
Overview
Background
Sebastian is an expert on molecular pharmacology of G protein-coupled receptors (GPCRs - the largest class of cell surface recpetors and major drug targets). His lab has a particular interest in those involved in communication between the gastrointestinal tract and brain (the so-called gut-brain axis). Current foccusses include ghrelin, melanocortin 4, dopamine D2, and cholecystokinin receptors and the lab has also worked on the calcitonin, glucagon-like peptide 1 and other receptors. His lab is interested in answering complelling biological questions relating to physiology and pathophysiology of the gut-brain axis all the way down to the level of the receptor.
Sebastian is from Adelaide and received his BSc(Hons) and PhD. from the University of Adelaide, where he worked on the Aryl Hydrocarbon receptor in the lab of Murray Whitelaw. He then did postdoctoral research on haematopoitic stem cell differentiation in Kelly McNagny’s lab at the Biomedical Research Centre at the University of British Columbia before joining Patrick Sexton to work on G protein-coupled receptors at Monash University .
Sebastian is now an ARC Future Fellow with his own research program in the School of Biomedical Sciences at the University of Queensland. He remains an adjunct member of MIPS DDB as well as CCeMMP.
Sebastian has honours and PhD positions for motivated students who have a strong desire to assume ownership of a project and work independently.
Availability
- Associate Professor Sebastian Furness is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, University of Adelaide
Research impacts
Sebastian is active in advocacy for improvements to STEM policy across education, science literacy and research funding, having worked for a number of years with an advisory group to his local federal MP, participated in Pint of Science and writing for The Conversation. He has been involved in commercialisation of some of his work into a startup biotech company (Apop biosciences). His main research focus has been instrumental in shifting the paradigm of how signalling works at G protein-coupled receptors (please see an explainer here), is cited in over 40 patents and has been influential in enabling structural biology approaches to understand the mechanism for activation of G protein-coupled receptors.
Works
Search Professor Sebastian Furness’s works on UQ eSpace
2007
Journal Article
The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors
Furness, Sebastian G.B., Lees, Michael J. and Whitelaw, Murray L. (2007). The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors. FEBS Letters, 581 (19), 3616-3625. doi: 10.1016/j.febslet.2007.04.011
2007
Journal Article
Identification of N,N epsilon-dimethyl-lysine in the murine dioxin receptor using MALDI-TOF/TOF- and ESI-LTQ-Orbitrap-FT-MS
Dave, KA, Hamilton, BR, Wallis, TP, Furness, SGB, Whitelaw, ML and Gorman, JJ (2007). Identification of N,N epsilon-dimethyl-lysine in the murine dioxin receptor using MALDI-TOF/TOF- and ESI-LTQ-Orbitrap-FT-MS. International Journal of Mass Spectrometry, 268 (2-3), 168-180. doi: 10.1016/j.ijms.2007.06.001
2006
Journal Article
Na+/H+ exchanger regulatory factor-1 is a hematopoietic ligand for a subset of the CD34 family of stem cell surface proteins
Tan, Poh C., Furness, Sebastian G.B., Merkens, Helen, Lin, Shujun, McCoy, Marcia L., Roskelley, Calvin D., Kast, Jürgen and McNagny, Kelly M. (2006). Na+/H+ exchanger regulatory factor-1 is a hematopoietic ligand for a subset of the CD34 family of stem cell surface proteins. Stem Cells, 24 (5), 1150-1161. doi: 10.1634/stemcells.2005-0426
2006
Journal Article
Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis
Furness, Sebastian George Barton and McNagny, Kelly (2006). Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis. Immunologic Research, 34 (1), 13-32. doi: 10.1385/ir:34:1:13
Supervision
Availability
- Associate Professor Sebastian Furness is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Understanding the molecular basis for cholesterol dependent modulation of G protein-coupled receptor signalling
Principal Advisor
Other advisors: Dr Farhad Dehkhoda
-
Doctor Philosophy
Ghrelin receptor modulation of GPCR signalling
Principal Advisor
Other advisors: Dr Farhad Dehkhoda
-
Doctor Philosophy
The Conformational Basis of MC4 Receptor Function and Regulation
Principal Advisor
Other advisors: Dr Farhad Dehkhoda
-
Doctor Philosophy
Understanding the molecular basis for cholesterol-dependent modulation of G protein-coupled receptor (GPCR) signaling
Principal Advisor
Other advisors: Dr Farhad Dehkhoda
-
Doctor Philosophy
The Conformational Basis of MC4 Receptor Function and Regulation
Principal Advisor
Other advisors: Dr Farhad Dehkhoda
-
Doctor Philosophy
Understanding the molecular basis for cholesterol dependent modulation of G protein-coupled receptor signalling
Principal Advisor
Other advisors: Dr Farhad Dehkhoda
-
Doctor Philosophy
Understanding the molecular basis for cholesterol dependent modulation of G protein-coupled receptor signalling
Principal Advisor
Other advisors: Dr Farhad Dehkhoda
-
Doctor Philosophy
New approaches to measuring single-molecule protein dynamics
Principal Advisor
Other advisors: Dr Farhad Dehkhoda
Completed supervision
-
2025
Doctor Philosophy
The Conformational Basis of MC4 Receptor Function and Regulation
Principal Advisor
Other advisors: Dr Farhad Dehkhoda
Media
Enquiries
Contact Associate Professor Sebastian Furness directly for media enquiries about:
- Anti-obesity medications
- Diabetes
- Discovery Research
- Obesity
- Science Funding
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