
Overview
Background
The research interests of the Hume Laboratory centre on the biology of macrophages and osteoclasts. These are cells of haematopoietic origin that are closely related to each other but have distinctly different activities.
David Hume was a group leader at the Institute for Molecular Bioscience (1988-2007) and subsequently Director of the Roslin Institute at the University of Edinburgh in Scotland from 2007-2017. He is currently a Professorial Research Fellow at the Mater Research Institute-UQ, located at the Translational Research Institute
Availability
- Professor David Hume is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), Australian National University
- Doctor of Philosophy, Australian National University
Research interests
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Macrophages Biology
Professor David Hume is a Professorial Research Fellow at the Mater Research Institute-UQ located at the Translational Research Institute. He was previously Director of The Roslin Institute at the University of Edinburgh (2007-2017). From 1988-2007, he was at the Institute for Molecular Bioscience at the University of Queensland, serving as Deputy Director of the CRC for Chronic Inflammatory Diseases, and Director of the ARC Special Centre for Functional and Applied Genomics. At Mater, David co-leads the Macrophage Biology Research Group with Dr Kate Irvine. He has authored over 450 scientific publications and has supervised more than 55 PhD graduates. He is an international authority in genome sciences, with a particular focus on the function of macrophages—specialised cells of the immune system involved in innate immunity against infections, inflammatory disease and cancer. David’s research focusses on macrophages in normal growth, development and physiology, infectious disease resistance and progression and complications of inflammation. His lab investigates mechanisms that regulate the biological functions of macrophages and explores avenues to boost their normal function and/or limit the damage they cause in inflammatory and infectious diseases. He is also interested in the genetic variations in macrophage function between individuals that contribute to susceptibility to inflammatory and infectious diseases. David has been elected to Fellowships in the Royal Society of Edinburgh, the UK Academy of Medical Sciences and the Royal Society of Biology. Since 2000, he has been a leading member of the FANTOM Consortium, which has made extensive contributions to mammalian genome and transcriptome annotation. David has a 35 year track record of attracting major strategic funding (CRC for Chronic Inflammatory Disease, ARC Special Research Centre in Australia; BBSRC Institute Strategic Programmes, Wellcome Trust Centres, UK Agritech Centre and Bill and Melinda Gates Centre Foundation in the UK) as well as continuous research project funding from NHMRC, ARC, BBSRC, MRC and the Wellcome Trust. "I trained as a metabolic biochemist at the Australian National University, and was very fortunate to have a great mentor in Dr Maurie Weidemann. Throughout my career, I have tried to mentor others with the same level of enthusiasm and support given to me. Being a biological scientist in the early 21st century is very much like being a physical scientist in the early 20th century. Each day brings new technologies and completely unexpected discoveries. I believe that the most novel breakthroughs and advances in human medicine and biotechnology come from basic discovery science, and fundamental understanding of macrophage biology has been my research focus for the whole of my career. That said, the applications of that understanding to human disease are clear, especially in the areas of tissue repair and regenerative medicine, and I am committed to pursuing those applications to benefit patients."
Works
Search Professor David Hume’s works on UQ eSpace
2005
Journal Article
Human tartrate-resistant acid phosphatase becomes an effective ATPase upon proteolytic activation
Mitic, N., Valizadeh, M., Leung, E. W. W., de Jersey, J., Hamilton, S., Hume, D. A., Cassady, A. I. and Schenk, G. (2005). Human tartrate-resistant acid phosphatase becomes an effective ATPase upon proteolytic activation. Archives of Biochemistry And Biophysics, 439 (2), 154-164. doi: 10.1016/j.abb.2005.05.013
2005
Journal Article
The Runx1 transcription factor controls CSF-1-dependent and -independent growth and survival of macrophages
Himes, S. R., Cronau, S., Mulford, C. and Hume, D. A. (2005). The Runx1 transcription factor controls CSF-1-dependent and -independent growth and survival of macrophages. Oncogene, 24 (34), 5278-5286. doi: 10.1038/sj.onc.1208657
2005
Conference Publication
Purified splenic B-cells do not respond to E. coli DNA
Roberts, Tara L., Dann, Jasmyn A., Sweet, Matthew J., Hume, David A., Lenert, Petar and Stacey, Katryn J. (2005). Purified splenic B-cells do not respond to E. coli DNA. 7th World Congress on Inflammation, Melbourne, Australia, 20-24 August 2005. Switzerland: Birkhaeuser Science.
2005
Journal Article
Macrophages overexpressing tartrate-resistant acid phosphatase show altered profile of free radical production and enhanced capacity of bacterial killing
Raisanen, S. R., Alatalo, S. L., Ylipahkala, H., Halleen, J. M., Cassady, A. I., Hume, D. A. and Vaananen, H. K. (2005). Macrophages overexpressing tartrate-resistant acid phosphatase show altered profile of free radical production and enhanced capacity of bacterial killing. Biochemical And Biophysical Research Communications, 331 (1), 120-126. doi: 10.1016/j.bbrc.2005.03.133
2005
Journal Article
Antisense transcription in the mammalian transcriptome
RIKEN GER Group,, Wells, C. A., Frith, M., Ravasi, T., Pang, K. C., Hallinan, J. S., Mattick, J. S., Hume, D. A., Katayama, S., Tomaru, Y., Kasukawa, T., Waki, K., Nakanishi, M., Nakamura, M. and Nishida, H. (2005). Antisense transcription in the mammalian transcriptome. Science, 309 (5740), 1564-1566. doi: 10.1126/science.1112009
2005
Book Chapter
Noncoding RNA's in mammals
Ravasi, T. and Hume, D. A. (2005). Noncoding RNA's in mammals. Encyclopedia of Genetics, Genomics, Proteomics and Bioformatics. (pp. xx-xx) edited by Michael J. Dunn, Lynn B. Jorde, Peter F. R. Little and Shankar Subramaniam. USA: John Wiley & Sons, Inc.. doi: 10.1002/047001153X.g203204
2005
Journal Article
S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo
Bozinovski, S., Cross, M., Vlahos, R., Jones, J. E., Hsuu, K., Tessier, P. A., Reynolds, E. C., Hume, D. A., Hamilton, J. A., Geczy, C. L. and Anderson, G. P. (2005). S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo. Journal of Proteome Research, 4 (1), 136-145. doi: 10.1021/pr049829t
2005
Conference Publication
Novel macrophage-restricted gene involved in inflammation
Ripoll, Vera M., Ravasi, Timothy and Hume, David A. (2005). Novel macrophage-restricted gene involved in inflammation. BASEL: BIRKHAUSER VERLAG AG.
2005
Journal Article
Inflammation suppressor genes: please switch out all the lights
Wells, C. A., Ravasi, T. and Hume, D. A. (2005). Inflammation suppressor genes: please switch out all the lights. Journal of Leukocyte Biology, 78 (1), 9-13. doi: 10.1189/jlb.1204710
2005
Journal Article
Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor
Rehli, M., Sulzbacher, S., Pape, S., Ravasi, T., Wells, C. A., Heinz, S., Sollner, L., El Chartouni, C., Krause, S. W., Steingrimsson, E., Hume, D. A. and Andreesen, R. (2005). Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor. Journal of Immunology, 174 (11), 7111-7122. doi: 10.4049/jimmunol.174.11.7111
2005
Journal Article
Differences in macrophage activation by bacterial DNA and CpG-containing oligonucleotides
Roberts, T. L., Dunn, J. A., Terry, T. D., Jennings, M. P., Hume, D. A., Sweet, M. J. and Stacey, K. J. (2005). Differences in macrophage activation by bacterial DNA and CpG-containing oligonucleotides. Journal of Immunology, 175 (6), 3569-3576. doi: 10.4049/jimmunol.175.6.3569
2005
Conference Publication
Blockade of CSF-1 action enhances CpG DNA responses in vivo
Trieu, Angela, Cronau, Steve, Roberts, Tara, Lottin, Jane, Vlahos, Ross, Stacey, Katryn J., Hume, David A. and Sweet, Matthew J. (2005). Blockade of CSF-1 action enhances CpG DNA responses in vivo. 7th World Congress on Inflammation, Melbourne, Australia, 20-24 August 2005. Switzerland: Birkhaeuser Science.
2005
Journal Article
Cutting edge: Species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified ohgonucleotides
Roberts, T. L., Sweet, M. J., Hume, D. A. and Stacey, K. J. (2005). Cutting edge: Species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified ohgonucleotides. Journal of Immunology, 174 (2), 605-608. doi: 10.4049/jimmunol.174.2.605
2005
Journal Article
An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: Relationship to cystatins and the tumor suppressor TIG1
Aagaard, A., Listwan, P., Cowieson, N. P., Huber, T. L., Ravasi, T., Wells, C. A., Flanagan, J. U., Kellie, S., Hume, D. A., Kobe, B. and Martin, J. L. (2005). An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: Relationship to cystatins and the tumor suppressor TIG1. Structure, 13 (2), 309-317. doi: 10.1016/j.str.2004.12.013
2005
Conference Publication
Beta-arrestin expression and function in macrophages
Lattin, Jane E., Blomberg, Lovisa M., Daly, Norelle L., Craik, David J., Robinson, Jodie A., Kellie, Stuart, Hume, David A. and Sweet, Matthew J. (2005). Beta-arrestin expression and function in macrophages. 7th World Congress on Inflammation: Inflammation 2005: Inflammation, the Key to much pathology, Melbourne, Australia, 20 - 24 August 2005. Basel, Switzerland: Birkhaeuser.
2004
Journal Article
Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible
Tagoh, Hiromi, Schebesta, Alexandra, Lefevre, Pascal, Wilson, Nicola, Hume, David, Busslinger, Meinrad and Bonifer, Constanze (2004). Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible. The EMBO Journal, 23 (21), 4275-4285. doi: 10.1038/sj.emboj.7600421
2004
Journal Article
Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases
Valizadeh, Mohsen, Schenk, Gerhard, Nash, Kevin, Oddie, Geoff W., Guddat, Luke W., Hume, David A., de Jersey, John, Burke, Terrence R. and Hamilton, Susan (2004). Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases. Archives of Biochemistry And Biophysics, 424 (2), 154-162. doi: 10.1016/j.abb.2004.01.008
2004
Book Chapter
The Biology of Macrophages
Sasmono, R.T. and Hume, D. A. (2004). The Biology of Macrophages. The Innate Immune Response to Infection. (pp. 71-94) edited by Kaufmann, SE.; Medzhitov, R.; Gordon and S.. Washington, DC, USA: ASM Press.
2004
Journal Article
Probing the S100 protein family through genomic and functional analysis
Ravasi, Timothy, Hsu, Kenneth, Goyette, Jesse, Schroder, Kate, Yang, Zheng, Rahimi, Farid, Miranda, Les P., Alewood, Paul F., Hume, David A. and Geczy, Carolyn (2004). Probing the S100 protein family through genomic and functional analysis. Genomics, 84 (1), 10-22. doi: 10.1016/j.ygeno.2004.02.002
2004
Journal Article
Interferon-gamma: an overview of signals, mechanisms and functions
Schroder, Kate, Hertzog, Paul J., Ravasi, Timothy and Hume, David A. (2004). Interferon-gamma: an overview of signals, mechanisms and functions. Journal of Leukocyte Biology, 75 (2), 163-189. doi: 10.1189/jlb.0603252
Funding
Current funding
Past funding
Supervision
Availability
- Professor David Hume is:
- Available for supervision
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Available projects
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The role of macrophages in postnatal development
This project is associated with a successful ARC Discovery Grant and builds upon the discovery that mutation in the CSF1R gene, which controls the deveelopment of macrophages, has severe impacts on postnatal growth and organ development (See paper below). The phenotype can be reversed by transfer of wild-type bone marrow. The PhD project will focus on analysing the precose mechanisms that enable transplanted macrophages to restore normal development. It will develop a wide range of skills in the braod areas of cell and developmental biology, genomics and bioinformatics.
Enquiries to david.hume@uq.edu.au or Katharine.Irvine@uq.edu.au
Keshvari S, Caruso M, Teakle N, Batoon L, Sehgal A, Patkar OL, Ferrari-Cestari M, Snell CE, Chen C, Stevenson A, Davis FM, Bush SJ, Pridans C, Summers KM, Pettit AR, Irvine KM, Hume DA.
CSF1R-dependent macrophages control postnatal somatic growth and organ maturation. PLoS Genet. 2021 Jun 3;17(6):e1009605. doi: 10.1371/journal.pgen.1009605. Online ahead of print.PMID: 34081701
Supervision history
Current supervision
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Doctor Philosophy
The redundant and non-redundant functions of CSF1R-dependent macrophages during postnatal development
Principal Advisor
Other advisors: Dr Katharine Irvine
-
Doctor Philosophy
Erythroid iron metabolism and its effect on systemic iron homeostasis
Principal Advisor
Other advisors: Dr Katharine Irvine
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Doctor Philosophy
Phenotypic impacts of hypomorphic mutations in the mouse Csf1r locus
Principal Advisor
Other advisors: Dr Katharine Irvine
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Doctor Philosophy
Regulation of Resident Tissue Macrophage Development and Function
Associate Advisor
Other advisors: Dr Sahar Keshvari, Dr Katharine Irvine
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Doctor Philosophy
Functions of CSF1R signalling in inflammation.
Associate Advisor
Other advisors: Professor Antje Blumenthal, Dr Katharine Irvine
Completed supervision
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2024
Doctor Philosophy
Macrophage colony-stimulating factor in the treatment of non-alcoholic fatty liver disease
Principal Advisor
Other advisors: Dr Katharine Irvine, Dr Sahar Keshvari
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2023
Doctor Philosophy
Characterisation of a novel mouse model with a disease-causing Colony Stimulating Factor 1 Receptor mutation
Principal Advisor
Other advisors: Dr Katharine Irvine
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2023
Doctor Philosophy
The role of macrophages in the regulation of systemic metabolism
Principal Advisor
Other advisors: Dr Katharine Irvine, Dr Sahar Keshvari
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2009
Doctor Philosophy
Regulation and Function of Schlafen in Macrophage Biology
Principal Advisor
Other advisors: Professor Matt Sweet
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2007
Doctor Philosophy
THE STRUCTURAL BASIS FOR INTERACTION BETWEEN COLONY- STIMULATING FACTOR-1 AND ITS RECEPTOR, CSF-1R
Principal Advisor
Other advisors: Associate Professor Mark Smythe, Professor Bostjan Kobe, Dr Ian Ross
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2007
Doctor Philosophy
TRANSCRIPTIONAL REGULATION OF THE c-fms PROMOTER BY THE ETS FAMILY OF TRANSCRIPTION FACTORS
Principal Advisor
Other advisors: Professor Kate Stacey
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2006
Doctor Philosophy
FUNCTIONAL CHARACTERISATION OF MACROPHAGE-SPECIFIC TRANSCRIPTS
Principal Advisor
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2005
Doctor Philosophy
MECHANISMS OF INTERFERON-GAMMA PRIMING OF MACROPHAGE ACTIVATION BY CpG DNA
Principal Advisor
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2004
Master Science
Study of gene expression profile of osteoclasts
Principal Advisor
-
2004
Doctor Philosophy
THE EXPRESSIONS AND FUNCTIONS OF G3BPs IN MACROPHAGES
Principal Advisor
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2004
Doctor Philosophy
TRANSCRIPTIONAL ANALYSIS OF MACROPHAGE SIGNALLING IN RESPONSE TO LIPOPOLYSACCHARIDE
Principal Advisor
Other advisors: Professor Brandon Wainwright
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2003
Doctor Philosophy
THE FUNCTION AND REGULATION OF TARTRATE-RESISTANT ACID PHOSPHATASE (TRAP)
Principal Advisor
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2003
Doctor Philosophy
Transcriptional regulation of c-fms gene expression
Principal Advisor
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2003
Doctor Philosophy
MECHANISMS OF ACTION OF BACTERIAL DNA ON MACROPHAGE ACTIVATION
Principal Advisor
Other advisors: Professor Kate Stacey
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2025
Doctor Philosophy
The role of IL34 in HPV-mediated epithelial cancers
Associate Advisor
Other advisors: Associate Professor Graham Leggatt, Dr Janin Chandra, Professor Ian Frazer
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2024
Doctor Philosophy
Preclinical modelling of central nervous system complications and toxicities of cellular and immunotherapies for cancer treatment
Associate Advisor
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2021
Master Philosophy
Developing a Novel Immune Cell Therapy for Glioblastoma: A Novel Monocyte-based Cell-therapy for the Treatment of Glioblastoma
Associate Advisor
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2012
Doctor Philosophy
Characterisation of Myeloid Cells in the Peritoneal Foreign Body Response: Evidence for Phenotypic Plasticity
Associate Advisor
Other advisors: Associate Professor Barbara Rolfe
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2010
Doctor Philosophy
Osteal macrophages (osteomacs) are pivotal for intramembranous bone formation in vivo: Osteomacs facilitate osteoblast maintenance in vivo and enhance osteoblast-mediated bone deposition in a murine model of bone healing
Associate Advisor
Other advisors: Professor Allison Pettit, Dr Liza Raggatt
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2009
Doctor Philosophy
Short Sequence Tags Reveal Global Transcription Of Repetitive Elements In Mammalian Genomes
Associate Advisor
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2009
Doctor Philosophy
Cellular activation and death in response to cytoplasmic DNA
Associate Advisor
Other advisors: Professor Kate Stacey
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2009
Doctor Philosophy
Role of macrophages, residing on the bone surface, in bone remodelling and repair
Associate Advisor
Other advisors: Professor Allison Pettit, Dr Liza Raggatt
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2007
Doctor Philosophy
FUNCTIONAL CHARACTERISATION OF THE ROLE OF PROTEIN TYROSINE PHOSPHATASE CD148 IN MACROPHAGES
Associate Advisor
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2006
Doctor Philosophy
THE ROLE OF MICROPHTHALMIA TRANSCRIPTION FACTOR (MITF) IN OSTEOCLAST GENE REGULATION
Associate Advisor
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2006
Doctor Philosophy
MOLECULAR AND FUNCTIONAL CHARACTERISATION OF POTENTIAL MURINE RENAL STEM CELLS
Associate Advisor
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2006
Doctor Philosophy
THE IMPORTANCE OF EPIGENETICS IN MAMMALS
Associate Advisor
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2005
Doctor Philosophy
SHADES OF DOMAINS: BIOINFORMATIC IDENTIFICATION OF PROTEIN DOMAIN SUBTYPES AND CORRELATION WITH FUNCTIONAL SPECIFICITY
Associate Advisor
Other advisors: Associate Professor Rohan Teasdale
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2005
Doctor Philosophy
CELLULAR RESPONSES TO IMMUNOSTIMULATORY DNA
Associate Advisor
Other advisors: Professor Matt Sweet, Professor Kate Stacey
Media
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