Overview
Background
Sebastian is an expert on molecular pharmacology of G protein-coupled receptors (GPCRs - the largest class of cell surface recpetors and major drug targets). His lab has a particular interest in those involved in communication between the gastrointestinal tract and brain (the so-called gut-brain axis). Current foccusses include ghrelin, melanocortin 4, dopamine D2, and cholecystokinin receptors and the lab has also worked on the calcitonin, glucagon-like peptide 1 and other receptors. His lab is interested in answering complelling biological questions relating to physiology and pathophysiology of the gut-brain axis all the way down to the level of the receptor.
Sebastian is from Adelaide and received his BSc(Hons) and PhD. from the University of Adelaide, where he worked on the Aryl Hydrocarbon receptor in the lab of Murray Whitelaw. He then did postdoctoral research on haematopoitic stem cell differentiation in Kelly McNagny’s lab at the Biomedical Research Centre at the University of British Columbia before joining Patrick Sexton to work on G protein-coupled receptors at Monash University .
Sebastian is now an ARC Future Fellow with his own research program in the School of Biomedical Sciences at the University of Queensland. He remains an adjunct member of MIPS DDB as well as CCeMMP.
Sebastian has honours and PhD positions for motivated students who have a strong desire to assume ownership of a project and work independently.
Availability
- Dr Sebastian Furness is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, University of Adelaide
Research impacts
Sebastian is active in advocacy for improvements to STEM policy across education, science literacy and research funding, having worked for a number of years with an advisory group to his local federal MP, participated in Pint of Science and writing for The Conversation. He has been involved in commercialisation of some of his work into a startup biotech company (Apop biosciences). His main research focus has been instrumental in shifting the paradigm of how signalling works at G protein-coupled receptors (please see an explainer here), is cited in over 40 patents and has been influential in enabling structural biology approaches to understand the mechanism for activation of G protein-coupled receptors.
Works
Search Professor Sebastian Furness’s works on UQ eSpace
2024
Journal Article
Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling
Harikumar, Kaleeckal G., Zhao, Peishen, Cary, Brian P., Xu, Xiaomeng, Desai, Aditya J., Dong, Maoqing, Mobbs, Jesse I., Toufaily, Chirine, Furness, Sebastian G.B., Christopoulos, Arthur, Belousoff, Matthew J., Wootten, Denise, Sexton, Patrick M. and Miller, Laurence J. (2024). Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling. PLoS Biology, 22 (7 July) e3002673, e3002673. doi: 10.1371/journal.pbio.3002673
2024
Journal Article
Role of G protein‐coupled receptor kinases (<scp>GRKs</scp>) in β<sub>2</sub>‐adrenoceptor‐mediated glucose uptake
Ham, Seungmin, Mukaida, Saori, Sato, Masaaki, Keov, Peter, Bengtsson, Tore, Furness, Sebastian, Holliday, Nicholas D., Evans, Bronwyn A., Summers, Roger J. and Hutchinson, Dana S. (2024). Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake. Pharmacology Research & Perspectives, 12 (1) e1176, e1176. doi: 10.1002/prp2.1176
2024
Journal Article
Cardiac human bitter taste receptors contain naturally occurring variants that alter function
Bloxham, Conor J., Hulme, Katina D., Fierro, Fabrizio, Fercher, Christian, Pegg, Cassandra L., O'Brien, Shannon L., Foster, Simon R., Short, Kirsty R., Furness, Sebastian G. B., Reichelt, Melissa E., Niv, Masha Y. and Thomas, Walter G. (2024). Cardiac human bitter taste receptors contain naturally occurring variants that alter function. Biochemical Pharmacology, 219 115932, 115932. doi: 10.1016/j.bcp.2023.115932
2023
Journal Article
Sites and mechanisms of action of colokinetics at dopamine, ghrelin and serotonin receptors in the rodent lumbosacral defecation centre
Ringuet, Mitchell T., Koo, Ada, Furness, Sebastian G. B., McDougall, Stuart J. and Furness, John B. (2023). Sites and mechanisms of action of colokinetics at dopamine, ghrelin and serotonin receptors in the rodent lumbosacral defecation centre. The Journal of Physiology, 601 (23), 5195-5211. doi: 10.1113/jp285217
2022
Journal Article
G protein‐coupled receptor interactions and modification of signalling involving the ghrelin receptor, GHSR1a
Ringuet, Mitchell Ty, Furness, John Barton and Furness, Sebastian George Barton (2022). G protein‐coupled receptor interactions and modification of signalling involving the ghrelin receptor, GHSR1a. Journal of Neuroendocrinology, 34 (9) e13077, 1-14. doi: 10.1111/jne.13077
2022
Journal Article
Targeting appetite and satiety in diabetes and obesity, via G protein-coupled receptors
Piper, Noah B.C., Whitfield, Emily A., Stewart, Gregory D., Xu, Xiaomeng and Furness, Sebastian G.B. (2022). Targeting appetite and satiety in diabetes and obesity, via G protein-coupled receptors. Biochemical Pharmacology, 202 115115, 1-21. doi: 10.1016/j.bcp.2022.115115
2021
Journal Article
Discovery of a positive allosteric modulator of cholecystokinin action at CCK1R in normal and elevated cholesterol
Harikumar, Kaleeckal G., Coudrat, Thomas, Desai, Aditya J., Dong, Maoqing, Dengler, Daniela G., Furness, Sebastian G. B., Christopoulos, Arthur, Wootten, Denise, Sergienko, Eduard A., Sexton, Patrick M. and Miller, Laurence J. (2021). Discovery of a positive allosteric modulator of cholecystokinin action at CCK1R in normal and elevated cholesterol. Frontiers in Endocrinology, 12 789957. doi: 10.3389/fendo.2021.789957
2021
Journal Article
Methods to measure calcitonin receptor activity, up-regulated in cell stress, apoptosis and autophagy
Wookey, Peter, Gupta, Pragya, Bittencourt, Lucas, Cheung, Shane, Hare, David and Furness, Sebastian (2021). Methods to measure calcitonin receptor activity, up-regulated in cell stress, apoptosis and autophagy. F1000Research, 10 1019, 1-6. doi: 10.12688/f1000research.72845.1
2021
Journal Article
Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity
Mobbs, Jesse I., Belousoff, Matthew J., Harikumar, Kaleeckal G., Piper, Sarah J., Xu, Xiaomeng, Furness, Sebastian G. B., Venugopal, Hari, Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Thal, David M., Miller, Laurence J. and Sexton, Patrick M. (2021). Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity. PLOS Biology, 19 (6) e3001295, e3001295. doi: 10.1371/journal.pbio.3001295
2021
Journal Article
AM833 is a novel agonist of calcitonin family G protein–coupled receptors: pharmacological comparison with six selective and nonselective agonists
Fletcher, Madeleine M., Keov, Peter, Truong, Tin T., Mennen, Grace, Hick, Caroline A., Zhao, Peishen, Furness, Sebastian G.B., Kruse, Thomas, Clausen, Trine R., Wootten, Denise and Sexton, Patrick M. (2021). AM833 is a novel agonist of calcitonin family G protein–coupled receptors: pharmacological comparison with six selective and nonselective agonists. Journal of Pharmacology and Experimental Therapeutics, 377 (3), 417-440. doi: 10.1124/jpet.121.000567
2021
Journal Article
Dopamine and ghrelin receptor co-expression and interaction in the spinal defecation centers
Furness, John B., Pustovit, Ruslan V., Syder, Andrew J., Ringuet, Mitchell T., Yoo, Eun Ji, Fanjul, Andrea, Wykosky, Jill, Fothergill, Linda J., Whitfield, Emily A. and Furness, Sebastian G. B. (2021). Dopamine and ghrelin receptor co-expression and interaction in the spinal defecation centers. Neurogastroenterology and Motility, 33 (5) e14051. doi: 10.1111/nmo.14051
2020
Journal Article
Design, synthesis and characterization of a fluorescently labeled functional analog of full-length human ghrelin
Liu, Mengjie, Whitfield, Emily A., Fothergill, Linda J., Furness, John B., Wade, John D., Furness, Sebastian G.B. and Hossain, Mohammed Akhter (2020). Design, synthesis and characterization of a fluorescently labeled functional analog of full-length human ghrelin. Biochemical and Biophysical Research Communications, 533 (3), 559-564. doi: 10.1016/j.bbrc.2020.09.028
2020
Journal Article
Differential GLP-1R binding and activation by peptide and non-peptide agonists
Zhang, Xin, Belousoff, Matthew J., Zhao, Peishen, Kooistra, Albert J., Truong, Tin T., Ang, Sheng Yu, Underwood, Christina Rye, Egebjerg, Thomas, Šenel, Petr, Stewart, Gregory D., Liang, Yi-Lynn, Glukhova, Alisa, Venugopal, Hari, Christopoulos, Arthur, Furness, Sebastian G.B., Miller, Laurence J., Reedtz-Runge, Steffen, Langmead, Christopher J., Gloriam, David E., Danev, Radostin, Sexton, Patrick M. and Wootten, Denise (2020). Differential GLP-1R binding and activation by peptide and non-peptide agonists. Molecular Cell, 80 (3), 485-500.e7. doi: 10.1016/j.molcel.2020.09.020
2020
Journal Article
Structure and dynamics of the active Gs-coupled human secretin receptor
Dong, Maoqing, Deganutti, Giuseppe, Piper, Sarah J., Liang, Yi-Lynn, Khoshouei, Maryam, Belousoff, Matthew J., Harikumar, Kaleeckal G., Reynolds, Christopher A., Glukhova, Alisa, Furness, Sebastian G. B., Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Sexton, Patrick M. and Miller, Laurence J. (2020). Structure and dynamics of the active Gs-coupled human secretin receptor. Nature Communications, 11 (1) 4137, 4137. doi: 10.1038/s41467-020-17791-4
2020
Journal Article
Structure and dynamics of adrenomedullin receptors AM1 and AM2 reveal key mechanisms in the control of receptor phenotype by receptor activity-modifying proteins
Liang, Yi-Lynn, Belousoff, Matthew J., Fletcher, Madeleine M., Zhang, Xin, Khoshouei, Maryam, Deganutti, Giuseppe, Koole, Cassandra, Furness, Sebastian G. B., Miller, Laurence J., Hay, Debbie L., Christopoulos, Arthur, Reynolds, Christopher A., Danev, Radostin, Wootten, Denise and Sexton, Patrick M. (2020). Structure and dynamics of adrenomedullin receptors AM1 and AM2 reveal key mechanisms in the control of receptor phenotype by receptor activity-modifying proteins. ACS Pharmacology and Translational Science, 3 (2), 263-284. doi: 10.1021/acsptsci.9b00080
2020
Journal Article
Activation of the GLP-1 receptor by a non-peptidic agonist
Zhao, Peishen, Liang, Yi-Lynn, Belousoff, Matthew J., Deganutti, Giuseppe, Fletcher, Madeleine M., Willard, Francis S., Bell, Michael G., Christe, Michael E., Sloop, Kyle W., Inoue, Asuka, Truong, Tin T., Clydesdale, Lachlan, Furness, Sebastian G. B., Christopoulos, Arthur, Wang, Ming-Wei, Miller, Laurence J., Reynolds, Christopher A., Danev, Radostin, Sexton, Patrick M. and Wootten, Denise (2020). Activation of the GLP-1 receptor by a non-peptidic agonist. Nature, 577 (7790), 432-436. doi: 10.1038/s41586-019-1902-z
2020
Journal Article
Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma
Gupta, Pragya, Furness, Sebastian G. B., Bittencourt, Lucas, Hare, David L. and Wookey, Peter J. (2020). Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma. Therapeutic Advances in Medical Oncology, 12, 175883592097811. doi: 10.1177/1758835920978110
2019
Journal Article
The nature of efficacy at G protein-coupled receptors
Zhao, Peishen and Furness, Sebastian G.B. (2019). The nature of efficacy at G protein-coupled receptors. Biochemical Pharmacology, 170 113647, 1-13. doi: 10.1016/j.bcp.2019.113647
2019
Journal Article
TrkB agonist LM22A-4 increases oligodendroglial populations during myelin repair in the corpus callosum
Nguyen, Huynh T. H., Wood, Rhiannon J., Prawdiuk, Alexa R., Furness, Sebastian G. B., Xiao, Junhua, Murray, Simon S. and Fletcher, Jessica L. (2019). TrkB agonist LM22A-4 increases oligodendroglial populations during myelin repair in the corpus callosum. Frontiers in Molecular Neuroscience, 12 205, 1-12. doi: 10.3389/fnmol.2019.00205
2019
Journal Article
Conformational transitions and the activation of heterotrimeric G proteins by G protein-coupled receptors
Draper-Joyce, Christopher and Furness, Sebastian George Barton (2019). Conformational transitions and the activation of heterotrimeric G proteins by G protein-coupled receptors. ACS Pharmacology and Translational Science, 2 (4), 285-290. doi: 10.1021/acsptsci.9b00054
Supervision
Availability
- Dr Sebastian Furness is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Understanding the molecular basis for cholesterol dependent modulation of G protein-coupled receptor signalling
Principal Advisor
Other advisors: Dr Farhad Dehkhoda
-
Doctor Philosophy
Ghrelin receptor modulation of GPCR signalling
Principal Advisor
Other advisors: Dr Farhad Dehkhoda
-
Doctor Philosophy
The Conformational Basis of MC4R Function and Regulation
Principal Advisor
Other advisors: Dr Farhad Dehkhoda
Media
Enquiries
Contact Dr Sebastian Furness directly for media enquiries about:
- Anti-obesity medications
- Diabetes
- Discovery Research
- Obesity
- Science Funding
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