Professor David Hume
Professor

David Hume

Email: 
Phone: 
+61 7 3443 7315

Background

The research interests of the Hume Laboratory centre on the biology of macrophages and osteoclasts. These are cells of haematopoietic origin that are closely related to each other but have distinctly different activities.

David Hume was a group leader at the Institute for Molecular Bioscience (1988-2007) and subsequently Director of the Roslin Institute at the University of Edinburgh in Scotland from 2007-2017. He is currently a Professorial Research Fellow at the Mater Research Institute-UQ, located at the Translational Research Institute

Availability

Professor David Hume is:
Available for supervision

Fields of research

Biological Sciences Genetics Immunology

Qualifications

  • Bachelor (Honours) of Science (Advanced), Australian National University
  • Doctor of Philosophy, Australian National University

Research interests

  • Macrophages Biology

    Professor David Hume is a Professorial Research Fellow at the Mater Research Institute-UQ located at the Translational Research Institute. He was previously Director of The Roslin Institute at the University of Edinburgh (2007-2017). From 1988-2007, he was at the Institute for Molecular Bioscience at the University of Queensland, serving as Deputy Director of the CRC for Chronic Inflammatory Diseases, and Director of the ARC Special Centre for Functional and Applied Genomics. At Mater, David co-leads the Macrophage Biology Research Group with Dr Kate Irvine. He has authored over 450 scientific publications and has supervised more than 55 PhD graduates. He is an international authority in genome sciences, with a particular focus on the function of macrophages—specialised cells of the immune system involved in innate immunity against infections, inflammatory disease and cancer. David’s research focusses on macrophages in normal growth, development and physiology, infectious disease resistance and progression and complications of inflammation. His lab investigates mechanisms that regulate the biological functions of macrophages and explores avenues to boost their normal function and/or limit the damage they cause in inflammatory and infectious diseases. He is also interested in the genetic variations in macrophage function between individuals that contribute to susceptibility to inflammatory and infectious diseases. David has been elected to Fellowships in the Royal Society of Edinburgh, the UK Academy of Medical Sciences and the Royal Society of Biology. Since 2000, he has been a leading member of the FANTOM Consortium, which has made extensive contributions to mammalian genome and transcriptome annotation. David has a 35 year track record of attracting major strategic funding (CRC for Chronic Inflammatory Disease, ARC Special Research Centre in Australia; BBSRC Institute Strategic Programmes, Wellcome Trust Centres, UK Agritech Centre and Bill and Melinda Gates Centre Foundation in the UK) as well as continuous research project funding from NHMRC, ARC, BBSRC, MRC and the Wellcome Trust. "I trained as a metabolic biochemist at the Australian National University, and was very fortunate to have a great mentor in Dr Maurie Weidemann. Throughout my career, I have tried to mentor others with the same level of enthusiasm and support given to me. Being a biological scientist in the early 21st century is very much like being a physical scientist in the early 20th century. Each day brings new technologies and completely unexpected discoveries. I believe that the most novel breakthroughs and advances in human medicine and biotechnology come from basic discovery science, and fundamental understanding of macrophage biology has been my research focus for the whole of my career. That said, the applications of that understanding to human disease are clear, especially in the areas of tissue repair and regenerative medicine, and I am committed to pursuing those applications to benefit patients."

Search Professor David Hume’s works on UQ eSpace

634 works between 1976 and 2025
All (634) Book (1) Journal Article (514) Other Outputs (3) Conference Publication (101) Book Chapter (15)

381 - 400 of 634 works

2006

Journal Article

Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase

Flanagan, J. U., Cassady, A. I., Schenk, G., Guddat, L. W. and Hume, D. A. (2006). Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase. Gene, 377 (1), 12-20. doi: 10.1016/j.gene.2006.02.031

Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase

2006

Journal Article

Focusing in on structural genomics: The University of Queensland structural biology pipeline

Puri, M., Robin, G., Cowieson, N., Forwood, J. K., Listwan, P., Hu, S. H., Guncar, G., Huber, T., Kellie, S., Hume, D. A., Kobe, B. and Martin, J. L. (2006). Focusing in on structural genomics: The University of Queensland structural biology pipeline. Biomolecular Engineering, 23 (6), 281-289. doi: 10.1016/j.bioeng.2006.09.002

Focusing in on structural genomics: The University of Queensland structural biology pipeline

2006

Journal Article

Incorporating a TEV cleavage site reduces the solubility of nine recombinant mouse proteins

Kurz, M., Cowieson, N. P., Robin, G., Hume, D. A., Martin, J. L., Kobe, B. and Listwan, P. (2006). Incorporating a TEV cleavage site reduces the solubility of nine recombinant mouse proteins. Protein Expression And Purification, 50 (1), 68-73. doi: 10.1016/j.pep.2006.05.006

Incorporating a TEV cleavage site reduces the solubility of nine recombinant mouse proteins

2006

Journal Article

Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes

Brahmachary, M., Schonbach, C., Yang, L., Huang, E. L., Tan, S. L., Chowdhary, R., Krishnan, S. P. T., Lin, C. Y., Hume, D. A., Kai, C., Kawai, J., Carninci, P., Hayashizaki, Y. and Bajic, V. B. (2006). Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes. Bmc Bioinformatics, 7 (Supp. 5) S8, Article number S8. doi: 10.1186/1471-2105-7-S5-S8

Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes

2006

Journal Article

Genetics and genomics of osteoclast differentiation: Integrating cell signaling pathways and gene networks

Sharma, S. M., Hu, R., Bronisz, A., Meadows, N., Lusby, T., Fletcher, B., Hume, D. A., Cassady, A. I. and Ostrowski, M. C. (2006). Genetics and genomics of osteoclast differentiation: Integrating cell signaling pathways and gene networks. Critical Reviews In Eukaryotic Gene Expression, 16 (3), 253-277. doi: 10.1615/critreveukargeneexpr.v16.i3.40

Genetics and genomics of osteoclast differentiation: Integrating cell signaling pathways and gene networks

2006

Journal Article

Signal integration between IFN gamma and TLR signalling pathways in macrophages

Schroder, K., Sweet, M. J. and Hume, D. A. (2006). Signal integration between IFN gamma and TLR signalling pathways in macrophages. Immunobiology, 211 (6-8), 511-524. doi: 10.1016/j.imbio.2006.05.007

Signal integration between IFN gamma and TLR signalling pathways in macrophages

2006

Journal Article

The mononuclear phagocyte system

Hume, D. A. (2006). The mononuclear phagocyte system. Current Opinion In Immunology, 18 (1), 49-53. doi: 10.1016/j.coi.2005.11.008

The mononuclear phagocyte system

2006

Journal Article

LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression

Aung, H. T., Schroder, K., Himes, S. R., Brion, K., van Zuylen, W., Trieu, A., Suzuki, H., Hayashizaki, Y., Hume, D. A., Sweet, M. J. and Ravasi, T. (2006). LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression. Faseb Journal, 20 (9), 1315-1327. doi: 10.1096/fj.05-5360com

LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression

2006

Conference Publication

Structure and function of mammalian fibrillin genes

Summers, K and Hume, D A (2006). Structure and function of mammalian fibrillin genes. 11th International Congress of Human Genetics, Brisbane, 6-10 Aug, 2006.

Structure and function of mammalian fibrillin genes

2006

Journal Article

Reduction of the in vitro pro-inflammatory response by macrophages to poly(3-hydroxybutyrate-co-3-hydroxyvalerate)

Wu, Andy C. K., Grondahl, Lisbeth, Jack, Kevin S., Foo, Michelle X., Trau, Matt, Hume, David A. and Cassady, Alan I. (2006). Reduction of the in vitro pro-inflammatory response by macrophages to poly(3-hydroxybutyrate-co-3-hydroxyvalerate). Biomaterials, 27 (27), 4715-4725. doi: 10.1016/j.biomaterials.2006.05.010

Reduction of the in vitro pro-inflammatory response by macrophages to poly(3-hydroxybutyrate-co-3-hydroxyvalerate)

2006

Journal Article

An automatable screen for the rapid identification of proteins amenable to refolding

Cowieson, Nathan P., Wensley, Beth, Listwan, Pawel, Hume, David A., Kobe, Bostjan and Martin, Jennifer L. (2006). An automatable screen for the rapid identification of proteins amenable to refolding. Proteomics, 6 (6), 1750-1757. doi: 10.1002/pmic.200500056

An automatable screen for the rapid identification of proteins amenable to refolding

2006

Journal Article

Genome-wide analysis of mammalian promoter architecture and evolution

Carninci, Piero, Sandelin, Albin, Lenhard, Boris, Frith, Martin C., Forrest, Alistair R. R., Ravasi, Timothy, Grimmond, Sean M., Wells, Christine A., Hume, David A. and Hayashizaki, Yoshihide (2006). Genome-wide analysis of mammalian promoter architecture and evolution. Nature Genetics, 38 (6), 626-635. doi: 10.1038/ng1789

Genome-wide analysis of mammalian promoter architecture and evolution

2006

Journal Article

Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking

Mouradov, D., Craven, A., Forwood, J. K., Flanagan, J. U., Garcia-Castellanos, R., Gomis-Ruth, F. X., Hume, D. A., Martin, J. L., Kobe, B. and Huber, T. (2006). Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking. Protein Engineering Design & Selection, 19 (1), 9-16. doi: 10.1093/protein/gzi070

Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking

2005

Journal Article

Therapeutic targets in inflammatory disease

Hume, David A. and Fairlie, David P. (2005). Therapeutic targets in inflammatory disease. Current Medicinal Chemistry, 12 (25), 2925-2929. doi: 10.2174/092986705774462923

Therapeutic targets in inflammatory disease

2005

Journal Article

Renal structural and functional repair in a mouse model of reversal of ureteral obstruction

Cochrane, Anita L., Kett, Michelle M., Samuel, Chrishan S., Campanale, Naomi V., Anderson, Warwick P., Hume, David A., Little, Melissa H., Bertram, John F. and Ricardo, Sharon D. (2005). Renal structural and functional repair in a mouse model of reversal of ureteral obstruction. Journal of The American Society of Nephrology, 16 (12), 3623-3630. doi: 10.1681/ASN.2004090771

Renal structural and functional repair in a mouse model of reversal of ureteral obstruction

2005

Journal Article

The transcriptional landscape of the mammalian genome

The FANTOM Consortium, Gough, J., Frith, M. C., Ravasi, T., Wells, C., Forrest, A. R. R., Davis, M. J., Aturaliya, R. N., Bailey, T. L., Crowe, M. L., Faulkner, G., Pang, K. C., Teasdale, R. D., Grimmond, S. M., Mattick, J. S., Hume, D. A. and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Core Team) (2005). The transcriptional landscape of the mammalian genome. Science, 309 (5740), 1559-1563. doi: 10.1126/science.1112014

The transcriptional landscape of the mammalian genome

2005

Journal Article

The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion

MacDonald, Kelli P. A., Rowe, Vanessa, Bofinger, Helen. M., Thomas, Ranjeny, Sasmono, Tedjo, Hume, David A. and Hill, Geoffrey R. (2005). The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion. Journal of Immunology, 175 (3), 1399-1405. doi: 10.4049/jimmunol.175.3.1399

The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion

2005

Conference Publication

PU.1 and ICSBP regulate the tlr9 promoter in mouse macrophages

Schroder, Kate, Irvine, Katharine M., Biron, Kristian, Lichtinger, Monika, Ravasi, Timothy, Rehli, Michael, Sweet, Matthen J. and Hume, David A. (2005). PU.1 and ICSBP regulate the tlr9 promoter in mouse macrophages. BASEL: BIRKHAUSER VERLAG AG.

PU.1 and ICSBP regulate the tlr9 promoter in mouse macrophages

2005

Conference Publication

A potent CSF-1 Receptor tyrosine kinase inhibitor targets survival and effector functions in marine macrophage populations

Irvine, Katharine M., Burns, Christopher J., Wilks, Andrew F., Bu, Xiangyong, Harte, Michael F., Su, Stephen, Hume, David A. and Sweet, Matthew J. (2005). A potent CSF-1 Receptor tyrosine kinase inhibitor targets survival and effector functions in marine macrophage populations. BASEL: BIRKHAUSER VERLAG AG.

A potent CSF-1 Receptor tyrosine kinase inhibitor targets survival and effector functions in marine macrophage populations

2005

Conference Publication

Regulation and function of toll-like receptor 9 in macrophages

Sweet, Matthew J., Schroder, Kate, Sester, David P., Trieu, Angela, Rehli, Michael, Risvanathan, Kumar, Stacey, Katryn J. and Hume, David A. (2005). Regulation and function of toll-like receptor 9 in macrophages. 7th World Congress on Inflammation, Melbourne, VIC Australia, 20-24 August 2005. Switzerland: Birkhaeuser Science.

Regulation and function of toll-like receptor 9 in macrophages

Current funding

  • 2024 - 2027
    A macrophage-centric holistic view of postnatal development
    ARC Discovery Projects
    Open grant
  • 2022 - 2026
    Macrophage Biology in Health and Disease
    NHMRC Investigator Grants
    Open grant

Past funding

  • 2021 - 2024
    Macrophage control of mammalian growth and development
    ARC Discovery Projects
    Open grant
  • 2019 - 2021
    Macrophage biology, inflammatory pathophysiology, transcriptional regulation, genetic analytics and clinical genetics
    Mater Foundation
    Open grant
  • 2019 - 2022
    CSF1 Therapy for Chronic Liver Disease
    NHMRC Project Grant
    Open grant
  • 2019 - 2021
    CSF1R and the control of microglial function
    NHMRC Project Grant
    Open grant
  • 2018 - 2020
    Osteal macrophages as therapeutic targets for fracture repair
    NHMRC Project Grant
    Open grant
  • 2008 - 2009
    Profiling the pro- and anti-inflammatory functions of histone deacetylases in macrophages
    Cancer Council Queensland
    Open grant
  • 2007 - 2010
    Cellular Activation and Apoptosis in Response to Foreign Cytoplasmic DNA
    NHMRC Project Grant
    Open grant
  • 2007 - 2008
    Regulation of human fibrillin genes in cardiovascular disease
    National Heart Foundation of Australia
    Open grant
  • 2007 - 2009
    Role of bone-associated macrophages in bone remodelling and bone disease
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    The c-type lectin, Mincle, is a macrophage receptor for Candida albicans.
    NHMRC Project Grant
    Open grant
  • 2006 - 2008
    Molecular genetics of the host response defect in cystic fibrosis
    NHMRC Project Grant
    Open grant
  • 2006 - 2007
    The role of DEP-1 as a tumour suppressor in breast cancer
    Queensland Cancer Fund
    Open grant
  • 2005 - 2008
    Human macrophage transcriptional network
    Riken Genomic Sciences Center
    Open grant
  • 2005
    Developmental Imaging Facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2005 - 2007
    Transcription control of the c-fms gene
    NHMRC Project Grant
    Open grant
  • 2004 - 2011
    Dynamic Imaging Facility for Cancer Biology
    Australian Cancer Research Foundation
    Open grant
  • 2004 - 2007
    The development of tyrosine kinase inhibitors for the treatment of inflammation and malignant disease.
    ARC Linkage Projects
    Open grant
  • 2004
    ARC Research Network in Microarray Technology
    ARC Seed Funding for Research Networks
    Open grant
  • 2004 - 2006
    Regulation Of Macrophage Function And Gene Expression By The Th2-Promoting Stimulus, ES-62
    NHMRC Project Grant
    Open grant
  • 2004 - 2006
    TLR9 And The Response To Foreign DNA
    NHMRC Project Grant
    Open grant
  • 2003 - 2006
    Gene expression profiling and de novo transcriptome sequencing using geneballs
    ARC Linkage Projects
    Open grant
  • 2003
    Agilent Microarray Scanner
    NHMRC Equipment Grant
    Open grant
  • 2003
    Alternative Splicing in the Mouse Transcriptome
    ARC Discovery Projects
    Open grant
  • 2003 - 2004
    Migration And Differentiation Of Dendritic Cells And Monocytes In Inflammatory Arthritis
    NHMRC Project Grant
    Open grant
  • 2003 - 2005
    Molecular genetics of cystic fibrosis
    NHMRC Project Grant
    Open grant
  • 2003 - 2005
    Molecular Genetics Of Macrophage Activation
    NHMRC Project Grant
    Open grant
  • 2003 - 2005
    Molecular genetics of macrophage activation
    NHMRC Project Grant - Standard
    Open grant
  • 2003
    Molecular Regulators of Cytokine Secretion
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2003
    Targeted Structural Genomics of Macrophage Proteins
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002 - 2006
    Towards Renal Regeneration
    United States National Institutes of Health
    Open grant
  • 2002 - 2008
    Education and training program
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Office
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Research Program 1
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Research Program 2
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Research Program 3
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Research Program 4
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Research Program 5
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002
    Defining the human and mammalian methylomes and implications for medical research
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002 - 2004
    Osteoclast-specific gene regulation
    NHMRC Project Grant
    Open grant
  • 2002 - 2004
    Transciptional regulation of the c-fms (CFS-1R) gene in macrophages
    NHMRC Project Grant
    Open grant
  • 2001 - 2002
    Transgenic animal studies of the function of artificial zinc finger transcription factors
    Sangamo Biosciences Inc.
    Open grant
  • 2001 - 2002
    Approaches to manipulating the expression of the c-fms gene
    Sangamo Biosciences Inc.
    Open grant
  • 2001
    MJ Research Tetrad - 4 x 96well block thermocycler
    Ramaciotti Foundation
    Open grant
  • 2000
    Control of osteociast differentiation
    Mayne Bequest Fund
    Open grant
  • 2000 - 2002
    Genes controlling the development of lung disease in cystic fibrosis mutant mice
    NHMRC Project Grant
    Open grant
  • 2000 - 2002
    Mechanisms of macrophage activation by immunostimulatory DNA
    NHMRC Project Grant
    Open grant
  • 2000
    Regulation of the Tartrate-Resistant Acid Phosphatase Gene.
    ARC Australian Research Council (Small grants)
    Open grant
  • 2000 - 2002
    The role of the microphthalmia transcription factor family in macrophage differentiation
    NHMRC Project Grant
    Open grant
  • 1999 - 2001
    Genetic interactions that regulate the response of macrophages to bacterial lipopolysaccharide
    Merck Genome Research Institute
    Open grant
  • 1999
    Function and regulation of the tartrate resistant acid phosphatase gene
    Mayne Bequest Fund
    Open grant
  • 1999 - 2001
    Human tartrate-resistant purple acid phosphatase: structure and function
    NHMRC Project Grant
    Open grant
  • 1999
    Mechanisms of action of CpG DNA as an activator of macrophage function
    Mayne Bequest Fund
    Open grant
  • 1999 - 2000
    Signal transduction from the macrophage colony-stimulating factor receptor
    Queensland Cancer Fund
    Open grant
  • 1999 - 2000
    Transcriptional regulation of the macrophage colony stimulating factor receptor (c-fms) gene
    NHMRC Project Grant
    Open grant
  • 1998 - 2000
    Transcriptional Regulation of the Macrophage Colony Stimulating Factor Receptor (c-fms) Gene
    NHMRC Project Grant
    Open grant
  • 1997 - 1998
    Crystallisation of tartrate resistant acid phosphatase
    Johnson & Johnson Research Pty Ltd
    Open grant
  • 1997
    Regulation of the HIV-1-LTR in macrophages
    NHMRC Extended Epidemiology Project Grant
    Open grant
  • 1997
    Development of candidate drugs for the treatment of osteoporosis
    Merck Sharp & Dohme Australia
    Open grant
  • 1997 - 1999
    Genes controlling the development of lung disease in normal and cystic fibrosis mice
    NHMRC Project Grant
    Open grant
  • 1997
    Microplate counting system
    NHMRC Equipment Grant
    Open grant
  • 1997
    Microplate counting system.
    Ramaciotti Foundation
    Open grant
  • 1996
    Macrophage DNA recepter project.
    CRC for Vaccine Technology
    Open grant
  • 1996 - 1998
    Function and regulation of the tartrate-resistant acid phosphatase gene
    NHMRC Project Grant
    Open grant
  • 1996 - 1998
    Protein tyrosine phosphatases in macrophages
    Queensland Cancer Fund
    Open grant
  • 1996 - 1998
    Regulation of the urokinase plasminogen activator gene by macrophaghe colony-stimulating factor
    NHMRC Project Grant
    Open grant
  • 1996
    Zeiss axiophot microscope
    NHMRC Equipment Grant
    Open grant
  • 1995 - 1997
    Regulation of HIV-1-LTR in macrophages
    NHMRC Project Grant - HIV/AIDS (CARG)
    Open grant
  • 1995 - 1997
    The role of c-fms and macrophage colony stimulating factor (CSF-1) in tumor progression
    Queensland Cancer Fund
    Open grant

Availability

Professor David Hume is:
Available for supervision

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Available projects

  • The role of macrophages in postnatal development

    This project is associated with a successful ARC Discovery Grant and builds upon the discovery that mutation in the CSF1R gene, which controls the deveelopment of macrophages, has severe impacts on postnatal growth and organ development (See paper below). The phenotype can be reversed by transfer of wild-type bone marrow. The PhD project will focus on analysing the precose mechanisms that enable transplanted macrophages to restore normal development. It will develop a wide range of skills in the braod areas of cell and developmental biology, genomics and bioinformatics.

    Enquiries to david.hume@uq.edu.au or Katharine.Irvine@uq.edu.au

    Keshvari S, Caruso M, Teakle N, Batoon L, Sehgal A, Patkar OL, Ferrari-Cestari M, Snell CE, Chen C, Stevenson A, Davis FM, Bush SJ, Pridans C, Summers KM, Pettit AR, Irvine KM, Hume DA.

    CSF1R-dependent macrophages control postnatal somatic growth and organ maturation. PLoS Genet. 2021 Jun 3;17(6):e1009605. doi: 10.1371/journal.pgen.1009605. Online ahead of print.PMID: 34081701

Supervision history

Current supervision

Completed supervision

Enquiries

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