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Dr Sebastian Furness
Dr

Sebastian Furness

Email: 

Overview

Background

Sebastian is an expert on molecular pharmacology of G protein-coupled receptors (GPCRs - the largest class of cell surface recpetors and major drug targets). His lab has a particular interest in those involved in communication between the gastrointestinal tract and brain (the so-called gut-brain axis). Current foccusses include ghrelin, melanocortin 4, dopamine D2, and cholecystokinin receptors and the lab has also worked on the calcitonin, glucagon-like peptide 1 and other receptors. His lab is interested in answering complelling biological questions relating to physiology and pathophysiology of the gut-brain axis all the way down to the level of the receptor.

Sebastian is from Adelaide and received his BSc(Hons) and PhD. from the University of Adelaide, where he worked on the Aryl Hydrocarbon receptor in the lab of Murray Whitelaw. He then did postdoctoral research on haematopoitic stem cell differentiation in Kelly McNagny’s lab at the Biomedical Research Centre at the University of British Columbia before joining Patrick Sexton to work on G protein-coupled receptors at Monash University .

Sebastian is now an ARC Future Fellow with his own research program in the School of Biomedical Sciences at the University of Queensland. He remains an adjunct member of MIPS DDB as well as CCeMMP.

Sebastian has honours and PhD positions for motivated students who have a strong desire to assume ownership of a project and work independently.

Availability

Dr Sebastian Furness is:
Available for supervision
Media expert

Qualifications

  • Doctor of Philosophy, University of Adelaide

Research impacts

Sebastian is active in advocacy for improvements to STEM policy across education, science literacy and research funding, having worked for a number of years with an advisory group to his local federal MP, participated in Pint of Science and writing for The Conversation. He has been involved in commercialisation of some of his work into a startup biotech company (Apop biosciences). His main research focus has been instrumental in shifting the paradigm of how signalling works at G protein-coupled receptors (please see an explainer here), is cited in over 40 patents and has been influential in enabling structural biology approaches to understand the mechanism for activation of G protein-coupled receptors.

Works

Search Professor Sebastian Furness’s works on UQ eSpace

59 works between 2006 and 2024

1 - 20 of 59 works

2024

Journal Article

Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling

Harikumar, Kaleeckal G., Zhao, Peishen, Cary, Brian P., Xu, Xiaomeng, Desai, Aditya J., Dong, Maoqing, Mobbs, Jesse I., Toufaily, Chirine, Furness, Sebastian G.B., Christopoulos, Arthur, Belousoff, Matthew J., Wootten, Denise, Sexton, Patrick M. and Miller, Laurence J. (2024). Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling. PLoS Biology, 22 (7 July) e3002673, e3002673. doi: 10.1371/journal.pbio.3002673

Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling

2024

Journal Article

Role of G protein‐coupled receptor kinases (<scp>GRKs</scp>) in β<sub>2</sub>‐adrenoceptor‐mediated glucose uptake

Ham, Seungmin, Mukaida, Saori, Sato, Masaaki, Keov, Peter, Bengtsson, Tore, Furness, Sebastian, Holliday, Nicholas D., Evans, Bronwyn A., Summers, Roger J. and Hutchinson, Dana S. (2024). Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake. Pharmacology Research & Perspectives, 12 (1) e1176, e1176. doi: 10.1002/prp2.1176

Role of G protein‐coupled receptor kinases (<scp>GRKs</scp>) in β<sub>2</sub>‐adrenoceptor‐mediated glucose uptake

2024

Journal Article

Cardiac human bitter taste receptors contain naturally occurring variants that alter function

Bloxham, Conor J., Hulme, Katina D., Fierro, Fabrizio, Fercher, Christian, Pegg, Cassandra L., O'Brien, Shannon L., Foster, Simon R., Short, Kirsty R., Furness, Sebastian G. B., Reichelt, Melissa E., Niv, Masha Y. and Thomas, Walter G. (2024). Cardiac human bitter taste receptors contain naturally occurring variants that alter function. Biochemical Pharmacology, 219 115932, 115932. doi: 10.1016/j.bcp.2023.115932

Cardiac human bitter taste receptors contain naturally occurring variants that alter function

2023

Journal Article

Sites and mechanisms of action of colokinetics at dopamine, ghrelin and serotonin receptors in the rodent lumbosacral defecation centre

Ringuet, Mitchell T., Koo, Ada, Furness, Sebastian G. B., McDougall, Stuart J. and Furness, John B. (2023). Sites and mechanisms of action of colokinetics at dopamine, ghrelin and serotonin receptors in the rodent lumbosacral defecation centre. The Journal of Physiology, 601 (23), 5195-5211. doi: 10.1113/jp285217

Sites and mechanisms of action of colokinetics at dopamine, ghrelin and serotonin receptors in the rodent lumbosacral defecation centre

2022

Journal Article

G protein‐coupled receptor interactions and modification of signalling involving the ghrelin receptor, GHSR1a

Ringuet, Mitchell Ty, Furness, John Barton and Furness, Sebastian George Barton (2022). G protein‐coupled receptor interactions and modification of signalling involving the ghrelin receptor, GHSR1a. Journal of Neuroendocrinology, 34 (9) e13077, 1-14. doi: 10.1111/jne.13077

G protein‐coupled receptor interactions and modification of signalling involving the ghrelin receptor, GHSR1a

2022

Journal Article

Targeting appetite and satiety in diabetes and obesity, via G protein-coupled receptors

Piper, Noah B.C., Whitfield, Emily A., Stewart, Gregory D., Xu, Xiaomeng and Furness, Sebastian G.B. (2022). Targeting appetite and satiety in diabetes and obesity, via G protein-coupled receptors. Biochemical Pharmacology, 202 115115, 1-21. doi: 10.1016/j.bcp.2022.115115

Targeting appetite and satiety in diabetes and obesity, via G protein-coupled receptors

2021

Journal Article

Discovery of a positive allosteric modulator of cholecystokinin action at CCK1R in normal and elevated cholesterol

Harikumar, Kaleeckal G., Coudrat, Thomas, Desai, Aditya J., Dong, Maoqing, Dengler, Daniela G., Furness, Sebastian G. B., Christopoulos, Arthur, Wootten, Denise, Sergienko, Eduard A., Sexton, Patrick M. and Miller, Laurence J. (2021). Discovery of a positive allosteric modulator of cholecystokinin action at CCK1R in normal and elevated cholesterol. Frontiers in Endocrinology, 12 789957. doi: 10.3389/fendo.2021.789957

Discovery of a positive allosteric modulator of cholecystokinin action at CCK1R in normal and elevated cholesterol

2021

Journal Article

Methods to measure calcitonin receptor activity, up-regulated in cell stress, apoptosis and autophagy

Wookey, Peter, Gupta, Pragya, Bittencourt, Lucas, Cheung, Shane, Hare, David and Furness, Sebastian (2021). Methods to measure calcitonin receptor activity, up-regulated in cell stress, apoptosis and autophagy. F1000Research, 10 1019, 1-6. doi: 10.12688/f1000research.72845.1

Methods to measure calcitonin receptor activity, up-regulated in cell stress, apoptosis and autophagy

2021

Journal Article

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

Mobbs, Jesse I., Belousoff, Matthew J., Harikumar, Kaleeckal G., Piper, Sarah J., Xu, Xiaomeng, Furness, Sebastian G. B., Venugopal, Hari, Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Thal, David M., Miller, Laurence J. and Sexton, Patrick M. (2021). Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity. PLOS Biology, 19 (6) e3001295, e3001295. doi: 10.1371/journal.pbio.3001295

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

2021

Journal Article

AM833 is a novel agonist of calcitonin family G protein–coupled receptors: pharmacological comparison with six selective and nonselective agonists

Fletcher, Madeleine M., Keov, Peter, Truong, Tin T., Mennen, Grace, Hick, Caroline A., Zhao, Peishen, Furness, Sebastian G.B., Kruse, Thomas, Clausen, Trine R., Wootten, Denise and Sexton, Patrick M. (2021). AM833 is a novel agonist of calcitonin family G protein–coupled receptors: pharmacological comparison with six selective and nonselective agonists. Journal of Pharmacology and Experimental Therapeutics, 377 (3), 417-440. doi: 10.1124/jpet.121.000567

AM833 is a novel agonist of calcitonin family G protein–coupled receptors: pharmacological comparison with six selective and nonselective agonists

2021

Journal Article

Dopamine and ghrelin receptor co-expression and interaction in the spinal defecation centers

Furness, John B., Pustovit, Ruslan V., Syder, Andrew J., Ringuet, Mitchell T., Yoo, Eun Ji, Fanjul, Andrea, Wykosky, Jill, Fothergill, Linda J., Whitfield, Emily A. and Furness, Sebastian G. B. (2021). Dopamine and ghrelin receptor co-expression and interaction in the spinal defecation centers. Neurogastroenterology and Motility, 33 (5) e14051. doi: 10.1111/nmo.14051

Dopamine and ghrelin receptor co-expression and interaction in the spinal defecation centers

2020

Journal Article

Design, synthesis and characterization of a fluorescently labeled functional analog of full-length human ghrelin

Liu, Mengjie, Whitfield, Emily A., Fothergill, Linda J., Furness, John B., Wade, John D., Furness, Sebastian G.B. and Hossain, Mohammed Akhter (2020). Design, synthesis and characterization of a fluorescently labeled functional analog of full-length human ghrelin. Biochemical and Biophysical Research Communications, 533 (3), 559-564. doi: 10.1016/j.bbrc.2020.09.028

Design, synthesis and characterization of a fluorescently labeled functional analog of full-length human ghrelin

2020

Journal Article

Differential GLP-1R binding and activation by peptide and non-peptide agonists

Zhang, Xin, Belousoff, Matthew J., Zhao, Peishen, Kooistra, Albert J., Truong, Tin T., Ang, Sheng Yu, Underwood, Christina Rye, Egebjerg, Thomas, Šenel, Petr, Stewart, Gregory D., Liang, Yi-Lynn, Glukhova, Alisa, Venugopal, Hari, Christopoulos, Arthur, Furness, Sebastian G.B., Miller, Laurence J., Reedtz-Runge, Steffen, Langmead, Christopher J., Gloriam, David E., Danev, Radostin, Sexton, Patrick M. and Wootten, Denise (2020). Differential GLP-1R binding and activation by peptide and non-peptide agonists. Molecular Cell, 80 (3), 485-500.e7. doi: 10.1016/j.molcel.2020.09.020

Differential GLP-1R binding and activation by peptide and non-peptide agonists

2020

Journal Article

Structure and dynamics of the active Gs-coupled human secretin receptor

Dong, Maoqing, Deganutti, Giuseppe, Piper, Sarah J., Liang, Yi-Lynn, Khoshouei, Maryam, Belousoff, Matthew J., Harikumar, Kaleeckal G., Reynolds, Christopher A., Glukhova, Alisa, Furness, Sebastian G. B., Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Sexton, Patrick M. and Miller, Laurence J. (2020). Structure and dynamics of the active Gs-coupled human secretin receptor. Nature Communications, 11 (1) 4137, 4137. doi: 10.1038/s41467-020-17791-4

Structure and dynamics of the active Gs-coupled human secretin receptor

2020

Journal Article

Structure and dynamics of adrenomedullin receptors AM1 and AM2 reveal key mechanisms in the control of receptor phenotype by receptor activity-modifying proteins

Liang, Yi-Lynn, Belousoff, Matthew J., Fletcher, Madeleine M., Zhang, Xin, Khoshouei, Maryam, Deganutti, Giuseppe, Koole, Cassandra, Furness, Sebastian G. B., Miller, Laurence J., Hay, Debbie L., Christopoulos, Arthur, Reynolds, Christopher A., Danev, Radostin, Wootten, Denise and Sexton, Patrick M. (2020). Structure and dynamics of adrenomedullin receptors AM1 and AM2 reveal key mechanisms in the control of receptor phenotype by receptor activity-modifying proteins. ACS Pharmacology and Translational Science, 3 (2), 263-284. doi: 10.1021/acsptsci.9b00080

Structure and dynamics of adrenomedullin receptors AM1 and AM2 reveal key mechanisms in the control of receptor phenotype by receptor activity-modifying proteins

2020

Journal Article

Activation of the GLP-1 receptor by a non-peptidic agonist

Zhao, Peishen, Liang, Yi-Lynn, Belousoff, Matthew J., Deganutti, Giuseppe, Fletcher, Madeleine M., Willard, Francis S., Bell, Michael G., Christe, Michael E., Sloop, Kyle W., Inoue, Asuka, Truong, Tin T., Clydesdale, Lachlan, Furness, Sebastian G. B., Christopoulos, Arthur, Wang, Ming-Wei, Miller, Laurence J., Reynolds, Christopher A., Danev, Radostin, Sexton, Patrick M. and Wootten, Denise (2020). Activation of the GLP-1 receptor by a non-peptidic agonist. Nature, 577 (7790), 432-436. doi: 10.1038/s41586-019-1902-z

Activation of the GLP-1 receptor by a non-peptidic agonist

2020

Journal Article

Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma

Gupta, Pragya, Furness, Sebastian G. B., Bittencourt, Lucas, Hare, David L. and Wookey, Peter J. (2020). Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma. Therapeutic Advances in Medical Oncology, 12, 175883592097811. doi: 10.1177/1758835920978110

Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma

2019

Journal Article

The nature of efficacy at G protein-coupled receptors

Zhao, Peishen and Furness, Sebastian G.B. (2019). The nature of efficacy at G protein-coupled receptors. Biochemical Pharmacology, 170 113647, 1-13. doi: 10.1016/j.bcp.2019.113647

The nature of efficacy at G protein-coupled receptors

2019

Journal Article

TrkB agonist LM22A-4 increases oligodendroglial populations during myelin repair in the corpus callosum

Nguyen, Huynh T. H., Wood, Rhiannon J., Prawdiuk, Alexa R., Furness, Sebastian G. B., Xiao, Junhua, Murray, Simon S. and Fletcher, Jessica L. (2019). TrkB agonist LM22A-4 increases oligodendroglial populations during myelin repair in the corpus callosum. Frontiers in Molecular Neuroscience, 12 205, 1-12. doi: 10.3389/fnmol.2019.00205

TrkB agonist LM22A-4 increases oligodendroglial populations during myelin repair in the corpus callosum

2019

Journal Article

Conformational transitions and the activation of heterotrimeric G proteins by G protein-coupled receptors

Draper-Joyce, Christopher and Furness, Sebastian George Barton (2019). Conformational transitions and the activation of heterotrimeric G proteins by G protein-coupled receptors. ACS Pharmacology and Translational Science, 2 (4), 285-290. doi: 10.1021/acsptsci.9b00054

Conformational transitions and the activation of heterotrimeric G proteins by G protein-coupled receptors

Funding

Current funding

  • 2023 - 2026
    Beyond structure - solving conformational dynamics for intractable proteins
    ARC Discovery Projects
    Open grant
  • 2022 - 2024
    A new frontier in receptor biology relevant to treatment of disease
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2021 - 2023
    The molecular basis for efficacy at G protein coupled receptors (GPCRs)
    ARC Future Fellowships
    Open grant

Supervision

Availability

Dr Sebastian Furness is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Understanding the molecular basis for cholesterol dependent modulation of G protein-coupled receptor signalling

    Principal Advisor

    Other advisors: Dr Farhad Dehkhoda

  • Doctor Philosophy

    Ghrelin receptor modulation of GPCR signalling

    Principal Advisor

    Other advisors: Dr Farhad Dehkhoda

  • Doctor Philosophy

    The Conformational Basis of MC4R Function and Regulation

    Principal Advisor

    Other advisors: Dr Farhad Dehkhoda

Media

Enquiries

Contact Dr Sebastian Furness directly for media enquiries about:

  • Anti-obesity medications
  • Diabetes
  • Discovery Research
  • Obesity
  • Science Funding

Need help?

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communications@uq.edu.au