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2020 Journal Article Open label long term treatment of add-on triheptanoin in adults with drug-resistant epilepsyBorges, Karin, Kaul, Neha, Germaine, Jack, Carrasco-Pozo, Catalina, Kwan, Patrick and O'Brien, Terence J. (2020). Open label long term treatment of add-on triheptanoin in adults with drug-resistant epilepsy. Epilepsia Open, 5 (2), 230-239. doi: 10.1002/epi4.12391 |
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2020 Journal Article Combined diffusion tensor imaging and quantitative susceptibility mapping discern discrete facets of white matter pathology post-injury in the rodent brainSoni, Neha, Vegh, Viktor, To, Xuan Vinh, Mohamed, Abdalla Z., Borges, Karin and Nasrallah, Fatima A. (2020). Combined diffusion tensor imaging and quantitative susceptibility mapping discern discrete facets of white matter pathology post-injury in the rodent brain. Frontiers in Neurology, 11 153, 1-16. doi: 10.3389/fneur.2020.00153 |
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2020 Journal Article Prenatal betamethasone exposure increases corticotropin-releasing hormone expression along with increased hippocampal slice excitability in the developing hippocampusBenson, Melissa J., Lauková, Marcela, Borges, Karin, Velíšková, Jana and Velíšek, Libor (2020). Prenatal betamethasone exposure increases corticotropin-releasing hormone expression along with increased hippocampal slice excitability in the developing hippocampus. Epilepsy Research, 160 106276, 106276. doi: 10.1016/j.eplepsyres.2020.106276 |
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2019 Journal Article Diffusion magnetic resonance imaging unveils the spatiotemporal microstructural gray matter changes following injury in the rodent brainSoni, Neha, Mohamed, Abdalla Z., Kurniawan, Nyoman D., Borges, Karin and Nasrallah, Fatima (2019). Diffusion magnetic resonance imaging unveils the spatiotemporal microstructural gray matter changes following injury in the rodent brain. Journal of Neurotrauma, 36 (8), 1306-1317. doi: 10.1089/neu.2018.5972 |
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2019 Journal Article Triheptanoin alters [U- 13 C 6 ]-glucose incorporation into glycolytic intermediates and increases TCA cycling by normalizing the activities of pyruvate dehydrogenase and oxoglutarate dehydrogenase in a chronic epilepsy mouse modelMcDonald, Tanya, Hodson, Mark P., Bederman, Ilya, Puchowicz, Michelle and Borges, Karin (2019). Triheptanoin alters [U- 13 C 6 ]-glucose incorporation into glycolytic intermediates and increases TCA cycling by normalizing the activities of pyruvate dehydrogenase and oxoglutarate dehydrogenase in a chronic epilepsy mouse model. Journal of Cerebral Blood Flow and Metabolism, 40 (3), 271678X19837380-691. doi: 10.1177/0271678X19837380 |
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2019 Journal Article Randomized trial of add-on triheptanoin vs medium chain triglycerides in adults with refractory epilepsyBorges, Karin, Kaul, Neha, Germaine, Jack, Kwan, Patrick and O'Brien, Terence J. (2019). Randomized trial of add-on triheptanoin vs medium chain triglycerides in adults with refractory epilepsy. Epilepsia Open, 4 (1), 153-163. doi: 10.1002/epi4.12308 |
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2019 Journal Article Impaired pentose phosphate pathway in the spinal cord of the hSOD1G93A mouse model of amyotrophic lateral sclerosisTefera, Tesfaye Wolde, Bartlett, Katherine, Tran, Shirley S., Hodson, Mark P. and Borges, Karin (2019). Impaired pentose phosphate pathway in the spinal cord of the hSOD1G93A mouse model of amyotrophic lateral sclerosis. Molecular Neurobiology, 56 (8), 5844-5855. doi: 10.1007/s12035-019-1485-6 |
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2018 Journal Article A companion to the preclinical common data elements for physiologic data in rodent epilepsy models. A report of the TASK3 Physiology Working Group of the ILAE/AES Joint Translational Task ForceGorter, Jan A., van Vliet, Erwin A., Dedeurwaerdere, Stefanie, Buchanan, Gordon F., Friedman, Daniel, Borges, Karin, Grabenstatter, Heidi, Lukasiuk, Katarzyna, Scharfman, Helen E. and Nehlig, Astrid (2018). A companion to the preclinical common data elements for physiologic data in rodent epilepsy models. A report of the TASK3 Physiology Working Group of the ILAE/AES Joint Translational Task Force. Epilepsia Open, 3 (S1), 69-89. doi: 10.1002/epi4.12261 |
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2018 Journal Article The effect of dichloroacetate in mouse models of epilepsyDurie, Dylan, McDonald, Tanya S. and Borges, Karin (2018). The effect of dichloroacetate in mouse models of epilepsy. Epilepsy Research, 145, 77-81. doi: 10.1016/j.eplepsyres.2018.06.004 |
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2018 Journal Article Impairments in oxidative glucose metabolism in epilepsy and metabolic treatments thereofMcDonald, Tanya, Puchowicz, Michelle and Borges, Karin (2018). Impairments in oxidative glucose metabolism in epilepsy and metabolic treatments thereof. Frontiers in Cellular Neuroscience, 12 274, 274. doi: 10.3389/fncel.2018.00274 |
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2018 Journal Article A pilot study of add-on oral triheptanoin treatment for children with medically refractory epilepsyCalvert, Sophie, Barwick, Katie, Par, Melody, Ni Tan, Kah and Borges, Karin (2018). A pilot study of add-on oral triheptanoin treatment for children with medically refractory epilepsy. European Journal of Paediatric Neurology, 22 (6), 1074-1080. doi: 10.1016/j.ejpn.2018.07.014 |
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2018 Journal Article Heptanoate is neuroprotective in vitro but triheptanoin post-treatment did not protect against middle cerebral artery occlusion in ratsTan, Kah Ni, Hood, Rebecca, Warren, Kirby, Pepperall, Debbie, Carrasco-Pozo, Catalina, Manzanero, Silvia, Borges, Karin and Spratt, Neil J. (2018). Heptanoate is neuroprotective in vitro but triheptanoin post-treatment did not protect against middle cerebral artery occlusion in rats. Neuroscience Letters, 683, 207-214. doi: 10.1016/j.neulet.2018.07.045 |
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2018 Journal Article Correction: Alterations in Cytosolic and Mitochondrial [U-13C]Glucose Metabolism in a Chronic Epilepsy Mouse Model (vol 4, e0341-16.2017, 2017)McDonald, Tanya S., Carrasco-Pozo, Catalina, Hodson, Mark P. and Borges, Karin (2018). Correction: Alterations in Cytosolic and Mitochondrial [U-13C]Glucose Metabolism in a Chronic Epilepsy Mouse Model (vol 4, e0341-16.2017, 2017). eNeuro, 5 (2). doi: 10.1523/ENEURO.0154-18.2018 |
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2018 Journal Article ACTH and PMX53 recover synaptic transcriptome alterations in a rat model of infantile spasmsIacobaş, Dumitru A., Chachua, Tamar, Iacobaş, Sanda, Benson, Melissa J., Borges, Karin, Velíšková, Jana and Velíšek, Libor (2018). ACTH and PMX53 recover synaptic transcriptome alterations in a rat model of infantile spasms. Scientific Reports, 8 (5722) 5722, 5722. doi: 10.1038/s41598-018-24013-x |
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2018 Journal Article Neuronal glucose metabolism is impaired while astrocytic TCA cycling is unaffected at symptomatic stages in the hSOD1G93A mouse model of amyotrophic lateral sclerosisTefera, Tesfaye W. and Borges, Karin (2018). Neuronal glucose metabolism is impaired while astrocytic TCA cycling is unaffected at symptomatic stages in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. Journal of Cerebral Blood Flow and Metabolism, 39 (9), 271678X18764775-1724. doi: 10.1177/0271678X18764775 |
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2018 Journal Article Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degenerationTan, Kah Ni, Simmons, David, Carrasco-Pozo, Catalina and Borges, Karin (2018). Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration. Journal of Neurochemistry, 144 (4), 431-442. doi: 10.1111/jnc.14275 |
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2017 Journal Article Impaired hippocampal glucose metabolism during and after flurothyl-induced seizures in mice: Reduced phosphorylation coincides with reduced activity of pyruvate dehydrogenaseMcDonald, Tanya S. and Borges, Karin (2017). Impaired hippocampal glucose metabolism during and after flurothyl-induced seizures in mice: Reduced phosphorylation coincides with reduced activity of pyruvate dehydrogenase. Epilepsia, 58 (7), 1172-1180. doi: 10.1111/epi.13796 |
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2017 Journal Article Sulforaphane protects against high cholesterol-induced mitochondrial bioenergetics impairments, inflammation, and oxidative stress and preserves pancreatic β-cells functionCarrasco-Pozo, Catalina, Tan, Kah Ni, Gotteland, Martin and Borges, Karin (2017). Sulforaphane protects against high cholesterol-induced mitochondrial bioenergetics impairments, inflammation, and oxidative stress and preserves pancreatic β-cells function. Oxidative Medicine and Cellular Longevity, 2017 (1) 3839756, 3839756-14. doi: 10.1155/2017/3839756 |
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2017 Journal Article The effects of C5aR1 on leukocyte infiltration following pilocarpine-induced status epilepticusBenson, Melissa J., Manzanero, Silvia and Borges, Karin (2017). The effects of C5aR1 on leukocyte infiltration following pilocarpine-induced status epilepticus. Epilepsia, 58 (4), e54-e58. doi: 10.1111/epi.13698 |
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2017 Journal Article Alterations in cytosolic and mitochondrial [U-13C] glucose metabolism in a chronic epilepsy mouse modelMcDonald, Tanya S., Carrasco-Pozo, Catalina, Hodson, Mark P. and Borges, Karin (2017). Alterations in cytosolic and mitochondrial [U-13C] glucose metabolism in a chronic epilepsy mouse model. eNeuro, 4 (1) e0341-16.2017, ENEURO.0341-16.2017. doi: 10.1523/ENEURO.0341-16.2017 |
