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Professor Denise Doolan
Professor

Denise Doolan

Email: 
Phone: 
+61 7 334 62159

Overview

Background

Professor Denise Doolan is Director of Research at the Institute for Molecular Bioscience. She joined IMB in 2022 and was previously Deputy Director of the Australian Institute of Tropical Health and Medicine, and Director of the JCU Centre for Molecular Therapeutics, at James Cook University.

She is a molecular immunologist, working on the development of vaccines, diagnostics and host-directed therapeutics for infectious and chronic diseases that impact global public health, with a particular focus on malaria. Her cross-disciplinary research program spans host-pathogen immunity, antigen discovery, vaccine engineering, and biomarker discovery. A particular interest is the application of state-of-the-art genome-based technologies and human models of disease system to identify novel targets for intervention against disease or that predict risk of disease.

She is a recognized world expert in malaria immunology, vaccinology, and omic-based approaches for therapeutic and diagnostic development. She has been honoured as a Fellow of the International Society for Vaccines (2017) and a Fellow of the Australian Society of Parasitology (2019) in recognition of her leadership and contribution to health and medical science in Australia and internationally.

Professor Doolan serves on a number of Executive Boards and Advisory Boards. Most recently, she has been elected as President of the International Society for Vaccines (2021-2023), and has been appointed to the Federal Government’s Australian Medical Research Advisory Board (AMRAB; 2021-2026) to provide specialist insights into Australia’s medical research and innovation priorities.

Availability

Professor Denise Doolan is:
Available for supervision

Fields of research

Qualifications

  • Bachelor of Science, The University of Queensland
  • B Sc Hons (Biochemistry), The University of Queensland
  • M Phil (Life Sciences), Griffith University
  • PhD (Molecular Immunology), The University of Queensland

Works

Search Professor Denise Doolan’s works on UQ eSpace

224 works between 1987 and 2025

21 - 40 of 224 works

2022

Journal Article

Meet the fellows: Everything about ISV

Doolan, Denise, Lu, Shan, Ross, Ted and Cox, Manon (2022). Meet the fellows: Everything about ISV. Human Vaccines and Immunotherapeutics, 18 (4) 2096964. doi: 10.1080/21645515.2022.2096964

Meet the fellows: Everything about ISV

2021

Journal Article

Malaria research in Australia: looking through the lens of the past towards the future

Doolan, Denise L. (2021). Malaria research in Australia: looking through the lens of the past towards the future. International Journal for Parasitology, 51 (13-14), 1255-1263. doi: 10.1016/j.ijpara.2021.11.005

Malaria research in Australia: looking through the lens of the past towards the future

2021

Journal Article

Characterization of the humoral immune response to the EBV proteome in extranodal NK/T-cell lymphoma

Liu, Zhiwei, Sarathkumara, Yomani D., Chan, John K. C., Kwong, Yok-Lam, Lam, Tai Hing, Ip, Dennis Kai Ming, Chiu, Brian C. -H., Xu, Jun, Su, Yu-Chieh, Proietti, Carla, Cooper, Martha M., Yu, Kelly J., Bassig, Bryan, Liang, Raymond, Hu, Wei, Ji, Bu-Tian, Coghill, Anna E., Pfeiffer, Ruth M., Hildesheim, Allan, Rothman, Nathaniel, Doolan, Denise L. and Lan, Qing (2021). Characterization of the humoral immune response to the EBV proteome in extranodal NK/T-cell lymphoma. Scientific Reports, 11 (1) 23664, 1-8. doi: 10.1038/s41598-021-02788-w

Characterization of the humoral immune response to the EBV proteome in extranodal NK/T-cell lymphoma

2021

Journal Article

Systems serology detects functionally distinct coronavirus antibody features in children and elderly

Selva, Kevin J., van de Sandt, Carolien E., Lemke, Melissa M., Lee, Christina Y., Shoffner, Suzanne K., Chua, Brendon Y., Davis, Samantha K., Nguyen, Thi H. O., Rowntree, Louise C., Hensen, Luca, Koutsakos, Marios, Wong, Chinn Yi, Mordant, Francesca, Jackson, David C., Flanagan, Katie L., Crowe, Jane, Tosif, Shidan, Neeland, Melanie R., Sutton, Philip, Licciardi, Paul V., Crawford, Nigel W., Cheng, Allen C., Doolan, Denise L., Amanat, Fatima, Krammer, Florian, Chappell, Keith, Modhiran, Naphak, Watterson, Daniel, Young, Paul ... Chung, Amy W. (2021). Systems serology detects functionally distinct coronavirus antibody features in children and elderly. Nature Communications, 12 (1) 2037, 2037. doi: 10.1038/s41467-021-22236-7

Systems serology detects functionally distinct coronavirus antibody features in children and elderly

2021

Journal Article

A point-of-care lateral flow assay for neutralising antibodies against SARS-CoV-2

Fulford, Thomas S., Van, Huy, Gherardin, Nicholas A., Zheng, Shuning, Ciula, Marcin, Drummer, Heidi E., Redmond, Samuel, Tan, Hyon-Xhi, Boo, Irene, Center, Rob J., Li, Fan, Grimley, Samantha L., Wines, Bruce D., Nguyen, Thi H. O., Mordant, Francesca L., Ellenberg, Paula, Rowntree, Louise C., Kedzierski, Lukasz, Cheng, Allen C., Doolan, Denise L., Matthews, Gail, Bond, Katherine, Hogarth, P. Mark, McQuilten, Zoe, Subbarao, Kanta, Kedzierska, Katherine, Juno, Jennifer A., Wheatley, Adam K., Kent, Stephen J. ... Godfrey, Dale (2021). A point-of-care lateral flow assay for neutralising antibodies against SARS-CoV-2. EBioMedicine, 74 103729, 1-16. doi: 10.1016/j.ebiom.2021.103729

A point-of-care lateral flow assay for neutralising antibodies against SARS-CoV-2

2021

Journal Article

Coronavirus Disease (COVID-19): Pathophysiology, epidemiology, clinical management and public health response

Doolan, Denise L., Kozlakidis, Zisis, Zhang, Zhongheng, Paessler, Slobodan, Su, Longxiang, Yokota, Yasuko Tsunetsugu, Shioda, Tatsuo, Rodriguez-Palacios, Alexander, Kaynar, Ata Murat, Ahmed, Rukhsana, Samy, Abdallah, Bradby, Hannah, Kalergis, Alexis M., Dutta, Mohan Jyoti, Kogut, Michael and Zhang, Shen-Ying (2021). Coronavirus Disease (COVID-19): Pathophysiology, epidemiology, clinical management and public health response. Frontiers in Public Health, 9 807159, 1-2. doi: 10.3389/fpubh.2021.807159

Coronavirus Disease (COVID-19): Pathophysiology, epidemiology, clinical management and public health response

2021

Journal Article

Immunomics-guided discovery of serum and urine antibodies for diagnosing urogenital schistosomiasis: a biomarker identification study

Pearson, Mark S., Tedla, Bemnet A., Mekonnen, Gebeyaw G., Proietti, Carla, Becker, Luke, Nakajima, Rie, Jasinskas, Al, Doolan, Denise L., Amoah, Abena S., Knopp, Stefanie, Rollinson, David, Ali, Said M., Kabole, Fatma, Hokke, Cornelis H., Adegnika, Akim A., Field, Matt A., van Dam, Govert, Corstjens, Paul L. A. M., Mduluza, Takafira, Mutapi, Francisca, Oeuvray, Claude, Greco, Beatrice, Chaiyadet, Sujittra, Laha, Thewarach, Cai, Pengfei, McManus, Donald P., Bottazzi, Maria Elena, Felgner, Philip L., Sotillo, Javier and Loukas, Alex (2021). Immunomics-guided discovery of serum and urine antibodies for diagnosing urogenital schistosomiasis: a biomarker identification study. The Lancet Microbe, 2 (11), E617-E626. doi: 10.1016/s2666-5247(21)00150-6

Immunomics-guided discovery of serum and urine antibodies for diagnosing urogenital schistosomiasis: a biomarker identification study

2021

Journal Article

Estimating the global burden of Epstein–Barr virus-related cancers

Wong, Yide, Meehan, Michael T., Burrows, Scott R., Doolan, Denise L. and Miles, John J. (2021). Estimating the global burden of Epstein–Barr virus-related cancers. Journal of Cancer Research and Clinical Oncology, 148 (1), 31-46. doi: 10.1007/s00432-021-03824-y

Estimating the global burden of Epstein–Barr virus-related cancers

2021

Journal Article

Identification of the Glycan binding profile of human and rodent Plasmodium sporozoites

Poole, Jessica, Hartley-Tassell, Lauren E., Day, Christopher J., Stanisic, Danielle, Groves, Penny L., Chakravarty, Sumana, Sim, B. Kim Lee, Hoffman, Stephen L., Tiralongo, Joe, Bovin, Nicolai, Doolan, Denise L. and Jennings, Michael P. (2021). Identification of the Glycan binding profile of human and rodent Plasmodium sporozoites. ACS Infectious Diseases, 7 (8), 2383-2389. doi: 10.1021/acsinfecdis.1c00084

Identification of the Glycan binding profile of human and rodent Plasmodium sporozoites

2021

Journal Article

CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity

Nguyen, Thi H. O., Rowntree, Louise C., Petersen, Jan, Chua, Brendon Y., Hensen, Luca, Kedzierski, Lukasz, van de Sandt, Carolien E., Chaurasia, Priyanka, Tan, Hyon-Xhi, Habel, Jennifer R., Zhang, Wuji, Allen, Lilith F., Earnest, Linda, Mak, Kai Yan, Juno, Jennifer A., Wragg, Kathleen, Mordant, Francesca L., Amanat, Fatima, Krammer, Florian, Mifsud, Nicole A., Doolan, Denise L., Flanagan, Katie L., Sonda, Sabrina, Kaur, Jasveen, Wakim, Linda M., Westall, Glen P., James, Fiona, Mouhtouris, Effie, Gordon, Claire L. ... Kedzierska, Katherine (2021). CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity. Immunity, 54 (5), 1066-1082+. doi: 10.1016/j.immuni.2021.04.009

CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity

2021

Journal Article

Integrated immune dynamics define correlates of COVID-19 severity and antibody responses

Koutsakos, Marios, Rowntree, Louise C., Hensen, Luca, Chua, Brendon Y., van de Sandt, Carolien E., Habel, Jennifer R., Zhang, Wuji, Jia, Xiaoxiao, Kedzierski, Lukasz, Ashhurst, Thomas M., Putri, Givanna H., Marsh-Wakefield, Felix, Read, Mark N., Edwards, Davis N., Clemens, E. Bridie, Wong, Chinn Yi, Mordant, Francesca L., Juno, Jennifer A., Amanat, Fatima, Audsley, Jennifer, Holmes, Natasha E., Gordon, Claire L., Smibert, Olivia C., Trubiano, Jason A., Hughes, Carly M., Catton, Mike, Denholm, Justin T., Tong, Steven Y. C., Doolan, Denise L. ... Kedzierska, Katherine (2021). Integrated immune dynamics define correlates of COVID-19 severity and antibody responses. Cell Reports Medicine, 2 (3) 100208, 1-21. doi: 10.1016/j.xcrm.2021.100208

Integrated immune dynamics define correlates of COVID-19 severity and antibody responses

2021

Journal Article

Robust correlations across six SARS-CoV-2 serology assays detecting distinct antibody features

Rowntree, Louise C., Chua, Brendon Y., Nicholson, Suellen, Koutsakos, Marios, Hensen, Luca, Douros, Celia, Selva, Kevin, Mordant, Francesca L., Wong, Chinn Yi, Habel, Jennifer R., Zhang, Wuji, Jia, Xiaoxiao, Allen, Lily, Doolan, Denise L., Jackson, David C., Wheatley, Adam K., Kent, Stephen J., Amanat, Fatima, Krammer, Florian, Subbarao, Kanta, Cheng, Allen C., Chung, Amy W., Catton, Mike, Nguyen, Thi H. O., van de Sandt, Carolien E. and Kedzierska, Katherine (2021). Robust correlations across six SARS-CoV-2 serology assays detecting distinct antibody features. Clinical and Translational Immunology, 10 (3) e1258, 1-18. doi: 10.1002/cti2.1258

Robust correlations across six SARS-CoV-2 serology assays detecting distinct antibody features

2021

Journal Article

A dual-antigen enzyme-linked immunosorbent assay allows the assessment of severe acute respiratory syndrome coronavirus 2 antibody seroprevalence in a low-transmission setting

Hicks, Sarah M., Pohl, Kai, Neeman, Teresa, McNamara, Hayley A., Parsons, Kate M., He, Jin-shu, Ali, Sidra A., Nazir, Samina, Rowntree, Louise C., Nguyen, Thi H. O., Kedzierska, Katherine, Doolan, Denise L., Vinuesa, Carola G., Cook, Matthew C., Coatsworth, Nicholas, Myles, Paul S., Kurth, Florian, Sander, Leif E., Mann, Graham J., Gruen, Russell L., George, Amee J., Gardiner, Elizabeth E. and Cockburn, Ian A. (2021). A dual-antigen enzyme-linked immunosorbent assay allows the assessment of severe acute respiratory syndrome coronavirus 2 antibody seroprevalence in a low-transmission setting. Journal of Infectious Diseases, 223 (1), 10-14. doi: 10.1093/infdis/jiaa623

A dual-antigen enzyme-linked immunosorbent assay allows the assessment of severe acute respiratory syndrome coronavirus 2 antibody seroprevalence in a low-transmission setting

2021

Journal Article

Memory CD8+ T cell compartment associated with delayed onset of Plasmodium falciparum infection and better parasite control in sickle-cell trait children

Loiseau, Claire, Traore, Boubacar, Ongoiba, Aissata, Kayentao, Kassoum, Doumbo, Safiatou, Doumtabe, Didier, de Sousa, Karina P., Brady, Jamie L., Proietti, Carla, Crompton, Peter D. and Doolan, Denise L. (2021). Memory CD8+ T cell compartment associated with delayed onset of Plasmodium falciparum infection and better parasite control in sickle-cell trait children. Clinical and Translational Immunology, 10 (3) e1265, 1-12. doi: 10.1002/cti2.1265

Memory CD8+ T cell compartment associated with delayed onset of Plasmodium falciparum infection and better parasite control in sickle-cell trait children

2020

Journal Article

Chimeric Virus-Like Particles and Capsomeres Induce Similar CD8+ T Cell Responses but Differ in Capacity to Induce CD4+ T Cell Responses and Antibody Responses

Pattinson, David J., Apte, Simon H., Wibowo, Nani, Rivera-Hernandez, Tania, Groves, Penny L., Middelberg, Anton P. J. and Doolan, Denise L. (2020). Chimeric Virus-Like Particles and Capsomeres Induce Similar CD8+ T Cell Responses but Differ in Capacity to Induce CD4+ T Cell Responses and Antibody Responses. Frontiers in Immunology, 11 564627, 1-13. doi: 10.3389/fimmu.2020.564627

Chimeric Virus-Like Particles and Capsomeres Induce Similar CD8+ T Cell Responses but Differ in Capacity to Induce CD4+ T Cell Responses and Antibody Responses

2020

Journal Article

Suboptimal SARS-CoV-2-specific CD8+ T cell response associated with the prominent HLA-A*02:01 phenotype

Habel, Jennifer R., Nguyen, Thi H. O., van de Sandt, Carolien E., Juno, Jennifer A., Chaurasia, Priyanka, Wragg, Kathleen, Koutsakos, Marios, Hensen, Luca, Jia, Xiaoxiao, Chua, Brendon, Zhang, Wuji, Tan, Hyon-Xhi, Flanagan, Katie L., Doolan, Denise L., Torresi, Joseph, Chen, Weisan, Wakim, Linda M., Cheng, Allen C., Doherty, Peter C., Petersen, Jan, Rossjohn, Jamie, Wheatley, Adam K., Kent, Stephen J., Rowntree, Louise C. and Kedzierska, Katherine (2020). Suboptimal SARS-CoV-2-specific CD8+ T cell response associated with the prominent HLA-A*02:01 phenotype. Proceedings of the National Academy of Sciences of the United States of America, 117 (39), 24384-24391. doi: 10.1073/pnas.2015486117

Suboptimal SARS-CoV-2-specific CD8+ T cell response associated with the prominent HLA-A*02:01 phenotype

2020

Journal Article

Evaluation of the antibody response to the EBV proteome in EBV-associated classical Hodgkin lymphoma

Liu, Zhiwei, Jarrett, Ruth F, Hjalgrim, Henrik, Proietti, Carla, Chang, Ellen T., Smedby, Karin E., Yu, Kelly J., Lake, Annette, Troy, Sally, McAulay, Karen A., Pfeiffer, Ruth M., Adami, Hans-Olov, Glimelius, Bengt, Melbye, Mads, Hildesheim, Allan, Doolan, Denise L. and Coghill, Anna E. (2020). Evaluation of the antibody response to the EBV proteome in EBV-associated classical Hodgkin lymphoma. International Journal of Cancer, 147 (3), 608-618. doi: 10.1002/ijc.32741

Evaluation of the antibody response to the EBV proteome in EBV-associated classical Hodgkin lymphoma

2020

Journal Article

Uptake of Schistosoma mansoni extracellular vesicles by human endothelial and monocytic cell lines and impact on vascular endothelial cell gene expression

Kifle, Desalegn Woldeyohannes, Chaiyadet, Sujittra, Waardenberg, Ashley J., Wise, Ingrid, Cooper, Martha, Becker, Luke, Doolan, Denise L., Laha, Thewarach, Sotillo, Javier, Pearson, Mark S. and Loukas, Alex (2020). Uptake of Schistosoma mansoni extracellular vesicles by human endothelial and monocytic cell lines and impact on vascular endothelial cell gene expression. International Journal for Parasitology, 50 (9), 685-696. doi: 10.1016/j.ijpara.2020.05.005

Uptake of Schistosoma mansoni extracellular vesicles by human endothelial and monocytic cell lines and impact on vascular endothelial cell gene expression

2020

Journal Article

Erratum: Correction: Identification of a Novel, EBV-based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan (Clinical cancer research : an official journal of the American Association for Cancer Research (2018) 24 6 (1305-1314))

Coghill, Anna E., Pfeiffer, Ruth M., Proietti, Carla, Hsu, Wan-Lun, Chien, Yin-Chu, Lekieffre, Lea, Krause, Lutz, Teng, Andy, Pablo, Jocelyn, Yu, Kelly J., Lou, Pei-Jen, Wang, Cheng-Ping, Liu, Zhiwei, Chen, Chien-Jen, Middeldorp, Jaap, Mulvenna, Jason, Bethony, Jeff, Hildesheim, Allan and Doolan, Denise L. (2020). Erratum: Correction: Identification of a Novel, EBV-based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan (Clinical cancer research : an official journal of the American Association for Cancer Research (2018) 24 6 (1305-1314)). Clinical Cancer Research, 26 (13), 3496-3496. doi: 10.1158/1078-0432.CCR-20-1828

Erratum: Correction: Identification of a Novel, EBV-based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan (Clinical cancer research : an official journal of the American Association for Cancer Research (2018) 24 6 (1305-1314))

2020

Journal Article

Validation of an Epstein-Barr virus antibody risk stratification signature for nasopharyngeal carcinoma by use of multiplex serology

Simon, Julia, Liu, Zhiwei, Brenner, Nicole, Yu, Kelly J., Hsu, Wan-Lun, Wang, Cheng-Ping, Chien, Yin-Chu, Coghill, Anna E., Chen, Chien-Jen, Butt, Julia, Proietti, Carla, Doolan, Denise L., Hildesheim, Allan and Waterboer, Tim (2020). Validation of an Epstein-Barr virus antibody risk stratification signature for nasopharyngeal carcinoma by use of multiplex serology. Journal of Clinical Microbiology, 58 (5) e00077-20, 1-9. doi: 10.1128/JCM.00077-20

Validation of an Epstein-Barr virus antibody risk stratification signature for nasopharyngeal carcinoma by use of multiplex serology

Funding

Current funding

  • 2026 - 2030
    Next-generation therapeutics for malaria designed using systems-based approaches
    NHMRC Investigator Grants
    Open grant
  • 2025 - 2026
    An mRNA T-cell Vaccine Against Malaria
    UQ - Sanofi Translational Science Hub Partnership Scheme
    Open grant
  • 2025 - 2026
    A Facility for Accelerated Microbial Phenotyping in Southeast Queensland
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2024 - 2026
    Development of a multi-antigen T-cell malaria vaccine (NFMRI grant administered by James Cook University)
    James Cook University
    Open grant
  • 2024 - 2026
    Effective Multiple Sclerosis diagnosis based on EBV proteome screening
    MS Research Australia Project Grant
    Open grant
  • 2023 - 2026
    Human-informed data-driven development of next-generation T cell vaccine against malaria
    United States National Institutes of Health
    Open grant

Past funding

  • 2013 - 2017
    Tropical disease - immunity, pathogenesis and vaccine development: global translation (NHMRC Program Grant administered by Griffith University)
    Griffith University
    Open grant
  • 2012 - 2014
    ResTeach Funding 2012 0.1 FTE School of Medicine/School of Chemisty and Molecular Biosciences
    UQ ResTeach
    Open grant

Supervision

Availability

Professor Denise Doolan is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Understanding the link between EBV and Multiple Sclerosis

    Principal Advisor

  • Doctor Philosophy

    Systems immunology and multi-omics approaches to understand protective immunity to human malaria

    Principal Advisor

    Other advisors: Dr Quan Nguyen

  • Doctor Philosophy

    Utilising high throughout spatial Transcriptomics to personlise treatment approaches for endometriosis patients

    Associate Advisor

    Other advisors: Dr Quan Nguyen, Associate Professor Akwasi Amoako, Dr Brett McKinnon

Completed supervision

Media

Enquiries

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