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2020

Journal Article

Open label long term treatment of add-on triheptanoin in adults with drug-resistant epilepsy

Borges, Karin, Kaul, Neha, Germaine, Jack, Carrasco-Pozo, Catalina, Kwan, Patrick and O'Brien, Terence J. (2020). Open label long term treatment of add-on triheptanoin in adults with drug-resistant epilepsy. Epilepsia Open, 5 (2), 230-239. doi: 10.1002/epi4.12391

Open label long term treatment of add-on triheptanoin in adults with drug-resistant epilepsy

2020

Journal Article

Combined diffusion tensor imaging and quantitative susceptibility mapping discern discrete facets of white matter pathology post-injury in the rodent brain

Soni, Neha, Vegh, Viktor, To, Xuan Vinh, Mohamed, Abdalla Z., Borges, Karin and Nasrallah, Fatima A. (2020). Combined diffusion tensor imaging and quantitative susceptibility mapping discern discrete facets of white matter pathology post-injury in the rodent brain. Frontiers in Neurology, 11 153, 1-16. doi: 10.3389/fneur.2020.00153

Combined diffusion tensor imaging and quantitative susceptibility mapping discern discrete facets of white matter pathology post-injury in the rodent brain

2020

Journal Article

Prenatal betamethasone exposure increases corticotropin-releasing hormone expression along with increased hippocampal slice excitability in the developing hippocampus

Benson, Melissa J., Lauková, Marcela, Borges, Karin, Velíšková, Jana and Velíšek, Libor (2020). Prenatal betamethasone exposure increases corticotropin-releasing hormone expression along with increased hippocampal slice excitability in the developing hippocampus. Epilepsy Research, 160 106276, 106276. doi: 10.1016/j.eplepsyres.2020.106276

Prenatal betamethasone exposure increases corticotropin-releasing hormone expression along with increased hippocampal slice excitability in the developing hippocampus

2019

Journal Article

Diffusion magnetic resonance imaging unveils the spatiotemporal microstructural gray matter changes following injury in the rodent brain

Soni, Neha, Mohamed, Abdalla Z., Kurniawan, Nyoman D., Borges, Karin and Nasrallah, Fatima (2019). Diffusion magnetic resonance imaging unveils the spatiotemporal microstructural gray matter changes following injury in the rodent brain. Journal of Neurotrauma, 36 (8), 1306-1317. doi: 10.1089/neu.2018.5972

Diffusion magnetic resonance imaging unveils the spatiotemporal microstructural gray matter changes following injury in the rodent brain

2019

Journal Article

Triheptanoin alters [U- 13 C 6 ]-glucose incorporation into glycolytic intermediates and increases TCA cycling by normalizing the activities of pyruvate dehydrogenase and oxoglutarate dehydrogenase in a chronic epilepsy mouse model

McDonald, Tanya, Hodson, Mark P., Bederman, Ilya, Puchowicz, Michelle and Borges, Karin (2019). Triheptanoin alters [U- 13 C 6 ]-glucose incorporation into glycolytic intermediates and increases TCA cycling by normalizing the activities of pyruvate dehydrogenase and oxoglutarate dehydrogenase in a chronic epilepsy mouse model. Journal of Cerebral Blood Flow and Metabolism, 40 (3), 271678X19837380-691. doi: 10.1177/0271678X19837380

Triheptanoin alters [U- 13 C 6 ]-glucose incorporation into glycolytic intermediates and increases TCA cycling by normalizing the activities of pyruvate dehydrogenase and oxoglutarate dehydrogenase in a chronic epilepsy mouse model

2019

Journal Article

Randomized trial of add-on triheptanoin vs medium chain triglycerides in adults with refractory epilepsy

Borges, Karin, Kaul, Neha, Germaine, Jack, Kwan, Patrick and O'Brien, Terence J. (2019). Randomized trial of add-on triheptanoin vs medium chain triglycerides in adults with refractory epilepsy. Epilepsia Open, 4 (1), 153-163. doi: 10.1002/epi4.12308

Randomized trial of add-on triheptanoin vs medium chain triglycerides in adults with refractory epilepsy

2019

Journal Article

Impaired pentose phosphate pathway in the spinal cord of the hSOD1G93A mouse model of amyotrophic lateral sclerosis

Tefera, Tesfaye Wolde, Bartlett, Katherine, Tran, Shirley S., Hodson, Mark P. and Borges, Karin (2019). Impaired pentose phosphate pathway in the spinal cord of the hSOD1G93A mouse model of amyotrophic lateral sclerosis. Molecular Neurobiology, 56 (8), 5844-5855. doi: 10.1007/s12035-019-1485-6

Impaired pentose phosphate pathway in the spinal cord of the hSOD1G93A mouse model of amyotrophic lateral sclerosis

2018

Journal Article

A companion to the preclinical common data elements for physiologic data in rodent epilepsy models. A report of the TASK3 Physiology Working Group of the ILAE/AES Joint Translational Task Force

Gorter, Jan A., van Vliet, Erwin A., Dedeurwaerdere, Stefanie, Buchanan, Gordon F., Friedman, Daniel, Borges, Karin, Grabenstatter, Heidi, Lukasiuk, Katarzyna, Scharfman, Helen E. and Nehlig, Astrid (2018). A companion to the preclinical common data elements for physiologic data in rodent epilepsy models. A report of the TASK3 Physiology Working Group of the ILAE/AES Joint Translational Task Force. Epilepsia Open, 3 (S1), 69-89. doi: 10.1002/epi4.12261

A companion to the preclinical common data elements for physiologic data in rodent epilepsy models. A report of the TASK3 Physiology Working Group of the ILAE/AES Joint Translational Task Force

2018

Journal Article

The effect of dichloroacetate in mouse models of epilepsy

Durie, Dylan, McDonald, Tanya S. and Borges, Karin (2018). The effect of dichloroacetate in mouse models of epilepsy. Epilepsy Research, 145, 77-81. doi: 10.1016/j.eplepsyres.2018.06.004

The effect of dichloroacetate in mouse models of epilepsy

2018

Journal Article

Impairments in oxidative glucose metabolism in epilepsy and metabolic treatments thereof

McDonald, Tanya, Puchowicz, Michelle and Borges, Karin (2018). Impairments in oxidative glucose metabolism in epilepsy and metabolic treatments thereof. Frontiers in Cellular Neuroscience, 12 274, 274. doi: 10.3389/fncel.2018.00274

Impairments in oxidative glucose metabolism in epilepsy and metabolic treatments thereof

2018

Journal Article

A pilot study of add-on oral triheptanoin treatment for children with medically refractory epilepsy

Calvert, Sophie, Barwick, Katie, Par, Melody, Ni Tan, Kah and Borges, Karin (2018). A pilot study of add-on oral triheptanoin treatment for children with medically refractory epilepsy. European Journal of Paediatric Neurology, 22 (6), 1074-1080. doi: 10.1016/j.ejpn.2018.07.014

A pilot study of add-on oral triheptanoin treatment for children with medically refractory epilepsy

2018

Journal Article

Heptanoate is neuroprotective in vitro but triheptanoin post-treatment did not protect against middle cerebral artery occlusion in rats

Tan, Kah Ni, Hood, Rebecca, Warren, Kirby, Pepperall, Debbie, Carrasco-Pozo, Catalina, Manzanero, Silvia, Borges, Karin and Spratt, Neil J. (2018). Heptanoate is neuroprotective in vitro but triheptanoin post-treatment did not protect against middle cerebral artery occlusion in rats. Neuroscience Letters, 683, 207-214. doi: 10.1016/j.neulet.2018.07.045

Heptanoate is neuroprotective in vitro but triheptanoin post-treatment did not protect against middle cerebral artery occlusion in rats

2018

Journal Article

Correction: Alterations in Cytosolic and Mitochondrial [U-13C]Glucose Metabolism in a Chronic Epilepsy Mouse Model (vol 4, e0341-16.2017, 2017)

McDonald, Tanya S., Carrasco-Pozo, Catalina, Hodson, Mark P. and Borges, Karin (2018). Correction: Alterations in Cytosolic and Mitochondrial [U-13C]Glucose Metabolism in a Chronic Epilepsy Mouse Model (vol 4, e0341-16.2017, 2017). eNeuro, 5 (2). doi: 10.1523/ENEURO.0154-18.2018

Correction: Alterations in Cytosolic and Mitochondrial [U-13C]Glucose Metabolism in a Chronic Epilepsy Mouse Model (vol 4, e0341-16.2017, 2017)

2018

Journal Article

ACTH and PMX53 recover synaptic transcriptome alterations in a rat model of infantile spasms

Iacobaş, Dumitru A., Chachua, Tamar, Iacobaş, Sanda, Benson, Melissa J., Borges, Karin, Velíšková, Jana and Velíšek, Libor (2018). ACTH and PMX53 recover synaptic transcriptome alterations in a rat model of infantile spasms. Scientific Reports, 8 (5722) 5722, 5722. doi: 10.1038/s41598-018-24013-x

ACTH and PMX53 recover synaptic transcriptome alterations in a rat model of infantile spasms

2018

Journal Article

Neuronal glucose metabolism is impaired while astrocytic TCA cycling is unaffected at symptomatic stages in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

Tefera, Tesfaye W. and Borges, Karin (2018). Neuronal glucose metabolism is impaired while astrocytic TCA cycling is unaffected at symptomatic stages in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. Journal of Cerebral Blood Flow and Metabolism, 39 (9), 271678X18764775-1724. doi: 10.1177/0271678X18764775

Neuronal glucose metabolism is impaired while astrocytic TCA cycling is unaffected at symptomatic stages in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

2018

Journal Article

Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration

Tan, Kah Ni, Simmons, David, Carrasco-Pozo, Catalina and Borges, Karin (2018). Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration. Journal of Neurochemistry, 144 (4), 431-442. doi: 10.1111/jnc.14275

Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration

2017

Journal Article

Impaired hippocampal glucose metabolism during and after flurothyl-induced seizures in mice: Reduced phosphorylation coincides with reduced activity of pyruvate dehydrogenase

McDonald, Tanya S. and Borges, Karin (2017). Impaired hippocampal glucose metabolism during and after flurothyl-induced seizures in mice: Reduced phosphorylation coincides with reduced activity of pyruvate dehydrogenase. Epilepsia, 58 (7), 1172-1180. doi: 10.1111/epi.13796

Impaired hippocampal glucose metabolism during and after flurothyl-induced seizures in mice: Reduced phosphorylation coincides with reduced activity of pyruvate dehydrogenase

2017

Journal Article

Sulforaphane protects against high cholesterol-induced mitochondrial bioenergetics impairments, inflammation, and oxidative stress and preserves pancreatic β-cells function

Carrasco-Pozo, Catalina, Tan, Kah Ni, Gotteland, Martin and Borges, Karin (2017). Sulforaphane protects against high cholesterol-induced mitochondrial bioenergetics impairments, inflammation, and oxidative stress and preserves pancreatic β-cells function. Oxidative Medicine and Cellular Longevity, 2017 (1) 3839756, 3839756-14. doi: 10.1155/2017/3839756

Sulforaphane protects against high cholesterol-induced mitochondrial bioenergetics impairments, inflammation, and oxidative stress and preserves pancreatic β-cells function

2017

Journal Article

The effects of C5aR1 on leukocyte infiltration following pilocarpine-induced status epilepticus

Benson, Melissa J., Manzanero, Silvia and Borges, Karin (2017). The effects of C5aR1 on leukocyte infiltration following pilocarpine-induced status epilepticus. Epilepsia, 58 (4), e54-e58. doi: 10.1111/epi.13698

The effects of C5aR1 on leukocyte infiltration following pilocarpine-induced status epilepticus

2017

Journal Article

Alterations in cytosolic and mitochondrial [U-13C] glucose metabolism in a chronic epilepsy mouse model

McDonald, Tanya S., Carrasco-Pozo, Catalina, Hodson, Mark P. and Borges, Karin (2017). Alterations in cytosolic and mitochondrial [U-13C] glucose metabolism in a chronic epilepsy mouse model. eNeuro, 4 (1) e0341-16.2017, ENEURO.0341-16.2017. doi: 10.1523/ENEURO.0341-16.2017

Alterations in cytosolic and mitochondrial [U-13C] glucose metabolism in a chronic epilepsy mouse model