
Overview
Background
Professor Denise Doolan is Director of Research at the Institute for Molecular Bioscience. She joined IMB in 2022 and was previously Deputy Director of the Australian Institute of Tropical Health and Medicine, and Director of the JCU Centre for Molecular Therapeutics, at James Cook University.
She is a molecular immunologist, working on the development of vaccines, diagnostics and host-directed therapeutics for infectious and chronic diseases that impact global public health, with a particular focus on malaria. Her cross-disciplinary research program spans host-pathogen immunity, antigen discovery, vaccine engineering, and biomarker discovery. A particular interest is the application of state-of-the-art genome-based technologies and human models of disease system to identify novel targets for intervention against disease or that predict risk of disease.
She is a recognized world expert in malaria immunology, vaccinology, and omic-based approaches for therapeutic and diagnostic development. She has been honoured as a Fellow of the International Society for Vaccines (2017) and a Fellow of the Australian Society of Parasitology (2019) in recognition of her leadership and contribution to health and medical science in Australia and internationally.
Professor Doolan serves on a number of Executive Boards and Advisory Boards. Most recently, she has been elected as President of the International Society for Vaccines (2021-2023), and has been appointed to the Federal Government’s Australian Medical Research Advisory Board (AMRAB; 2021-2026) to provide specialist insights into Australia’s medical research and innovation priorities.
Availability
- Professor Denise Doolan is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- B Sc Hons (Biochemistry), The University of Queensland
- M Phil (Life Sciences), Griffith University
- PhD (Molecular Immunology), The University of Queensland
Works
Search Professor Denise Doolan’s works on UQ eSpace
2025
Journal Article
When venom calms the storm: Stonefish venoms suppress LPS-induced Th1 cytokine expression and secretion in human PBMCs
Saggiomo, Silvia Luiza, Browne, Daniel, Wong, Yide, Miles, John J., Doolan, Denise, Daly, Norelle L. and Wilson, David Thomas (2025). When venom calms the storm: Stonefish venoms suppress LPS-induced Th1 cytokine expression and secretion in human PBMCs. Toxicon, 267 108579, 108579. doi: 10.1016/j.toxicon.2025.108579
2025
Journal Article
Differential reactivity of <scp>SARS</scp>‐<scp>C</scp>o<scp>V</scp>‐2 S‐protein T‐cell epitopes in vaccinated versus naturally infected individuals
Browne, Daniel J, Crooks, Pauline, Smith, Corey and Doolan, Denise L (2025). Differential reactivity of SARS‐CoV‐2 S‐protein T‐cell epitopes in vaccinated versus naturally infected individuals. Clinical & Translational Immunology, 14 (5) e70031, e70031. doi: 10.1002/cti2.70031
2025
Journal Article
Distal airway epithelial progenitors mediate TGF-β release to drive lung CD8+ TRM induction following mucosal BCG vaccination
Blake, Judith A., Seifert, Julia, Miranda-Hernandez, Socorro, Ruscher, Roland, Giacomin, Paul R., Doolan, Denise L. and Kupz, Andreas (2025). Distal airway epithelial progenitors mediate TGF-β release to drive lung CD8+ TRM induction following mucosal BCG vaccination. Mucosal Immunology, 18 (4), 973-988. doi: 10.1016/j.mucimm.2025.05.007
2025
Journal Article
Differential antibody response to EBV proteome following EBVST immunotherapy in EBV-associated lymphomas
Sarathkumara, Yomani D., Van Bibber, Nathan W., Liu, Zhiwei, Heslop, Helen E., Rouce, Rayne H., Coghill, Anna Elizabeth, Rooney, Cliona M., Proietti, Carla and Doolan, Denise L. (2025). Differential antibody response to EBV proteome following EBVST immunotherapy in EBV-associated lymphomas. Blood Advances, 9 (7), 1658-1669. doi: 10.1182/bloodadvances.2024014937
2025
Journal Article
Sex differences in Anti–Epstein-Barr virus antibody responses
Jackson, Sarah S., Francis, Julia, Pfeiffer, Ruth M., Proietti, Carla, Coghill, Anna E., Yu, Kelly J., Sarathkumara, Yomani D., Hsu, Wan-Lun, Argirion, Ilona, Wang, Cheng-Ping, Chen, Chien-Jen, Rothman, Nathaniel, Lan, Qing, Hildesheim, Allan, Doolan, Denise L. and Liu, Zhiwei (2025). Sex differences in Anti–Epstein-Barr virus antibody responses. The Journal of Infectious Diseases. doi: 10.1093/infdis/jiaf067
2024
Journal Article
Aboriginal families living with MJD in remote Australia: questions of access and equity
Massey, Libby, Gilroy, John, Kowal, Emma, Doolan, Denise and Clough, Alan (2024). Aboriginal families living with MJD in remote Australia: questions of access and equity. International Journal for Equity in Health, 23 (1) 187, 1. doi: 10.1186/s12939-024-02228-x
2024
Journal Article
A proteome‐wide analysis unveils a core Epstein–Barr virus antibody signature of classic Hodgkin lymphoma across ethnically diverse populations
Sarathkumara, Yomani D., Xian, Rena R., Liu, Zhiwei, Yu, Kelly J., Chan, John K. C., Kwong, Yok‐Lam, Lam, Tai Hing, Liang, Raymond, Chiu, Brian, Xu, Jun, Hu, Wei, Ji, Bu‐Tian, Coghill, Anna E., Kelly, Ashton M., Pfeiffer, Ruth M., Rothman, Nathaniel, Ambinder, Richard F., Hildesheim, Allan, Lan, Qing, Proietti, Carla and Doolan, Denise L. (2024). A proteome‐wide analysis unveils a core Epstein–Barr virus antibody signature of classic Hodgkin lymphoma across ethnically diverse populations. International Journal of Cancer, 155 (8), 1476-1486. doi: 10.1002/ijc.35072
2024
Journal Article
Optimization and application of bacterial environmental DNA and RNA isolation for qualitative and quantitative studies
Browne, Daniel J., Miller, Catherine M., O'Hara, Emily P., Courtney, Robert, Seymour, Jamie, Doolan, Denise L. and Orr, Ryan (2024). Optimization and application of bacterial environmental DNA and RNA isolation for qualitative and quantitative studies. Environmental DNA, 6 (4) e589, 1-19. doi: 10.1002/edn3.589
2024
Journal Article
Technical pitfalls when collecting, cryopreserving, thawing, and stimulating human T-cells
Browne, Daniel J., Miller, Catherine M. and Doolan, Denise L. (2024). Technical pitfalls when collecting, cryopreserving, thawing, and stimulating human T-cells. Frontiers in Immunology, 15 1382192, 1-10. doi: 10.3389/fimmu.2024.1382192
2023
Journal Article
Evaluating the stability of host-reference gene expression and simultaneously quantifying parasite burden and host immune responses in murine malaria
Browne, Daniel J., Kelly, Ashton M., Brady, Jamie, Proietti, Carla, Sarathkumara, Yomani D., Pattinson, David J. and Doolan, Denise L. (2023). Evaluating the stability of host-reference gene expression and simultaneously quantifying parasite burden and host immune responses in murine malaria. Scientific Reports, 13 (1) 21071, 1-11. doi: 10.1038/s41598-023-48066-9
2023
Journal Article
Association of serum microRNAs with abdominal aortic aneurysm diagnosis and growth
Thanigaimani, Shivshankar, Iyer, Vikram, Bingley, John, Browne, Daniel, Phie, James, Doolan, Denise and Golledge, Jonathan (2023). Association of serum microRNAs with abdominal aortic aneurysm diagnosis and growth. European Journal of Vascular and Endovascular Surgery, 65 (4), 573-581. doi: 10.1016/j.ejvs.2022.12.028
2023
Journal Article
Comparative analysis of the humoral immune response to the EBV proteome across EBV-related malignancies
Argirion, Ilona, Pfeiffer, Ruth M., Proietti, Carla, Coghill, Anna E., Yu, Kelly J., Middeldorp, Jaap M., Sarathkumara, Yomani D., Hsu, Wan-Lun, Chien, Yin-Chu, Lou, Pei-Jen, Wang, Cheng-Ping, Rothman, Nathaniel, Lan, Qing, Chen, Chien-Jen, Mbulaiteye, Sam M., Jarrett, Ruth F., Glimelius, Ingrid, Smedby, Karin E., Hjalgrim, Henrik, Hildesheim, Allan, Doolan, Denise L. and Liu, Zhiwei (2023). Comparative analysis of the humoral immune response to the EBV proteome across EBV-related malignancies. Cancer Epidemiology, Biomarkers and Prevention, 32 (5), OF1-OF10. doi: 10.1158/1055-9965.epi-22-0452
2023
Journal Article
Recommendations for Epstein-Barr virus-based screening for nasopharyngeal cancer in high- and intermediate-risk regions
Lam, W K Jacky, King, Ann D, Miller, Jacob A, Liu, Zhiwei, Yu, Kelly J, Chua, Melvin L K, Ma, Brigette B Y, Chen, Ming Yuan, Pinsky, Benjamin A, Lou, Pei-Jen, Woo, John K S, Hsu, Wan-Lun, Simon, Julia, Doolan, Denise L, Waterboer, Tim, Hui, Edwin P, Li, Hui, Tsang, Raymond K, Wong, Kenneth C W, Goh, Julian P, Vlantis, Alexander C, Ai, Qi Yong, Wong, Lun M, Abdullah, Victor, Lin, Jin Ching, Chen, Chien-Jen, Pfeiffer, Ruth M, Le, Quynh-Thu, Lee, Anne W M ... Hildesheim, Allan (2023). Recommendations for Epstein-Barr virus-based screening for nasopharyngeal cancer in high- and intermediate-risk regions. JNCI: Journal of the National Cancer Institute, 115 (4), 355-364. doi: 10.1093/jnci/djad012
2022
Journal Article
Characterizing and correcting immune dysfunction in non-tuberculous mycobacterial disease
Ratnatunga, Champa N., Tungatt, Katie, Proietti, Carla, Halstrom, Sam, Holt, Michael R., Lutzky, Viviana P., Price, Patricia, Doolan, Denise L., Bell, Scott C., Field, Matt A., Kupz, Andreas, Thomson, Rachel M. and Miles, John J. (2022). Characterizing and correcting immune dysfunction in non-tuberculous mycobacterial disease. Frontiers in Immunology, 13 1047781, 1-20. doi: 10.3389/fimmu.2022.1047781
2022
Journal Article
Novel antiinflammatory biologics shaped by parasite-host coevolution
Ryan, Stephanie M., Ruscher, Roland, Johnston, Wayne A., Pickering, Darren A., Kennedy, Malcolm W., Smith, Brian O., Jones, Linda, Buitrago, Geraldine, Field, Matt A., Esterman, Adrian J., McHugh, Connor P., Browne, Daniel J., Cooper, Martha M., Ryan, Rachael Y M, Doolan, Denise L., Engwerda, Christian R., Miles, Kim, Mitreva, Makedonka, Croese, John, Rahman, Tony, Alexandrov, Kirill, Giacomin, Paul R. and Loukas, Alex (2022). Novel antiinflammatory biologics shaped by parasite-host coevolution. Proceedings of the National Academy of Sciences of the United States of America, 119 (36) 2202795119, 1-9. doi: 10.1073/pnas.2202795119
2022
Journal Article
The effect of tropical temperatures on the quality of RNA extracted from stabilized whole-blood samples
Sarathkumara, Yomani D., Browne, Daniel J., Kelly, Ashton M., Pattinson, David J., Rush, Catherine M., Warner, Jeffrey, Proietti, Carla and Doolan, Denise L. (2022). The effect of tropical temperatures on the quality of RNA extracted from stabilized whole-blood samples. International Journal of Molecular Sciences, 23 (18) 10609, 1-15. doi: 10.3390/ijms231810609
2022
Journal Article
A high-throughput screening RT-qPCR assay for quantifying surrogate markers of immunity from PBMCs
Browne, Daniel J., Kelly, Ashton M., Brady, Jamie L. and Doolan, Denise L. (2022). A high-throughput screening RT-qPCR assay for quantifying surrogate markers of immunity from PBMCs. Frontiers in Immunology, 13 962220, 1-12. doi: 10.3389/fimmu.2022.962220
2022
Journal Article
CD161 expression defines new human γδ T cell subsets
Karunathilaka, Amali, Halstrom, Samuel, Price, Patricia, Holt, Michael, Lutzky, Viviana P., Doolan, Denise L., Kupz, Andreas, Bell, Scott C., Thomson, Rachel M., Miles, John J. and Ratnatunga, Champa N. (2022). CD161 expression defines new human γδ T cell subsets. Immunity and Ageing, 19 (1) 11, 1-8. doi: 10.1186/s12979-022-00269-w
2022
Journal Article
Proteomic identification of the contents of small extracellular vesicles from in vivo Plasmodium yoelii infection
De Sousa, Karina P., Potriquet, Jeremy, Mulvenna, Jason, Sotillo, Javier, Groves, Penny L., Loukas, Alex, Apte, Simon H. and Doolan, Denise L. (2022). Proteomic identification of the contents of small extracellular vesicles from in vivo Plasmodium yoelii infection. International Journal for Parasitology, 52 (1), 35-45. doi: 10.1016/j.ijpara.2021.06.001
2022
Journal Article
Identifying Epstein-Barr virus peptide sequences associated with differential IgG antibody response
Coghill, Anna E., Fang, Jianwen, Liu, Zhiwei, Chen, Chien-Jen, Jarrett, Ruth F., Hjalgrim, Henrik, Proietti, Carla, Yu, Kelly J., Hsu, Wan-Lun, Lou, Pei-Jen, Wang, Chen-Ping, Zhao, Yingdong, Doolan, Denise L. and Hildesheim, Allan (2022). Identifying Epstein-Barr virus peptide sequences associated with differential IgG antibody response. International Journal of Infectious Diseases, 114, 65-71. doi: 10.1016/j.ijid.2021.10.054
Funding
Current funding
Past funding
Supervision
Availability
- Professor Denise Doolan is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Understanding the link between EBV and Multiple Sclerosis
Principal Advisor
-
Doctor Philosophy
Systems immunology and multi-omics approaches to understand protective immunity to human malaria
Principal Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
Utilising high throughout spatial Transcriptomics to personlise treatment approaches for endometriosis patients
Associate Advisor
Other advisors: Dr Quan Nguyen, Associate Professor Akwasi Amoako, Dr Brett McKinnon
Completed supervision
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2025
Doctor Philosophy
Understanding the Molecular Basis of Immune Heterogeneity using Systems Immunology
Principal Advisor
-
2018
Doctor Philosophy
Characterization of cross-reactive immune responses in the context of a complex host-pathogen system.
Principal Advisor
-
2015
Doctor Philosophy
Molecular profiling of cellular immune responses to Plasmodium spp. blood-stage infection in humans using systems immunology
Principal Advisor
-
2014
Doctor Philosophy
Evaluation of novel DNA vaccine delivery strategies targeting dendritic cells: mechanisms of action, immunogenicity and protective efficacy
Principal Advisor
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2014
Doctor Philosophy
Evaluation of novel antigens identified in genome-wide screening approaches for next-generation malaria vaccines
Principal Advisor
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2013
Doctor Philosophy
Design and use of a schistosome protein microarray to investigate Asian schistosomiasis
Associate Advisor
Other advisors: Professor Malcolm Jones
Media
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