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Associate Professor Sebastian Furness
Associate Professor

Sebastian Furness

Email: 

Overview

Background

Sebastian is an expert on molecular pharmacology of G protein-coupled receptors (GPCRs - the largest class of cell surface recpetors and major drug targets). His lab has a particular interest in those involved in communication between the gastrointestinal tract and brain (the so-called gut-brain axis). Current foccusses include ghrelin, melanocortin 4, dopamine D2, and cholecystokinin receptors and the lab has also worked on the calcitonin, glucagon-like peptide 1 and other receptors. His lab is interested in answering complelling biological questions relating to physiology and pathophysiology of the gut-brain axis all the way down to the level of the receptor.

Sebastian is from Adelaide and received his BSc(Hons) and PhD. from the University of Adelaide, where he worked on the Aryl Hydrocarbon receptor in the lab of Murray Whitelaw. He then did postdoctoral research on haematopoitic stem cell differentiation in Kelly McNagny’s lab at the Biomedical Research Centre at the University of British Columbia before joining Patrick Sexton to work on G protein-coupled receptors at Monash University .

Sebastian is now an ARC Future Fellow with his own research program in the School of Biomedical Sciences at the University of Queensland. He remains an adjunct member of MIPS DDB as well as CCeMMP.

Sebastian has honours and PhD positions for motivated students who have a strong desire to assume ownership of a project and work independently.

Availability

Associate Professor Sebastian Furness is:
Available for supervision
Media expert

Qualifications

  • Doctor of Philosophy, University of Adelaide

Research impacts

Sebastian is active in advocacy for improvements to STEM policy across education, science literacy and research funding, having worked for a number of years with an advisory group to his local federal MP, participated in Pint of Science and writing for The Conversation. He has been involved in commercialisation of some of his work into a startup biotech company (Apop biosciences). His main research focus has been instrumental in shifting the paradigm of how signalling works at G protein-coupled receptors (please see an explainer here), is cited in over 40 patents and has been influential in enabling structural biology approaches to understand the mechanism for activation of G protein-coupled receptors.

Works

Search Professor Sebastian Furness’s works on UQ eSpace

64 works between 2006 and 2025

61 - 64 of 64 works

2007

Journal Article

The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors

Furness, Sebastian G.B., Lees, Michael J. and Whitelaw, Murray L. (2007). The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors. FEBS Letters, 581 (19), 3616-3625. doi: 10.1016/j.febslet.2007.04.011

The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors

2007

Journal Article

Identification of N,N epsilon-dimethyl-lysine in the murine dioxin receptor using MALDI-TOF/TOF- and ESI-LTQ-Orbitrap-FT-MS

Dave, KA, Hamilton, BR, Wallis, TP, Furness, SGB, Whitelaw, ML and Gorman, JJ (2007). Identification of N,N epsilon-dimethyl-lysine in the murine dioxin receptor using MALDI-TOF/TOF- and ESI-LTQ-Orbitrap-FT-MS. International Journal of Mass Spectrometry, 268 (2-3), 168-180. doi: 10.1016/j.ijms.2007.06.001

Identification of N,N epsilon-dimethyl-lysine in the murine dioxin receptor using MALDI-TOF/TOF- and ESI-LTQ-Orbitrap-FT-MS

2006

Journal Article

Na+/H+ exchanger regulatory factor-1 is a hematopoietic ligand for a subset of the CD34 family of stem cell surface proteins

Tan, Poh C., Furness, Sebastian G.B., Merkens, Helen, Lin, Shujun, McCoy, Marcia L., Roskelley, Calvin D., Kast, Jürgen and McNagny, Kelly M. (2006). Na+/H+ exchanger regulatory factor-1 is a hematopoietic ligand for a subset of the CD34 family of stem cell surface proteins. Stem Cells, 24 (5), 1150-1161. doi: 10.1634/stemcells.2005-0426

Na+/H+ exchanger regulatory factor-1 is a hematopoietic ligand for a subset of the CD34 family of stem cell surface proteins

2006

Journal Article

Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis

Furness, Sebastian George Barton and McNagny, Kelly (2006). Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis. Immunologic Research, 34 (1), 13-32. doi: 10.1385/ir:34:1:13

Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis

Funding

Current funding

  • 2025 - 2028
    Solving a major complication of Parkinson's Disease: targeting debilitating constipation through novel pharmacology
    United States Congressionally Directed Medical Research Programs - Parkinson's Research Program
    Open grant
  • 2023 - 2026
    Beyond structure - solving conformational dynamics for intractable proteins
    ARC Discovery Projects
    Open grant
  • 2022 - 2025
    A new frontier in receptor biology relevant to treatment of disease
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2021 - 2023
    The molecular basis for efficacy at G protein coupled receptors (GPCRs)
    ARC Future Fellowships
    Open grant

Supervision

Availability

Associate Professor Sebastian Furness is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Understanding the molecular basis for cholesterol dependent modulation of G protein-coupled receptor signalling

    Principal Advisor

    Other advisors: Dr Farhad Dehkhoda

  • Doctor Philosophy

    Ghrelin receptor modulation of GPCR signalling

    Principal Advisor

    Other advisors: Dr Farhad Dehkhoda

  • Doctor Philosophy

    The Conformational Basis of MC4 Receptor Function and Regulation

    Principal Advisor

    Other advisors: Dr Farhad Dehkhoda

  • Doctor Philosophy

    Understanding the molecular basis for cholesterol-dependent modulation of G protein-coupled receptor (GPCR) signaling

    Principal Advisor

    Other advisors: Dr Farhad Dehkhoda

  • Doctor Philosophy

    The Conformational Basis of MC4 Receptor Function and Regulation

    Principal Advisor

    Other advisors: Dr Farhad Dehkhoda

  • Doctor Philosophy

    Understanding the molecular basis for cholesterol dependent modulation of G protein-coupled receptor signalling

    Principal Advisor

    Other advisors: Dr Farhad Dehkhoda

  • Doctor Philosophy

    Understanding the molecular basis for cholesterol dependent modulation of G protein-coupled receptor signalling

    Principal Advisor

    Other advisors: Dr Farhad Dehkhoda

  • Doctor Philosophy

    New approaches to measuring single-molecule protein dynamics

    Principal Advisor

    Other advisors: Dr Farhad Dehkhoda

Completed supervision

Media

Enquiries

Contact Associate Professor Sebastian Furness directly for media enquiries about:

  • Anti-obesity medications
  • Diabetes
  • Discovery Research
  • Obesity
  • Science Funding

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