Overview
Availability
- Dr Farhad Dehkhoda is:
- Available for supervision
Works
Search Professor Farhad Dehkhoda’s works on UQ eSpace
2025
Journal Article
Constitutive ghrelin receptor activity enables reversal of dopamine D2 receptor signaling
Dehkhoda, Farhad, Ringuet, Mitchell T., Whitfield, Emily A., Mutunduwe, Keith, Whelan, Fiona, Nowell, Cameron J., Misganaw, Desye, Xu, Zheng, Piper, Noah B. C., Clark, Richard J., Hossain, Mohammed Akhter, Fothergill, Linda J., McDougall, Stuart J., Furness, John B. and Furness, Sebastian G. B. (2025). Constitutive ghrelin receptor activity enables reversal of dopamine D2 receptor signaling. Molecular Cell, 85 (11), 2246-2260.e10. doi: 10.1016/j.molcel.2025.05.005
2025
Conference Publication
The Molecular Mechanism for Reversed Dopamine D2 Receptor Cellular Output and Defecation Control, Enabled by Constitutive Ghrelin Receptor Activity
Furness, Sebastian, Dehkhoda, Farhad, Ringuet, Mitchell, Nowell, Cameron, Misganaw, Desye, Xu, Zheng, McDougall, Stuart and Furness, John (2025). The Molecular Mechanism for Reversed Dopamine D2 Receptor Cellular Output and Defecation Control, Enabled by Constitutive Ghrelin Receptor Activity. 2025 ASBMB Annual Meeting, Brisbane, QLD Australia, 29 September - 1 October 2025. Bethesda, MD United States: American Society for Biochemistry and Molecular Biology. doi: 10.1016/j.jbc.2025.110108
2025
Conference Publication
CCK-58 and CCK-8 are non-equivalent in signal transduction at human cholecystokinin 1 receptor (CCK1R) in transfected cell lines
Xing, Jingjing, Dehkhoda, Farhad and Furness, Sebastian (2025). CCK-58 and CCK-8 are non-equivalent in signal transduction at human cholecystokinin 1 receptor (CCK1R) in transfected cell lines. ASPET 2025, Portland, OR, United States, 3-6 April 2025. Rockville, MD, United States: American Society for Pharmacology and Experimental Therapeutics. doi: 10.1016/j.jpet.2025.103430
2025
Other Outputs
Molecular Cell Dataset "Determination of the mechanism for reversed dopamine D2 receptor cellular output enabled by constitutive ghrelin receptor activity."
Furness, Sebastian, Ambaw, Desye Misganaw, Mutunduwe, Keith, Dehkhoda, Farhad and Piper, Noah (2025). Molecular Cell Dataset "Determination of the mechanism for reversed dopamine D2 receptor cellular output enabled by constitutive ghrelin receptor activity.". The University of Queensland. (Dataset) doi: 10.48610/005d1e7
2025
Journal Article
Be CLEAR to ensure methodological and data transparency
George, Christopher H., Bate, Simon T., Stanford, S. Clare, Ahluwalia, Amrita, Curtis, Michael J., Dehkhoda, Farhad, Kolassa, John, Minervini, Vanessa, Nikam, Vandana, Omotoso, Taiwo O., Spedding, Michael and Hay, Debbie L. (2025). Be CLEAR to ensure methodological and data transparency. Trends in Pharmacological Sciences. doi: 10.1016/j.tips.2025.09.001
2024
Journal Article
The ATM Ser49Cys variant effects ATM function as a regulator of oncogene-induced senescence
Atkinson, Caroline, McInerney-Leo, Aideen, Proctor, Martina, Lanagan, Catherine, Stevenson, Alexander, Dehkhoda, Farhad, Caole, Mary, Maas, Ellie, Ainger, Stephen, Pritchard, Antonia, Johansson, Peter, Leo, Paul, Hayward, Nicholas, Sturm, Richard, Duncan, Emma and Gabrielli, Brian (2024). The ATM Ser49Cys variant effects ATM function as a regulator of oncogene-induced senescence. International Journal of Molecular Sciences, 25 (3) 1664, 1-12. doi: 10.3390/ijms25031664
2023
Journal Article
Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation
Chhabra, Yash, Seiffert, Pernille, Gormal, Rachel S., Vullings, Manon, Lee, Christine Mei Mei, Wallis, Tristan P., Dehkhoda, Farhad, Indrakumar, Sowmya, Jacobsen, Nina L., Lindorff-Larsen, Kresten, Durisic, Nela, Waters, Michael J., Meunier, Frederic A., Kragelund, Birthe B. and Brooks, Andrew J. (2023). Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation. Cell Reports, 42 (5) 112490, 112490. doi: 10.1016/j.celrep.2023.112490
2023
Journal Article
The SOCS1 KIR and SH2 domain are both required for suppression of cytokine signaling in vivo
Doggett, Karen, Keating, Narelle, Dehkhoda, Farhad, Bidgood, Grace M., Meza Guzman, Lizeth G., Leong, Evelyn, Kueh, Andrew, Nicola, Nicos A., Kershaw, Nadia J., Babon, Jeffrey J., Alexander, Warren S. and Nicholson, Sandra E. (2023). The SOCS1 KIR and SH2 domain are both required for suppression of cytokine signaling in vivo. Cytokine, 165 156167, 1-8. doi: 10.1016/j.cyto.2023.156167
2023
Conference Publication
Modulation of dopamine's effect at dopamine 2 receptors (D2R) mediated by association with the ghrelin receptor, GHSR
Furness, John, Dehkhoda, Farhad, Whitfield, Emily, Fothergill, Linda, Misgenaw, Desye, Ringuet, Mitchell and Furness, Sebastian (2023). Modulation of dopamine's effect at dopamine 2 receptors (D2R) mediated by association with the ghrelin receptor, GHSR. American Physiology Summit 2023, Long Beach, CA, United States, 20-23 April 2023. Rockville, MD, United States: American Physiological Society. doi: 10.1152/physiol.2023.38.s1.5731818
2022
Journal Article
Optimization of phosphotyrosine peptides that target the SH2 domain of SOCS1 and block substrate ubiquitination
Chen, Hao, Wu, Yuntong, Li, Kunlun, Currie, Iain, Keating, Narelle, Dehkhoda, Farhad, Grohmann, Christoph, Babon, Jeffrey J., Nicholson, Sandra E. and Sleebs, Brad E. (2022). Optimization of phosphotyrosine peptides that target the SH2 domain of SOCS1 and block substrate ubiquitination. ACS Chemical Biology, 17 (2), 449-462. doi: 10.1021/acschembio.1c00884
2021
Journal Article
Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands
Linossi, Edmond M., Li, Kunlun, Veggiani, Gianluca, Tan, Cyrus, Dehkhoda, Farhad, Hockings, Colin, Calleja, Dale J., Keating, Narelle, Feltham, Rebecca, Brooks, Andrew J., Li, Shawn S., Sidhu, Sachdev S., Babon, Jeffrey J., Kershaw, Nadia J. and Nicholson, Sandra E. (2021). Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. Nature Communications, 12 (1) 7032, 7032. doi: 10.1038/s41467-021-26983-5
2018
Journal Article
The growth hormone receptor: mechanism of receptor activation, cell signaling, and physiological aspects
Dehkhoda, Farhad , Lee, Christine M. M. , Medina, Johan and Brooks, Andrew J. (2018). The growth hormone receptor: mechanism of receptor activation, cell signaling, and physiological aspects. Frontiers in Endocrinology, 9 (35) 35, 35. doi: 10.3389/fendo.2018.00035
2018
Book Chapter
Cytokine receptors
Brooks, Andrew J., Dehkhoda, Farhad and Kragelund, Birthe (2018). Cytokine receptors. Endocrinology: principles of endocrinology and hormone action. (pp. 157-185) edited by Antonino Belfiore and Derek LeRoith. Amsterdam, The Netherlands: Springer. doi: 10.1007/978-3-319-44675-2_8
2013
Journal Article
The N550K/H mutations in FGFR2 confer differential resistance to PD173074, dovitinib, and ponatinib ATP-competitive inhibitors
Byron, Sara A., Chen, Huaibin, Wortmann, Andreas, Loch, David, Gartside, Michael G., Dehkhoda, Farhad, Blais, Steven P., Neubert, Thomas A., Mohammadi, Moosa and Pollock, Pamela M. (2013). The N550K/H mutations in FGFR2 confer differential resistance to PD173074, dovitinib, and ponatinib ATP-competitive inhibitors. NeoPlasia, 15 (8), 975-988. doi: 10.1593/neo.121106
Supervision
Availability
- Dr Farhad Dehkhoda is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
New approaches to measuring single-molecule protein dynamics
Associate Advisor
Other advisors: Associate Professor Sebastian Furness
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Doctor Philosophy
Ghrelin receptor modulation of GPCR signalling
Associate Advisor
Other advisors: Associate Professor Sebastian Furness
Completed supervision
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2025
Doctor Philosophy
Understanding the molecular basis for cholesterol-dependent modulation of G protein-coupled receptor (GPCR) signaling
Associate Advisor
Other advisors: Associate Professor Sebastian Furness
-
2025
Doctor Philosophy
The Conformational Basis of MC4 Receptor Function and Regulation
Associate Advisor
Other advisors: Associate Professor Sebastian Furness
Media
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