Overview
Background
Sebastian is an expert on molecular pharmacology of G protein-coupled receptors (GPCRs - the largest class of cell surface recpetors and major drug targets). His lab has a particular interest in those involved in communication between the gastrointestinal tract and brain (the so-called gut-brain axis). Current foccusses include ghrelin, melanocortin 4, dopamine D2, and cholecystokinin receptors and the lab has also worked on the calcitonin, glucagon-like peptide 1 and other receptors. His lab is interested in answering complelling biological questions relating to physiology and pathophysiology of the gut-brain axis all the way down to the level of the receptor.
Sebastian is from Adelaide and received his BSc(Hons) and PhD. from the University of Adelaide, where he worked on the Aryl Hydrocarbon receptor in the lab of Murray Whitelaw. He then did postdoctoral research on haematopoitic stem cell differentiation in Kelly McNagny’s lab at the Biomedical Research Centre at the University of British Columbia before joining Patrick Sexton to work on G protein-coupled receptors at Monash University .
Sebastian is now an ARC Future Fellow with his own research program in the School of Biomedical Sciences at the University of Queensland. He remains an adjunct member of MIPS DDB as well as CCeMMP.
Sebastian has honours and PhD positions for motivated students who have a strong desire to assume ownership of a project and work independently.
Availability
- Associate Professor Sebastian Furness is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, University of Adelaide
Research impacts
Sebastian is active in advocacy for improvements to STEM policy across education, science literacy and research funding, having worked for a number of years with an advisory group to his local federal MP, participated in Pint of Science and writing for The Conversation. He has been involved in commercialisation of some of his work into a startup biotech company (Apop biosciences). His main research focus has been instrumental in shifting the paradigm of how signalling works at G protein-coupled receptors (please see an explainer here), is cited in over 40 patents and has been influential in enabling structural biology approaches to understand the mechanism for activation of G protein-coupled receptors.
Works
Search Professor Sebastian Furness’s works on UQ eSpace
2015
Journal Article
Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics
Cook, A. E., Mistry, S. N., Gregory, K. J., Furness, S. G. B., Sexton, P. M., Scammells, P. J., Conigrave, A. D., Christopoulos, A. and Leach, K. (2015). Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics. British Journal of Pharmacology, 172 (1), 185-200. doi: 10.1111/bph.12937
2014
Journal Article
Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias
Andreassen, Kim Vietz, Hjuler, Sara Toftegaard, Furness, Sebastian G., Sexton, Patrick M., Christopoulos, Arthur, Nosjean, Olivier, Karsdal, Morten Asser and Henriksen, Kim (2014). Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias. PLoS One, 9 (3) e92042, e92042. doi: 10.1371/journal.pone.0092042
2014
Journal Article
Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation
Pabreja, K., Mohd, M. A., Koole, C., Wootten, D. and Furness, S. G.B. (2014). Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation. British Journal of Pharmacology, 171 (5), 1114-1128. doi: 10.1111/bph.12313
2013
Journal Article
A simple method to generate stable cell lines for the analysis of transient protein-protein interactions
Savage, Emilia Elizabeth, Wootten, Denise, Christopoulos, Arthur, Sexton, Patrick Michael and Furness, Sebastian George Barton (2013). A simple method to generate stable cell lines for the analysis of transient protein-protein interactions. BioTechniques, 54 (4), 217-221. doi: 10.2144/000114013
2013
Conference Publication
Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function
Koole, Cassandra, Pabreja, Kavita, Savage, Emilia E., Wootten, Denise, Furness, Sebastian G. B., Miller, Laurence J., Christopoulos, Arthur and Sexton, Patrick M. (2013). Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function. Biochemical Society Meeting, London, United Kingdom: Portland Press. doi: 10.1042/BST20120236
2012
Journal Article
Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling
Hao, Nan, Lee, Kian Leong, Furness, Sebastian G. B., Bosdotter, Cecilia, Poellinger, Lorenz and Whitelaw, Murray L. (2012). Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling. Molecular Pharmacology, 82 (6), 1082-1093. doi: 10.1124/mol.112.078873
2012
Journal Article
Small molecule allosteric modulation of the glucagon-like peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin
Willard, Francis S., Wootten, Denise, Showalter, Aaron D., Savage, Emilia E., Ficorilli, James, Farb, Thomas B., Bokvist, Krister, Alsina-Fernandez, Jorge, Furness, Sebastian G. B., Christopoulos, Arthur, Sexton, Patrick M. and Sloop, Kyle W. (2012). Small molecule allosteric modulation of the glucagon-like peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin. Molecular Pharmacology, 82 (6), 1066-1073. doi: 10.1124/mol.112.080432
2012
Journal Article
Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery
Harikumar, Kaleeckal G., Wootten, Denise, Pinon, Delia I., Koole, Cassandra, Ball, Alicja M., Furness, Sebastian G. B., Graham, Bim, Dong, Maoqing, Christopoulos, Arthur, Miller, Laurence J. and Sexton, Patrick M. (2012). Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery. Proceedings of the National Academy of Sciences of the United States of America, 109 (45), 18607-18612. doi: 10.1073/pnas.1205227109
2012
Journal Article
Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptor
Sato, Masaaki, Hutchinson, Dana S., Halls, Michelle L., Furness, Sebastian G. B., Bengtsson, Tore, Evans, Bronwyn A. and Summers, Roger J. (2012). Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptor. Journal of Biological Chemistry, 287 (24), 20674-20688. doi: 10.1074/jbc.M111.280651
2012
Journal Article
Consequences of splice variation on Secretin family G protein-coupled receptor function
Furness, Sebastian G.B., Wootten, Denise, Christopoulos, Arthur and Sexton, Patrick M. (2012). Consequences of splice variation on Secretin family G protein-coupled receptor function. British Journal of Pharmacology, 166 (1), 98-109. doi: 10.1111/j.1476-5381.2011.01571.x
2012
Journal Article
The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172
Wookey, Peter J., Mclean, Catriona A., Hwang, Peter, Furness, Sebastian G.B., Nguyen, Sandy, Kourakis, Angela, Hare, David L. and Rosenfeld, Jeffrey V. (2012). The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172. Histopathology, 60 (6), 895-910. doi: 10.1111/j.1365-2559.2011.04146.x
2010
Journal Article
Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator
Whelan, Fiona, Hao, Nan, Furness, Sebastian G. B., Whitelaw, Murray L. and Chapman-Smith, Anne (2010). Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator. Molecular Pharmacology, 77 (6), 1037-1046. doi: 10.1124/mol.109.062927
2009
Journal Article
The pleiotropy of dioxin toxicity - Xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles
Furness, Sebastian G.B. and Whelan, Fiona (2009). The pleiotropy of dioxin toxicity - Xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles. Pharmacology and Therapeutics, 124 (3), 336-353. doi: 10.1016/j.pharmthera.2009.09.004
2009
Book Chapter
Understanding amylin receptors
Just, Rasmus, Simms, John, Furness, Sebastian G. B., Christopoulos, Arthur and Sexton, Patrick M. (2009). Understanding amylin receptors. The calcitonin gene-related peptide family. (pp. 41-57) Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/978-90-481-2909-6_3
2009
Journal Article
Sulfonation and phosphorylation of regions of the dioxin receptor susceptible to methionine modifications
Dave, Keyur A., Whelan, Fiona, Bindloss, Colleen, Furness, Sebastian G. B., Chapman-Smith, Anne, Whitelaw, Murray L. and Gorman, Jeffrey J. (2009). Sulfonation and phosphorylation of regions of the dioxin receptor susceptible to methionine modifications. Molecular & Cellular Proteomics, 8 (4), 706-719. doi: 10.1074/mcp.M800459-MCP200
2008
Journal Article
Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors
Morfis, Maria, Tilakaratne, Nanda, Furness, Sebastian G. B., Christopoulos, George, Werry, Tim D., Christopoulos, Arthur and Sexton, Patrick M. (2008). Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors. Endocrinology, 149 (11), 5423-5431. doi: 10.1210/en.2007-1735
2007
Journal Article
The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors
Furness, Sebastian G.B., Lees, Michael J. and Whitelaw, Murray L. (2007). The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors. FEBS Letters, 581 (19), 3616-3625. doi: 10.1016/j.febslet.2007.04.011
2007
Journal Article
Identification of N,N epsilon-dimethyl-lysine in the murine dioxin receptor using MALDI-TOF/TOF- and ESI-LTQ-Orbitrap-FT-MS
Dave, KA, Hamilton, BR, Wallis, TP, Furness, SGB, Whitelaw, ML and Gorman, JJ (2007). Identification of N,N epsilon-dimethyl-lysine in the murine dioxin receptor using MALDI-TOF/TOF- and ESI-LTQ-Orbitrap-FT-MS. International Journal of Mass Spectrometry, 268 (2-3), 168-180. doi: 10.1016/j.ijms.2007.06.001
2006
Journal Article
Na+/H+ exchanger regulatory factor-1 is a hematopoietic ligand for a subset of the CD34 family of stem cell surface proteins
Tan, Poh C., Furness, Sebastian G.B., Merkens, Helen, Lin, Shujun, McCoy, Marcia L., Roskelley, Calvin D., Kast, Jürgen and McNagny, Kelly M. (2006). Na+/H+ exchanger regulatory factor-1 is a hematopoietic ligand for a subset of the CD34 family of stem cell surface proteins. Stem Cells, 24 (5), 1150-1161. doi: 10.1634/stemcells.2005-0426
2006
Journal Article
Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis
Furness, Sebastian George Barton and McNagny, Kelly (2006). Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis. Immunologic Research, 34 (1), 13-32. doi: 10.1385/ir:34:1:13
Supervision
Availability
- Associate Professor Sebastian Furness is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
The Conformational Basis of MC4R Function and Regulation
Principal Advisor
Other advisors: Dr Farhad Dehkhoda
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Doctor Philosophy
Understanding the molecular basis for cholesterol dependent modulation of G protein-coupled receptor signalling
Principal Advisor
Other advisors: Dr Farhad Dehkhoda
-
Doctor Philosophy
New approaches to measuring single-molecule protein dynamics
Principal Advisor
Other advisors: Dr Farhad Dehkhoda
-
Doctor Philosophy
Ghrelin receptor modulation of GPCR signalling
Principal Advisor
Other advisors: Dr Farhad Dehkhoda
Media
Enquiries
Contact Associate Professor Sebastian Furness directly for media enquiries about:
- Anti-obesity medications
- Diabetes
- Discovery Research
- Obesity
- Science Funding
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