Overview
Background
Prof Holtmann is a Clinical Academic in the field of Gastroenterology & Hepatology and Director of Clinical Innovation. He is also Director of the Department of Gastroenterology & Hepatology at the Princess Alexandra Hospital in Queensland and serves on the Board of Directors of the West Moreton Hospital and Health Service and UQ Healthcare. He is a Fellow of Royal Australian Collge of Physicians (RACP, Sydney), the Royal College of Physicians (RCP, London) and Fellow of the Australian Academy of Health and Medical Sciences (AAHMS, Canberra). Besides his Medical Qualifications he also obtained a Master of Business Administration. After completing the clinical training in Medicine and Gastroenterology at the University of Essen in Germany and the Mayo Clinic in Rochester, Minnesota in the United States, he has gained substantial leadership and managerial experience within the health care setting as Director of large Gastroenterology Departments, CEO and General Manager of a University Hospital and Health Care Facilities and has served on the Board of the University Hospital Essen in Germany. His research is in the field of Neurogastroenterology has resulted in peer reviewed publications in key journal including the NEJM, Lancet, Gastroenterology and Gut. More recently his rersearch focus is on the role of the gut microbiome, mucosal and systemic inflammation and brain-gut interactions.
Availability
- Professor Gerald Holtmann is:
- Available for supervision
- Media expert
Works
Search Professor Gerald Holtmann’s works on UQ eSpace
2022
Conference Publication
Strain-level functional and phenotypic resolution of the duodenal mucosa-associated microbiota in functional dyspepsia and healthy control subjects via a novel ex vivo combination of microbe culture and metagenomic sequencing
Schooth, Lauren F., Ahmed, Ahmed Sid, Kang, Seungha, Shah, Ayesha, Fairlie, Thomas, Teh, Jing Jie, Lim, Yenkai, Hoedt, Emily C., Talley, Nicholas J., Keely, Simon, Holtmann, Gerald J. and Morrison, Mark (2022). Strain-level functional and phenotypic resolution of the duodenal mucosa-associated microbiota in functional dyspepsia and healthy control subjects via a novel ex vivo combination of microbe culture and metagenomic sequencing. American Gastroenterological Association Conference 2022, Chicago, IL United States, 6-9 May 2022. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(22)61208-3
2022
Conference Publication
Influence of proton pump inhibitors on the mucosa associated microbiome in the small intestine and colon
Shah, Ayesha, Sternes, Peter R., Pintos, Camila Ayala, Kang, Seungha, Jones, Michael P., Tyson, Gene, Morrison, Mark and Holtmann, Gerald J. (2022). Influence of proton pump inhibitors on the mucosa associated microbiome in the small intestine and colon. American Gastroenterological Association Conference 2022, Chicago, IL United States, 6-9 May 2022. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(22)62401-6
2022
Journal Article
Letter: non‐invasive transabdominal stimulation device for the treatment of chronic constipation—proof‐of‐principle study in adults
Talley, Nicholas J., Holtmann, Gerald J., Southwell, Bridget R., Fisher, David, Koloski, Natasha A. and Jones, Michael (2022). Letter: non‐invasive transabdominal stimulation device for the treatment of chronic constipation—proof‐of‐principle study in adults. Alimentary Pharmacology and Therapeutics, 55 (10), 1354-1356. doi: 10.1111/apt.16877
2022
Journal Article
Role of the duodenal microbiota in functional dyspepsia
Brown, Georgia, Hoedt, Emily C., Keely, Simon, Shah, Ayesha, Walker, Marjorie M., Holtmann, Gerald and Talley, Nicholas J. (2022). Role of the duodenal microbiota in functional dyspepsia. Neurogastroenterology and Motility, 34 (11) e14372, e14372. doi: 10.1111/nmo.14372
2022
Journal Article
Evaluation of a multidisciplinary integrated treatment approach versus standard model of care for Functional Gastrointestinal Disorders (FGIDS): a matched cohort study
Bray, Nicola A., Koloski, Natasha A., Jones, Michael P., Do, Anh, Pang, Siong, Coombes, Jeff S., McAllister, Sarah, Campos, Jane, Arthur, Leela, Stanley, Paul, DeMaria, Katherine, Chao, Che-yung, Catague, Rachel, Whaley, Amanda, Talley, Nicholas J. and Holtmann, Gerald J. (2022). Evaluation of a multidisciplinary integrated treatment approach versus standard model of care for Functional Gastrointestinal Disorders (FGIDS): a matched cohort study. Digestive Diseases and Sciences, 67 (12), 1-9. doi: 10.1007/s10620-022-07464-1
2022
Journal Article
Overlap of heartburn, functional dyspepsia, and irritable bowel syndrome in a population sample: prevalence, temporal stability, and associated comorbidities
Jones, Michael P., Shah, Ayesha, Walker, Marjorie M., Koloski, Natasha A., Holtmann, Gerald and Talley, Nicholas J. (2022). Overlap of heartburn, functional dyspepsia, and irritable bowel syndrome in a population sample: prevalence, temporal stability, and associated comorbidities. Neurogastroenterology and Motility, 34 (9) e14349, e14349. doi: 10.1111/nmo.14349
2022
Journal Article
Defects in NLRP6, autophagy and goblet cell homeostasis are associated with reduced duodenal CRH receptor 2 expression in patients with functional dyspepsia
Bruce, Jessica K., Burns, Grace L., Sinn Soh, Wai, Nair, Prema M., Sherwin, Simonne, Fan, KeNing, Dowling, Laura R., Goggins, Bridie J., Koloski, Natasha, Potter, Michael, Bollipo, Steven, Foster, Robert, Gan, Lay T., Veysey, Martin, Philpott, Dana J., Girardin, Stephen E., Holtmann, Gerald, Kaiko, Gerard E., Walker, Marjorie M., Talley, Nicholas J. and Keely, Simon (2022). Defects in NLRP6, autophagy and goblet cell homeostasis are associated with reduced duodenal CRH receptor 2 expression in patients with functional dyspepsia. Brain, Behavior, and Immunity, 101, 335-345. doi: 10.1016/j.bbi.2022.01.019
2022
Journal Article
Etrolizumab as induction and maintenance therapy for ulcerative colitis in patients previously treated with tumour necrosis factor inhibitors (HICKORY): a phase 3, randomised, controlled trial
Peyrin-Biroulet, Laurent, Hart, Ailsa, Bossuyt, Peter, Long, Millie, Allez, Matthieu, Juillerat, Pascal, Armuzzi, Alessandro, Loftus, Edward V, Ostad-Saffari, Elham, Scalori, Astrid, Oh, Young S, Tole, Swati, Chai, Akiko, Pulley, Jennifer, Lacey, Stuart, Sandborn, William J, Aguilar, Humberto, Ahmad, Tariq, Akriviadis, Evangelos, Aldeguer Mante, Xavier, Altorjay, Istvan, Ananthakrishnan, Ashwin, Andersen, Vibeke, Andreu Garcia, Montserrat, Aumais, Guy, Avni-Biron, Irit, Axler, Jeffrey, Ayub, Kamran, Baert, Filip ... Zeuzem, Stefan (2022). Etrolizumab as induction and maintenance therapy for ulcerative colitis in patients previously treated with tumour necrosis factor inhibitors (HICKORY): a phase 3, randomised, controlled trial. The Lancet Gastroenterology and Hepatology, 7 (2), 128-140. doi: 10.1016/S2468-1253(21)00298-3
2022
Journal Article
Updated S3 guideline on intestinal motility disorders: Definition, pathophysiology, diagnosis and treatment. Joint guideline of the German Society for Gastroenterology, Digestive and Metabolic Diseases (DGVS) and the German Society for Neurogastroenterology and Motility (DGNM). June 2021 - AWMF Register No.: 021-018 Update S3-Leitlinie Intestinale Motilitätsstörungen: Definition, Pathophysiologie, Diagnostik und Therapie. Gemeinsame Leitlinie der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie und Motilität (DGNM)
Keller, Jutta, Wedel, Thilo, Seidl, Holger, Kreis, Martin E., Van Der Voort, Ivo, Gebhard, Maximilian, Langhorst, Jost, Lynen Jansen, Petra, Schwandner, Oliver, Storr, Martin, Van Leeuwen, Pia, Andresen, Viola, Preiβ, Jan C., Layer, Peter, Allescher, H., Andus, T., Bischoff, S. C., Buderus, S., Claβen, M., Ehlert, U., Elsenbruch, S., Engel, M., Enninger, A., Fischbach, W., Freitag, M., Frieling, T., Gillessen, A., Goebel-Stengel, M., Gschossmann, J. ... Von Schönfeld, J. (2022). Updated S3 guideline on intestinal motility disorders: Definition, pathophysiology, diagnosis and treatment. Joint guideline of the German Society for Gastroenterology, Digestive and Metabolic Diseases (DGVS) and the German Society for Neurogastroenterology and Motility (DGNM). June 2021 - AWMF Register No.: 021-018 Update S3-Leitlinie Intestinale Motilitätsstörungen: Definition, Pathophysiologie, Diagnostik und Therapie. Gemeinsame Leitlinie der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie und Motilität (DGNM). Zeitschrift fur Gastroenterologie, 60 (2), 192-218. doi: 10.1055/a-1646-1279
2022
Journal Article
Duodenal eosinophils and mast cells in functional dyspepsia: a systematic review and meta-analysis of case-control studies
Shah, Ayesha, Fairlie, Thomas, Brown, Georgia, Jones, Michael P., Eslick, Guy D., Duncanson, Kerith, Thapar, Nikhil, Keely, Simon, Koloski, Natasha, Shahi, Mohit, Walker, Marjorie M., Talley, Nicholas J. and Holtmann, Gerald (2022). Duodenal eosinophils and mast cells in functional dyspepsia: a systematic review and meta-analysis of case-control studies. Clinical Gastroenterology and Hepatology, 20 (10), 2229-2242.e29. doi: 10.1016/j.cgh.2022.01.014
2022
Journal Article
Etrolizumab versus adalimumab or placebo as induction therapy for moderately to severely active ulcerative colitis (HIBISCUS): two phase 3 randomised, controlled trials
Rubin, David T, Dotan, Iris, DuVall, Aaron, Bouhnik, Yoram, Radford-Smith, Graham, Higgins, Peter D R, Mishkin, Daniel S, Arrisi, Pablo, Scalori, Astrid, Oh, Young S, Tole, Swati, Chai, Akiko, Chamberlain-James, Kirsten, Lacey, Stuart, McBride, Jacqueline, Panés, Julian, Abdulkhakov, Rustem, Abu Bakar, Norasiah, Aguilar, Humberto, Aizenberg, Diego, Akpinar, Hale, Akriviadis, Evangelos, Alexeeva, Olga, Alikhanov, Bagdadi, Alvarisqueta, Andres, Ananthakrishnan, Ashwin, Andrews, Jane, Arlukowicz, Tomasz, Atkinson, Nathan ... on behalf of the HIBISCUS Study Group (2022). Etrolizumab versus adalimumab or placebo as induction therapy for moderately to severely active ulcerative colitis (HIBISCUS): two phase 3 randomised, controlled trials. The Lancet Gastroenterology and Hepatology, 7 (1), 17-27. doi: 10.1016/S2468-1253(21)00338-1
2022
Journal Article
Small intestinal bacterial overgrowth in inflammatory bowel disease
Shah, Ayesha and Holtmann, Gerald (2022). Small intestinal bacterial overgrowth in inflammatory bowel disease. Indian Journal of Gastroenterology, 41 (1), 23-29. doi: 10.1007/s12664-021-01235-y
2021
Journal Article
The role of mood state and emotion regulation in the discrepancy between gastrointestinal symptom burden recorded prospectively and via recall questionnaire
Jones, Michael P., Yun, Grace, Wass, Fiona, Rixon, Hayley, Shah, Ayesha, Walker, Marjorie M., Koloski, Natasha A., Holtmann, Gerald, Talley, Nicholas J. and Beath, Alissa P. (2021). The role of mood state and emotion regulation in the discrepancy between gastrointestinal symptom burden recorded prospectively and via recall questionnaire. Neurogastroenterology and Motility, 34 (7) e14304, 1-8. doi: 10.1111/nmo.14304
2021
Journal Article
S3 guideline update on irritable bowel syndrome: Definition, pathophysiology, diagnosis and treatment. Joint guidelines of the German Society for Gastroenterology, Digestive and Metabolic Diseases (DGVS) and the German Society for Neurogastroenterology and Motility (DGNM). June 2021 - AWMF Register No.: 021/016 Update S3-leitlinie reizdarmsyndrom: Definition, pathophysiologie, diagnostik und therapie. Gemeinsame Leitlinie der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für neurogastroenterologie und Motilität (DGNM) Juni 2021 - AWMF-registriernummer: 021/016
Layer, Peter, Andresen, Viola, Allescher, H., Bischoff, S. C., Claßen, M., Elsenbruch, S., Freitag, M., Frieling, T., Gebhard, M., Goebel-Stengel, M., Häuser, W., Holtmann, G., Keller, J., Kreis, M. E., Kruis, W., Langhorst, J., Jansen, P. Lynen, Madisch, A., Mönnikes, H., Müller-Lissner, S., Niesler, B., Pehl, C., Pohl, D., Raithel, M., Röhrig-Herzog, G., Schemann, M., Schmiedel, S., Schwille-Kiuntke, J., Storr, M. ... Wedel, T. (2021). S3 guideline update on irritable bowel syndrome: Definition, pathophysiology, diagnosis and treatment. Joint guidelines of the German Society for Gastroenterology, Digestive and Metabolic Diseases (DGVS) and the German Society for Neurogastroenterology and Motility (DGNM). June 2021 - AWMF Register No.: 021/016 Update S3-leitlinie reizdarmsyndrom: Definition, pathophysiologie, diagnostik und therapie. Gemeinsame Leitlinie der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für neurogastroenterologie und Motilität (DGNM) Juni 2021 - AWMF-registriernummer: 021/016. Zeitschrift fur Gastroenterologie, 59 (12), 1323-1415. doi: 10.1055/a-1591-4794
2021
Journal Article
Electroencephalographic evidence of unconscious and conscious attentional bias in people with functional gastrointestinal disorders: A pilot study
Ejova, Anastasia, Badcock, Nicholas A., McKerchar, Sarah, Beath, Alissa P., Swift, Claire, Talley, Nicholas J., Holtmann, Gerald, Walker, Marjorie M. and Jones, Michael P. (2021). Electroencephalographic evidence of unconscious and conscious attentional bias in people with functional gastrointestinal disorders: A pilot study. International Journal of Psychophysiology, 170, 30-42. doi: 10.1016/j.ijpsycho.2021.09.006
2021
Journal Article
Clusters of community-dwelling individuals empirically derived from stool diaries correspond with clinically meaningful outcomes
Jones, Michael P., Walter, Susanna, Talley, Nicholas J., Walker, Marjorie M., Holtmann, Gerald J., Shah, Ayesha, D'Amato, Mauro, Agréus, Lars and Andreasson, Anna (2021). Clusters of community-dwelling individuals empirically derived from stool diaries correspond with clinically meaningful outcomes. European Journal of Gastroenterology and Hepatology, 33 (S1), e740-e745. doi: 10.1097/MEG.0000000000002236
2021
Journal Article
Autism-related dietary preferences mediate autism-gut microbiome associations
Yap, Chloe X., Henders, Anjali K., Alvares, Gail A., Wood, David L.A., Krause, Lutz, Tyson, Gene W., Restuadi, Restuadi, Wallace, Leanne, McLaren, Tiana, Hansell, Narelle K., Cleary, Dominique, Grove, Rachel, Hafekost, Claire, Harun, Alexis, Holdsworth, Helen, Jellett, Rachel, Khan, Feroza, Lawson, Lauren P., Leslie, Jodie, Frenk, Mira Levis, Masi, Anne, Mathew, Nisha E., Muniandy, Melanie, Nothard, Michaela, Miller, Jessica L., Nunn, Lorelle, Holtmann, Gerald, Strike, Lachlan T., de Zubicaray, Greig I. ... Gratten, Jacob (2021). Autism-related dietary preferences mediate autism-gut microbiome associations. Cell, 184 (24), 5916-5931.e17. doi: 10.1016/j.cell.2021.10.015
2021
Journal Article
Antibiotic use but not gastrointestinal infection frequently precedes first diagnosis of functional gastrointestinal disorders
Jones, Michael P., Shah, Ayesha, Walker, Marjorie M., Koloski, Natasha A., Holtmann, Gerald and Talley, Nicholas J. (2021). Antibiotic use but not gastrointestinal infection frequently precedes first diagnosis of functional gastrointestinal disorders. United European Gastroenterology Journal, 9 (9), 1074-1080. doi: 10.1002/ueg2.12164
2021
Journal Article
Physician perceptions on the use of antibiotics and probiotics in adults: an international survey in the Asia-Pacific area
Ghoshal, Uday C., Gwee, Kok-Ann, Holtmann, Gerald, Li, Yanmei, Park, Soo Jung, Simadibrata, Marcellus, Sugano, Kentaro, Cohen, Henry and Quigley, Eamonn M. M. (2021). Physician perceptions on the use of antibiotics and probiotics in adults: an international survey in the Asia-Pacific area. Frontiers in Cellular and Infection Microbiology, 11 722700, 722700. doi: 10.3389/fcimb.2021.722700
2021
Journal Article
Draft genome sequence of streptococcus salivarius AGIRA0003, isolated from functional gastrointestinal disorder duodenal tissue
Hoedt, Emily C., Shanahan, Erin R., Keely, Simon, Shah, Ayesha, Burns, Grace L., Holtmann, Gerald J., Talley, Nicholas J. and Morrison, Mark (2021). Draft genome sequence of streptococcus salivarius AGIRA0003, isolated from functional gastrointestinal disorder duodenal tissue. Microbiology Resource Announcements, 10 (39) e00758, e0075821. doi: 10.1128/MRA.00758-21
Funding
Current funding
Past funding
Supervision
Availability
- Professor Gerald Holtmann is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Effects the COVID-19 pandemic on the outcome and management of highly prevalent gastrointestinal conditions
Principal Advisor
Other advisors: Dr Ayesha Shah
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Doctor Philosophy
Effects the COVID-19 pandemic on the outcome and management of highly prevalent gastrointestinal conditions
Principal Advisor
Other advisors: Dr Ayesha Shah
-
Doctor Philosophy
Reimagining Health Equity and Access in Colorectal Cancer Screening. A population perspective.
Principal Advisor
Other advisors: Dr Ayesha Shah
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Doctor Philosophy
Equitability and Accessibility of Faecal Occult Blood Test Based Colorectal Cancer Screening for Disadvantaged Communities.
Principal Advisor
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Doctor Philosophy
Reimagining Health Equity and Access in Colorectal Cancer Screening. A population perspective
Principal Advisor
Other advisors: Dr Ayesha Shah
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Doctor Philosophy
IBD and mental health tools: a holistic approach to discovery and appropriate tool.
Principal Advisor
Other advisors: Dr Ayesha Shah
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Doctor Philosophy
Exercise training on people with severe chronic, clinically unexplained gastrointestinal symptoms: A randomised, controlled trial.
Associate Advisor
Other advisors: Professor Jeff Coombes
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Doctor Philosophy
The role of the gut microbiome in alcohol related liver disease
Associate Advisor
Other advisors: Professor Jason Connor, Dr Paul Clark
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Doctor Philosophy
Study of TOfacitinib for the treatment of chronic Pouchitis
Associate Advisor
Other advisors: Associate Professor Jakob Begun
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Doctor Philosophy
Study of TOfacitinib for the treatment of chronic Pouchitis
Associate Advisor
Other advisors: Associate Professor Jakob Begun
Completed supervision
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2020
Doctor Philosophy
Characterization of the Human Duodenal Microbiome in Health and Disease
Principal Advisor
Other advisors: Associate Professor Graeme Macdonald
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2019
Doctor Philosophy
Mechanisms of action of the duodenal-jejunal bypass sleeve
Principal Advisor
Other advisors: Associate Professor Graeme Macdonald
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2023
Doctor Philosophy
Structure-function relationships of the mucosa-associated microbiota in Crohn's disease
Associate Advisor
Other advisors: Associate Professor Jakob Begun, Professor Mark Morrison
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2022
Doctor Philosophy
Genomic- and culture-enabled analyses of host-associated methanogenic archaea
Associate Advisor
Other advisors: Professor Mark Morrison
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2022
Doctor Philosophy
Multi-omics data offer systemic insights into autism
Associate Advisor
Other advisors: Professor Naomi Wray, Honorary Professor Jake Gratten
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Doctor Philosophy
The role of small intestinal permeability and gut microbiota in chronic liver disease
Associate Advisor
Other advisors: Associate Professor Graeme Macdonald
Media
Enquiries
Contact Professor Gerald Holtmann directly for media enquiries about:
- colon cancer screening
- Gastroenterology
- Gut Health
- Microbiome
- Neurogastroenterology
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