowship (2021-2022) and UQ School of Pharmacy Strategic Grant (2022) to study cannabinoids and Atg7 in UC, Translational Research Institute LINC Grant (2023) to study cannabinoids in palliative care of patients with advanced cancer, and Metro South Health SERTA (2024-2025) to study non-antibiotic treatment of SI dysbiosis in patients with DGBI. His current work focuses on how small intestinal dysbiosis controls the mucosal immune microenvironment and contributes to the pathogenesis of DGBI, including irritable bowel syndrome (IBS), functional dyspepsia (FD), and gastroparesis.
Availability
- Dr Md Moniruzzaman is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Pharmacy, Stamford University Bangladesh
- Masters (Research) of Pharmacy, Dongguk University
- Doctoral (Research) of Biochemistry and Cell Biology, The University of Queensland
Research interests
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Immune regulation in mucosal inflammation
Intestinal epithelial cells produce various antimicrobial peptides and cytokines that contribute to immune regulation and barrier integrity. The gut microbiota also plays a critical role in mucosal immune regulation through its interaction with the immune system and helps shape its development and function. Dysbiosis, an imbalance in the gut microbial composition, can lead to impaired immune regulation and contribute to mucosal inflammation. Understanding the mechanisms of immune regulation in mucosal inflammation is crucial for developing therapeutic interventions. Targeting immune cells and microbiota and promoting barrier integrity are potential strategies for restoring immune balance and alleviating mucosal inflammation-related diseases.
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Intestinal microbial dysbiosis in Disorders of Gut-Brain Interaction (DGBI)
Gut-brain interactions refer to the bidirectional communication and connection between the gut (digestive system) and the brain (central nervous system). The gut-brain axis is a complex network involving various pathways and signalling mechanisms that facilitate communication between these two systems. The enteric nervous system, also known as the "second brain," is a network of neurons within the gut that can function independently and communicate with the central nervous system. The vagus nerve, a major nerve connecting the gut and the brain, plays a crucial role in transmitting signals and information between these two systems. Gut-brain interactions are involved in regulating a wide range of functions, including digestion, appetite, mood, stress response, and immune function. The gut microbiota, the collection of microorganisms residing in the gut, also influences gut-brain interactions through the production of neurotransmitters and other signalling molecules. However, any disturbance in communication could lead to a variety of symptoms and conditions, called disorders of gut-brain interaction (DGBI), which include motility disturbance, visceral hypersensitivity, altered mucosal and immune function, altered gut microbiota, and altered CNS processing. Therefore, understanding and studying gut-brain interactions is essential for gaining insights into various disorders and developing potential treatments.
Works
Search Professor Md Moniruzzaman’s works on UQ eSpace
2019
Conference Publication
A novel role of IL-22 in regulating epithelial MHC molecule expression and antigen presentation during viral infection
Wang, R., Taylor, S., Moniruzzaman, M., Wong, K., Upham, J., Spann, K., McGuckin, M., Phipps, S. and Hasnain, S. (2019). A novel role of IL-22 in regulating epithelial MHC molecule expression and antigen presentation during viral infection. 17th International Congress of Immunology (IUIS), Beijing, People's Republic of China, 9-23 October 2019. Weinheim, Germany: Wiley.
2018
Journal Article
The leaves of Crataeva nurvala Buch-Ham. modulate locomotor and anxiety behaviors possibly through GABAergic system
Moniruzzaman, Md, Mannan, Md Abdul, Hossen Khan, Md Farhad, Abir, Ariful Basher and Afroze, Mirola (2018). The leaves of Crataeva nurvala Buch-Ham. modulate locomotor and anxiety behaviors possibly through GABAergic system. BMC Complementary and Alternative Medicine, 18 (1) 283, 283. doi: 10.1186/s12906-018-2338-y
2018
Conference Publication
Enteric microbiota shape the inflammatory response in mice with a Muc2 misfolding mutation
Wang, R., Giri, R., Moniruzzaman, M., Tong, H., Wong, K. Y., Begun, J., McGuckin, M. A. and Hasnain, S. Z. (2018). Enteric microbiota shape the inflammatory response in mice with a Muc2 misfolding mutation. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) “Gut Matters”, Brisbane, QLD, Australia, 8-10 September 2018. Richmond, VIC, Australia: John Wiley & Sons.
2018
Conference Publication
Interleukin-22: A potential therapy to control intestinal inflammation
Moniruzzaman, M., Wang, R., Wong, K. Y., Tong, H., McGuckin, M. A. and Hasnain, S. Z. (2018). Interleukin-22: A potential therapy to control intestinal inflammation. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) “Gut Matters”, Brisbane, QLD, Australia, 8-10 September 2018. Richmond, VIC, Australia: John Wiley & Sons.
2018
Journal Article
HO-1 dependent antioxidant effects of ethyl acetate fraction from Physalis alkekengi fruit ameliorates scopolamine-induced cognitive impairments
Moniruzzaman, M., Chin, Young-Won and Cho, Jungsook (2018). HO-1 dependent antioxidant effects of ethyl acetate fraction from Physalis alkekengi fruit ameliorates scopolamine-induced cognitive impairments. Cell Stress and Chaperones, 23 (4), 763-772. doi: 10.1007/s12192-018-0887-0
2018
Journal Article
Immune regulation of the unfolded protein response at the mucosal barrier in viral infection
Wang, Ran, Moniruzzaman, Md., Shuffle, Eric, Lourie, Rohan and Hasnain, Sumaira Z. (2018). Immune regulation of the unfolded protein response at the mucosal barrier in viral infection. Clinical & Translational Immunology, 7 (4) e1014, e1014. doi: 10.1002/cti2.1014
2016
Journal Article
Evaluation of antinociceptive activity of methanolic extract of leaves of Stephania japonica Linn
Moniruzzaman, Md., Hossain, Md. Sarwar and Bhattacharjee, Partha Sharoti (2016). Evaluation of antinociceptive activity of methanolic extract of leaves of Stephania japonica Linn. Journal of Ethnopharmacology, 186, 205-208. doi: 10.1016/j.jep.2016.04.008
2016
Journal Article
Effect of CCL2 on BV2 microglial cell migration: involvement of probable signaling pathways
Bose, Shambhunath, Kim, Sunyoung, Oh, Yeonsoo, Moniruzzaman, Md., Lee, Gyeongjun and Cho, Jungsook (2016). Effect of CCL2 on BV2 microglial cell migration: involvement of probable signaling pathways. Cytokine, 81, 39-49. doi: 10.1016/j.cyto.2016.02.001
2016
Journal Article
Sedative and anxiolytic-like actions of ethanol extract of leaves of Glinus oppositifolius (Linn.) Aug. DC
Moniruzzaman, Md., Sharoti Bhattacharjee, Partha, Rahman Pretty, Moushumi and Sarwar Hossain, Md. (2016). Sedative and anxiolytic-like actions of ethanol extract of leaves of Glinus oppositifolius (Linn.) Aug. DC. Evidence-Based Complementary and Alternative Medicine, 2016 (1) 8541017. doi: 10.1155/2016/8541017
2016
Journal Article
The methanolic extract from Murraya koenigii L. inhibits glutamate-induced pain and involves ATP-sensitive K+ Channel as antinociceptive mechanism
Sharmin Ani, Nushrat, Chakraborty, Sudip and Moniruzzaman, Md. (2016). The methanolic extract from Murraya koenigii L. inhibits glutamate-induced pain and involves ATP-sensitive K+ Channel as antinociceptive mechanism. Advances in Pharmacological Sciences, 2016 3790860, 1-6. doi: 10.1155/2016/3790860
2015
Journal Article
Antioxidant and anti-inflammatory activities of N-((3,4-Dihydro-2H-benzo[h]chromene-2-yl)methyl)-4-methoxyaniline in LPS-induced BV2 microglial cells
Moniruzzaman, Md, Lee, Gyeongjun, Bose, Shambhunath, Choi, Minho, Jung, Jae-Kyung, Lee, Heesoon and Cho, Jungsook (2015). Antioxidant and anti-inflammatory activities of N-((3,4-Dihydro-2H-benzo[h]chromene-2-yl)methyl)-4-methoxyaniline in LPS-induced BV2 microglial cells. Biological & Pharmaceutical Bulletin, 38 (12), 1831-1835. doi: 10.1248/bpb.b15-00473
2015
Journal Article
Evaluation of antinociceptive activity of ethanol extract of bark of Polyalthia longifolia
Moniruzzaman, Md., Ferdous, Afia and Bokul, Fatama Wahid (2015). Evaluation of antinociceptive activity of ethanol extract of bark of Polyalthia longifolia. Journal of Ethnopharmacology, 172, 364-367. doi: 10.1016/j.jep.2015.06.053
2015
Journal Article
Evaluation of antinociceptive effect of ethanol extract of Hedyotis corymbosa Linn. whole plant in mice
Moniruzzaman, Md, Ferdous, Afia and Irin, Shamima (2015). Evaluation of antinociceptive effect of ethanol extract of Hedyotis corymbosa Linn. whole plant in mice. Journal of Ethnopharmacology, 161, 82-85. doi: 10.1016/j.jep.2014.12.011
2015
Journal Article
Evaluation of sedative and hypnotic activity of ethanolic extract of Scoparia dulcis Linn
Moniruzzaman, Md., Rahman, Md. Atikur and Ferdous, Afia (2015). Evaluation of sedative and hypnotic activity of ethanolic extract of Scoparia dulcis Linn. Evidence-Based Complementary and Alternative Medicine, 2015 873954. doi: 10.1155/2015/873954
2015
Journal Article
Evaluation of antinociceptive activity of ethanol extract of leaves of Adenanthera pavonina
Moniruzzaman, Md., Khatun, Ambia and Imam, Mohammad Zafar (2015). Evaluation of antinociceptive activity of ethanol extract of leaves of Adenanthera pavonina. Evidence-Based Complementary and Alternative Medicine, 2015 412497, 1-8. doi: 10.1155/2015/412497
2014
Journal Article
Evaluation of antinociceptive effect of methanolic extract of leaves of Crataeva nurvala Buch.-Ham.
Moniruzzaman, Md and Imam, Mohammad Zafar (2014). Evaluation of antinociceptive effect of methanolic extract of leaves of Crataeva nurvala Buch.-Ham.. BMC Complementary and Alternative Medicine, 14 (1) 354, 1-7. doi: 10.1186/1472-6882-14-354
2014
Journal Article
Antinociceptive effect of ethanol extract of leaves of Lannea coromandelica
Imam, Mohammad Zafar and Moniruzzaman, Md (2014). Antinociceptive effect of ethanol extract of leaves of Lannea coromandelica. Journal of Ethnopharmacology, 154 (1), 109-115. doi: 10.1016/j.jep.2014.03.032
Funding
Current funding
Supervision
Availability
- Dr Md Moniruzzaman is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Designer Nanoparticles for Oral and Targeted Delivery of Protein Therapeutics
Associate Advisor
Other advisors: Associate Professor Jakob Begun, Professor Amirali Popat, Dr Rabina Giri
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Doctor Philosophy
Designer Nanoparticles for Oral and Targeted Delivery of Protein Therapeutics
Associate Advisor
Other advisors: Associate Professor Jakob Begun, Professor Amirali Popat
Media
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