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Associate Professor Sebastian Furness
Associate Professor

Sebastian Furness

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Overview

Background

Sebastian is an expert on molecular pharmacology of G protein-coupled receptors (GPCRs - the largest class of cell surface recpetors and major drug targets). His lab has a particular interest in those involved in communication between the gastrointestinal tract and brain (the so-called gut-brain axis). Current foccusses include ghrelin, melanocortin 4, dopamine D2, and cholecystokinin receptors and the lab has also worked on the calcitonin, glucagon-like peptide 1 and other receptors. His lab is interested in answering complelling biological questions relating to physiology and pathophysiology of the gut-brain axis all the way down to the level of the receptor.

Sebastian is from Adelaide and received his BSc(Hons) and PhD. from the University of Adelaide, where he worked on the Aryl Hydrocarbon receptor in the lab of Murray Whitelaw. He then did postdoctoral research on haematopoitic stem cell differentiation in Kelly McNagny’s lab at the Biomedical Research Centre at the University of British Columbia before joining Patrick Sexton to work on G protein-coupled receptors at Monash University .

Sebastian is now an ARC Future Fellow with his own research program in the School of Biomedical Sciences at the University of Queensland. He remains an adjunct member of MIPS DDB as well as CCeMMP.

Sebastian has honours and PhD positions for motivated students who have a strong desire to assume ownership of a project and work independently.

Availability

Associate Professor Sebastian Furness is:
Available for supervision
Media expert

Qualifications

  • Doctor of Philosophy, University of Adelaide

Research impacts

Sebastian is active in advocacy for improvements to STEM policy across education, science literacy and research funding, having worked for a number of years with an advisory group to his local federal MP, participated in Pint of Science and writing for The Conversation. He has been involved in commercialisation of some of his work into a startup biotech company (Apop biosciences). His main research focus has been instrumental in shifting the paradigm of how signalling works at G protein-coupled receptors (please see an explainer here), is cited in over 40 patents and has been influential in enabling structural biology approaches to understand the mechanism for activation of G protein-coupled receptors.

Works

Search Professor Sebastian Furness’s works on UQ eSpace

60 works between 2006 and 2024

41 - 60 of 60 works

2015

Journal Article

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

Cook, A. E., Mistry, S. N., Gregory, K. J., Furness, S. G. B., Sexton, P. M., Scammells, P. J., Conigrave, A. D., Christopoulos, A. and Leach, K. (2015). Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics. British Journal of Pharmacology, 172 (1), 185-200. doi: 10.1111/bph.12937

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

2014

Journal Article

Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias

Andreassen, Kim Vietz, Hjuler, Sara Toftegaard, Furness, Sebastian G., Sexton, Patrick M., Christopoulos, Arthur, Nosjean, Olivier, Karsdal, Morten Asser and Henriksen, Kim (2014). Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias. PLoS One, 9 (3) e92042, e92042. doi: 10.1371/journal.pone.0092042

Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias

2014

Journal Article

Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation

Pabreja, K., Mohd, M. A., Koole, C., Wootten, D. and Furness, S. G.B. (2014). Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation. British Journal of Pharmacology, 171 (5), 1114-1128. doi: 10.1111/bph.12313

Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation

2013

Journal Article

A simple method to generate stable cell lines for the analysis of transient protein-protein interactions

Savage, Emilia Elizabeth, Wootten, Denise, Christopoulos, Arthur, Sexton, Patrick Michael and Furness, Sebastian George Barton (2013). A simple method to generate stable cell lines for the analysis of transient protein-protein interactions. BioTechniques, 54 (4), 217-221. doi: 10.2144/000114013

A simple method to generate stable cell lines for the analysis of transient protein-protein interactions

2013

Conference Publication

Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function

Koole, Cassandra, Pabreja, Kavita, Savage, Emilia E., Wootten, Denise, Furness, Sebastian G. B., Miller, Laurence J., Christopoulos, Arthur and Sexton, Patrick M. (2013). Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function. Biochemical Society Meeting, London, United Kingdom: Portland Press. doi: 10.1042/BST20120236

Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function

2012

Journal Article

Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling

Hao, Nan, Lee, Kian Leong, Furness, Sebastian G. B., Bosdotter, Cecilia, Poellinger, Lorenz and Whitelaw, Murray L. (2012). Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling. Molecular Pharmacology, 82 (6), 1082-1093. doi: 10.1124/mol.112.078873

Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling

2012

Journal Article

Small molecule allosteric modulation of the glucagon-like peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin

Willard, Francis S., Wootten, Denise, Showalter, Aaron D., Savage, Emilia E., Ficorilli, James, Farb, Thomas B., Bokvist, Krister, Alsina-Fernandez, Jorge, Furness, Sebastian G. B., Christopoulos, Arthur, Sexton, Patrick M. and Sloop, Kyle W. (2012). Small molecule allosteric modulation of the glucagon-like peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin. Molecular Pharmacology, 82 (6), 1066-1073. doi: 10.1124/mol.112.080432

Small molecule allosteric modulation of the glucagon-like peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin

2012

Journal Article

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery

Harikumar, Kaleeckal G., Wootten, Denise, Pinon, Delia I., Koole, Cassandra, Ball, Alicja M., Furness, Sebastian G. B., Graham, Bim, Dong, Maoqing, Christopoulos, Arthur, Miller, Laurence J. and Sexton, Patrick M. (2012). Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery. Proceedings of the National Academy of Sciences of the United States of America, 109 (45), 18607-18612. doi: 10.1073/pnas.1205227109

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery

2012

Journal Article

Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptor

Sato, Masaaki, Hutchinson, Dana S., Halls, Michelle L., Furness, Sebastian G. B., Bengtsson, Tore, Evans, Bronwyn A. and Summers, Roger J. (2012). Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptor. Journal of Biological Chemistry, 287 (24), 20674-20688. doi: 10.1074/jbc.M111.280651

Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptor

2012

Journal Article

Consequences of splice variation on Secretin family G protein-coupled receptor function

Furness, Sebastian G.B., Wootten, Denise, Christopoulos, Arthur and Sexton, Patrick M. (2012). Consequences of splice variation on Secretin family G protein-coupled receptor function. British Journal of Pharmacology, 166 (1), 98-109. doi: 10.1111/j.1476-5381.2011.01571.x

Consequences of splice variation on Secretin family G protein-coupled receptor function

2012

Journal Article

The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172

Wookey, Peter J., Mclean, Catriona A., Hwang, Peter, Furness, Sebastian G.B., Nguyen, Sandy, Kourakis, Angela, Hare, David L. and Rosenfeld, Jeffrey V. (2012). The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172. Histopathology, 60 (6), 895-910. doi: 10.1111/j.1365-2559.2011.04146.x

The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172

2010

Journal Article

Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator

Whelan, Fiona, Hao, Nan, Furness, Sebastian G. B., Whitelaw, Murray L. and Chapman-Smith, Anne (2010). Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator. Molecular Pharmacology, 77 (6), 1037-1046. doi: 10.1124/mol.109.062927

Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator

2009

Journal Article

The pleiotropy of dioxin toxicity - Xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles

Furness, Sebastian G.B. and Whelan, Fiona (2009). The pleiotropy of dioxin toxicity - Xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles. Pharmacology and Therapeutics, 124 (3), 336-353. doi: 10.1016/j.pharmthera.2009.09.004

The pleiotropy of dioxin toxicity - Xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles

2009

Book Chapter

Understanding amylin receptors

Just, Rasmus, Simms, John, Furness, Sebastian G. B., Christopoulos, Arthur and Sexton, Patrick M. (2009). Understanding amylin receptors. The calcitonin gene-related peptide family. (pp. 41-57) Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/978-90-481-2909-6_3

Understanding amylin receptors

2009

Journal Article

Sulfonation and phosphorylation of regions of the dioxin receptor susceptible to methionine modifications

Dave, Keyur A., Whelan, Fiona, Bindloss, Colleen, Furness, Sebastian G. B., Chapman-Smith, Anne, Whitelaw, Murray L. and Gorman, Jeffrey J. (2009). Sulfonation and phosphorylation of regions of the dioxin receptor susceptible to methionine modifications. Molecular & Cellular Proteomics, 8 (4), 706-719. doi: 10.1074/mcp.M800459-MCP200

Sulfonation and phosphorylation of regions of the dioxin receptor susceptible to methionine modifications

2008

Journal Article

Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors

Morfis, Maria, Tilakaratne, Nanda, Furness, Sebastian G. B., Christopoulos, George, Werry, Tim D., Christopoulos, Arthur and Sexton, Patrick M. (2008). Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors. Endocrinology, 149 (11), 5423-5431. doi: 10.1210/en.2007-1735

Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors

2007

Journal Article

The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors

Furness, Sebastian G.B., Lees, Michael J. and Whitelaw, Murray L. (2007). The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors. FEBS Letters, 581 (19), 3616-3625. doi: 10.1016/j.febslet.2007.04.011

The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors

2007

Journal Article

Identification of N,N epsilon-dimethyl-lysine in the murine dioxin receptor using MALDI-TOF/TOF- and ESI-LTQ-Orbitrap-FT-MS

Dave, KA, Hamilton, BR, Wallis, TP, Furness, SGB, Whitelaw, ML and Gorman, JJ (2007). Identification of N,N epsilon-dimethyl-lysine in the murine dioxin receptor using MALDI-TOF/TOF- and ESI-LTQ-Orbitrap-FT-MS. International Journal of Mass Spectrometry, 268 (2-3), 168-180. doi: 10.1016/j.ijms.2007.06.001

Identification of N,N epsilon-dimethyl-lysine in the murine dioxin receptor using MALDI-TOF/TOF- and ESI-LTQ-Orbitrap-FT-MS

2006

Journal Article

Na+/H+ exchanger regulatory factor-1 is a hematopoietic ligand for a subset of the CD34 family of stem cell surface proteins

Tan, Poh C., Furness, Sebastian G.B., Merkens, Helen, Lin, Shujun, McCoy, Marcia L., Roskelley, Calvin D., Kast, Jürgen and McNagny, Kelly M. (2006). Na+/H+ exchanger regulatory factor-1 is a hematopoietic ligand for a subset of the CD34 family of stem cell surface proteins. Stem Cells, 24 (5), 1150-1161. doi: 10.1634/stemcells.2005-0426

Na+/H+ exchanger regulatory factor-1 is a hematopoietic ligand for a subset of the CD34 family of stem cell surface proteins

2006

Journal Article

Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis

Furness, Sebastian George Barton and McNagny, Kelly (2006). Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis. Immunologic Research, 34 (1), 13-32. doi: 10.1385/ir:34:1:13

Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis

Funding

Current funding

  • 2023 - 2026
    Beyond structure - solving conformational dynamics for intractable proteins
    ARC Discovery Projects
    Open grant
  • 2022 - 2025
    A new frontier in receptor biology relevant to treatment of disease
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2021 - 2023
    The molecular basis for efficacy at G protein coupled receptors (GPCRs)
    ARC Future Fellowships
    Open grant

Supervision

Availability

Associate Professor Sebastian Furness is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    The Conformational Basis of MC4R Function and Regulation

    Principal Advisor

    Other advisors: Dr Farhad Dehkhoda

  • Doctor Philosophy

    Understanding the molecular basis for cholesterol dependent modulation of G protein-coupled receptor signalling

    Principal Advisor

    Other advisors: Dr Farhad Dehkhoda

  • Doctor Philosophy

    New approaches to measuring single-molecule protein dynamics

    Principal Advisor

    Other advisors: Dr Farhad Dehkhoda

  • Doctor Philosophy

    Ghrelin receptor modulation of GPCR signalling

    Principal Advisor

    Other advisors: Dr Farhad Dehkhoda

Media

Enquiries

Contact Associate Professor Sebastian Furness directly for media enquiries about:

  • Anti-obesity medications
  • Diabetes
  • Discovery Research
  • Obesity
  • Science Funding

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au