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2024

Journal Article

Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis

Sajiir, Haressh, Keshvari, Sahar, Wong, Kuan Yau, Borg, Danielle J., Steyn, Frederik J., Fercher, Christian, Taylor, Karin, Taylor, Breten, Barnard, Ross T., Müller, Alexandra, Moniruzzaman, Md, Miller, Gregory, Wang, Ran, Fotheringham, Amelia, Schreiber, Veronika, Sheng, Yong Hua, Hancock, Janelle Louise, Loo, Dorothy, Burr, Lucy, Huynh, Tony, Lockett, Jack, Ramm, Grant A., Macdonald, Graeme A., Prins, Johannes B., McGuckin, Michael A. and Hasnain, Sumaira Z. (2024). Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis. Nature Communications, 15 (1) 4528, 1-13. doi: 10.1038/s41467-024-48317-x

Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis

2024

Journal Article

Cannabidiol - help and hype in targeting mucosal diseases

Moniruzzaman, Md, Janjua, Taskeen Iqbal, Martin, Jennifer H., Begun, Jakob and Popat, Amirali (2024). Cannabidiol - help and hype in targeting mucosal diseases. Journal of Controlled Release, 365, 530-543. doi: 10.1016/j.jconrel.2023.11.010

Cannabidiol - help and hype in targeting mucosal diseases

2023

Journal Article

Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells

Moniruzzaman, Md, Rahman, M. Arifur, Wang, Ran, Wong, Kuan Yau, Chen, Alice C. -H., Mueller, Alexandra, Taylor, Steven, Harding, Alexa, Illankoon, Thishan, Wiid, Percival, Sajiir, Haressh, Schreiber, Veronika, Burr, Lucy D., McGuckin, Michael A., Phipps, Simon and Hasnain, Sumaira Z. (2023). Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells. The Journal of Experimental Medicine, 220 (11) e20230106. doi: 10.1084/jem.20230106

Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells

2023

Conference Publication

Enhancing the efficacy of cannabidiol using protein nanoparticles to treat inflammatory bowel disease

Moniruzzaman, M., Rewatkar, P., Begun, J. and Popat, A. (2023). Enhancing the efficacy of cannabidiol using protein nanoparticles to treat inflammatory bowel disease. 18th Congress of ECCO, Copenhagen, Denmark, 1-4 March 2023. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjac190.0167

Enhancing the efficacy of cannabidiol using protein nanoparticles to treat inflammatory bowel disease

2022

Journal Article

IL-20 activates ERK1/2 and suppresses splicing of X-box protein-1 in intestinal epithelial cells but does not improve pathology in acute or chronic models of colitis

Moniruzzaman, Md., Wong, Kuan Yau, Wang, Ran, Symon, Hamish, Mueller, Alexandra, Rahman, M. Arifur and Hasnain, Sumaira Z. (2022). IL-20 activates ERK1/2 and suppresses splicing of X-box protein-1 in intestinal epithelial cells but does not improve pathology in acute or chronic models of colitis. International Journal of Molecular Sciences, 24 (1) 174, 174. doi: 10.3390/ijms24010174

IL-20 activates ERK1/2 and suppresses splicing of X-box protein-1 in intestinal epithelial cells but does not improve pathology in acute or chronic models of colitis

2021

Journal Article

Facile synthesis of dendrimer like mesoporous silica nanoparticles to enhance targeted delivery of interleukin-22

Elshaer, Dana, Moniruzzaman, Md., Ong, Yi Theng, Qu, Zhi, Schreiber, Veronika, Begun, Jakob and Popat, Amirali (2021). Facile synthesis of dendrimer like mesoporous silica nanoparticles to enhance targeted delivery of interleukin-22. Biomaterials Science, 9 (22), 7402-7411. doi: 10.1039/d1bm01352a

Facile synthesis of dendrimer like mesoporous silica nanoparticles to enhance targeted delivery of interleukin-22

2021

Journal Article

Gut microbiota shape the inflammatory response in mice with an epithelial defect

Wang, Ran, Moniruzzaman, Md, Wong, Kuan Yau, Wiid, Percival, Harding, Alexa, Giri, Rabina, Tong, Wendy Hui, Creagh, Jackie, Begun, Jakob, McGuckin, Michael A. and Hasnain, Sumaira Z. (2021). Gut microbiota shape the inflammatory response in mice with an epithelial defect. Gut microbes, 13 (1), 1-18. doi: 10.1080/19490976.2021.1887720

Gut microbiota shape the inflammatory response in mice with an epithelial defect

2020

Journal Article

The leaves of Bougainvillea spectabilis suppressed inflammation and nociception in vivo through the modulation of glutamatergic, cGMP, and ATP-sensitive K+ channel pathways

Ferdous, Afia, Janta, Rabir Ahmed, Arpa, Rubaiya Nushin, Afroze, Mirola, Khan, Mala and Moniruzzaman, Md. (2020). The leaves of Bougainvillea spectabilis suppressed inflammation and nociception in vivo through the modulation of glutamatergic, cGMP, and ATP-sensitive K+ channel pathways. Journal of Ethnopharmacology, 261 113148, 113148. doi: 10.1016/j.jep.2020.113148

The leaves of Bougainvillea spectabilis suppressed inflammation and nociception in vivo through the modulation of glutamatergic, cGMP, and ATP-sensitive K+ channel pathways

2019

Journal Article

Interleukin (IL)-22 from IL-20 Subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway

Moniruzzaman, Md., Wang, Ran, Jeet, Varinder, McGuckin, Michael A. and Hasnain, Sumaira Z. (2019). Interleukin (IL)-22 from IL-20 Subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway. International Journal of Molecular Sciences, 20 (14) 3468, 3468. doi: 10.3390/ijms20143468

Interleukin (IL)-22 from IL-20 Subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway

2016

Journal Article

The ethyl acetate fraction from Physalis alkekengi inhibits LPS-induced pro-inflammatory mediators in BV2 cells and inflammatory pain in mice

Moniruzzaman, Md., Bose, Shambhunath, Kim, Young-Mi, Chin, Young-Won and Cho, Jungsook (2016). The ethyl acetate fraction from Physalis alkekengi inhibits LPS-induced pro-inflammatory mediators in BV2 cells and inflammatory pain in mice. Journal of Ethnopharmacology, 181, 26-36. doi: 10.1016/j.jep.2016.01.023

The ethyl acetate fraction from Physalis alkekengi inhibits LPS-induced pro-inflammatory mediators in BV2 cells and inflammatory pain in mice

2025

Journal Article

Decoding the Gut-Brain Axis: A Journey Towards Targeted Interventions for Disorders-of-Gut-Brain Interaction

Holtmann, Gerald, Moniruzzaman, M D and Shah, Ayesha (2025). Decoding the Gut-Brain Axis: A Journey Towards Targeted Interventions for Disorders-of-Gut-Brain Interaction. Digestive diseases (Basel, Switzerland), 1-14. doi: 10.1159/000543845

Decoding the Gut-Brain Axis: A Journey Towards Targeted Interventions for Disorders-of-Gut-Brain Interaction

2025

Journal Article

Cannabidiol targets colorectal cancer cells via cannabinoid receptor 2, independent of common mutations

Moniruzzaman, Md, Wong, Kuan Yau, Janjua, Taskeen Iqbal, Martin, Jennifer H., Begun, Jakob and Popat, Amirali (2025). Cannabidiol targets colorectal cancer cells via cannabinoid receptor 2, independent of common mutations. ACS Pharmacology and Translational Science, 8 (2), 543-556. doi: 10.1021/acsptsci.4c00644

Cannabidiol targets colorectal cancer cells via cannabinoid receptor 2, independent of common mutations

2025

Conference Publication

P0112 Cannabidiol (CBD) targeting of colorectal cancer cells is mutation-independent and via CB2 receptor

Moniruzzaman, M., Janjua, T., Begun, J. and Popat, A. (2025). P0112 Cannabidiol (CBD) targeting of colorectal cancer cells is mutation-independent and via CB2 receptor. 20th Congress of ECCO, Berlin, Germany, 19-22 February 2025. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjae190.0286

P0112 Cannabidiol (CBD) targeting of colorectal cancer cells is mutation-independent and via CB2 receptor

2024

Conference Publication

Unveiling The Gut-brain Connectivity And Links With The Immune System: Utilising Self-reported Symptoms Or The Response To A Standardised Nutrient Challenge

Moniruzzaman, Md, Shah, Ayesha, Fairlie, Thomas, Noon, Ebony, Morrison, Mark, Talley, Nicholas J., Koloski, Natasha A., Jones, Michael P. and Holtmann, Gerald J. (2024). Unveiling The Gut-brain Connectivity And Links With The Immune System: Utilising Self-reported Symptoms Or The Response To A Standardised Nutrient Challenge. Digestive Disease Week (DDW) 2024, Washington, DC United States, 18-21 May 2024. Elsevier. doi: 10.1016/s0016-5085(24)01585-3

Unveiling The Gut-brain Connectivity And Links With The Immune System: Utilising Self-reported Symptoms Or The Response To A Standardised Nutrient Challenge

2024

Journal Article

Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Steinmetz, Jaimie D, Seeher, Katrin Maria, Schiess, Nicoline, Nichols, Emma, Cao, Bochen, Servili, Chiara, Cavallera, Vanessa, Cousin, Ewerton, Hagins, Hailey, Moberg, Madeline E, Mehlman, Max L, Abate, Yohannes Habtegiorgis, Abbas, Jaffar, Abbasi, Madineh Akram, Abbasian, Mohammadreza, Abbastabar, Hedayat, Abdelmasseh, Michael, Abdollahi, Mohammad, Abdollahi, Mozhan, Abdollahifar, Mohammad-Amin, Abd-Rabu, Rami, Abdulah, Deldar Morad, Abdullahi, Auwal, Abedi, Aidin, Abedi, Vida, Abeldaño Zuñiga, Roberto Ariel, Abidi, Hassan, Abiodun, Olumide, Aboagye, Richard Gyan ... Dua, Tarun (2024). Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet Neurology, 23 (4), 344-381. doi: 10.1016/s1474-4422(24)00038-3

Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

2023

Conference Publication

Small intestinal bacterial overgrowth in chronic liver disease: a systematic review and meta-analysis of case-control studies

Spannenburg, L., Shah, A., Thite, P., Fairlie, T., Moniruzzaman, M., Stuart, K. A., Koloski, N. A., Morrison, M., Jones, M. P. and Holtmann, G. J. (2023). Small intestinal bacterial overgrowth in chronic liver disease: a systematic review and meta-analysis of case-control studies. 31st United European Gastroenterology Week 2023, Copenhagen, Denmark, 14-17 October 2023. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/ueg2.1246

Small intestinal bacterial overgrowth in chronic liver disease: a systematic review and meta-analysis of case-control studies

2023

Journal Article

Exploring potential anti-inflammatory effects of medicinal cannabis

Gurgenci, Taylan, Kijanka, Gregor, Greer, Ristan, Huggett, Georgie, Good, Phillip, Moniruzzaman, Md and Hardy, Janet (2023). Exploring potential anti-inflammatory effects of medicinal cannabis. Supportive Care in Cancer, 31 (12) 629, 629. doi: 10.1007/s00520-023-08069-8

Exploring potential anti-inflammatory effects of medicinal cannabis

2023

Journal Article

Global, regional, and national burden of rheumatoid arthritis, 1990-2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021

GBD 2021 Rheumatoid Arthritis Collaborators and Moniruzzaman, Md (2023). Global, regional, and national burden of rheumatoid arthritis, 1990-2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. The Lancet. Rheumatology, 5 (10), e594-e610. doi: 10.1016/S2665-9913(23)00211-4

Global, regional, and national burden of rheumatoid arthritis, 1990-2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021

2023

Journal Article

Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019

GBD 2019 IMID Collaborators, Moni, Mohammad Ali, Moniruzzaman, Md and Pak, Anton (2023). Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019. EClinicalMedicine, 64 102193, 102193. doi: 10.1016/j.eclinm.2023.102193

Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019

2023

Journal Article

MUC13 cell surface mucin limits Salmonella Typhimurium infection by protecting the mucosal epithelial barrier

McGuckin, Michael A., Davies, Julie M., Felgner, Pascal, Wong, Kuan Yau, Giri, Rabina, He, Yaowu, Moniruzzaman, Md., Kryza, Thomas, Sajiir, Haressh, Hooper, John D., Florin, Timothy H., Begun, Jakob, Oussalah, Abderrahim, Hasnain, Sumaira Z., Hensel, Michael and Sheng, Yong H. (2023). MUC13 cell surface mucin limits Salmonella Typhimurium infection by protecting the mucosal epithelial barrier. Cellular and Molecular Gastroenterology and Hepatology, 16 (6), 985-1009. doi: 10.1016/j.jcmgh.2023.08.011

MUC13 cell surface mucin limits Salmonella Typhimurium infection by protecting the mucosal epithelial barrier