Overview
Background
Dr Moniruzzaman is working as a Senior Postdoctoral Research Fellow at the UQ Faculty of Medicine and PA Hospital of Metro South Health. His research focuses on the molecular pathobiology of inflammatory diseases, in particular, how mucosal epithelial cells and gut microbiota regulate immune function in the gastrointestinal (GI) tract and contribute to different diseases, including inflammatory bowel diseases (IBD) and functional GI symptoms called disorders of gut-brain interactions (DGBI). Dr Moniruzzaman received his PhD from The University of Queensland in 2020, where he studied how the interleukin(IL)-20 family of cytokines (IL-20, IL-22, and IL-24) regulate mucosal epithelial and immune function in inflammatory and infectious diseases, including ulcerative colitis (UC) and respiratory syncytial virus. After graduation, he received postdoctoral training in the IBD Lab at Mater Research Institute – UQ and Nanomedicine Lab at UQ School of Pharmacy, where he investigated the role of cannabinoid receptors in UC and colitis-associated colorectal cancer, development of cannabinoid formulations to treat UC, and involvement of autophagy gene Atg7 in 6-Thioguanin mediated protection from UC. He was awarded a highly competitive UQ Postdoctoral Research Fellowship (2021-2022) and UQ School of Pharmacy Strategic Grant (2022) to study cannabinoids and Atg7 in UC, Translational Research Institute LINC Grant (2023) to study cannabinoids in palliative care of patients with advanced cancer, and Metro South Health SERTA (2024-2025) to study non-antibiotic treatment of SI dysbiosis in patients with DGBI. His current work focuses on how small intestinal dysbiosis controls the mucosal immune microenvironment and contributes to the pathogenesis of DGBI, including irritable bowel syndrome (IBS), functional dyspepsia (FD), and gastroparesis.
Availability
- Dr Md Moniruzzaman is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Pharmacy, Stamford University Bangladesh
- Masters (Research) of Pharmacy, Dongguk University
- Doctoral (Research) of Biochemistry and Cell Biology, The University of Queensland
Research interests
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Immune regulation in mucosal inflammation
Intestinal epithelial cells produce various antimicrobial peptides and cytokines that contribute to immune regulation and barrier integrity. The gut microbiota also plays a critical role in mucosal immune regulation through its interaction with the immune system and helps shape its development and function. Dysbiosis, an imbalance in the gut microbial composition, can lead to impaired immune regulation and contribute to mucosal inflammation. Understanding the mechanisms of immune regulation in mucosal inflammation is crucial for developing therapeutic interventions. Targeting immune cells and microbiota and promoting barrier integrity are potential strategies for restoring immune balance and alleviating mucosal inflammation-related diseases.
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Intestinal microbial dysbiosis in Disorders of Gut-Brain Interaction (DGBI)
Gut-brain interactions refer to the bidirectional communication and connection between the gut (digestive system) and the brain (central nervous system). The gut-brain axis is a complex network involving various pathways and signalling mechanisms that facilitate communication between these two systems. The enteric nervous system, also known as the "second brain," is a network of neurons within the gut that can function independently and communicate with the central nervous system. The vagus nerve, a major nerve connecting the gut and the brain, plays a crucial role in transmitting signals and information between these two systems. Gut-brain interactions are involved in regulating a wide range of functions, including digestion, appetite, mood, stress response, and immune function. The gut microbiota, the collection of microorganisms residing in the gut, also influences gut-brain interactions through the production of neurotransmitters and other signalling molecules. However, any disturbance in communication could lead to a variety of symptoms and conditions, called disorders of gut-brain interaction (DGBI), which include motility disturbance, visceral hypersensitivity, altered mucosal and immune function, altered gut microbiota, and altered CNS processing. Therefore, understanding and studying gut-brain interactions is essential for gaining insights into various disorders and developing potential treatments.
Works
Search Professor Md Moniruzzaman’s works on UQ eSpace
2023
Conference Publication
Small intestinal bacterial overgrowth in chronic liver disease: A systematic review and meta-analysis of case-control studies
Spannenburg, L., Shah, A., Thite, P., Fairlie, T., Koloski, N., Moniruzzaman, M., Morrison, M., Jones, M. and Holtmann, G. (2023). Small intestinal bacterial overgrowth in chronic liver disease: A systematic review and meta-analysis of case-control studies. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2023, Brisbane, QLD Australia, 2-5 September 2023. Richmond, VIC Australia: John Wiley & Sons.
2023
Conference Publication
Targeted interleukin-22 therapy improves glycemic control, steatohepatitis, and fibrosis in experimental models of metabolic dysfunction-associated steatohepatitis
Sajiir, H., Keshvari, S., Wong, K. Y., Borg, D., Mueller, A., Moniruzzaman, M., Wang, R., Fotheringham, A., Schreiber, V., Sheng, Y., Lockett, J., Ramm, G., Macdonald, G., Prins, J. B., Mcguckin, M. A. and Hasnain, S. Z. (2023). Targeted interleukin-22 therapy improves glycemic control, steatohepatitis, and fibrosis in experimental models of metabolic dysfunction-associated steatohepatitis. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2023, Brisbane, QLD, Australia, 2-5 September 2023. Richmond, VIC, Australia: John Wiley & Sons. doi: 10.1111/jgh.16288
2023
Journal Article
Global, regional, and national burden of allergic disorders and their risk factors in 204 countries and territories, from 1990 to 2019: A systematic analysis for the Global Burden of Disease Study 2019
Shin, Youn Ho, Hwang, Jimin, Kwon, Rosie, Lee, Seung Won, Kim, Min Seo, Shin, Youn Ho, Hwang, Jimin, Kwon, Rosie, Lee, Seung Won, Kim, Min Seo, Abate, Yohannes Habtegiorgis, Abbasi-Kangevari, Mohsen, Abbasi-Kangevari, Zeinab, Abdelmasseh, Michael, Abdulah, Deldar Morad, Aboagye, Richard Gyan, Abolhassani, Hassan, Abrams, Elissa M., Abtew, Yonas Derso, Abu-Gharbieh, Eman, Adane, Denberu Eshetie Adane, Adane, Tigist Demssew, Addo, Isaac Yeboah, Adha, Rishan, Adibi, Amin, Adnani, Qorinah Estiningtyas Sakilah, Agrawal, Anurag, Ahmad, Sohail, Ahmadi, Ali ... Yon, Dong Keon (2023). Global, regional, and national burden of allergic disorders and their risk factors in 204 countries and territories, from 1990 to 2019: A systematic analysis for the Global Burden of Disease Study 2019. Allergy: European Journal of Allergy and Clinical Immunology, 78 (8), 2232-2254. doi: 10.1111/all.15807
2023
Journal Article
Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021
Ong, Kanyin Liane, Stafford, Lauryn K., Mclaughlin, Susan A., Boyko, Edward J., Vollset, Stein Emil, Smith, Amanda E., Dalton, Bronte E., Duprey, Joe, Cruz, Jessica A., Hagins, Hailey, Lindstedt, Paulina A., Aali, Amirali, Abate, Yohannes Habtegiorgis, Abate, Melsew Dagne, Abbasian, Mohammadreza, Abbasi-Kangevari, Zeinab, Abbasi-Kangevari, Mohsen, Abd ElHafeez, Samar, Abd-Rabu, Rami, Abdulah, Deldar Morad, Abdullah, Abu Yousuf Md, Abedi, Vida, Abidi, Hassan, Aboagye, Richard Gyan, Abolhassani, Hassan, Abu-Gharbieh, Eman, Abu-Zaid, Ahmed, Adane, Tigist Demssew, Adane, Denberu Eshetie ... Vos, Theo (2023). Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet, 402 (10397), 203-234. doi: 10.1016/S0140-6736(23)01301-6
2023
Journal Article
Virus-like silica nanoparticles enhance macromolecule permeation in vivo
Cao, Yuxue, Janjua, Taskeen Iqbal, Qu, Zhi, Draphoen, Bastian, Bai, Yunfan, Linden, Mika, Moniruzzaman, Md., Hasnain, Sumaira Z., Kumeria, Tushar and Popat, Amirali (2023). Virus-like silica nanoparticles enhance macromolecule permeation in vivo. Biomaterials Science, 11 (13), 4508-4521. doi: 10.1039/d3bm00137g
2023
Journal Article
Global burden of chronic respiratory diseases and risk factors, 1990–2019: an update from the Global Burden of Disease Study 2019
Momtazmanesh, Sara, Moghaddam, Sahar Saeedi, Ghamari, Seyyed-Hadi, Rad, Elaheh Malakan, Rezaei, Negar, Shobeiri, Parnian, Aali, Amirali, Abbasi-Kangevari, Mohsen, Abbasi-Kangevari, Zeinab, Abdelmasseh, Michael, Abdoun, Meriem, Abdulah, Deldar Morad, Md Abdullah, Abu Yousuf, Abedi, Aidin, Abolhassani, Hassan, Abrehdari-Tafreshi, Zahra, Achappa, Basavaprabhu, Adane Adane, Denberu Eshetie, Adane, Tigist Demssew, Addo, Isaac Yeboah, Adnan, Mohammad, Sakilah Adnani, Qorinah Estiningtyas, Ahmad, Sajjad, Ahmadi, Ali, Ahmadi, Keivan, Ahmed, Ali, Ahmed, Ayman, Rashid, Tarik Ahmed, Al Hamad, Hanadi ... GBD 2019 Chronic Respiratory Diseases Collaborators (2023). Global burden of chronic respiratory diseases and risk factors, 1990–2019: an update from the Global Burden of Disease Study 2019. eClinicalMedicine, 59 101936, 101936. doi: 10.1016/j.eclinm.2023.101936
2023
Journal Article
Efficient delivery of Temozolomide using ultrasmall large-pore silica nanoparticles for glioblastoma
Janjua, Taskeen Iqbal, Cao, Yuxue, Ahmed-Cox, Aria, Raza, Aun, Moniruzzaman, Md, Akhter, Dewan Taslima, Fletcher, Nicholas L., Kavallaris, Maria, Thurecht, Kristofer J. and Popat, Amirali (2023). Efficient delivery of Temozolomide using ultrasmall large-pore silica nanoparticles for glioblastoma. Journal of Controlled Release, 357, 161-174. doi: 10.1016/j.jconrel.2023.03.040
2022
Conference Publication
Post-induction IL-12/23 levels correlate with clinical response and remission after ustekinumab in a multicenter prospective cohort study of patients with Crohn’s disease: Preliminary induction results of the AURORA study, including the Australia New Zealand IBD Consortium Cohort
An,Yoon-Kyo, Lindsay, Niamh, Allan, Natalie, Khoo, Emi, Amiss, Anna, Moniruzzaman, Md, Fernandes, Richard, Ooi, Soong-Yuan J., Thin, Lena W.Y., Mstj, Daniel Lightowler, Connor, Susan, Williams, Astrid-Jane, De Cruz, Peter, Suen, Christopher Li Wai, Kariyawasam, Viraj C., Mitrev, Nicola, Ghaly, Simon, Andrews, Jane M., Christensen, Britt, Sparrow, Miles, White, Lauren, Bryant, Robert, Ding, Nik S., Leong, Rupert W., Van Langenberg, Daniel R., Seltenreich, Hans, Subramaniam, Kavitha, Radford-Smith, Graham and Begun, Jakob (2022). Post-induction IL-12/23 levels correlate with clinical response and remission after ustekinumab in a multicenter prospective cohort study of patients with Crohn’s disease: Preliminary induction results of the AURORA study, including the Australia New Zealand IBD Consortium Cohort. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2022, Sydney, NSW Australia, 9–11 September 2022. Richmond, VIC Australia: John Wiley & Sons. doi: 10.1111/jgh.15953
2022
Conference Publication
A novel role for interleukin-22 signaling in modulating mucosal epithelial cell antigen presentation machinery to control disease
Rahman, M. A., Moniruzzaman, M., Wang, R., Harding, A., Wiid, P., Sajiir, H., Yong, K. Y., Sheng, Y., Mueller, A., Symon, H., Varelias, A., McGuckin, M., Phipps, S. and Hasnain, S. (2022). A novel role for interleukin-22 signaling in modulating mucosal epithelial cell antigen presentation machinery to control disease. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW), Sydney, NSW, Australia, 9–11 September 2022. Richmond, VIC, Australia: John Wiley & Sons.
2022
Journal Article
Age-sex differences in the global burden of lower respiratory infections and risk factors, 1990-2019: results from the Global Burden of Disease Study 2019
GBD 2019 LRI Collaborators and Moniruzzaman, Md (2022). Age-sex differences in the global burden of lower respiratory infections and risk factors, 1990-2019: results from the Global Burden of Disease Study 2019. The Lancet Infectious Diseases, 22 (11), 1626-1647. doi: 10.1016/S1473-3099(22)00510-2
2022
Journal Article
Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019
GBD 2019 Dementia Forecasting Collaborators, Moniruzzaman, Md and Moni, Mohammad Ali (2022). Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019. The Lancet. Public health, 7 (2), e105-e125. doi: 10.1016/S2468-2667(21)00249-8
2022
Journal Article
A novel role for Interleukin-22 in suppressing major histocompatibility complex II in mucosal epithelial cells
Moniruzzaman, Md, Rahman, M. Arifur, Wang, Ran, Wong, Kuan Yau, Chen, Alice C-H, Mueller, Alexandra, Taylor, Steven, Harding, Alexa, Illankoon, Thishan, Wiid, Percival, Sajiir, Haressh, Schreiber, Veronika, Martin, Megan L., Burr, Lucy D., McGuckin, Michael A., Phipps, Simon and Hasnain, Sumaira Zia (2022). A novel role for Interleukin-22 in suppressing major histocompatibility complex II in mucosal epithelial cells. SSRN Electronic Journal. doi: 10.2139/ssrn.4185134
2021
Journal Article
Tacrolimus encapsulated mesoporous silica nanoparticles embedded hydrogel for the treatment of atopic dermatitis
Parekh, Khushali, Hariharan, Kartik, Qu, Zhi, Rewatkar, Prarthana, Cao, Yuxue, Moniruzzaman, Md., Pandey, Preeti, Popat, Amirali and Mehta, Tejal (2021). Tacrolimus encapsulated mesoporous silica nanoparticles embedded hydrogel for the treatment of atopic dermatitis. International Journal of Pharmaceutics, 608 121079, 121079. doi: 10.1016/j.ijpharm.2021.121079
2021
Journal Article
pH – responsive colloidal carriers assembled from β-lactoglobulin and epsilon poly-l-lysine for oral drug delivery
Pujara, Naisarg, Giri, Rabina, Yau Wong, Kuan, Qu, Zhi, Rewatkar, Prarthana, Moniruzzaman, Md., Begun, Jakob, Ross, Benjamin P., McGuckin, Michael and Popat, Amirali (2021). pH – responsive colloidal carriers assembled from β-lactoglobulin and epsilon poly-l-lysine for oral drug delivery. Journal of Colloid and Interface Science, 589, 45-55. doi: 10.1016/j.jcis.2020.12.054
2020
Journal Article
One‐pot synthesis of pH‐responsive eudragit‐mesoporous silica nanocomposites enable colonic delivery of glucocorticoids for the treatment of inflammatory bowel disease
Qu, Zhi, Wong, Kuan Yau, Moniruzzaman, Md., Begun, Jakob, Santos, Hélder A, Hasnain, Sumaira Z., Kumeria, Tushar, McGuckin, Michael A. and Popat, Amirali (2020). One‐pot synthesis of pH‐responsive eudragit‐mesoporous silica nanocomposites enable colonic delivery of glucocorticoids for the treatment of inflammatory bowel disease. Advanced Therapeutics, 4 (2) 2000165, 2000165. doi: 10.1002/adtp.202000165
2020
Other Outputs
Therapeutic manipulation of interleukin-20 subfamily of cytokines in ulcerative colitis
Moniruzzaman, Md (2020). Therapeutic manipulation of interleukin-20 subfamily of cytokines in ulcerative colitis. PhD Thesis, Faculty of Medicine, The University of Queensland. doi: 10.14264/uql.2020.859
2020
Journal Article
Oral delivery of β-lactoglobulin nanospheres encapsulated resveratrol alleviates inflammation in Winnie mice with spontaneous ulcerative colitis
Pujara, Naisarg, Wong, Kuan Yau, Qu, Zhi, Wang, Ran, Moniruzzaman, Md., Rewatkar, Prarthana, Kumeria, Tushar, Ross, Benjamin P., McGuckin, Michael and Popat, Amirali (2020). Oral delivery of β-lactoglobulin nanospheres encapsulated resveratrol alleviates inflammation in Winnie mice with spontaneous ulcerative colitis. Molecular Pharmaceutics, 18 (2) acs.molpharmaceut.0c00048, 627-640. doi: 10.1021/acs.molpharmaceut.0c00048
2020
Conference Publication
Harnessing the therapeutic potential of interleukin-22 in neonatal respiratory viral infection
Hasnain, S., Wang, R., Taylor, S., Wong, K. Y., Moniruzzaman, M., Upham, J., Spann, K., Mcguckin, M. A., Burr, L. and Phipps, S. (2020). Harnessing the therapeutic potential of interleukin-22 in neonatal respiratory viral infection. TSANZSRS 2020 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science, Melbourne, VIC, Australia, 27–31 March 2020. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.13777
2020
Conference Publication
Blocking endogenous IL-22 is associated with reduced viral load and improved lung pathology in respiratory viral infections
Wang, R., Moniruzzaman, M., Wang, K., Upham, J. W., McGuckin, M., Phipps, S. and Hasnain, S. Z. (2020). Blocking endogenous IL-22 is associated with reduced viral load and improved lung pathology in respiratory viral infections. International Conference of the American-Thoracic-Society (ATS), Online, 10 November 2020. New York, NY, United States: American Thoracic Society. doi: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6530
2019
Conference Publication
Interleukin-20 subfamily cytokines in controlling intestinal inflammation and epithelial barrier integrity
Moniruzzaman, M., Wang, R., Wong, K., Tong, H., McGuckin, M. and Hasnain, S. (2019). Interleukin-20 subfamily cytokines in controlling intestinal inflammation and epithelial barrier integrity. Congress of ECCO, Copenhagen, Denmark, 6-9 March 2019. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjy222.044
Funding
Current funding
Supervision
Availability
- Dr Md Moniruzzaman is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Designer Nanoparticles for Oral and Targeted Delivery of Protein Therapeutics
Associate Advisor
Other advisors: Associate Professor Jakob Begun, Professor Amirali Popat
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Doctor Philosophy
Designer Nanoparticles for Oral and Targeted Delivery of Protein Therapeutics
Associate Advisor
Other advisors: Associate Professor Jakob Begun, Professor Amirali Popat, Dr Rabina Giri
Media
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