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Dr Md Moniruzzaman
Dr

Md Moniruzzaman

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Overview

Background

Dr Moniruzzaman is working as a Senior Postdoctoral Research Fellow at the UQ Faculty of Medicine and PA Hospital of Metro South Health. His research focuses on the molecular pathobiology of inflammatory diseases, in particular, how mucosal epithelial cells and gut microbiota regulate immune function in the gastrointestinal (GI) tract and contribute to different diseases, including inflammatory bowel diseases (IBD) and functional GI symptoms called disorders of gut-brain interactions (DGBI). Dr Moniruzzaman received his PhD from The University of Queensland in 2020, where he studied how the interleukin(IL)-20 family of cytokines (IL-20, IL-22, and IL-24) regulate mucosal epithelial and immune function in inflammatory and infectious diseases, including ulcerative colitis (UC) and respiratory syncytial virus. After graduation, he received postdoctoral training in the IBD Lab at Mater Research Institute – UQ and Nanomedicine Lab at UQ School of Pharmacy, where he investigated the role of cannabinoid receptors in UC and colitis-associated colorectal cancer, development of cannabinoid formulations to treat UC, and involvement of autophagy gene Atg7 in 6-Thioguanin mediated protection from UC. He was awarded a highly competitive UQ Postdoctoral Research Fellowship (2021-2022) and UQ School of Pharmacy Strategic Grant (2022) to study cannabinoids and Atg7 in UC, Translational Research Institute LINC Grant (2023) to study cannabinoids in palliative care of patients with advanced cancer, and Metro South Health SERTA (2024-2025) to study non-antibiotic treatment of SI dysbiosis in patients with DGBI. His current work focuses on how small intestinal dysbiosis controls the mucosal immune microenvironment and contributes to the pathogenesis of DGBI, including irritable bowel syndrome (IBS), functional dyspepsia (FD), and gastroparesis.

Availability

Dr Md Moniruzzaman is:
Not available for supervision

Qualifications

  • Bachelor (Honours) of Pharmacy, Stamford University Bangladesh
  • Masters (Research) of Pharmacy, Dongguk University
  • Doctoral (Research) of Biochemistry and Cell Biology, The University of Queensland

Research interests

  • Immune regulation in mucosal inflammation

    Intestinal epithelial cells produce various antimicrobial peptides and cytokines that contribute to immune regulation and barrier integrity. The gut microbiota also plays a critical role in mucosal immune regulation through its interaction with the immune system and helps shape its development and function. Dysbiosis, an imbalance in the gut microbial composition, can lead to impaired immune regulation and contribute to mucosal inflammation. Understanding the mechanisms of immune regulation in mucosal inflammation is crucial for developing therapeutic interventions. Targeting immune cells and microbiota and promoting barrier integrity are potential strategies for restoring immune balance and alleviating mucosal inflammation-related diseases.

  • Intestinal microbial dysbiosis in Disorders of Gut-Brain Interaction (DGBI)

    Gut-brain interactions refer to the bidirectional communication and connection between the gut (digestive system) and the brain (central nervous system). The gut-brain axis is a complex network involving various pathways and signalling mechanisms that facilitate communication between these two systems. The enteric nervous system, also known as the "second brain," is a network of neurons within the gut that can function independently and communicate with the central nervous system. The vagus nerve, a major nerve connecting the gut and the brain, plays a crucial role in transmitting signals and information between these two systems. Gut-brain interactions are involved in regulating a wide range of functions, including digestion, appetite, mood, stress response, and immune function. The gut microbiota, the collection of microorganisms residing in the gut, also influences gut-brain interactions through the production of neurotransmitters and other signalling molecules. However, any disturbance in communication could lead to a variety of symptoms and conditions, called disorders of gut-brain interaction (DGBI), which include motility disturbance, visceral hypersensitivity, altered mucosal and immune function, altered gut microbiota, and altered CNS processing. Therefore, understanding and studying gut-brain interactions is essential for gaining insights into various disorders and developing potential treatments.

Works

Search Professor Md Moniruzzaman’s works on UQ eSpace

61 works between 2014 and 2025

41 - 60 of 61 works

2020

Journal Article

Oral delivery of β-lactoglobulin nanospheres encapsulated resveratrol alleviates inflammation in Winnie mice with spontaneous ulcerative colitis

Pujara, Naisarg, Wong, Kuan Yau, Qu, Zhi, Wang, Ran, Moniruzzaman, Md., Rewatkar, Prarthana, Kumeria, Tushar, Ross, Benjamin P., McGuckin, Michael and Popat, Amirali (2020). Oral delivery of β-lactoglobulin nanospheres encapsulated resveratrol alleviates inflammation in Winnie mice with spontaneous ulcerative colitis. Molecular Pharmaceutics, 18 (2) acs.molpharmaceut.0c00048, 627-640. doi: 10.1021/acs.molpharmaceut.0c00048

Oral delivery of β-lactoglobulin nanospheres encapsulated resveratrol alleviates inflammation in Winnie mice with spontaneous ulcerative colitis

2020

Conference Publication

Harnessing the therapeutic potential of interleukin-22 in neonatal respiratory viral infection

Hasnain, S., Wang, R., Taylor, S., Wong, K. Y., Moniruzzaman, M., Upham, J., Spann, K., Mcguckin, M. A., Burr, L. and Phipps, S. (2020). Harnessing the therapeutic potential of interleukin-22 in neonatal respiratory viral infection. TSANZSRS 2020 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science, Melbourne, VIC, Australia, 27–31 March 2020. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.13777

Harnessing the therapeutic potential of interleukin-22 in neonatal respiratory viral infection

2020

Conference Publication

Blocking endogenous IL-22 is associated with reduced viral load and improved lung pathology in respiratory viral infections

Wang, R., Moniruzzaman, M., Wang, K., Upham, J. W., McGuckin, M., Phipps, S. and Hasnain, S. Z. (2020). Blocking endogenous IL-22 is associated with reduced viral load and improved lung pathology in respiratory viral infections. International Conference of the American-Thoracic-Society (ATS), Online, 10 November 2020. New York, NY, United States: American Thoracic Society. doi: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6530

Blocking endogenous IL-22 is associated with reduced viral load and improved lung pathology in respiratory viral infections

2019

Conference Publication

Interleukin-20 subfamily cytokines in controlling intestinal inflammation and epithelial barrier integrity

Moniruzzaman, M., Wang, R., Wong, K., Tong, H., McGuckin, M. and Hasnain, S. (2019). Interleukin-20 subfamily cytokines in controlling intestinal inflammation and epithelial barrier integrity. Congress of ECCO, Copenhagen, Denmark, 6-9 March 2019. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjy222.044

Interleukin-20 subfamily cytokines in controlling intestinal inflammation and epithelial barrier integrity

2019

Conference Publication

A novel role of IL-22 in regulating epithelial MHC molecule expression and antigen presentation during viral infection

Wang, R., Taylor, S., Moniruzzaman, M., Wong, K., Upham, J., Spann, K., McGuckin, M., Phipps, S. and Hasnain, S. (2019). A novel role of IL-22 in regulating epithelial MHC molecule expression and antigen presentation during viral infection. 17th International Congress of Immunology (IUIS), Beijing, People's Republic of China, 9-23 October 2019. Weinheim, Germany: Wiley.

A novel role of IL-22 in regulating epithelial MHC molecule expression and antigen presentation during viral infection

2018

Journal Article

The leaves of Crataeva nurvala Buch-Ham. modulate locomotor and anxiety behaviors possibly through GABAergic system

Moniruzzaman, Md, Mannan, Md Abdul, Hossen Khan, Md Farhad, Abir, Ariful Basher and Afroze, Mirola (2018). The leaves of Crataeva nurvala Buch-Ham. modulate locomotor and anxiety behaviors possibly through GABAergic system. BMC Complementary and Alternative Medicine, 18 (1) 283, 283. doi: 10.1186/s12906-018-2338-y

The leaves of Crataeva nurvala Buch-Ham. modulate locomotor and anxiety behaviors possibly through GABAergic system

2018

Conference Publication

Enteric microbiota shape the inflammatory response in mice with a Muc2 misfolding mutation

Wang, R., Giri, R., Moniruzzaman, M., Tong, H., Wong, K. Y., Begun, J., McGuckin, M. A. and Hasnain, S. Z. (2018). Enteric microbiota shape the inflammatory response in mice with a Muc2 misfolding mutation. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) “Gut Matters”, Brisbane, QLD, Australia, 8-10 September 2018. Richmond, VIC, Australia: John Wiley & Sons.

Enteric microbiota shape the inflammatory response in mice with a Muc2 misfolding mutation

2018

Conference Publication

Interleukin-22: A potential therapy to control intestinal inflammation

Moniruzzaman, M., Wang, R., Wong, K. Y., Tong, H., McGuckin, M. A. and Hasnain, S. Z. (2018). Interleukin-22: A potential therapy to control intestinal inflammation. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) “Gut Matters”, Brisbane, QLD, Australia, 8-10 September 2018. Richmond, VIC, Australia: John Wiley & Sons.

Interleukin-22: A potential therapy to control intestinal inflammation

2018

Journal Article

HO-1 dependent antioxidant effects of ethyl acetate fraction from Physalis alkekengi fruit ameliorates scopolamine-induced cognitive impairments

Moniruzzaman, M., Chin, Young-Won and Cho, Jungsook (2018). HO-1 dependent antioxidant effects of ethyl acetate fraction from Physalis alkekengi fruit ameliorates scopolamine-induced cognitive impairments. Cell Stress and Chaperones, 23 (4), 763-772. doi: 10.1007/s12192-018-0887-0

HO-1 dependent antioxidant effects of ethyl acetate fraction from Physalis alkekengi fruit ameliorates scopolamine-induced cognitive impairments

2018

Journal Article

Immune regulation of the unfolded protein response at the mucosal barrier in viral infection

Wang, Ran, Moniruzzaman, Md., Shuffle, Eric, Lourie, Rohan and Hasnain, Sumaira Z. (2018). Immune regulation of the unfolded protein response at the mucosal barrier in viral infection. Clinical & Translational Immunology, 7 (4) e1014, e1014. doi: 10.1002/cti2.1014

Immune regulation of the unfolded protein response at the mucosal barrier in viral infection

2016

Journal Article

Evaluation of antinociceptive activity of methanolic extract of leaves of Stephania japonica Linn

Moniruzzaman, Md., Hossain, Md. Sarwar and Bhattacharjee, Partha Sharoti (2016). Evaluation of antinociceptive activity of methanolic extract of leaves of Stephania japonica Linn. Journal of Ethnopharmacology, 186, 205-208. doi: 10.1016/j.jep.2016.04.008

Evaluation of antinociceptive activity of methanolic extract of leaves of Stephania japonica Linn

2016

Journal Article

Effect of CCL2 on BV2 microglial cell migration: involvement of probable signaling pathways

Bose, Shambhunath, Kim, Sunyoung, Oh, Yeonsoo, Moniruzzaman, Md., Lee, Gyeongjun and Cho, Jungsook (2016). Effect of CCL2 on BV2 microglial cell migration: involvement of probable signaling pathways. Cytokine, 81, 39-49. doi: 10.1016/j.cyto.2016.02.001

Effect of CCL2 on BV2 microglial cell migration: involvement of probable signaling pathways

2016

Journal Article

The methanolic extract from Murraya koenigii L. inhibits glutamate-induced pain and involves ATP-sensitive K+ Channel as antinociceptive mechanism

Sharmin Ani, Nushrat, Chakraborty, Sudip and Moniruzzaman, Md. (2016). The methanolic extract from Murraya koenigii L. inhibits glutamate-induced pain and involves ATP-sensitive K+ Channel as antinociceptive mechanism. Advances in Pharmacological Sciences, 2016 3790860, 1-6. doi: 10.1155/2016/3790860

The methanolic extract from Murraya koenigii L. inhibits glutamate-induced pain and involves ATP-sensitive K+ Channel as antinociceptive mechanism

2016

Journal Article

Sedative and anxiolytic-like actions of ethanol extract of leaves of Glinus oppositifolius (Linn.) Aug. DC

Moniruzzaman, Md., Sharoti Bhattacharjee, Partha, Rahman Pretty, Moushumi and Sarwar Hossain, Md. (2016). Sedative and anxiolytic-like actions of ethanol extract of leaves of Glinus oppositifolius (Linn.) Aug. DC. Evidence-Based Complementary and Alternative Medicine, 2016 (1) 8541017. doi: 10.1155/2016/8541017

Sedative and anxiolytic-like actions of ethanol extract of leaves of Glinus oppositifolius (Linn.) Aug. DC

2015

Journal Article

Antioxidant and anti-inflammatory activities of N-((3,4-Dihydro-2H-benzo[h]chromene-2-yl)methyl)-4-methoxyaniline in LPS-induced BV2 microglial cells

Moniruzzaman, Md, Lee, Gyeongjun, Bose, Shambhunath, Choi, Minho, Jung, Jae-Kyung, Lee, Heesoon and Cho, Jungsook (2015). Antioxidant and anti-inflammatory activities of N-((3,4-Dihydro-2H-benzo[h]chromene-2-yl)methyl)-4-methoxyaniline in LPS-induced BV2 microglial cells. Biological & Pharmaceutical Bulletin, 38 (12), 1831-1835. doi: 10.1248/bpb.b15-00473

Antioxidant and anti-inflammatory activities of N-((3,4-Dihydro-2H-benzo[h]chromene-2-yl)methyl)-4-methoxyaniline in LPS-induced BV2 microglial cells

2015

Journal Article

Evaluation of antinociceptive activity of ethanol extract of bark of Polyalthia longifolia

Moniruzzaman, Md., Ferdous, Afia and Bokul, Fatama Wahid (2015). Evaluation of antinociceptive activity of ethanol extract of bark of Polyalthia longifolia. Journal of Ethnopharmacology, 172, 364-367. doi: 10.1016/j.jep.2015.06.053

Evaluation of antinociceptive activity of ethanol extract of bark of Polyalthia longifolia

2015

Journal Article

Evaluation of antinociceptive effect of ethanol extract of Hedyotis corymbosa Linn. whole plant in mice

Moniruzzaman, Md, Ferdous, Afia and Irin, Shamima (2015). Evaluation of antinociceptive effect of ethanol extract of Hedyotis corymbosa Linn. whole plant in mice. Journal of Ethnopharmacology, 161, 82-85. doi: 10.1016/j.jep.2014.12.011

Evaluation of antinociceptive effect of ethanol extract of Hedyotis corymbosa Linn. whole plant in mice

2015

Journal Article

Evaluation of antinociceptive activity of ethanol extract of leaves of Adenanthera pavonina

Moniruzzaman, Md., Khatun, Ambia and Imam, Mohammad Zafar (2015). Evaluation of antinociceptive activity of ethanol extract of leaves of Adenanthera pavonina. Evidence-Based Complementary and Alternative Medicine, 2015 412497, 1-8. doi: 10.1155/2015/412497

Evaluation of antinociceptive activity of ethanol extract of leaves of Adenanthera pavonina

2015

Journal Article

Evaluation of sedative and hypnotic activity of ethanolic extract of Scoparia dulcis Linn

Moniruzzaman, Md., Rahman, Md. Atikur and Ferdous, Afia (2015). Evaluation of sedative and hypnotic activity of ethanolic extract of Scoparia dulcis Linn. Evidence-Based Complementary and Alternative Medicine, 2015 873954, 1-6. doi: 10.1155/2015/873954

Evaluation of sedative and hypnotic activity of ethanolic extract of Scoparia dulcis Linn

2014

Journal Article

Evaluation of antinociceptive effect of methanolic extract of leaves of Crataeva nurvala Buch.-Ham.

Moniruzzaman, Md and Imam, Mohammad Zafar (2014). Evaluation of antinociceptive effect of methanolic extract of leaves of Crataeva nurvala Buch.-Ham.. BMC Complementary and Alternative Medicine, 14 (1) 354, 1-7. doi: 10.1186/1472-6882-14-354

Evaluation of antinociceptive effect of methanolic extract of leaves of Crataeva nurvala Buch.-Ham.

Funding

Current funding

  • 2023 - 2026
    Exploring potential anti-inflammatory effects of THC/CBD 1:20 medicinal cannabis product in patients with advanced cancer - Cann-inflamm (TRI-LINC project led by Mater Research)
    Mater Research Ltd
    Open grant

Supervision

Availability

Dr Md Moniruzzaman is:
Not available for supervision

Supervision history

Current supervision

Media

Enquiries

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